tetrachlorodecaoxide and Varicose-Ulcer

Local tetrachlorodecaoxygen anion complex (TCDO) had three therapeutic effects in difficult wounds, substantiated on day 14 in a multicentre double-blind randomised clinical trial on 271 inpatients with 0.9% saline as control. Wound cleansing was intensified, the formation of new tissue (granulations, epithelium) was promoted, and, irrespective of the different wound types, wound surfaces decreased more quickly, by a factor of 2.4. A novel quantity (eta) was derived as an indicator of wound healing promotion. eta NaCl (= -0.14) did not differ among different wound diagnoses. eta TCDO values were significantly better in relation to wound diagnosis, to smear (detritus), and to epithelialisation. Local TCDO was well tolerated.

Topics: Administration, Topical; Aged; Biological Dressings; Chlorine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxides; Random Allocation; Regression Analysis; Skin Ulcer; Surgical Wound Infection; Time Factors; Varicose Ulcer; Wound Healing

63 transcutaneous measurements of oxygen pressure and 36 series of infrared thermograms in 9 hypoxic wounds showed that topical administration of tetrachlorine decaoxide (TCDO) results in increased oxygen supply of the wound. This effect is associated with improvement of the skin temperature and decrease of the pathological temperature difference between the wound and the surrounding tissue. TCDO can induce physiological wound healing, since it improves the mechanisms of the immune defence system, wound cleansing, granulation, and epithelialization in slow-healing wounds.

Topics: Adult; Aged; Amputation, Surgical; Blood Gas Monitoring, Transcutaneous; Chlorine; Female; Foot Diseases; Humans; Male; Middle Aged; Oxides; Postoperative Complications; Skin Temperature; Skin Ulcer; Telemetry; Thermography; Varicose Ulcer; Wound Healing