tetracarboxyphenylporphine and Staphylococcal-Infections

Ultrasound (US)-driven sonodynamic therapy (SDT) has demonstrated wide application prospects in the eradication of deep-seated bacterial infections due to its noninvasiveness, site-confined irradiation, and high-tissue-penetrating capability. However, the ineffective accumulation of sonosensitizers at the infection site, the hypoxic microenvironment, as well as rapid depletion of oxygen during SDT greatly hamper the therapeutic efficacy of SDT. Herein, an US-switchable nanozyme system was proposed for the controllable generation of catalytic oxygen and sonosensitizer-mediated reactive oxygen species during ultrasound activation, thereby alleviating the hypoxia-associated barrier and augmenting SDT efficacy. This nanoplatform (Pd@Pt-T790) was easily prepared by bridging enzyme-catalytic Pd@Pt nanoplates with the organic sonosensitizer

Topics: Animals; Anti-Bacterial Agents; Cell Survival; Drug Resistance, Multiple, Bacterial; Male; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Optical Imaging; Organometallic Compounds; Palladium; Particle Size; Platinum; Porphyrins; Reactive Oxygen Species; Staphylococcal Infections; Surface Properties; Ultrasonic Therapy; Ultrasonic Waves