tetracaine has been researched along with Methemoglobinemia in 18 studies
Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.
tetracaine : A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.
Methemoglobinemia: The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Acquired methemoglobinemia is a rare but severe condition associated with oxidizing stressors, most notably medications." | 5.33 | Methemoglobinemia and acute hemolysis after tetracaine lozenge use. ( Azoulay, E; Darmon, M; Lavergne, S; Levy, V, 2006) |
| "A 2-month-old infant developed severe methemoglobinemia following topical pharyngeal application of a common benzocaine containing agent ( Cetacaine )." | 3.67 | Infantile methemoglobinemia induced by a topical anesthetic, Cetacaine. ( Seibert, JJ; Seibert, RW, 1984) |
| "Acquired methemoglobinemia is a rare but severe condition associated with oxidizing stressors, most notably medications." | 1.33 | Methemoglobinemia and acute hemolysis after tetracaine lozenge use. ( Azoulay, E; Darmon, M; Lavergne, S; Levy, V, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (27.78) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 9 (50.00) | 29.6817 |
| 2010's | 2 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guay, J | 1 |
| Mogos, M | 1 |
| Thangathurai, D | 1 |
| Roffey, P | 1 |
| Tay, C | 1 |
| Whited, C | 1 |
| Cohen, SM | 1 |
| Raymond, P | 1 |
| Byrne, MF | 1 |
| Mitchell, RM | 1 |
| Gerke, H | 1 |
| Goller, S | 1 |
| Stiffler, HL | 1 |
| Golioto, M | 1 |
| Branch, MS | 1 |
| Jowell, PS | 1 |
| Baillie, J | 1 |
| Lunenfeld, E | 1 |
| Kane, GC | 1 |
| Paparella, S | 1 |
| Lavergne, S | 1 |
| Darmon, M | 1 |
| Levy, V | 1 |
| Azoulay, E | 1 |
| Basra, SK | 1 |
| Vives, MJ | 1 |
| Reilly, MC | 1 |
| Reiter, MF | 1 |
| Kushins, LG | 1 |
| Seibert, RW | 1 |
| Seibert, JJ | 1 |
| Sandza, JG | 1 |
| Roberts, RW | 1 |
| Shaw, RC | 1 |
| Connors, JP | 1 |
| Olson, ML | 1 |
| McEvoy, GK | 1 |
| Vessely, MB | 1 |
| Zitsch, RP | 1 |
| Khan, NA | 1 |
| Kruse, JA | 1 |
| Gregory, PJ | 1 |
| Matsuda, K | 1 |
| Friedman, PM | 1 |
| Mafong, EA | 1 |
| Friedman, ES | 1 |
| Geronemus, RG | 1 |
| Douglas, WW | 1 |
| Fairbanks, VF | 1 |
| Ferraro, L | 1 |
| Zeichner, S | 1 |
| Greenblott, G | 1 |
| Groeger, JS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Prilocaine Versus Lidocaine[NCT01402869] | 91 participants (Actual) | Interventional | 2011-08-31 | Completed | |||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change in percentage of methemoglobin in blood from baseline level to peak level (NCT01402869)
Timeframe: From administration of local anesthetic or start of restorative procedures to time at which maximum methemoglobin blood level was documented during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 2.73 |
| Lidocaine | 0.78 |
| No Local Anesthetic | 0.76 |
The maximum percentage of methemoglobin in blood (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | percentage of methemoglobin in blood (Mean) |
|---|---|
| Prilocaine | 3.55 |
| Lidocaine | 1.63 |
| No Local Anesthetic | 1.60 |
The length of time between the administration of local anesthetic (Prilocaine and Lidocaine Groups) or start of restorative dental procedures (No local anesthetic Group) and the time at which the maximum methemoglobin blood level is observed. (NCT01402869)
Timeframe: Measured at 10 second intervals during dental treatment for an average of 2 hours
| Intervention | minutes (Mean) |
|---|---|
| Prilocaine | 62.73 |
| Lidocaine | 57.50 |
| No Local Anesthetic | 29.50 |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
4 reviews available for tetracaine and Methemoglobinemia
| Article | Year |
|---|---|
Methemoglobinemia related to local anesthetics: a summary of 242 episodes.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Anemia; Anesthetics, Local; Benzocaine; Chi | 2009 |
Topical anesthetic sprays directly associated with a serious, sometimes fatal adverse drug reaction: methemoglobinemia.
Topics: Administration, Topical; Aerosols; Anesthetics, Local; Benzocaine; Dose-Response Relationship, Drug; | 2005 |
Topical anesthetic-induced methemoglobinemia: a case report and review of the literature.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 1993 |
Methemoglobinemia induced by topical anesthesia: a case report and review.
Topics: 4-Aminobenzoic Acid; Aged; Anesthesia, Local; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 1999 |
14 other studies available for tetracaine and Methemoglobinemia
| Article | Year |
|---|---|
Cetacaine-induced complication during transesophageal echocardiography placement.
Topics: Aged, 80 and over; Benzalkonium Compounds; Benzocaine; Cetrimonium Compounds; Drug Combinations; Ech | 2010 |
Nasal tetracaine spray-induced methemoglobinemia.
Topics: Administration, Intranasal; Aged; Anesthetics, Local; Diagnosis, Differential; Female; Humans; Methe | 2012 |
Bye-bye benzocaine?
Topics: 4-Aminobenzoic Acid; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimonium Compounds; | 2003 |
The need for caution with topical anesthesia during endoscopic procedures, as liberal use may result in methemoglobinemia.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Aged; Anesthetics, Local; Benzalkonium Compounds; Benz | 2004 |
Methemoglobinemia: sudden dyspnea and oxyhemoglobin desaturation after esophagoduodenoscopy.
Topics: 4-Aminobenzoic Acid; Administration, Topical; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 2004 |
Methemoglobinemia and acute hemolysis after tetracaine lozenge use.
Topics: Acute Disease; Administration, Oral; Adult; Anesthetics, Local; Diagnosis, Differential; Hemolysis; | 2006 |
Methemoglobinemia after fiberoptic intubation in a patient with an unstable cervical fracture: a case report.
Topics: 4-Aminobenzoic Acid; Adult; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimonium Comp | 2006 |
Infantile methemoglobinemia induced by a topical anesthetic, Cetacaine.
Topics: 4-Aminobenzoic Acid; Aminobenzoates; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; Cetrimo | 1984 |
Symptomatic methemoglobinemia with a commonly used topical anesthetic, cetacaine.
Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Anesthetics, Local; Benzalkonium Compounds; Benzocaine; | 1980 |
Methemoglobinemia induced by local anesthetics.
Topics: 4-Aminobenzoic Acid; Adult; Aminobenzoates; Anesthetics, Local; Benzocaine; Cyanosis; Humans; Intuba | 1981 |
Cetacaine spray-induced methemoglobinemia after transesophageal echocardiography.
Topics: 4-Aminobenzoic Acid; Aged; Aged, 80 and over; Anesthetics, Local; Benzalkonium Compounds; Benzocaine | 2000 |
Topical anesthetics update: EMLA and beyond.
Topics: Anesthetics, Local; Drug Combinations; Drug Costs; Gels; Humans; Lidocaine; Lidocaine, Prilocaine Dr | 2001 |
Methemoglobinemia induced by a topical anesthetic spray (cetacaine).
Topics: Administration, Topical; Aerosols; Aged; Aminobenzoates; Anesthesia, Local; Benzalkonium Compounds; | 1977 |
Cetacaine-induced acute methemoglobinemia.
Topics: 4-Aminobenzoic Acid; Acute Disease; Aged; Aminobenzoates; Benzalkonium Compounds; Benzocaine; Cetrim | 1988 |