Page last updated: 2024-11-04

tetracaine and Melanoma

tetracaine has been researched along with Melanoma in 3 studies

Tetracaine: A potent local anesthetic of the ester type used for surface and spinal anesthesia.
tetracaine : A benzoate ester in which 4-N-butylbenzoic acid and 2-(dimethylamino)ethanol have combined to form the ester bond; a local ester anaesthetic (ester caine) used for surface and spinal anaesthesia.

Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)

Research Excerpts

ExcerptRelevanceReference
" Specifically, tetracaine has a potent antitumor effect in diverse cancers, including neuroblastoma, breast cancer, and melanoma; however, the underlying molecular mechanisms remain unclear."8.12Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1. ( Chen, Y; Feng, J; Huang, X; Jia, J; Jiang, X; Liao, Y; Yi, J; Yi, P, 2022)
" Specifically, tetracaine has a potent antitumor effect in diverse cancers, including neuroblastoma, breast cancer, and melanoma; however, the underlying molecular mechanisms remain unclear."4.12Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1. ( Chen, Y; Feng, J; Huang, X; Jia, J; Jiang, X; Liao, Y; Yi, J; Yi, P, 2022)
"Tertiary amine local anesthetics, such as dibucaine and tetracaine, have been found to reversibly modify the blood-borne implantation and experimental metastatic properties of B16 melanoma cells in syngeneic C57BL/6 mice."3.67Effects of tertiary amine local anesthetics on the blood-borne implantation and cell surface properties of metastatic mouse melanoma cells. ( Fidler, IJ; Nicolson, GL; Poste, G, 1986)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19901 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's2 (66.67)2.80

Authors

AuthorsStudies
Huang, X1
Chen, Y1
Yi, J1
Yi, P1
Jia, J1
Liao, Y1
Feng, J1
Jiang, X1
Tibensky, M1
Blasko, F1
Vargovic, P1
Jakubikova, J1
Cholujova, D1
Jakubechova, J1
Mravec, B1
Nicolson, GL1
Fidler, IJ1
Poste, G1

Other Studies

3 other studies available for tetracaine and Melanoma

ArticleYear
Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1.
    Toxicology and applied pharmacology, 2022, 01-01, Volume: 434

    Topics: Animals; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Down-Regulati

2022
Topical application of local anesthetics to melanoma increases the efficacy of anti-PD-1 therapy.
    Neoplasma, 2023, Volume: 70, Issue:3

    Topics: Anesthetics, Local; Animals; Lidocaine; Melanoma; Mice; Tetracaine

2023
Effects of tertiary amine local anesthetics on the blood-borne implantation and cell surface properties of metastatic mouse melanoma cells.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:3

    Topics: Anesthetics, Local; Animals; Calcium; Cell Adhesion; Cell Membrane; Cytoskeleton; Female; Glycoprote

1986