terrein and Inflammation

terrein has been researched along with Inflammation* in 2 studies

Other Studies

2 other study(ies) available for terrein and Inflammation

Article	Year
Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells. Journal of pharmacological sciences, 2020, Volume: 143, Issue:3 Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Cyclopentanes; Cytokines; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Lipopolysaccharides; Microglia; NF-E2-Related Factor 2; NF-kappa B; Rats; Signal Transduction	2020
Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells. Cell biochemistry and function, 2015, Volume: 33, Issue:7 This study investigated whether multiple bioactivity of terrein such as anti-inflammatory and anti-oxidant inhibits age-related inflammation by promoting an antioxidant response in aged human diploid fibroblast (HDF) cells. HDF cells were cultured serially for in vitro replicative senescence. To create the ageing cell phenotype, intermediate stage (PD31) HDF cells were brought to stress-induced premature senescence (SIPS) using hydrogen peroxide (H2 O2). Terrein increased cell viability even with H2O2 stress and reduced inflammatory molecules such as intracellular adhesion molecule-1 (ICAM-1), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1β) and tumour necrosis factor-alpha (TNF-α). Terrein reduced also phospho-extracellular kinase receptor1/2 (p-EKR1/2) signalling in aged HDF cells. SIPS cells were attenuated for age-related biological markers including reactive oxygen species (ROS), senescence associated beta-galactosidase (SA β-gal.) and the aforementioned inflammatory molecules. Terrein induced the induction of anti-oxidant molecules, copper/zinc-superoxide defence (Cu/ZnSOD), manganese superoxide dismutase (MnSOD) and heme oxygenase-1 (HO-1) in SIPS cells. Terrein also alleviated reactive oxygen species formation through the Nrf2/HO-1/p-ERK1/2 pathway in aged cells. The results indicate that terrein has an alleviative function of age-related inflammation characterized as an anti-oxidant. Terrein might be a useful nutraceutical compound for anti-ageing. Topics: Aging; Antioxidants; Cell Culture Techniques; Cells, Cultured; Cyclopentanes; Fibroblasts; Humans; Inflammation; MAP Kinase Signaling System; Oxidative Stress	2015

Article

Year

Terrein suppressed lipopolysaccharide-induced neuroinflammation through inhibition of NF-κB pathway by activating Nrf2/HO-1 signaling in BV2 and primary microglial cells.

Journal of pharmacological sciences, 2020, Volume: 143, Issue:3

Topics: Animals; Anti-Inflammatory Agents; Cell Line; Cells, Cultured; Cyclopentanes; Cytokines; Heme Oxygenase-1; Inflammation; Inflammation Mediators; Lipopolysaccharides; Microglia; NF-E2-Related Factor 2; NF-kappa B; Rats; Signal Transduction

2020

Terrein reduces age-related inflammation induced by oxidative stress through Nrf2/ERK1/2/HO-1 signalling in aged HDF cells.

Cell biochemistry and function, 2015, Volume: 33, Issue:7

This study investigated whether multiple bioactivity of terrein such as anti-inflammatory and anti-oxidant inhibits age-related inflammation by promoting an antioxidant response in aged human diploid fibroblast (HDF) cells. HDF cells were cultured serially for in vitro replicative senescence. To create the ageing cell phenotype, intermediate stage (PD31) HDF cells were brought to stress-induced premature senescence (SIPS) using hydrogen peroxide (H2 O2). Terrein increased cell viability even with H2O2 stress and reduced inflammatory molecules such as intracellular adhesion molecule-1 (ICAM-1), cyclooxygenase-2 (COX-2), interleukin-1beta (IL-1β) and tumour necrosis factor-alpha (TNF-α). Terrein reduced also phospho-extracellular kinase receptor1/2 (p-EKR1/2) signalling in aged HDF cells. SIPS cells were attenuated for age-related biological markers including reactive oxygen species (ROS), senescence associated beta-galactosidase (SA β-gal.) and the aforementioned inflammatory molecules. Terrein induced the induction of anti-oxidant molecules, copper/zinc-superoxide defence (Cu/ZnSOD), manganese superoxide dismutase (MnSOD) and heme oxygenase-1 (HO-1) in SIPS cells. Terrein also alleviated reactive oxygen species formation through the Nrf2/HO-1/p-ERK1/2 pathway in aged cells. The results indicate that terrein has an alleviative function of age-related inflammation characterized as an anti-oxidant. Terrein might be a useful nutraceutical compound for anti-ageing.

Topics: Aging; Antioxidants; Cell Culture Techniques; Cells, Cultured; Cyclopentanes; Fibroblasts; Humans; Inflammation; MAP Kinase Signaling System; Oxidative Stress

2015