terpestacin and Hypoxia

terpestacin has been researched along with Hypoxia* in 1 studies

Other Studies

1 other study(ies) available for terpestacin and Hypoxia

ArticleYear
Terpestacin inhibits tumor angiogenesis by targeting UQCRB of mitochondrial complex III and suppressing hypoxia-induced reactive oxygen species production and cellular oxygen sensing.
    The Journal of biological chemistry, 2010, Apr-09, Volume: 285, Issue:15

    Cellular oxygen sensing is required for hypoxia-inducible factor-1alpha stabilization, which is important for tumor cell survival, proliferation, and angiogenesis. Here we find that terpestacin, a small molecule previously identified in a screen of microbial extracts, binds to the 13.4-kDa subunit (UQCRB) of mitochondrial Complex III, resulting in inhibition of hypoxia-induced reactive oxygen species generation. Consequently, such inhibition blocks hypoxia-inducible factor activation and tumor angiogenesis in vivo, without inhibiting mitochondrial respiration. Overexpression of UQCRB or its suppression using RNA interference demonstrates that it plays a crucial role in the oxygen sensing mechanism that regulates responses to hypoxia. These findings provide a novel molecular basis of terpestacin targeting UQCRB of Complex III in selective suppression of tumor progression.

    Topics: Animals; Bridged Bicyclo Compounds; Carrier Proteins; Electron Transport Complex III; Endothelium, Vascular; Female; Hypoxia; Mice; Mice, Inbred C3H; Mitochondria; Neoplasm Transplantation; Neovascularization, Pathologic; Oxygen; Reactive Oxygen Species; Vascular Endothelial Growth Factor A

2010