ternatin-(flavonoid) has been researched along with Reperfusion-Injury* in 1 studies
1 other study(ies) available for ternatin-(flavonoid) and Reperfusion-Injury
Article | Year |
---|---|
Ternatin pretreatment attenuates testicular injury induced by torsion/detorsion in Wistar rats.
To investigate the possible protective role of the bioflavonoid ternatin (TTN) when administered before induction of ischemia/reperfusion injury in rat testis.. Thirty-six Wistar rats were randomly assigned to 3 groups (n=12), divided in 2 subgroups (n=6). Saline 2.0ml (G-1), dimethylsulfoxide (DMSO) 3% solution (G-2) or TTN 12 mg/kg/dose (G-3) was administered ip. to all rats, respectively, 21, 12 and 1 hour before torsion. Anesthetized rats were subjected to ischemia (3 hours) induced by 720ยบ torsion of the spermatic cord. Right testis and arterial blood samples were collected at the end of ischemia (T-0), and 3 hours later (T-3) for assessment of testis malonaldehyde (MDA), reduced glutathione (GSH), and plasma total antioxidant power (TAP).. MDA decreased significantly (p<0,001) in G-2 and G-3 in T-0 and T-3 timepoints. Additional decrease in MDA was seen in G-3 after 3 hours of reperfusion (T-3). GSH increased significantly in G-2 (p<0.001) and G-3 (p<0.05) at the end the ischemia (T-0). A significant increase in GSH was seen 3 hours after testis detorsion (T-3) in G-2 rats. TAP values remained unchanged.. The data provides in vivo evidence of the antiperoxidative and antioxidative properties of TTN in torted rat testis. Topics: Animals; Antioxidants; Flavonoids; Glutathione; Ischemia; Lipid Peroxidation; Male; Oxidative Stress; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Spermatic Cord Torsion; Testis; Time Factors | 2011 |