teriflunomide and Pancreatitis

teriflunomide has been researched along with Pancreatitis* in 1 studies

Other Studies

1 other study(ies) available for teriflunomide and Pancreatitis

ArticleYear
Store-Operated Calcium Entry as a Therapeutic Target in Acute Pancreatitis: Discovery and Development of Drug-Like SOCE Inhibitors.
    Journal of medicinal chemistry, 2020, 12-10, Volume: 63, Issue:23

    Store-operated calcium entry (SOCE) is important in the maintenance of calcium homeostasis and alterations in this mechanism are responsible for several pathological conditions, including acute pancreatitis. Since the discovery of SOCE, many inhibitors have been identified and extensively used as chemical probes to better elucidate the role played by this cellular mechanism. Nevertheless, only a few have demonstrated drug-like properties so far. Here, we report a class of biphenyl triazoles among which stands out a lead compound,

    Topics: Animals; Biphenyl Compounds; Calcium; Calcium Channel Blockers; Cell Line; Dihydroorotate Dehydrogenase; Drug Discovery; Drug Stability; Enzyme Inhibitors; Humans; Male; Mice, Inbred C57BL; Molecular Structure; Oxidoreductases Acting on CH-CH Group Donors; Pancreatitis; Solubility; Structure-Activity Relationship; Triazoles

2020