terfenadine has been researched along with Ventricular Fibrillation in 5 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "For terfenadine, TRIaD predicts drug-induced proarrhythmia: with λ prolongation, Torsade de Pointes is preferred, otherwise ventricular tachycardia/ventricular fibrillation." | 3.77 | Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine. ( De Clerck, F; Dujardin, K; Dumotier, B; Hoffmann, P; Hondeghem, LM, 2011) |
| "Terfenadine has been reported to cause cardiac death." | 1.38 | Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes? ( Gallacher, DJ; Hermans, AN; Lu, HR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hondeghem, LM | 1 |
| Dujardin, K | 1 |
| Hoffmann, P | 1 |
| Dumotier, B | 1 |
| De Clerck, F | 1 |
| Lu, HR | 1 |
| Hermans, AN | 1 |
| Gallacher, DJ | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Pinto, YM | 1 |
| van Gelder, IC | 1 |
| Heeringa, M | 1 |
| Crijns, HJ | 1 |
| Bastecký, J | 1 |
| Kvasnicka, J | 1 |
| Vortel, J | 1 |
| Tauchman, M | 1 |
| Wasylivová, V | 1 |
5 other studies available for terfenadine and Ventricular Fibrillation
| Article | Year |
|---|---|
Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Hi | 2011 |
Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Appendage; Biological Transport; Cells, C | 2012 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
Topics: Aged; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Syncope; Tachyc | 1999 |
[Severe antihistamine poisoning complicated by ventricular tachycardia].
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonists; Humans; T | 1990 |