Page last updated: 2024-11-04

terfenadine and Tachycardia, Ventricular

terfenadine has been researched along with Tachycardia, Ventricular in 10 studies

Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).

Research Excerpts

ExcerptRelevanceReference
"For terfenadine, TRIaD predicts drug-induced proarrhythmia: with λ prolongation, Torsade de Pointes is preferred, otherwise ventricular tachycardia/ventricular fibrillation."3.77Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine. ( De Clerck, F; Dujardin, K; Dumotier, B; Hoffmann, P; Hondeghem, LM, 2011)
"Terfenadine is a second generation histamine receptor antagonist which is widely used as a non‑sedating antihistamine to relieve allergic responses."1.40Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: a potential role of terfenadine. ( Li, S; Liu, B; Su, Y; Xiong, M; Xu, Y, 2014)
"Terfenadine has been reported to cause cardiac death."1.38Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes? ( Gallacher, DJ; Hermans, AN; Lu, HR, 2012)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (60.00)18.2507
2000's1 (10.00)29.6817
2010's3 (30.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, B1
Li, S1
Su, Y1
Xiong, M1
Xu, Y1
Hondeghem, LM1
Dujardin, K1
Hoffmann, P1
Dumotier, B1
De Clerck, F1
Lu, HR1
Hermans, AN1
Gallacher, DJ1
Aiba, T1
Shimizu, W1
Hidaka, I1
Uemura, K1
Noda, T1
Zheng, C1
Kamiya, A1
Inagaki, M1
Sugimachi, M1
Sunagawa, K1
Woosley, R1
Darrow, WR1
Kothari, SS1
Sharma, S1
Wasir, HS1
DuBuske, LM1
de Abajo, FJ1
Rodríguez, LA1
Pinto, YM1
van Gelder, IC1
Heeringa, M1
Crijns, HJ1

Reviews

1 review available for terfenadine and Tachycardia, Ventricular

ArticleYear
Second-generation antihistamines: the risk of ventricular arrhythmias.
    Clinical therapeutics, 1999, Volume: 21, Issue:2

    Topics: Animals; Astemizole; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Heart;

1999

Other Studies

9 other studies available for terfenadine and Tachycardia, Ventricular

ArticleYear
Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: a potential role of terfenadine.
    Molecular medicine reports, 2014, Volume: 10, Issue:6

    Topics: Aconitine; Amiodarone; Animals; Anti-Arrhythmia Agents; Barium Compounds; Chlorides; Electrocardiogr

2014
Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine.
    Journal of cardiovascular pharmacology, 2011, Volume: 57, Issue:5

    Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Hi

2011
Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
    British journal of pharmacology, 2012, Volume: 166, Issue:4

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Appendage; Biological Transport; Cells, C

2012
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
    Journal of the American College of Cardiology, 2006, May-16, Volume: 47, Issue:10

    Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography

2006
Analysis of potential adverse drug reactions--a case of mistaken identity.
    The American journal of cardiology, 1994, Jul-15, Volume: 74, Issue:2

    Topics: Astemizole; Atrial Fibrillation; Drug Interactions; Electrocardiography; Humans; Loratadine; Quinidi

1994
Terfenadine overdose induced polymorphous ventricular tachycardia.
    Indian pediatrics, 1995, Volume: 32, Issue:10

    Topics: Child; Drug Overdose; Heart Septal Defects, Ventricular; Histamine H1 Antagonists; Humans; Male; Pos

1995
FDA announces plan to halt marketing of terfenadine.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1997, Feb-15, Volume: 54, Issue:4

    Topics: Drug and Narcotic Control; Drug Interactions; Histamine H1 Antagonists; Humans; Tachycardia, Ventric

1997
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
    British journal of clinical pharmacology, 1999, Volume: 47, Issue:3

    Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child;

1999
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
    Lancet (London, England), 1999, Mar-20, Volume: 353, Issue:9157

    Topics: Aged; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Syncope; Tachyc

1999