terfenadine has been researched along with Tachycardia, Ventricular in 10 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
| Excerpt | Relevance | Reference |
|---|---|---|
| "For terfenadine, TRIaD predicts drug-induced proarrhythmia: with λ prolongation, Torsade de Pointes is preferred, otherwise ventricular tachycardia/ventricular fibrillation." | 3.77 | Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine. ( De Clerck, F; Dujardin, K; Dumotier, B; Hoffmann, P; Hondeghem, LM, 2011) |
| "Terfenadine is a second generation histamine receptor antagonist which is widely used as a non‑sedating antihistamine to relieve allergic responses." | 1.40 | Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: a potential role of terfenadine. ( Li, S; Liu, B; Su, Y; Xiong, M; Xu, Y, 2014) |
| "Terfenadine has been reported to cause cardiac death." | 1.38 | Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes? ( Gallacher, DJ; Hermans, AN; Lu, HR, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, B | 1 |
| Li, S | 1 |
| Su, Y | 1 |
| Xiong, M | 1 |
| Xu, Y | 1 |
| Hondeghem, LM | 1 |
| Dujardin, K | 1 |
| Hoffmann, P | 1 |
| Dumotier, B | 1 |
| De Clerck, F | 1 |
| Lu, HR | 1 |
| Hermans, AN | 1 |
| Gallacher, DJ | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Woosley, R | 1 |
| Darrow, WR | 1 |
| Kothari, SS | 1 |
| Sharma, S | 1 |
| Wasir, HS | 1 |
| DuBuske, LM | 1 |
| de Abajo, FJ | 1 |
| Rodríguez, LA | 1 |
| Pinto, YM | 1 |
| van Gelder, IC | 1 |
| Heeringa, M | 1 |
| Crijns, HJ | 1 |
1 review available for terfenadine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Second-generation antihistamines: the risk of ventricular arrhythmias.
Topics: Animals; Astemizole; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Heart; | 1999 |
9 other studies available for terfenadine and Tachycardia, Ventricular
| Article | Year |
|---|---|
Comparative study of the protective effects of terfenadine and amiodarone on barium chloride/aconitine-induced ventricular arrhythmias in rats: a potential role of terfenadine.
Topics: Aconitine; Amiodarone; Animals; Anti-Arrhythmia Agents; Barium Compounds; Chlorides; Electrocardiogr | 2014 |
Drug-induced QTC prolongation dangerously underestimates proarrhythmic potential: lessons from terfenadine.
Topics: Action Potentials; Animals; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart; Hi | 2011 |
Does terfenadine-induced ventricular tachycardia/fibrillation directly relate to its QT prolongation and Torsades de Pointes?
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Appendage; Biological Transport; Cells, C | 2012 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Analysis of potential adverse drug reactions--a case of mistaken identity.
Topics: Astemizole; Atrial Fibrillation; Drug Interactions; Electrocardiography; Humans; Loratadine; Quinidi | 1994 |
Terfenadine overdose induced polymorphous ventricular tachycardia.
Topics: Child; Drug Overdose; Heart Septal Defects, Ventricular; Histamine H1 Antagonists; Humans; Male; Pos | 1995 |
FDA announces plan to halt marketing of terfenadine.
Topics: Drug and Narcotic Control; Drug Interactions; Histamine H1 Antagonists; Humans; Tachycardia, Ventric | 1997 |
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; | 1999 |
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
Topics: Aged; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Syncope; Tachyc | 1999 |