terfenadine has been researched along with Syncope in 7 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Syncope: A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 7.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis." | 7.69 | [Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997) |
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 3.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis." | 3.69 | [Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (85.71) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCord, JL | 1 |
| Pellinger, TK | 1 |
| Lynn, BM | 1 |
| Halliwill, JR | 1 |
| Hanrahan, JP | 1 |
| Choo, PW | 1 |
| Carlson, W | 1 |
| Greineder, D | 1 |
| Faich, GA | 1 |
| Platt, R | 1 |
| Crane, JK | 1 |
| Shih, HT | 1 |
| Romkes, JH | 1 |
| Froger, CL | 1 |
| Wever, EF | 1 |
| Westerhof, PW | 1 |
| de Wildt, SN | 1 |
| van den Anker, JN | 1 |
| Lekkerkerker, JF | 1 |
| Broekmans, AW | 1 |
| Pinto, YM | 1 |
| van Gelder, IC | 1 |
| Heeringa, M | 1 |
| Crijns, HJ | 1 |
1 trial available for terfenadine and Syncope
| Article | Year |
|---|---|
Potential benefit from an H1-receptor antagonist on postexercise syncope in the heat.
Topics: Adolescent; Adult; Exercise; Female; Histamine H1 Antagonists, Non-Sedating; Hot Temperature; Humans | 2008 |
6 other studies available for terfenadine and Syncope
| Article | Year |
|---|---|
Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Boston; Cohort Studies; Death, | 1995 |
Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.
Topics: Bradycardia; Drug Interactions; Humans; Itraconazole; Male; Middle Aged; Syncope; Terfenadine | 1993 |
[Syncopes during simultaneous use of terfenadine and itraconazole].
Topics: Adult; Anti-Allergic Agents; Antifungal Agents; Cardiotonic Agents; Female; Humans; Isoproterenol; I | 1997 |
[Syncopes with simultaneous use of terfenadine and itraconazole].
Topics: Anti-Allergic Agents; Antifungal Agents; Drug Interactions; Humans; Itraconazole; Syncope; Terfenadi | 1997 |
[Syncopes with simultaneous use of terfenadine and itraconazole. Drug Monitoring Board].
Topics: Anti-Allergic Agents; Antifungal Agents; Drug Monitoring; Humans; Itraconazole; Syncope; Terfenadine | 1997 |
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
Topics: Aged; Electrocardiography; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Syncope; Tachyc | 1999 |