terfenadine has been researched along with Sensitivity and Specificity in 24 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 7.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 3.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| " However, the effect of long-term use of montelukast, a cystenil leukotriene receptor antagonist, on skin prick test hasn't been full elucidated." | 2.78 | The effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial. ( Aydogan, M; Aydogmus, CY; Bulan, K; Siraneci, R, 2013) |
| "Fexofenadine enantiomers were separated using a mobile phase of 0." | 2.73 | Determination of fexofenadine enantiomers in human plasma with high-performance liquid chromatography. ( Miura, M; Suzuki, T; Tateishi, T; Uno, T, 2007) |
| "Fexofenadine (FEX) has been extensively used for therapeutic benefits after the market withdrawal of terfenadine." | 2.48 | Quantification of fexofenadine in biological matrices: a review of bioanalytical methods. ( Srinivas, NR; Yao, M, 2012) |
| " The validated method was applied to a pharmacokinetic study in human volunteers following oral administration of 60 or 120 mg fexofenadine formulations, successfully." | 1.36 | Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: application to a clinical pharmacokinetic study. ( Fan, H; Guo, D; Lou, S; Qin, Q; Zhu, Y; Zou, J, 2010) |
| "The objective of the current study was to develop a simple, accurate, precise and rapid reversed-phase HPLC method and subsequent validation using ICH suggested approach for the determination of antihistaminic-decongestant pharmaceutical dosage forms containing binary mixtures of pseudoephedrine hydrochloride (PSE) with fexofenadine hydrochloride (FEX) or cetirizine dihydrochloride (CET)." | 1.35 | Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms. ( Karakuş, S; Küçükgüzel, I; Küçükgüzel, SG, 2008) |
| "To support the pharmacokinetic and bioavailability study of a once-daily fexofenadine/pseudoephedrine combination, a high-performance liquid chromatography/positive ion electrospray tandem mass spectrometry (HPLC/ESI-MS/MS) method for the simultaneous quantification of fexofenadine and pseudoephedrine was developed and validated with 500 microL human plasma using mosapride as an internal standard (IS)." | 1.33 | Simultaneous quantification of fexofenadine and pseudoephedrine in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: method development, validation and application to a clinical study. ( Kandikere, VN; Komarneni, P; Maurya, S; Mudigonda, K; Nirogi, RV; Shukla, M, 2006) |
| "Terfenadine metabolites were extracted from basified microsomal incubates into methylene chloride." | 1.31 | Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry. ( Howald, WN; Lawrence, RF; Madani, S; Shen, DD, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (16.67) | 18.2507 |
| 2000's | 11 (45.83) | 29.6817 |
| 2010's | 8 (33.33) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Wu, W | 1 |
| Cheng, R | 1 |
| Jiang, Z | 1 |
| Zhang, L | 1 |
| Huang, X | 1 |
| Cao, X | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Matsukura, S | 1 |
| Izumi-Nakaseko, H | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Sugiyama, A | 1 |
| King-Ahmad, AJ | 1 |
| Kalgutkar, AS | 1 |
| Niosi, M | 1 |
| Eng, H | 1 |
| Holliman, C | 1 |
| Bulan, K | 1 |
| Aydogan, M | 1 |
| Siraneci, R | 1 |
| Aydogmus, CY | 1 |
| Muppavarapu, R | 1 |
| Guttikar, S | 1 |
| Rajappan, M | 1 |
| Kamarajan, K | 1 |
| Mullangi, R | 1 |
| Khaled, E | 1 |
| Guo, D | 1 |
| Zou, J | 1 |
| Zhu, Y | 1 |
| Lou, S | 1 |
| Fan, H | 1 |
| Qin, Q | 1 |
| Flynn, CA | 1 |
| Alnouti, Y | 1 |
| Reed, GA | 1 |
| Eikel, D | 1 |
| Vavrek, M | 1 |
| Smith, S | 1 |
| Bason, C | 1 |
| Yeh, S | 1 |
| Korfmacher, WA | 1 |
| Henion, JD | 1 |
| Yao, M | 1 |
| Srinivas, NR | 1 |
| Lennox, RD | 1 |
| Leahy, MJ | 1 |
| Herniman, JM | 1 |
| Bristow, TW | 1 |
| O'Connor, G | 1 |
| Jarvis, J | 1 |
| Langley, GJ | 1 |
| Leclercq, L | 1 |
| Delatour, C | 1 |
| Hoes, I | 1 |
| Brunelle, F | 1 |
| Labrique, X | 1 |
| Castro-Perez, J | 1 |
| Miura, M | 1 |
| Uno, T | 1 |
| Tateishi, T | 1 |
| Suzuki, T | 1 |
| Nirogi, RV | 1 |
| Kandikere, VN | 1 |
| Shukla, M | 1 |
| Mudigonda, K | 1 |
| Maurya, S | 1 |
| Komarneni, P | 1 |
| Nemes, P | 1 |
| Vertes, A | 1 |
| Karakuş, S | 1 |
| Küçükgüzel, I | 1 |
| Küçükgüzel, SG | 1 |
| Christensen, M | 1 |
| Moelby, L | 1 |
| Svendsen, F | 1 |
| Yang, JM | 1 |
| Goldenberg, S | 1 |
| Gottesman, MM | 1 |
| Hait, WN | 1 |
| Martens, J | 1 |
| Adams, DA | 1 |
| Murray, S | 1 |
| Clifford, CP | 1 |
| Rendell, NB | 1 |
| Davies, DS | 1 |
| Taylor, GW | 1 |
| Madani, S | 1 |
| Howald, WN | 1 |
| Lawrence, RF | 1 |
| Shen, DD | 1 |
| Radhakrishna, T | 1 |
| Om Reddy, G | 1 |
1 review available for terfenadine and Sensitivity and Specificity
| Article | Year |
|---|---|
Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.
Topics: Animals; Chromatography, Liquid; Humans; Reproducibility of Results; Sensitivity and Specificity; Ta | 2012 |
5 trials available for terfenadine and Sensitivity and Specificity
| Article | Year |
|---|---|
The effect of montelukast on wheal reactions in skin prick tests: a double-blind-placebo-controlled randomized trial.
Topics: Acetates; Allergens; Animals; Asthma; Chi-Square Distribution; Child; Cyclopropanes; Dose-Response R | 2013 |
Sensitive LC-MS/MS-ESI method for simultaneous determination of montelukast and fexofenadine in human plasma: application to a bioequivalence study.
Topics: Acetates; Adult; Chromatography, High Pressure Liquid; Cross-Over Studies; Cyclopropanes; Drug Stabi | 2014 |
Validation of the Dermatology Life Quality Index as an outcome measure for urticaria-related quality of life.
Topics: Chronic Disease; Dermatology; Dose-Response Relationship, Drug; Double-Blind Method; Histamine H1 An | 2004 |
Determination of fexofenadine enantiomers in human plasma with high-performance liquid chromatography.
Topics: Acetonitriles; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Histamine H1 Antag | 2007 |
Reliability of skin prick tests during terfenadine treatment in adults with pollen rhinitis. A clinical study.
Topics: Adolescent; Adult; Allergens; Cross-Over Studies; Double-Blind Method; Drug Hypersensitivity; Humans | 1994 |
18 other studies available for terfenadine and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
UPLC-MS/MS method for the simultaneous quantification of pravastatin, fexofenadine, rosuvastatin, and methotrexate in a hepatic uptake model and its application to the possible drug-drug interaction study of triptolide.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Diterpenes; Drug Interactions; Epoxy | 2021 |
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose | 2017 |
A sensitive method for the quantitation of the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in plasma using microfluidics chromatography tandem MS.
Topics: Administration, Intravenous; Animals; Chromatography, Liquid; Glucagon-Like Peptide-1 Receptor; Huma | 2018 |
Spectrophotometric determination of terfenadine in pharmaceutical preparations by charge-transfer reactions.
Topics: Benzoquinones; Ethylenes; Histamine H1 Antagonists, Non-Sedating; Indicators and Reagents; Nitriles; | 2008 |
Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: application to a clinical pharmacokinetic study.
Topics: Adolescent; Adult; Chromatography, Liquid; Female; Fractional Precipitation; Histamine H1 Antagonist | 2010 |
Quantification of the transporter substrate fexofenadine in cell lysates by liquid chromatography/tandem mass spectrometry.
Topics: Cell Extracts; Cetirizine; Chromatography, Liquid; HEK293 Cells; Humans; Least-Squares Analysis; Rep | 2011 |
Liquid extraction surface analysis mass spectrometry (LESA-MS) as a novel profiling tool for drug distribution and metabolism analysis: the terfenadine example.
Topics: Animals; Autoradiography; Histocytochemistry; Histocytological Preparation Techniques; Liquid-Liquid | 2011 |
Improved precision and accuracy for high-performance liquid chromatography/Fourier transform ion cyclotron resonance mass spectrometric exact mass measurement of small molecules from the simultaneous and controlled introduction of internal calibrants via
Topics: Calibration; Chromatography, High Pressure Liquid; Cyclotrons; Gramicidin; Mandelic Acids; Molecular | 2004 |
Use of a five-channel multiplexed electrospray quadrupole time-of-flight hybrid mass spectrometer for metabolite identification.
Topics: Animals; Bile; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; Humans; Ketotifen | 2005 |
Simultaneous quantification of fexofenadine and pseudoephedrine in human plasma by liquid chromatography/tandem mass spectrometry with electrospray ionization: method development, validation and application to a clinical study.
Topics: Blood Chemical Analysis; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Complex Mix | 2006 |
Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry.
Topics: Atmospheric Pressure; Humans; Molecular Weight; Particle Size; Plant Leaves; Plant Roots; Plant Stem | 2007 |
Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms.
Topics: Cetirizine; Chromatography, High Pressure Liquid; Dosage Forms; Histamine H1 Antagonists; Pharmaceut | 2008 |
Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Pro | 1994 |
Determination of the terfenadine metabolite azacyclonol in human serum using gas chromatography-mass spectrometry.
Topics: Anti-Anxiety Agents; Gas Chromatography-Mass Spectrometry; Humans; Piperidines; Sensitivity and Spec | 1996 |
Analysis of terfenadine in human plasma using microbore high-performace liquid chromatography-electrospray ionisation mass spectrometry.
Topics: Anti-Allergic Agents; Anti-Asthmatic Agents; Chromatography, High Pressure Liquid; Histamine H1 Anta | 1997 |
Analysis of hydroxylated and N-dealkylated metabolites of terfenadine in microsomal incubates by liquid chromatography--mass spectrometry.
Topics: Alkylation; Chromatography, Liquid; Histamine H1 Antagonists; Humans; Hydroxylation; Mass Spectromet | 2000 |
Simultaneous determination of fexofenadine and its related compounds by HPLC.
Topics: Capsules; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Histamine H1 Ant | 2002 |