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terfenadine and Rhinitis

terfenadine has been researched along with Rhinitis in 22 studies

Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Rhinitis: Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.

Research Excerpts

ExcerptRelevanceReference
"The role of histamine in the pathogenesis of infectious rhinitis is unclear, as is the efficacy of antihistaminic drugs in the treatment of the common cold."9.06Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms. ( Gaffey, MJ; Hayden, FG; Kaiser, DL, 1988)
"We have assessed the effects of terfenadine on rhinitis symptoms associated with the common cold in 91 patients in a double-blind placebo-controlled study."9.06Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo. ( Glück, U; Henauer, SA, 1988)
"Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells."5.33Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005)
"Nasal instillation of bradykinin elicits many of the characteristic features of rhinitis."5.07The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage. ( Church, MK; Holgate, ST; Howarth, PH; Lau, LC; Polosa, R; Rajakulasingam, K, 1992)
"The role of histamine in the pathogenesis of infectious rhinitis is unclear, as is the efficacy of antihistaminic drugs in the treatment of the common cold."5.06Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms. ( Gaffey, MJ; Hayden, FG; Kaiser, DL, 1988)
"We have assessed the effects of terfenadine on rhinitis symptoms associated with the common cold in 91 patients in a double-blind placebo-controlled study."5.06Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo. ( Glück, U; Henauer, SA, 1988)
"With cetirizine, there was also a reduction in the levels of LTC4 (not measured in terfenadine studies) but not in those of recovered histamine and prostaglandin D2."2.66The effects of H1 antihistamines on the early allergic response. ( Baroody, F; Freidhoff, L; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Norman, PS; Proud, D, 1989)
"Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells."1.33Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005)
"Allergic rhinitis is manifested by watery discharge; however its clinical effect on the watery volume in the oral cavity is unknown."1.33Saliva secretion in patients with allergic rhinitis. ( Elad, S; Heisler, S; Shalit, M, 2006)
" Terfenadine, at concentrations achievable at standard dosing regimens, has anti-inflammatory properties in vitro."1.29Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide. ( Eda, R; Hopp, RJ; Townley, RG, 1994)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19908 (36.36)18.7374
1990's9 (40.91)18.2507
2000's5 (22.73)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Duchateau, J1
Heenen, M1
Sternon, J1
Sakairi, T1
Suzuki, K1
Makita, S1
Wajima, T1
Shakuto, S1
Yoshida, Y1
Yaguchi, M1
Elad, S1
Heisler, S1
Shalit, M1
Backhouse, CI1
Brewster, BS1
Lockhart, JD1
Maneksha, S1
Purvis, CR1
Vallé-Jones, JC1
Melillo, G1
D'Amato, G1
Zanussi, C1
Ortolani, C1
Pastorello, E1
Loy, M1
Di Tucci, A1
Locci, F1
Del Giacco, GS1
Lenzini, L1
Sestini, P1
Rottoli, P1
Eda, R1
Townley, RG1
Hopp, RJ1
Masheter, HC1
Howarth, PH2
Harrison, K1
Smith, S1
Soto, J1
Sacristan, JA1
Alsar, MJ1
Sainz, C1
Wroblewski, BA1
Purohit, A1
Duvernelle, C1
Melac, M1
Pauli, G1
Frossard, N1
Wilson, AM1
Druce, HM1
Spector, SL1
Fireman, P2
Kaiser, H1
Meltzer, EO1
Boggs, P1
Wood, CC1
Paluch, EP1
Rajakulasingam, K1
Polosa, R1
Lau, LC1
Church, MK1
Holgate, ST1
Skoner, DP1
Doyle, WJ1
Boehm, S1
Dijkman, JH1
Hekking, PR1
Molkenboer, JF1
Nierop, G1
Vanderschueren, R1
Bernheim, J1
Van Ganse, EH1
Baroody, F1
Proud, D1
Kagey-Sobotka, A1
Freidhoff, L1
Norman, PS1
Lichtenstein, LM1
Naclerio, RM1
Gaffey, MJ1
Kaiser, DL1
Hayden, FG1
Henauer, SA1
Glück, U1

Reviews

3 reviews available for terfenadine and Rhinitis

ArticleYear
[H1 histamine antagonists].
    Revue medicale de Bruxelles, 2003, Volume: 24, Issue:2

    Topics: Acetates; Anti-Allergic Agents; Cetirizine; Chemistry, Pharmaceutical; Histamine H1 Antagonists; Hum

2003
Terfenadine. The first nonsedating antihistamine.
    Clinical reviews in allergy, 1993,Spring, Volume: 11, Issue:1

    Topics: Adult; Asthma; Child; Drug Interactions; Electroencephalography; Humans; Rhinitis; Skin Tests; Terfe

1993
Are antihistamines useful in managing asthma?
    Current opinion in allergy and clinical immunology, 2002, Volume: 2, Issue:1

    Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropa

2002

Trials

12 trials available for terfenadine and Rhinitis

ArticleYear
Terfenadine in allergic rhinitis. A comparative trial of a new antihistamine versus chlorpheniramine and placebo.
    The Practitioner, 1982, Volume: 226, Issue:1364

    Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Chlorpheniramine; Clinical Trials as Topic; Do

1982
A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a

    Topics: Adolescent; Adult; Aging; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-B

1982
The influence of terfenadine and pseudo-ephedrine alone and in combination on allergen-induced rhinitis.
    International archives of allergy and immunology, 1993, Volume: 101, Issue:3

    Topics: Adult; Allergens; Double-Blind Method; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Ag

1993
Twenty-four hours of activity of cetirizine and fexofenadine in the skin.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 86, Issue:4

    Topics: Adolescent; Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Double-

2001
Double-blind study of intranasal ipratropium bromide in nonallergic perennial rhinitis.
    Annals of allergy, 1992, Volume: 69, Issue:1

    Topics: Administration, Intranasal; Adolescent; Adult; Aged; Double-Blind Method; Evaluation Studies as Topi

1992
The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1992, Volume: 22, Issue:7

    Topics: Adult; Airway Resistance; Blood Proteins; Bradykinin; Double-Blind Method; Drug Therapy, Combination

1992
Effect of terfenadine on nasal, eustachian tube, and pulmonary function after provocative intranasal histamine challenge.
    Annals of allergy, 1991, Volume: 67, Issue:6

    Topics: Administration, Intranasal; Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Bl

1991
Prophylactic treatment of grass pollen-induced asthma with cetirizine.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1990, Volume: 20, Issue:5

    Topics: Adolescent; Adult; Aged; Asthma; Benzhydryl Compounds; Cetirizine; Child; Double-Blind Method; Femal

1990
The effects of H1 antihistamines on the early allergic response.
    Annals of allergy, 1989, Volume: 63, Issue:6 Pt 2

    Topics: Benzhydryl Compounds; Calcium Channels; Cetirizine; Dopamine; Histamine H1 Antagonists; Humans; Hydr

1989
Terfenadine--a non-sedating antihistamine.
    The Medical letter on drugs and therapeutics, 1985, Aug-02, Volume: 27, Issue:693

    Topics: Adult; Benzhydryl Compounds; Child; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hypn

1985
Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms.
    The Pediatric infectious disease journal, 1988, Volume: 7, Issue:3

    Topics: Adult; Benzhydryl Compounds; Common Cold; Female; Histamine; Histamine H1 Antagonists; Humans; Male;

1988
Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo.
    European journal of clinical pharmacology, 1988, Volume: 34, Issue:1

    Topics: Adult; Benzhydryl Compounds; Clinical Trials as Topic; Common Cold; Consumer Behavior; Double-Blind

1988

Other Studies

7 other studies available for terfenadine and Rhinitis

ArticleYear
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
    Pharmacology, 2005, Volume: 75, Issue:2

    Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Anim

2005
Saliva secretion in patients with allergic rhinitis.
    International archives of allergy and immunology, 2006, Volume: 141, Issue:3

    Topics: Adolescent; Adult; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Patient

2006
Non-sedative antihistamines: terfenadine and astemizole.
    Drug and therapeutics bulletin, 1984, Mar-23, Volume: 22, Issue:6

    Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Brain; Histamine H1 Antagonists; Humans; Rhinitis;

1984
Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.
    Annals of allergy, 1994, Volume: 73, Issue:2

    Topics: Adult; Asthma; Calcimycin; Cell Degranulation; Cell Separation; Chemotaxis, Leukocyte; Dose-Response

1994
Terfenadine-induced tremor.
    Annals of neurology, 1993, Volume: 33, Issue:2

    Topics: Adolescent; Adult; Female; Humans; Hypersensitivity; Male; Rhinitis; Terfenadine; Tremor

1993
Antihistamines.
    The Journal of head trauma rehabilitation, 1998, Volume: 13, Issue:1

    Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis; Terfenadine

1998
Terfenadine approved for allergic rhinitis.
    FDA drug bulletin, 1985, Volume: 15, Issue:2

    Topics: Benzhydryl Compounds; Child; Humans; Rhinitis; Terfenadine; United States; United States Food and Dr

1985