terfenadine has been researched along with Rhinitis in 22 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Rhinitis: Inflammation of the NASAL MUCOSA, the mucous membrane lining the NASAL CAVITIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The role of histamine in the pathogenesis of infectious rhinitis is unclear, as is the efficacy of antihistaminic drugs in the treatment of the common cold." | 9.06 | Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms. ( Gaffey, MJ; Hayden, FG; Kaiser, DL, 1988) |
| "We have assessed the effects of terfenadine on rhinitis symptoms associated with the common cold in 91 patients in a double-blind placebo-controlled study." | 9.06 | Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo. ( Glück, U; Henauer, SA, 1988) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 5.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Nasal instillation of bradykinin elicits many of the characteristic features of rhinitis." | 5.07 | The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage. ( Church, MK; Holgate, ST; Howarth, PH; Lau, LC; Polosa, R; Rajakulasingam, K, 1992) |
| "The role of histamine in the pathogenesis of infectious rhinitis is unclear, as is the efficacy of antihistaminic drugs in the treatment of the common cold." | 5.06 | Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms. ( Gaffey, MJ; Hayden, FG; Kaiser, DL, 1988) |
| "We have assessed the effects of terfenadine on rhinitis symptoms associated with the common cold in 91 patients in a double-blind placebo-controlled study." | 5.06 | Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo. ( Glück, U; Henauer, SA, 1988) |
| "With cetirizine, there was also a reduction in the levels of LTC4 (not measured in terfenadine studies) but not in those of recovered histamine and prostaglandin D2." | 2.66 | The effects of H1 antihistamines on the early allergic response. ( Baroody, F; Freidhoff, L; Kagey-Sobotka, A; Lichtenstein, LM; Naclerio, RM; Norman, PS; Proud, D, 1989) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 1.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Allergic rhinitis is manifested by watery discharge; however its clinical effect on the watery volume in the oral cavity is unknown." | 1.33 | Saliva secretion in patients with allergic rhinitis. ( Elad, S; Heisler, S; Shalit, M, 2006) |
| " Terfenadine, at concentrations achievable at standard dosing regimens, has anti-inflammatory properties in vitro." | 1.29 | Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide. ( Eda, R; Hopp, RJ; Townley, RG, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (36.36) | 18.7374 |
| 1990's | 9 (40.91) | 18.2507 |
| 2000's | 5 (22.73) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Duchateau, J | 1 |
| Heenen, M | 1 |
| Sternon, J | 1 |
| Sakairi, T | 1 |
| Suzuki, K | 1 |
| Makita, S | 1 |
| Wajima, T | 1 |
| Shakuto, S | 1 |
| Yoshida, Y | 1 |
| Yaguchi, M | 1 |
| Elad, S | 1 |
| Heisler, S | 1 |
| Shalit, M | 1 |
| Backhouse, CI | 1 |
| Brewster, BS | 1 |
| Lockhart, JD | 1 |
| Maneksha, S | 1 |
| Purvis, CR | 1 |
| Vallé-Jones, JC | 1 |
| Melillo, G | 1 |
| D'Amato, G | 1 |
| Zanussi, C | 1 |
| Ortolani, C | 1 |
| Pastorello, E | 1 |
| Loy, M | 1 |
| Di Tucci, A | 1 |
| Locci, F | 1 |
| Del Giacco, GS | 1 |
| Lenzini, L | 1 |
| Sestini, P | 1 |
| Rottoli, P | 1 |
| Eda, R | 1 |
| Townley, RG | 1 |
| Hopp, RJ | 1 |
| Masheter, HC | 1 |
| Howarth, PH | 2 |
| Harrison, K | 1 |
| Smith, S | 1 |
| Soto, J | 1 |
| Sacristan, JA | 1 |
| Alsar, MJ | 1 |
| Sainz, C | 1 |
| Wroblewski, BA | 1 |
| Purohit, A | 1 |
| Duvernelle, C | 1 |
| Melac, M | 1 |
| Pauli, G | 1 |
| Frossard, N | 1 |
| Wilson, AM | 1 |
| Druce, HM | 1 |
| Spector, SL | 1 |
| Fireman, P | 2 |
| Kaiser, H | 1 |
| Meltzer, EO | 1 |
| Boggs, P | 1 |
| Wood, CC | 1 |
| Paluch, EP | 1 |
| Rajakulasingam, K | 1 |
| Polosa, R | 1 |
| Lau, LC | 1 |
| Church, MK | 1 |
| Holgate, ST | 1 |
| Skoner, DP | 1 |
| Doyle, WJ | 1 |
| Boehm, S | 1 |
| Dijkman, JH | 1 |
| Hekking, PR | 1 |
| Molkenboer, JF | 1 |
| Nierop, G | 1 |
| Vanderschueren, R | 1 |
| Bernheim, J | 1 |
| Van Ganse, EH | 1 |
| Baroody, F | 1 |
| Proud, D | 1 |
| Kagey-Sobotka, A | 1 |
| Freidhoff, L | 1 |
| Norman, PS | 1 |
| Lichtenstein, LM | 1 |
| Naclerio, RM | 1 |
| Gaffey, MJ | 1 |
| Kaiser, DL | 1 |
| Hayden, FG | 1 |
| Henauer, SA | 1 |
| Glück, U | 1 |
3 reviews available for terfenadine and Rhinitis
| Article | Year |
|---|---|
[H1 histamine antagonists].
Topics: Acetates; Anti-Allergic Agents; Cetirizine; Chemistry, Pharmaceutical; Histamine H1 Antagonists; Hum | 2003 |
Terfenadine. The first nonsedating antihistamine.
Topics: Adult; Asthma; Child; Drug Interactions; Electroencephalography; Humans; Rhinitis; Skin Tests; Terfe | 1993 |
Are antihistamines useful in managing asthma?
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Asthma; Bronchospirometry; Cetirizine; Cyclopropa | 2002 |
12 trials available for terfenadine and Rhinitis
| Article | Year |
|---|---|
Terfenadine in allergic rhinitis. A comparative trial of a new antihistamine versus chlorpheniramine and placebo.
Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Chlorpheniramine; Clinical Trials as Topic; Do | 1982 |
A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis.
Topics: Adolescent; Adult; Aging; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-B | 1982 |
The influence of terfenadine and pseudo-ephedrine alone and in combination on allergen-induced rhinitis.
Topics: Adult; Allergens; Double-Blind Method; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Ag | 1993 |
Twenty-four hours of activity of cetirizine and fexofenadine in the skin.
Topics: Adolescent; Adult; Anti-Allergic Agents; Cetirizine; Cross-Over Studies; Dermatitis, Atopic; Double- | 2001 |
Double-blind study of intranasal ipratropium bromide in nonallergic perennial rhinitis.
Topics: Administration, Intranasal; Adolescent; Adult; Aged; Double-Blind Method; Evaluation Studies as Topi | 1992 |
The influence of terfenadine and ipratropium bromide alone and in combination on bradykinin-induced nasal symptoms and plasma protein leakage.
Topics: Adult; Airway Resistance; Blood Proteins; Bradykinin; Double-Blind Method; Drug Therapy, Combination | 1992 |
Effect of terfenadine on nasal, eustachian tube, and pulmonary function after provocative intranasal histamine challenge.
Topics: Administration, Intranasal; Administration, Oral; Adult; Dose-Response Relationship, Drug; Double-Bl | 1991 |
Prophylactic treatment of grass pollen-induced asthma with cetirizine.
Topics: Adolescent; Adult; Aged; Asthma; Benzhydryl Compounds; Cetirizine; Child; Double-Blind Method; Femal | 1990 |
The effects of H1 antihistamines on the early allergic response.
Topics: Benzhydryl Compounds; Calcium Channels; Cetirizine; Dopamine; Histamine H1 Antagonists; Humans; Hydr | 1989 |
Terfenadine--a non-sedating antihistamine.
Topics: Adult; Benzhydryl Compounds; Child; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hypn | 1985 |
Ineffectiveness of oral terfenadine in natural colds: evidence against histamine as a mediator of common cold symptoms.
Topics: Adult; Benzhydryl Compounds; Common Cold; Female; Histamine; Histamine H1 Antagonists; Humans; Male; | 1988 |
Efficacy of terfenadine in the treatment of common cold. A double-blind comparison with placebo.
Topics: Adult; Benzhydryl Compounds; Clinical Trials as Topic; Common Cold; Consumer Behavior; Double-Blind | 1988 |
7 other studies available for terfenadine and Rhinitis
| Article | Year |
|---|---|
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Anim | 2005 |
Saliva secretion in patients with allergic rhinitis.
Topics: Adolescent; Adult; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Middle Aged; Patient | 2006 |
Non-sedative antihistamines: terfenadine and astemizole.
Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Brain; Histamine H1 Antagonists; Humans; Rhinitis; | 1984 |
Effect of terfenadine on human eosinophil and neutrophil chemotactic response and generation of superoxide.
Topics: Adult; Asthma; Calcimycin; Cell Degranulation; Cell Separation; Chemotaxis, Leukocyte; Dose-Response | 1994 |
Terfenadine-induced tremor.
Topics: Adolescent; Adult; Female; Humans; Hypersensitivity; Male; Rhinitis; Terfenadine; Tremor | 1993 |
Antihistamines.
Topics: Astemizole; Histamine H1 Antagonists; Humans; Loratadine; Rhinitis; Terfenadine | 1998 |
Terfenadine approved for allergic rhinitis.
Topics: Benzhydryl Compounds; Child; Humans; Rhinitis; Terfenadine; United States; United States Food and Dr | 1985 |