terfenadine and Rhinitis, Allergic, Seasonal studies

Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

Rhinitis, Allergic, Seasonal: Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.

Research Excerpts

Excerpt	Relevance	Reference
"Forty-two ragweed hay fever patients participated in a study which examined the profile of symptom relief provided by terfenadine, and the relative adequacy of symptom control with the drug given from the beginning of the season compared with treatment started after symptoms were well established."	10.16	Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. ( Brooks, CD; Francom, SF; Karl, KJ, 1990)
"To evaluate whether 1 year of continuous treatment with intranasal fluticasone propionate would lead to atrophy in the nasal mucosa compared with an active control, oral terfenadine."	9.09	Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray. ( Baroody, FM; Cheng, CC; Cook, CK; Corey, JP; deTineo, M; Haney, L; Moylan, B; Naclerio, RM; Reed, KD; Sengupta, E; Togias, A; Westlund, RE, 2001)
"Clinical trials of a new histamine H1-blocker of the III generation zyrtec (cetirizine) manufactured in Belgium (UCB) demonstrated its high efficacy in pollenosis and chronic idiopathic urticaria."	9.07	[The efficacy of the Zirtek (cetirizine) preparation in chronic recurrent urticaria and seasonal allergic rhinitis]. ( Androsov, VN; Belostotskaia, OI; Il'ina, NI, 1994)
"A study was carried out in general practice during the summer months of 1985 to compare the efficacy and tolerance of astemizole suspension with terfenadine suspension in the treatment of paediatric hay fever."	9.06	Astemizole suspension in the maintenance treatment of paediatric hay fever: a comparison with terfenadine suspension. ( Grillage, MG; Harcup, JW; Huddlestone, L; Mayhew, SR, 1986)
"A double-blind study of terfenadine and placebo in 110 patients suffering from hay fever (confirmed by skin tests) was conducted."	9.05	A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders. ( Dabrowicki, E; Huddlestone, L; Kagan, G; Kapur, TR; Wolstencroft, P, 1980)
"Ninety patients participated in a randomised, double blind, placebo controlled comparison of terfenadine with astemizole in the treatment of hay fever."	9.05	Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. ( Holgate, ST; Howarth, PH, 1984)
"Eighty patients with hay fever took part in a double-blind study to compare the efficacy of two doses of terfenadine, namely 60 mg b."	9.05	Comparative trial of two dose regimens of terfenadine in patients with hay fever. ( Murphy-O'Connor, JC; Renton, RL; Westlake, DM, 1984)
"A multiclinic, double-blind, parallel and controlled study was conducted in the 1982 spring pollen season to evaluate and compare the effects of terfenadine, 60 mg bid with those of chlorpheniramine 4 mg tid and placebo for a treatment period of seven days in patients with seasonal allergic rhinitis and conjunctivitis."	9.05	Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. ( Buchman, E; Buckley, CE; Cascio, FL; Chretien, JH; Foster, TS; Gershwin, ME; Gordon, WE; Jakle, C; Kemp, JP; Klemawesch, SJ, 1985)
"In this double-blind study forty-seven patients with hay fever were treated for 8 days with either terfenadine 60 mg twice a day, astemizole 10 mg once a day or placebo."	9.05	Double-blind comparison of astemizole, terfenadine and placebo in hay fever with special regard to onset of action. ( Bigliardi, P; Girard, JP; Henauer, SA; Sommacal-Schopf, D, 1985)
"fexofenadine is clinically effective in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria for which it is a suitable option for first-line therapy."	7.70	Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria. ( Jarvis, B; Simpson, K, 2000)
"A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis."	7.69	[Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997)
"Astemizole, a new long acting and non sedative antihistamine, and Terfenadine, an H1 antagonist widely used, were compared in a randomized double-blind study over 4 weeks in 55 patients suffering from hay fever."	7.67	A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever. ( Cilli, P; Negrini, AC; Troise, C; Voltolini, S, 1989)
"While hay fever is a very common experience, its treatment in primary care setting has been little reported in controlled studies."	6.67	Budesonide and terfenadine, separately and in combination, in the treatment of hay fever. ( Simpson, RJ, 1994)
"85 patients suffering from pollinosis wee studied randomly on single-blind basis during the hay fever season of 1983."	6.66	[Comparison of astemizole and terfenadine in maintenance therapy of hay fever]. ( Repp, V, 1985)
"Forty-two ragweed hay fever patients participated in a study which examined the profile of symptom relief provided by terfenadine, and the relative adequacy of symptom control with the drug given from the beginning of the season compared with treatment started after symptoms were well established."	6.16	Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. ( Brooks, CD; Francom, SF; Karl, KJ, 1990)
"The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season."	5.14	Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009)
"To evaluate whether 1 year of continuous treatment with intranasal fluticasone propionate would lead to atrophy in the nasal mucosa compared with an active control, oral terfenadine."	5.09	Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray. ( Baroody, FM; Cheng, CC; Cook, CK; Corey, JP; deTineo, M; Haney, L; Moylan, B; Naclerio, RM; Reed, KD; Sengupta, E; Togias, A; Westlund, RE, 2001)
" However from 22 to 24 h after the first dose cetirizine was significantly superior to fexofenadine for the major symptom complex score and for sneezing."	5.09	Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis. ( Burtin, B; De Vos, C; Donnelly, F; Horak, F; Kavina, A; Stübner, P; Zieglmayer, R, 2001)
"To determine whether better health-related quality of life (HRQL) is achieved by initiating treatment of seasonal (ragweed) rhinoconjunctivitis (hay fever) with a nasal steroid (fluticasone) backed up by a nonsedating antihistamine (terfenadine) or whether it is better to start with the antihistamine and add the nasal steroid when necessary."	5.08	First-line treatment of seasonal (ragweed) rhinoconjunctivitis. A randomized management trial comparing a nasal steroid spray and a nonsedating antihistamine. ( Ferrie, PJ; Griffith, LE; Guyatt, GH; Juniper, EF, 1997)
"Clinical trials of a new histamine H1-blocker of the III generation zyrtec (cetirizine) manufactured in Belgium (UCB) demonstrated its high efficacy in pollenosis and chronic idiopathic urticaria."	5.07	[The efficacy of the Zirtek (cetirizine) preparation in chronic recurrent urticaria and seasonal allergic rhinitis]. ( Androsov, VN; Belostotskaia, OI; Il'ina, NI, 1994)
"A study was carried out in general practice during the summer months of 1985 to compare the efficacy and tolerance of astemizole suspension with terfenadine suspension in the treatment of paediatric hay fever."	5.06	Astemizole suspension in the maintenance treatment of paediatric hay fever: a comparison with terfenadine suspension. ( Grillage, MG; Harcup, JW; Huddlestone, L; Mayhew, SR, 1986)
"The efficacy and safety of loratadine, 40 mg once daily, were compared with terfenadine, 60 mg twice daily, and placebo in controlling symptoms of ragweed hay fever."	5.06	Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis. ( Bedard, P; Del Carpio, J; Gutkowski, A; Hebert, J; Prevost, M; Schulz, J; Turenne, Y; Yeadon, C, 1988)
"A study of ninety-nine hay fever sufferers was conducted to compare the effect of treatment with flunisolide nasal spray plus terfenadine tablets with that of terfenadine alone."	5.06	Treatment of seasonal allergic rhinitis with flunisolide and terfenadine. ( Backhouse, CI; Finnamore, VP; Gosden, CW, 1986)
"A double-blind study of terfenadine and placebo in 110 patients suffering from hay fever (confirmed by skin tests) was conducted."	5.05	A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders. ( Dabrowicki, E; Huddlestone, L; Kagan, G; Kapur, TR; Wolstencroft, P, 1980)
"Ninety patients participated in a randomised, double blind, placebo controlled comparison of terfenadine with astemizole in the treatment of hay fever."	5.05	Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. ( Holgate, ST; Howarth, PH, 1984)
"Eighty patients with hay fever took part in a double-blind study to compare the efficacy of two doses of terfenadine, namely 60 mg b."	5.05	Comparative trial of two dose regimens of terfenadine in patients with hay fever. ( Murphy-O'Connor, JC; Renton, RL; Westlake, DM, 1984)
"In a double blind study patients with hay fever were treated with Astemizole or Terfenadine for 3 to 4 weeks, 12 patients with Astemizole and 6 patients with Terfenadine."	5.05	[Hay fever therapy with 2 non-sedating antihistaminics]. ( Bäurle, G, 1985)
"A multiclinic, double-blind, parallel and controlled study was conducted in the 1982 spring pollen season to evaluate and compare the effects of terfenadine, 60 mg bid with those of chlorpheniramine 4 mg tid and placebo for a treatment period of seven days in patients with seasonal allergic rhinitis and conjunctivitis."	5.05	Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. ( Buchman, E; Buckley, CE; Cascio, FL; Chretien, JH; Foster, TS; Gershwin, ME; Gordon, WE; Jakle, C; Kemp, JP; Klemawesch, SJ, 1985)
"Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever."	5.05	A comparative study of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in seasonal allergic rhinitis. ( Beswick, KB; Cherry, JR; Kenyon, GS, 1985)
"In this double-blind study forty-seven patients with hay fever were treated for 8 days with either terfenadine 60 mg twice a day, astemizole 10 mg once a day or placebo."	5.05	Double-blind comparison of astemizole, terfenadine and placebo in hay fever with special regard to onset of action. ( Bigliardi, P; Girard, JP; Henauer, SA; Sommacal-Schopf, D, 1985)
"We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drug terfenadine and the glucocorticoid dexamethasone on antigen-induced sneezing, biphasic nasal blockage and nasal hyperresponsiveness to histamine using a guinea pig model of allergic rhinitis."	3.71	Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. ( Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M, 2001)
"fexofenadine is clinically effective in the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria for which it is a suitable option for first-line therapy."	3.70	Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria. ( Jarvis, B; Simpson, K, 2000)
"A 36-year-old female was given terfenadine 120 mg/day for hay fever, and itraconazole 100 mg twice daily for mycosis."	3.69	[Syncopes during simultaneous use of terfenadine and itraconazole]. ( Froger, CL; Romkes, JH; Westerhof, PW; Wever, EF, 1997)
"Astemizole, a new long acting and non sedative antihistamine, and Terfenadine, an H1 antagonist widely used, were compared in a randomized double-blind study over 4 weeks in 55 patients suffering from hay fever."	3.67	A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever. ( Cilli, P; Negrini, AC; Troise, C; Voltolini, S, 1989)
"Cetirizine was similar."	2.75	The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. ( Horak, F; Lemell, P; Zieglmayer, P; Zieglmayer, R, 2010)
" Before the amendment, assessments included physical examination, vital signs reporting (oral temperature, heart rate, and respiratory rate), and adverse event (AE) reporting."	2.73	Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. ( Hampel, FC; Kittner, B; Lanier, R; Milgrom, H, 2007)
"Pretreatment with fexofenadine 2 hours before immunotherapy significantly reduced the occurrence of severe SRs (P = ."	2.72	Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis. ( Murata, K; Nakai, Y; Ohashi, Y, 2006)
" The absolute and percent change in TSC score and the percent change in MSC score were significantly decreased at all time points from 45 minutes after dosing for FEX60/PSE120 compared with placebo (all, P < 0."	2.72	Onset of action of fexofenadine hydrochloride 60 mg/pseudoephedrine hydrochloride 120 mg in subjects aged 12 years with moderate to severe seasonal allergic rhinitis: a pooled analysis of two single-dose, randomized, double-blind, placebo-controlled aller ( Bazelmans, D; Berkowitz, RB; Georges, G; Godfrey, P; Liao, Y; Lutz, C; McCafferty, F; Meeves, S, 2006)
"Fexofenadine was significantly superior to placebo in the primary efficacy analysis (P	2.71	Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis. ( Bachert, C; Baena-Cagnani, C; Decosta, P; Finn, AF; Hedlin, G; Kowalski, ML; Meltzer, EO; Potter, P; Rosado Pinto, JE; Ruuth, E; Scheinmann, P; Simons, FE; Wahn, U, 2003)
"Mizolastine was associated with early phase reduction of: i) clinical symptoms (p < 0."	2.71	Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge. ( Ciprandi, G; Cirillo, I; Vizzaccaro, A, 2004)
" Patients (and investigators) reported any adverse events during the trial."	2.71	Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies. ( Bachert, C; Finn, AF; Hedlin, G; Meltzer, EO; Rosado Pinto, JE; Ruuth, E; Scheinmann, P; Wahn, U, 2004)
"Emedastine is a new H1-receptor antagonist endowed with potent and selective antihistamine activity."	2.71	Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus terfenadine in the treatment of seasonal allergic rhinitis. ( Assandri, A; Corrado, ME; Hartwig, J; Mion, A; Oldeman, HG; Radicioni, MM, 2004)
"Japanese cedar pollinosis, a common disease with morbidity of approximately 20% in the Japanese population, is characterized by subjectively irritating symptoms during an annual 3-month period."	2.71	The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen. ( Fujieda, S; Hyo, S; Kawada, R; Kitazawa, S; Takenaka, H, 2005)
" and adverse events were recorded in diary cards by the patients in form of scores as well as by the investigator at each visit."	2.71	The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis. ( Direkwattanachai, C; Ngamphaiboon, J; Tiensuwan, M; Vangveeravong, M; Visitsunthorn, N, 2005)
" Incidence of treatment-related adverse events was 1."	2.70	Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit. ( Berkowitz, RB; Lutz, C; Meeves, S; Moss, M; Weiler, J; Weiler, K; Woodworth, GG, 2002)
"Treatment with fexofenadine resulted in inhibition of allergen-induced symptoms and increased vascular permeability, but not the release of histamine and tryptase."	2.70	Effects of fexofenadine on the early response to nasal allergen challenge. ( Allocco, FT; Baroody, FM; deTineo, M; Naclerio, RM; Votypka, V, 2002)
" Safety was evaluated through adverse event reporting, electrocardiograms, and pre- and posttreatment laboratory panels and physical examinations."	2.70	Safety of fexofenadine in children treated for seasonal allergic rhinitis. ( Bernstein, DI; Goldsobel, A; Graft, DF; Long, J; Meltzer, EO; Portnoy, J, 2001)
"Parietaria pollinosis and cypress pollinosis, have been scarcely investigated, so far."	2.70	Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen. ( Bariletto, G; Caiaffa, MF; De Michele, G; Di Paola, R; Iudice, A; Macchia, L; Tursi, A, 2001)
"Fexofenadine was administered in daily doses of 120 or 240 mg, each in single and divided units given over 5 days."	2.69	Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. ( O'Hanlon, JF; Vermeeren, A, 1998)
"Fexofenadine was as potent as terfenadine in limiting pruritus and nasal congestion."	2.69	Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen. ( Fellrath, JM; Rahm, F; Spertini, F; Terrien, MH, 1999)
"Fexofenadine HCl is a nonsedating, long-acting H1 receptor antagonist that provides fast and effective relief from SAR."	2.69	The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis. ( Compton, D; Mason, J; Ricard, N; Stewart, J; Sussman, GL, 1999)
"Fexofenadine HCl has been investigated more extensively for possible electrophysiological effects than any other antihistamine."	2.69	Cardiovascular safety of fexofenadine HCl. ( Ahlbrandt, R; Brown, AM; Mason, J; Pratt, C; Rampe, D; Reynolds, R; Russell, T, 1999)
"Fexofenadine HCl (Allegra, Telfast) is approved in the US for twice-daily dosing for treatment of seasonal allergic rhinitis."	2.69	Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. ( Casale, TB; Meltzer, EO; Nathan, RA; Thompson, AK, 1999)
" In addition, assessment was made immediately before dosing in the morning for the previous 30 minutes."	2.69	Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. ( Bousquet, J; Howarth, PH; Reynolds, R; Roi, L; Stern, MA, 1999)
"Fexofenadine HCl was also significantly better than loratadine (P	2.69	Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. ( Juniper, EF; Van Cauwenberge, P, 2000)
"Terfenadine was more efficient than budesonide against histamine-mediated symptoms such as sneezing and itching."	2.68	Effect of terfenadine and budesonide on nasal symptoms, olfaction, and nasal airway patency following allergen challenge. ( Hilberg, O, 1995)
" Evaluation criteria were: (a) clinical: signs and symptoms (recorded daily in a diary card by patients); (b) cytological: inflammatory cell count (neutrophils, eosinophils, metachromatic cells) from nasal lavage at T0 and T7; (c) immunocytochemical: ICAM-1/CD54 expression on nasal epithelial cells at T0 and T7; and (d) mediators dosage (ECP-MPO) on nasal lavage at T0 and T7."	2.68	Terfenadine exerts antiallergic activity reducing ICAM-1 expression on nasal epithelial cells in patients with pollen allergy. ( Canonica, GW; Ciprandi, G; Del Giacco, GS; Pronzato, C; Ricca, V; Varese, P, 1995)
"Cetirizine is a new antihistamine with greater selectivity for the histamine H1 receptor and a low rate of hepatic metabolism."	2.68	Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis. ( Dockhorn, R; Grossman, J; Lockey, RF; Lumry, W; Mitchell, DQ; Widlitz, MD; Woehler, T, 1996)
"Terfenadine was not statistically different from placebo on the basis of clinician-related nasal symptom scores, except for sneezing."	2.68	Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. ( Blumenthal, M; Boltansky, H; Bronsky, EA; Dockhorn, RJ; Field, E; LaForce, C; Meltzer, EO; Ransom, J; Rogenes, P; Shapiro, G; Weakley, S; Weiler, JM; Wisniewski, M, 1996)
"Terfenadine was significantly better (P < or = ."	2.68	Brompheniramine, terfenadine, and placebo in allergic rhinitis. ( Furey, SA; Klein, GL; Littlejohn, T; Lockhart, EA, 1996)
"Mizolastine is a new, nonsedating antihistamine providing satisfactory symptom relief in allergic conditions."	2.68	Can an antihistamine delay appearance of hay fever symptoms when given prior to pollen season? ( Darnell, R; Stern, MA; Tudor, D, 1997)
" The frequency of adverse events was similar among fexofenadine HCl and placebo groups, with no dose-related trends."	2.68	Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. ( Ahlbrandt, R; Bernstein, DI; Mason, J; Nathan, RA; Schoenwetter, WF; Storms, W, 1997)
"of terfenadine or placebo was made on the response to histamine and grass pollen skin-prick testing."	2.67	Comparison of a new antihistaminic and antiallergic compound KW 4679 with terfenadine and placebo on skin and nasal provocation in atopic individuals. ( Davies, RJ; Duddle, J; Hamilton, SA; Herdman, MJ; Trigg, CJ, 1994)
"Levocabastine was significantly more effective than terfenadine in relieving ocular itching (p = ."	2.67	Safety and efficacy of topical levocabastine compared with oral terfenadine. ( Bahmer, FA; Ruprecht, KW, 1994)
"While hay fever is a very common experience, its treatment in primary care setting has been little reported in controlled studies."	2.67	Budesonide and terfenadine, separately and in combination, in the treatment of hay fever. ( Simpson, RJ, 1994)
"Levocabastine was significantly more effective than terfenadine in relieving sneezing, rhinorrhea, lacrimation, itch, and burning sensation (p < 0."	2.67	Topical levocabastine compared with orally administered terfenadine for the prophylaxis and treatment of seasonal rhinoconjunctivitis. ( Freng, BA; Garud, O; Korsrud, FR; Kramer, J; Olsen, AK; Poppe, S; Rebo, R; Søhoel, P; Woxen, OJ, 1993)
"7% for the two adverse events, respectively) than in the T/Ps group (10."	2.67	Safety and efficacy of terfenadine/pseudoephedrine versus clemastine/phenylpropanolamine in the treatment of seasonal allergic rhinitis. ( Falliers, CJ; Grant, JA; Huster, WJ; McNutt, B; Podleski, WK; Segal, AT; Woehler, TR, 1993)
"Terfenadine was more effective than both loratadine (P less than ."	2.67	Suppression of epicutaneous reactivity by terfenadine and loratadine. ( Small, P, 1992)
"Pre-treatment with terfenadine resulted in a significantly higher allergen threshold dose than placebo (p less than 0."	2.67	Protective effect of different doses of terfenadine on the conjunctival provocation test. ( Buscaglia, S; Canonica, GW; Ciprandi, G; Iudice, A, 1992)
"In a three-way, double-blind, crossover study the onset of action and effects at the end of the dosing interval of 10 mg/day astemizole, 10 mg/day loratadine and 120 mg/day terfenadine forte given for 3 days to six atopic volunteers were assessed using the Vienna challenge chamber (VCC)."	2.67	Onset and duration of the effects of three antihistamines in current use--astemizole, loratadine and terfenadine forte--studied during prolonged, controlled allergen challenges in volunteers. ( Berger, U; Horak, F; Jäger, S, 1992)
" Recommended dosage of loratadine (CAS 79794-75-5) is 10 mg once daily, whereas terfenadine (CAS 50679-08-8) until recently has been recommended as 60 mg twice daily."	2.67	Comparison of loratadine and terfenadine in allergic seasonal rhinoconjunctivitis with emphasis on nasal stuffiness and peak flow. ( Hindberg Rasmussen, W; Høi, L; Lorentzen, KA; Nüchel Petersen, L; Olsen, OT; Svendsen, UG, 1992)
"Of 88 known hayfever sufferers recruited during the 1988 season 86 were evaluable for efficacy."	2.67	Treatment of seasonal allergic rhinitis: a comparison of a combination tablet of terfenadine and pseudoephedrine with the individual ingredients. ( Backhouse, CI; Fidler, C; Rosenberg, RM, 1990)
"One hundred and twenty patients with hayfever were enrolled in a single-centre, double-blind crossover study designed to compare the efficacy and safety of terfenadine at doses of 60 mg bd and 120 mg bd."	2.67	A comparative study of terfenadine at two dose levels in the management of hayfever. ( Fidler, C; Rosenberg, RM; Smith, R; Stern, MA, 1990)
"Loratadine was particularly effective compared with placebo in relieving nasal discharge, sneezing, and itching/burning eyes."	2.66	Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis. ( Bedard, PM; Del Carpio, J; Gutkowski, A; Hebert, J; Kabbash, L; Nedilski, M; Prevost, M; Schulz, J; Turenne, Y, 1989)
"Terfenadine was compared for efficacy in treatment regimens of 120 mg once daily (qd) and 60 mg twice daily (bid) in patients with seasonal allergic rhinitis in double blind, randomized, parallel 1-week studies, three in Europe (one multicenter study, three sites; n = 191) and one in the US (single center; n = 201)."	2.66	Once versus twice daily dosing of terfenadine in the treatment of seasonal allergic rhinitis: US and European studies. ( Biedermann, AA; Chu, TJ; Goldsobel, AB; Wolfe, JD; Yamate, M, 1989)
"85 patients suffering from pollinosis wee studied randomly on single-blind basis during the hay fever season of 1983."	2.66	[Comparison of astemizole and terfenadine in maintenance therapy of hay fever]. ( Repp, V, 1985)
"Dexchlorpheniramine was associated with a significant increase in the score for tiredness in contrast to terfenadine which caused no significant change."	2.66	Treatment of seasonal allergic rhinitis--a double blind, group comparative study of terfenadine and dexchlorpheniramine. ( Bjerrum, P; Illum, P; Johansen, LV, 1987)
"Terfenadine was well tolerated and side-effects incidence was significantly lower (p less than 0."	2.66	Antihistaminic treatment of allergic rhinitis: a double-blind study with terfenadine versus dexchlorpheniramine. ( Codecasa, LR; Fugazza, A; Gerosa, S; Ortolani, C; Pastorello, EA; Pravettoni, V; Zanussi, C, 1987)
"Patients with proven allergic pollinosis were entered into a 1-week initial treatment period taking terfenadine 60 mg bid and only those who responded to the initial treatment with "moderate" to "complete" relief continued on terfenadine throughout a 4 to 11-week pollen season for evaluation of continued efficacy."	2.66	A multicenter, open study of the non-sedating antihistamine, terfenadine (Seldane), in the maintenance therapy of seasonal allergic rhinitis. ( Falliers, CJ; Fox, RW; Guill, MF; Kemp, JP; Segal, AT; Sjoerdsma, A; Tsai, TH, 1988)
"The flurbiprofen-treated patients experienced less severe symptoms, demonstrating maximum benefit 3 to 5 days into the drug trial with some loss of effect thereafter."	2.66	Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs. ( Brooks, CD; Karl, KJ, 1988)
"Two comparable groups, a total of 191 hay fever patients, were treated for 1 week."	2.66	[Administration of terfenadine in a single dose: comparison to standard treatment, as a double blind study, in patients presenting with allergic rhinitis]. ( Beaumont, D; Gastpar, H; Henauer, S; Hugonot, L; Hugonot, R; Köhler, M; Kurzeja, A; Rauch-Riedelsheimer, B, 1988)
"for efficacy in controlling Ragweed Hay Fever symptoms, as well as tolerance and occurrence of adverse reactions."	2.66	Comparative study of the efficacy, tolerance and side-effects of dexchlorpheniramine maleate 6 mg b.i.d. with terfenadine 60 mg b.i.d. ( Del Carpio, J; Gelinas, B; Gutkowski, A; Schulz, J; Turenne, Y, 1985)
" None of the terfenadine dosage schedules up to 200 mg 3 times a day caused sedation significantly different from that of placebo or efficacy greater than that seen with 20 mg 3 times a day."	2.65	Clinical studies of terfenadine in seasonal allergic rhinitis. ( Brandon, ML; Weiner, M, 1982)
"Fexofenadine has been used for its efficacy and safety in the treatment of allergic rhinitis (AR) for many years although no meta-analyses supporting its use currently exist."	2.47	Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. ( Badellino, H; Baena-Cagnani, CE; Baena-Cagnani, R; Braido, F; Canonica, GW; Compalati, E; Gómez, RM; Penagos, M, 2011)
"Fexofenadine was associated with significantly lower nasal congestion scores compared with placebo in 4 studies (P <- 0."	2.45	A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. ( Bachert, C, 2009)
" No major cytochrome P450 inhibition has been reported with desloratadine, fexofenadine and levocetirizine, and the bioavailability of desloratadine is minimally affected by drugs interfering with transporter molecules."	2.44	Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. ( Devillier, P; Faisy, C; Roche, N, 2008)
" In addition, small tablet size and once-daily dosing may provide patients with increased convenience and improve adherence."	2.43	Once-daily immediate-release fexofenadine and sustained-release pseudoephedrine combination: a new treatment option for allergic rhinitis. ( Mansfield, LE, 2006)
"Fexofenadine has also been shown to have a favorable effect on nasal congestion."	2.42	Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment. ( Appajosyula, S; Meeves, SG, 2003)
"Authors treated 50 seasonal allergic rhinitis ragweed sensitive patients with a second generation antihistamine, terfenadine containing suspension given twice/day for two weeks in the weeds season of 1996."	2.40	[Multicenter studies of terfenadine-containing suspensions in children with hayfever]. ( Börzsönyi, L; Cserháti, E; Endre, L; Kósa, L; Mezei, G, 1998)
" Twelve-lead electrocardiographic data were collected once before and after dosing or serially throughout these studies."	2.40	Cardiovascular safety of fexofenadine HCl. ( Ahlbrandt, R; Mason, J; Pratt, CM; Reynolds, R; Russell, T, 1999)
"Fluticasone propionate was superior to beclomethasone dipropionate in one trial according to patient evaluations of symptoms, but response to fluticasone propionate and beclomethasone dipropionate was similar in the second study."	2.39	Treatment of seasonal allergic rhinitis with fluticasone propionate aqueous nasal spray: review of comparator studies. ( Storms, WW, 1995)
"In this review of the current treatment of seasonal allergic rhinitis, the clinical studies that compare these four new second-generation H1-receptor antagonists are discussed."	2.38	H1-receptor antagonist treatment of seasonal allergic rhinitis. ( Kaiser, HB, 1990)
"Terfenadine is a selective H1-histamine receptor antagonist."	2.37	Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy. ( Heel, RC; Sorkin, EM, 1985)
"Patients with Japanese cedar pollinosis were treated orally with FEX twice a day at a single dose of 60 mg for two weeks during Japanese cedar pollen season (February 2011 to April 2011)."	1.38	Enhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride. ( Asano, K; Furuta, A; Kanai, K; Kanei, A; Nogaki, T; Suzaki, H; Suzaki, I, 2012)
"CD14+ cells prepared from patients with pollinosis to Japanese cedar pollen were stimulated with specific allergen extracted from Japanese cedar pollen (Cry j 1) in the presence of azelastine (AZE), ketotifen (KET), fexofenadine (FEX) and oxatomide (OXA) for 6 days."	1.37	Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. ( Asano, K; Furuta, A; Hirano, K; Shoji, N; Suzaki, H, 2011)
"Olopatadine hydrochloride (olopatadine) is an antiallergic agent with histamine H(1) receptor antagonistic action."	1.35	Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats. ( Kimoto, N; Tamura, T, 2009)
" Second-generation antihistamines have become increasingly popular because of their comparable efficacy and lower incidence of adverse effects relative to their first-generation counterparts, and the safety and efficacy of this drug class are established in the adult population."	1.35	Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. ( Moeller, ML; Nahata, MC; Phan, H, 2009)
"Fexofenadine is a second-generation histamine receptor blocker well known for its potent interaction with this inflammatory process."	1.35	Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. ( Ewert, R; Gläser, S; Gustavus, B; Hanf, G; Koch, B; Kunkel, G; Noga, O; Schäper, C, 2009)
"The long QT syndrome is a rare disease."	1.33	Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. ( Codreanu, A; de Chillou, C; Moneret-Vautrin, DA, 2006)
"PBL prepared from donors with pollinosis were cultured with either Japanese cedar pollen allergen, Cry j 1, or interleukin (IL)-4 in the presence of various doses of FEX for 6 days."	1.32	Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro. ( Asano, K; Kanai, K; Suzaki, H, 2004)
"Fexofenadine hydrochloride is a non-sedating antihistamine that is used in the treatment of symptoms associated with seasonal allergic rhinitis and chronic idiopathic urticaria."	1.32	The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride. ( Jensen, BK; Kittner, B; Krishna, R; Krishnaswami, S; Sankoh, AJ, 2004)
" The cumulative results indicate that the nonsedative antihistamine terfenadine, given orally at a dosage of 60 mg twice daily, is effective in the treatment of seasonal allergic rhinitis in both adults and children."	1.27	The use of antihistamines for the treatment of airway disease. ( Meltzer, EO, 1988)
"Terfenadine was applied prophylactically against seasonal allergic rhinitis."	1.26	Prophylaxis of seasonal allergic rhinitis with a new antihistaminic drug. ( Dieterich, HA; Gastpar, H, 1982)

Research

Studies (200)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Change From Baseline in Other Symptom Score Over 2 Week Randomized Treatment Period

Timeframe	Studies, this research(%)	All Research%
pre-1990	56 (28.00)	18.7374
1990's	69 (34.50)	18.2507
2000's	63 (31.50)	29.6817
2010's	12 (6.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Liu, Y	1
Ye, XJ	1
Zhao, CL	1
Ji, Q	1
Otsuka, H	1
Otsuka, K	1
Matsune, S	1
Okubo, K	3
Sawatsubashi, M	1
Gotoh, M	2
Asako, M	1
Nomura, Y	1
Togawa, M	1
Saito, A	1
Honda, T	1
Ohashi, Y	2
Izumi, N	1
Mizuguchi, H	2
Umehara, H	1
Ogino, S	1
Fukui, H	2
Takasaki, K	1
Enatsu, K	1
Kumagami, H	1
Takahashi, H	1
Sagara, H	1
Yukawa, T	1
Kashima, R	1
Okada, T	1
Fukuda, T	1
Bachert, C	3
Enomoto, T	1
Lu, HQ	1
Yin, M	1
Sakoda, T	1
Dake, Y	1
Enomoto, K	1
Ide, T	1
Cheng, L	1
Tamura, T	1
Kimoto, N	1
Horak, F	4
Zieglmayer, P	1
Zieglmayer, R	2
Lemell, P	1
Phan, H	1
Moeller, ML	1
Nahata, MC	1
Schäper, C	1
Gustavus, B	1
Koch, B	1
Ewert, R	1
Hanf, G	1
Kunkel, G	2
Noga, O	1
Gläser, S	1
Mösges, R	2
Lehmacher, W	1
Pasch, N	1
Vent, J	1
Shoji, N	1
Asano, K	3
Furuta, A	2
Hirano, K	1
Suzaki, H	3
Compalati, E	1
Baena-Cagnani, R	1
Penagos, M	1
Badellino, H	1
Braido, F	1
Gómez, RM	1
Canonica, GW	4
Baena-Cagnani, CE	1
Kamei, H	1
Isaji, A	1
Noda, Y	1
Ishikawa, K	1
Senzaki, K	1
Yamada, K	1
Sugiura, K	1
Tomita, Y	1
Nabeshima, T	1
Takahashi, G	1
Matsuzaki, Z	1
Okamoto, A	1
Ito, E	1
Matsuoka, T	1
Nakayama, T	1
Masuyama, K	1
Stokes, JR	1
Romero, FA	1
Allan, RJ	1
Phillips, PG	1
Hackman, F	1
Misfeldt, J	1
Casale, TB	2
Kitamura, Y	1
Ogishi, H	1
Kuroda, W	1
Hattori, M	1
Takeda, N	1
Nogaki, T	1
Kanai, K	2
Suzaki, I	1
Kanei, A	1
Berkowitz, RB	2
Woodworth, GG	2
Lutz, C	2
Weiler, K	1
Weiler, J	1
Moss, M	1
Meeves, S	3
Wilson, AM	2
Haggart, K	1
Sims, EJ	2
Lipworth, BJ	3
Koop, A	1
Mohler, SR	1
Nicholson, A	1
Harvey, P	1
Miura, Y	1
Meeves, SG	2
Allocco, FT	1
Votypka, V	1
deTineo, M	3
Naclerio, RM	5
Baroody, FM	3
Miyabe, S	1
Koizuka, I	1
Ochi, K	1
Tanaka, K	1
Kuroda, H	1
Takatsu, M	1
Kinoshita, H	1
Sugiyama, Y	1
Lee, DK	1
Jackson, CM	1
Wahn, U	2
Meltzer, EO	6
Finn, AF	2
Kowalski, ML	1
Decosta, P	1
Hedlin, G	2
Scheinmann, P	2
Rosado Pinto, JE	2
Baena-Cagnani, C	1
Potter, P	1
Simons, FE	1
Ruuth, E	2
Glass, DJ	1
Harper, AS	1
Appajosyula, S	1
Portnoy, JM	1
Simon, SD	1
Hampel, F	1
Ratner, P	1
Mansfield, L	1
Liao, Y	2
Georges, G	2
Moinuddin, R	1
Maleckar, B	1
Ciprandi, G	4
Cirillo, I	1
Vizzaccaro, A	1
LaForce, CF	1
Corren, J	1
Wheeler, WJ	1
Berger, WE	1
Krishna, R	1
Krishnaswami, S	1
Kittner, B	2
Sankoh, AJ	1
Jensen, BK	1
Corrado, ME	1
Radicioni, MM	1
Hartwig, J	1
Assandri, A	1
Oldeman, HG	1
Mion, A	1
Shimada, K	1
Ritsu, M	1
Okuda, M	1
Crawford, B	1
Hyo, S	1
Fujieda, S	1
Kawada, R	1
Kitazawa, S	1
Takenaka, H	1
Conboy-Ellis, K	1
Green, GR	1
Górska-Ciebiada, M	1
Ciebiada, M	1
Zakrzewska, A	1
Górski, P	1
Grzelewska-Rzymowska, I	1
Rufke, C	1
Nieber, K	1
Ngamphaiboon, J	1
Direkwattanachai, C	1
Visitsunthorn, N	1
Vangveeravong, M	1
Tiensuwan, M	1
Mansfield, LE	2
Nakai, Y	1
Murata, K	1
Spangler, DL	1
Brunton, S	1
McCafferty, F	1
Bazelmans, D	1
Godfrey, P	1
Lehman, JM	1
Blaiss, MS	1
Moneret-Vautrin, DA	1
de Chillou, C	1
Codreanu, A	1
Gamzatova, AA	1
Gadzhimirzaev, GA	1
Abusuev, SA	1
Gamzatova, EG	1
Milgrom, H	1
Lanier, R	1
Hampel, FC	1
Devillier, P	1
Roche, N	1
Faisy, C	1
De Vos, C	2
Mitchev, K	1
Pinelli, ME	1
Derde, MP	1
Boev, R	1
Kagan, G	1
Dabrowicki, E	1
Huddlestone, L	2
Kapur, TR	1
Wolstencroft, P	1
Wüthrich, B	1
Dieterich, HA	4
Weiner, M	2
Brandon, ML	1
Dugue, P	1
Birnbaum, J	1
Poisson, A	1
Charpin, J	2
Gastpar, H	4
Brewster, BS	1
Barlow, JL	1
Beitman, RE	1
Tsai, TH	3
Howarth, PH	2
Holgate, ST	1
Murphy-O'Connor, JC	1
Renton, RL	1
Westlake, DM	1
Obel, AO	1
Cipolla, C	1
D'Antuono, G	1
Giannini, A	1
Golfera, A	1
Varonier, HS	1
Hilberg, O	1
Takeyama, M	1
Mori, K	1
Morikawa, N	1
Asakura, S	1
Chaen, T	1
Watanabe, N	1
Mogi, G	1
Storms, WW	1
Bahmer, FA	2
Hamilton, SA	1
Duddle, J	1
Herdman, MJ	1
Trigg, CJ	1
Davies, RJ	2
Darnell, R	2
Pecoud, A	1
Richards, DH	1
Androsov, VN	1
Belostotskaia, OI	1
Il'ina, NI	1
Ruprecht, KW	1
Nolte, D	1
Aurich, R	1
Brendt, P	1
Enzmann, H	1
Giesemann, G	1
Petzold, U	1
Renz, W	1
Schata, M	1
Althaus, MA	1
Pichler, WJ	1
Simpson, RJ	1
Sabbah, A	2
Hassoun, S	2
Le Sellin, J	1
André, C	2
Sicard, H	2
Søhoel, P	1
Freng, BA	1
Kramer, J	1
Poppe, S	1
Rebo, R	1
Korsrud, FR	1
Garud, O	1
Woxen, OJ	1
Olsen, AK	1
Lesellin, J	1
Bousquet, J	3
Chanal, I	2
Alquié, MC	1
Charpin, D	1
Didier, A	1
Germouty, J	1
Greillier, P	1
Ickovic, MH	1
Maria, Y	1
Montané, F	1
Lockey, RF	2
Findley, S	1
Mitchell, DQ	2
Woehler, T	2
Lieberman, P	1
Nicodemus, CF	1
Segal, AT	4
Falliers, CJ	3
Grant, JA	1
Podleski, WK	1
Woehler, TR	1
Huster, WJ	1
McNutt, B	1
Pronzato, C	1
Ricca, V	1
Varese, P	1
Del Giacco, GS	1
Widlitz, MD	1
Lumry, W	1
Dockhorn, R	1
Grossman, J	1
Harvey, RP	1
Comer, C	1
Sanders, B	1
Westley, R	1
Marsh, W	1
Shapiro, H	1
Wiener, M	1
Bronsky, EA	1
Dockhorn, RJ	1
Shapiro, G	1
Boltansky, H	1
LaForce, C	1
Ransom, J	1
Weiler, JM	2
Blumenthal, M	1
Weakley, S	1
Wisniewski, M	1
Field, E	1
Rogenes, P	1
Juliusson, S	1
Bende, M	1
Klein, GL	1
Littlejohn, T	1
Lockhart, EA	1
Furey, SA	1
Josefson, D	1
Chakravarti, A	1
Lal, A	1
Vishwakarma, SK	1
Juniper, EF	3
Guyatt, GH	1
Ferrie, PJ	1
Griffith, LE	1
Freedman, SO	1
Wise, J	1
Stern, MA	3
Tudor, D	1
Day, JH	1
Briscoe, MP	1
Clark, RH	1
Ellis, AK	1
Gervais, P	2
Pabian, C	1
French, L	1
Romkes, JH	1
Froger, CL	1
Wever, EF	1
Westerhof, PW	1
Rankin, AC	1
Bernstein, DI	2
Schoenwetter, WF	1
Nathan, RA	2
Storms, W	1
Ahlbrandt, R	3
Mason, J	4
Endre, L	1
Mezei, G	1
Kósa, L	1
Börzsönyi, L	1
Cserháti, E	1
Markham, A	1
Wagstaff, AJ	1
Vermeeren, A	1
O'Hanlon, JF	1
Abdelaziz, MM	1
Devalia, JL	1
Khair, OA	1
Bayram, H	1
Prior, AJ	1
Por, CP	1
Evans, MF	1
Rihoux, JP	1
Donnelly, F	2
Burtin, B	2
Pratt, CM	1
Russell, T	2
Reynolds, R	3
Terrien, MH	1
Rahm, F	1
Fellrath, JM	1
Spertini, F	1
Sussman, GL	1
Compton, D	1
Stewart, J	1
Ricard, N	1
Pratt, C	1
Brown, AM	1
Rampe, D	1
Thompson, AK	1
Roi, L	1
Bloomfield, JR	1
Grant, AR	1
Layton, TA	1
Brown, TL	1
McKenzie, DR	1
Baker, TW	1
Watson, GS	1
Simpson, K	1
Jarvis, B	1
Van Cauwenberge, P	1
Prenner, BM	1
Capano, D	1
Harris, AG	1
Shaikh, WA	1
Cheng, CC	1
Moylan, B	1
Haney, L	1
Reed, KD	1
Cook, CK	1
Westlund, RE	1
Sengupta, E	1
Corey, JP	1
Togias, A	1
Amichai, B	1
Grunwald, MH	1
Brenner, L	1
Stübner, P	1
Kavina, A	1
Graft, DF	1
Goldsobel, A	1
Portnoy, J	1
Long, J	1
Yamasaki, M	1
Mizutani, N	2
Sasaki, K	2
Nabe, T	2
Matsumoto, T	2
Ashida, Y	2
Kohno, S	2
Yamasaki, ML	1
Sakura, Y	1
Macchia, L	1
Caiaffa, MF	1
Di Paola, R	1
De Michele, G	1
Bariletto, G	1
Iudice, A	3
Tursi, A	1
Orr, LC	1
Coutie, WJ	1
Small, P	2
Andri, L	1
Senna, GE	1
Betteli, C	1
Givanni, S	1
Andri, G	1
Scaricabarozzi, I	1
Mezzelani, P	1
Wood, SF	2
Buscaglia, S	2
Jäger, S	1
Berger, U	1
Olsen, OT	1
Nüchel Petersen, L	1
Høi, L	1
Lorentzen, KA	1
Hindberg Rasmussen, W	1
Svendsen, UG	1
Frazier, CA	1
Biskin, N	1
Barrett, D	1
Zimmermann, M	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
A Randomized, Double-Blind, 4 Way Cross-over, Placebo Controlled Trial to Evaluate the Onset of Action of Bilastine 20 mg vs. Placebo, Cetirizine 10 mg, and Fexofenadine 120 mg in the Vienna Challenge Chamber[NCT00420082]	Phase 2	75 participants (Actual)	Interventional	2006-10-31	Completed
A Multicentre, International, Adaptive, Open-label, Repeated Administration Pharmacokinetic Study of Bilastine in Children From 2 to <12 Years of Age With Allergic Rhinoconjunctivitis or Chronic Urticaria[NCT01081574]	Phase 1/Phase 2	36 participants (Actual)	Interventional	2010-01-31	Completed
Effectiveness of Montelukast Versus Intranasal Fluticasone Propionate in the Management of Allergic Rhinitis Among Children 02 to 05 Years of Age[NCT04957927]	Phase 4	60 participants (Anticipated)	Interventional	2020-12-12	Recruiting
The Addition of Montelukast to Fluticasone in the Treatment of Perennial Allergic Rhinitis[NCT00119015]	Phase 4	102 participants (Actual)	Interventional	2005-07-31	Terminated (stopped due to Difficulty in recruitment)
Nasal Ocular Reflexes Contribute to Eye Symptoms in Patients With Allergic Rhinitis[NCT00117832]		20 participants	Interventional	2005-03-31	Completed
Quality of Life in Patients With Allergic Rhinitis: a Clinical Trial Comparing the Use of Bilastine Versus Loratadine[NCT02513290]	Phase 4	73 participants (Actual)	Interventional	2013-08-31	Completed
Phase III Study Comparing Coristina® D to Resfenol® in the Symptomatic Treatment of Common Cold[NCT02735070]	Phase 3	366 participants (Anticipated)	Interventional	2016-09-30	Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"Patients recorded the severity of other symptoms, including itchy nose/eyes and post-nasal drip, twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The other symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Change From Baseline in Runny Nose Symptom Score Over 2 Week Randomized Treatment Period

Intervention	units on a scale (Median)
Fluticasone Propionate + Montelukast	-0.24
Fluticasone Propionate + Placebo	-0.14

"Patients recorded the severity of runny nose twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The runny nose symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Change From Baseline in Sneezing Symptom Score Over 2 Week Randomized Treatment Period

Intervention	units on a scale (Median)
Fluticasone Propionate + Montelukast	-0.52
Fluticasone Propionate + Placebo	-0.29

"Patients recorded the severity of sneezing twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The sneezing symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Change From Baseline in Stuffy Nose Symptom Score Over 2 Week Randomized Treatment Period

Intervention	units on a scale (Median)
Fluticasone Propionate + Montelukast	-0.22
Fluticasone Propionate + Placebo	-0.25

"Patients recorded the severity of stuffy nose twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The stuffy nose symptom score was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 6.~The baseline symptom score used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Change From Baseline in Total Nasal Symptom Score (TNSS) Over 2 Week Randomized Treatment Period

Intervention	units on a scale (Median)
Fluticasone Propionate + Montelukast	-0.41
Fluticasone Propionate + Placebo	-0.47

"Patients recorded the severity of sneezing, runny nose, stuffy nose, and other symptoms (itchy nose/eyes and post-nasal drip) twice a day on a scale from 0 to 3 (0 = no symptoms, 1 = mild, 2 = moderate, and 3 = severe). The TNSS was calculated as the sum of all scores for morning and evening recordings with a range of 0 to 24.~The baseline TNSS used in the analysis was the average of the symptom scores from the last 5 days of fluticasone propionate therapy prior to randomized treatment period.~The change from baseline for each subsequent day of treatment was then calculated for each subject. So that each subject only had one observation, the average of these changes was calculated for each subject, and this summary measure was used in the analysis comparing the two treatment groups. We report the median and full range of these average changes for each group.~A negative value indicates an improvement in symptoms." (NCT00119015)
Timeframe: Baseline and 2 weeks

Article	Year
[Clinical Management of Japanese Cedar Pollinosis]. Fukuoka igaku zasshi = Hukuoka acta medica, 2016, Volume: 107, Issue:1 Topics: Administration, Inhalation; Cedrus; Desensitization, Immunologic; Disorders of Excessive Somnolence;	2016
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. Clinical therapeutics, 2009, Volume: 31, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Clinical Trials as Topic; Female; His	2009
Systematic review on the efficacy of fexofenadine in seasonal allergic rhinitis: a meta-analysis of randomized, double-blind, placebo-controlled clinical trials. International archives of allergy and immunology, 2011, Volume: 156, Issue:1 Topics: Adult; Child, Preschool; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; Humans; Random	2011
Efficacy and safety profile of fexofenadine HCl: a unique therapeutic option in H1-receptor antagonist treatment. The Journal of allergy and clinical immunology, 2003, Volume: 112, Issue:4 Suppl Topics: Anti-Allergic Agents; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; T	2003
Management of seasonal allergic rhinitis: comparative efficacy of the newer-generation prescription antihistamines. Journal of the American Academy of Nurse Practitioners, 2005, Volume: 17, Issue:8 Topics: Adolescent; Adult; Cetirizine; Child; Child, Preschool; Histamine H1 Antagonists; Histamine H1 Antag	2005
[Long QT interval. Interaction of terfenadine and itraconazole]. Medizinische Monatsschrift fur Pharmazeuten, 2006, Volume: 29, Issue:1 Topics: Antifungal Agents; Histamine H1 Antagonists; Humans; Itraconazole; Long QT Syndrome; Onychomycosis;	2006
Once-daily immediate-release fexofenadine and sustained-release pseudoephedrine combination: a new treatment option for allergic rhinitis. Expert opinion on pharmacotherapy, 2006, Volume: 7, Issue:7 Topics: Animals; Delayed-Action Preparations; Drug Therapy, Combination; Ephedrine; Humans; Rhinitis, Allerg	2006
Efficacy and central nervous system impairment of newer-generation prescription antihistamines in seasonal allergic rhinitis. Southern medical journal, 2006, Volume: 99, Issue:6 Topics: Central Nervous System; Cetirizine; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating	2006
Selecting the optimal oral antihistamine for patients with allergic rhinitis. Drugs, 2006, Volume: 66, Issue:18 Topics: Administration, Oral; Cardiovascular System; Central Nervous System; Cetirizine; Drug Interactions;	2006
Fexofenadine in pediatrics: oral tablet and suspension formulations. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:2 Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Child; Child, Preschool; Deglutition; Huma	2008
Clinical pharmacokinetics and pharmacodynamics of desloratadine, fexofenadine and levocetirizine : a comparative review. Clinical pharmacokinetics, 2008, Volume: 47, Issue:4 Topics: Cetirizine; Drug Interactions; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Rhinitis,	2008
Treatment of seasonal allergic rhinitis with fluticasone propionate aqueous nasal spray: review of comparator studies. Allergy, 1995, Volume: 50, Issue:23 Suppl Topics: Administration, Topical; Aerosols; Androstadienes; Anti-Inflammatory Agents; Astemizole; Beclomethas	1995
Topical levocabastine--an effective alternative to oral antihistamines in seasonal allergic rhinoconjunctivitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:3 Topics: Administration, Oral; Administration, Topical; Clinical Trials as Topic; Conjunctivitis, Allergic; D	1995
[Multicenter studies of terfenadine-containing suspensions in children with hayfever]. Orvosi hetilap, 1998, Jan-04, Volume: 139, Issue:1 Topics: Anti-Allergic Agents; Child; Humans; Rhinitis, Allergic, Seasonal; Suspensions; Terfenadine	1998
Fexofenadine. Drugs, 1998, Volume: 55, Issue:2 Topics: Animals; Histamine Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Urticaria	1998
Cardiovascular safety of fexofenadine HCl. The American journal of cardiology, 1999, May-15, Volume: 83, Issue:10 Topics: Double-Blind Method; Drug Interactions; Electrocardiography; Heart Conduction System; Histamine Anta	1999
Fexofenadine hydrochloride--a new anti-histaminic drug. The Israel Medical Association journal : IMAJ, 2001, Volume: 3, Issue:3 Topics: Chronic Disease; Clinical Trials as Topic; Drug Interactions; Histamine H1 Antagonists; Humans; Pati	2001
Clinical experience with non-sedating antihistamines in paediatric allergic rhinitis. Rhinology. Supplement, 1992, Volume: 13 Topics: Adolescent; Astemizole; Asthma; Child; Child, Preschool; Chlorpheniramine; Clinical Trials as Topic;	1992
Comparative effects of terfenadine and loratadine in the treatment of hay fever. Journal of investigational allergology & clinical immunology, 1991, Volume: 1, Issue:6 Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, All	1991
H1-receptor antagonist treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Cetirizine; Chlorpheniramine; Clemastine; Cyprohep	1990
The effects of antihistamines beyond H1 antagonism in allergic inflammation. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Benzhydryl Compounds; Cetirizine; Cyproheptadine; Dermatitis, Atopic; Histamine H1 Antagonists; Hist	1990
Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1990, Volume: 20, Issue:1 Topics: Adult; Benzhydryl Compounds; Double-Blind Method; Female; Humans; Male; Medical Records; Plants; Ran	1990
Terfenadine. A review of its pharmacodynamic properties and therapeutic efficacy. Drugs, 1985, Volume: 29, Issue:1 Topics: Animals; Asthma; Benzhydryl Compounds; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Ki	1985

Article	Year
[The effect of combined therapy on seasonal allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2016, Jul-05, Volume: 30, Issue:13 Topics: Administration, Intranasal; Budesonide; Double-Blind Method; Glucocorticoids; Humans; Leukotriene An	2016
Efficacy and safety of bilastine in Japanese patients with perennial allergic rhinitis: A multicenter, randomized, double-blind, placebo-controlled, parallel-group phase III study. Allergology international : official journal of the Japanese Society of Allergology, 2017, Volume: 66, Issue:1 Topics: Adult; Asian People; Benzimidazoles; Double-Blind Method; Female; Humans; Japan; Male; Middle Aged;	2017
Relationship between airborne pollen count and treatment outcome in Japanese cedar pollinosis patients. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2009, Volume: 266, Issue:5 Topics: Adult; Air; Anti-Allergic Agents; Anti-Inflammatory Agents; Cryptomeria; Female; Humans; Male; Polle	2009
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. Allergology international : official journal of the Japanese Society of Allergology, 2009, Volume: 58, Issue:2 Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig	2009
Evaluation of the efficacy and safety of olopatadine and fexofenadine compared with placebo in Japanese cedar pollinosis using an environmental exposure unit. Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:4 Topics: Adult; Allergens; Cryptomeria; Dibenzoxepins; Double-Blind Method; Female; Follow-Up Studies; Histam	2009
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5 Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies;	2010
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5 Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies;	2010
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5 Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies;	2010
The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010, Volume: 59, Issue:5 Topics: Adolescent; Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Cetirizine; Cross-Over Studies;	2010
Assessment of the antiobstructive effect of fexofenadine on nasal allergy challenge in patients with seasonal allergic rhinitis. Asian Pacific journal of allergy and immunology, 2009, Volume: 27, Issue:4 Topics: Administration, Oral; Antigens, Plant; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating;	2009
Effects of single therapeutic doses of promethazine, fexofenadine and olopatadine on psychomotor function and histamine-induced wheal- and flare-responses: a randomized double-blind, placebo-controlled study in healthy volunteers. Archives of dermatological research, 2012, Volume: 304, Issue:4 Topics: Adolescent; Dibenzoxepins; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Olop	2012
A randomized control trail of stepwise treatment with fluticasone propionate nasal spray and fexofenadine hydrochloride tablet for seasonal allergic rhinitis. Allergology international : official journal of the Japanese Society of Allergology, 2012, Volume: 61, Issue:1 Topics: Adult; Androstadienes; Anti-Allergic Agents; Female; Fluticasone; Humans; Male; Middle Aged; Nasal S	2012
The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. The Journal of allergy and clinical immunology, 2012, Volume: 129, Issue:2 Topics: Adult; Ambrosia; Anti-Allergic Agents; Cross-Over Studies; Cyclobutanes; Double-Blind Method; Drug C	2012
Onset of action, efficacy, and safety of fexofenadine 60 mg/pseudoephedrine 120 mg versus placebo in the Atlanta allergen exposure unit. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:1 Topics: Adolescent; Adult; Aged; Child; Double-Blind Method; Drug Therapy, Combination; Ephedrine; Female; H	2002
Effects of fexofenadine and desloratadine on subjective and objective measures of nasal congestion in seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:10 Topics: Adult; Air Pollutants; Allergens; Cross-Over Studies; Double-Blind Method; Environmental Exposure; F	2002
The use of handheld computers in clinical trials. Controlled clinical trials, 2002, Volume: 23, Issue:5 Topics: Adult; Anti-Allergic Agents; Data Collection; Databases, Factual; Double-Blind Method; Humans; Mathe	2002
Effects of fexofenadine on the early response to nasal allergen challenge. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:6 Topics: Adolescent; Adult; Allergens; Biomarkers; Capillary Permeability; Cross-Over Studies; Double-Blind M	2002
Effect of fexofenadine hydrochloride on cedar pollinosis. Auris, nasus, larynx, 2003, Volume: 30 Suppl Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cedrus; Drug Administration Schedule; Female; Histami	2003
Fexofenadine is efficacious and safe in children (aged 6-11 years) with seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:4 Topics: Anti-Allergic Agents; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Rh	2003
Fexofenadine hydrochloride, 180 mg, exhibits equivalent efficacy to cetirizine, 10 mg, with less drowsiness in patients with moderate-to-severe seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Double-Blind Method; Female; Human	2003
Comparison of the combinations of fexofenadine-pseudoephedrine and loratadine-montelukast in the treatment of seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 92, Issue:1 Topics: Acetates; Adolescent; Adult; Ambrosia; Anti-Allergic Agents; Cyclopropanes; Double-Blind Method; Dru	2004
Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge. European annals of allergy and clinical immunology, 2004, Volume: 36, Issue:4 Topics: Adult; Allergens; Anti-Allergic Agents; Benzimidazoles; Conjunctivitis, Allergic; Cytokines; Double-	2004
Safety and efficacy of oral fexofenadine in children with seasonal allergic rhinitis--a pooled analysis of three studies. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2004, Volume: 15, Issue:3 Topics: Anti-Allergic Agents; Child; Double-Blind Method; Female; Headache; Histamine H1 Antagonists; Humans	2004
Efficacy of azelastine nasal spray in seasonal allergic rhinitis patients who remain symptomatic after treatment with fexofenadine. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2004, Volume: 93, Issue:2 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Double-Blind Method; Drug Therapy, Combination; F	2004
Clinical study of the therapeutic efficacy and safety of emedastine difumarate versus terfenadine in the treatment of seasonal allergic rhinitis. Arzneimittel-Forschung, 2004, Volume: 54, Issue:10 Topics: Adolescent; Adult; Anti-Allergic Agents; Benzimidazoles; Cross-Over Studies; Double-Blind Method; Fe	2004
Fexofenadine improves the quality of life and work productivity in Japanese patients with seasonal allergic rhinitis during the peak cedar pollinosis season. International archives of allergy and immunology, 2005, Volume: 136, Issue:2 Topics: Adult; Allergens; Cryptomeria; Double-Blind Method; Efficiency; Female; Histamine H1 Antagonists; Hu	2005
The efficacy of short-term administration of 3 antihistamines vs placebo under natural exposure to Japanese cedar pollen. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:4 Topics: Adult; Cetirizine; Cryptomeria; Double-Blind Method; Drug Administration Schedule; Female; Histamine	2005
[Serum sICAM-1 in patients suffering from allergic rhinitis treated with fexofenadine or fluticasone]. Pneumonologia i alergologia polska, 2004, Volume: 72, Issue:11-12 Topics: Adolescent; Adult; Androstadienes; Anti-Allergic Agents; Female; Fluticasone; Humans; Intercellular	2004
The efficacy and safety of 30 mg fexofenadine HCl bid in pediatric patients with allergic rhinitis. Asian Pacific journal of allergy and immunology, 2005, Volume: 23, Issue:4 Topics: Anti-Allergic Agents; Asian People; Child; Female; Histamine H1 Antagonists; Humans; Male; Multicent	2005
Effect of pretreatment with fexofenadine on the safety of immunotherapy in patients with allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 96, Issue:4 Topics: Adult; Anti-Allergic Agents; Cedrus; Dermatophagoides farinae; Desensitization, Immunologic; Female;	2006
Onset of action of fexofenadine hydrochloride 60 mg/pseudoephedrine hydrochloride 120 mg in subjects aged 12 years with moderate to severe seasonal allergic rhinitis: a pooled analysis of two single-dose, randomized, double-blind, placebo-controlled aller Clinical therapeutics, 2006, Volume: 28, Issue:10 Topics: Adult; Allergens; Anti-Allergic Agents; Demography; Double-Blind Method; Ephedrine; Female; Humans;	2006
Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2007, Volume: 99, Issue:4 Topics: Age Factors; Anti-Allergic Agents; Body Temperature; Child, Preschool; Cough; Double-Blind Method; E	2007
A double blind trial of terfenadine and placebo in hay fever using a substitution technique for non-responders. The Journal of international medical research, 1980, Volume: 8, Issue:6 Topics: Adult; Benzhydryl Compounds; Chlorpheniramine; Double-Blind Method; Female; Histamine H1 Antagonists	1980
[Efficacy and tolerability of new antiallergic drugs in acute pollinosis]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1982, Sep-07, Volume: 71, Issue:36 Topics: Acute Disease; Adult; Benzhydryl Compounds; Clemastine; Clinical Trials as Topic; Double-Blind Metho	1982
Clinical studies of terfenadine in seasonal allergic rhinitis. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Benzhydryl Compounds; Double-Blind Method; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Sea	1982
Clinical studies with terfenadine in seasonal allergic rhinitis in France. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Chlorpheniramine; Circadian Rhythm; Female; Fr	1982
Comparative study of the efficacy and tolerance of terfenadine and clemastine in patients with seasonal allergic rhinitis. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Adolescent; Adult; Benzhydryl Compounds; Clemastine; Female; Histamine H1 Antagonists; Humans; Male;	1982
Summary of four UK clinical trials with terfenadine. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Benzhydryl Compounds; Chlorpheniramine; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Perenn	1982
Terfenadine, safety and tolerance in controlled clinical trials. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Benzhydryl Compounds; Clinical Trials as Topic; Dermatitis; Double-Blind Method; Histamine H1 Antago	1982
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1984, Volume: 39, Issue:9 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Doubl	1984
Comparative trial of two dose regimens of terfenadine in patients with hay fever. The Journal of international medical research, 1984, Volume: 12, Issue:6 Topics: Adolescent; Adult; Benzhydryl Compounds; Dose-Response Relationship, Drug; Double-Blind Method; Fema	1984
[Terfenadine suspension versus clemastine syrup in children with acute hay fever]. Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis, 1984, May-22, Volume: 73, Issue:21 Topics: Acute Disease; Age Factors; Benzhydryl Compounds; Chemical Phenomena; Chemistry; Child; Clemastine;	1984
Effect of terfenadine and budesonide on nasal symptoms, olfaction, and nasal airway patency following allergen challenge. Allergy, 1995, Volume: 50, Issue:8 Topics: Administration, Inhalation; Administration, Topical; Adult; Allergens; Anti-Inflammatory Agents; Bro	1995
Comparison of a new antihistaminic and antiallergic compound KW 4679 with terfenadine and placebo on skin and nasal provocation in atopic individuals. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1994, Volume: 24, Issue:10 Topics: Adult; Airway Resistance; Cross-Over Studies; Dibenzoxepins; Double-Blind Method; Female; Humans; Ma	1994
A double-blind comparison of fluticasone propionate aqueous nasal spray, terfenadine tablets and placebo in the treatment of patients with seasonal allergic rhinitis to grass pollen. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1994, Volume: 24, Issue:12 Topics: Administration, Topical; Adolescent; Adult; Aged; Allergens; Androstadienes; Anti-Inflammatory Agent	1994
[The efficacy of the Zirtek (cetirizine) preparation in chronic recurrent urticaria and seasonal allergic rhinitis]. Terapevticheskii arkhiv, 1994, Volume: 66, Issue:11 Topics: Adolescent; Adult; Cetirizine; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Mid	1994
A comparison of topical levocabastine and oral terfenadine in the treatment of allergic rhinoconjunctivitis. The Livostin Study Group. Allergy, 1993, Volume: 48, Issue:7 Topics: Administration, Intranasal; Administration, Oral; Adult; Conjunctivitis, Allergic; Double-Blind Meth	1993
Safety and efficacy of topical levocabastine compared with oral terfenadine. Annals of allergy, 1994, Volume: 72, Issue:5 Topics: Administration, Oral; Administration, Topical; Adult; Conjunctivitis, Allergic; Double-Blind Method;	1994
Comparative efficacy of azelastine nasal spray and terfenadine in seasonal and perennial rhinitis. Allergy, 1994, Volume: 49, Issue:3 Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Double-Blind Method; Female; Ge	1994
Nasal application of a gel formulation of N-acetyl-aspartyl glutamic acid (NAAGA) compared with placebo and disodium cromoglycate in the symptomatic treatment of pollinosis. Allergy, 1994, Volume: 49, Issue:3 Topics: Administration, Intranasal; Adolescent; Adult; Analysis of Variance; Cromolyn Sodium; Dipeptides; Do	1994
Budesonide and terfenadine, separately and in combination, in the treatment of hay fever. Annals of allergy, 1994, Volume: 73, Issue:6 Topics: Adolescent; Adult; Budesonide; Double-Blind Method; Drug Evaluation; Drug Therapy, Combination; Fema	1994
A double-blind, placebo-controlled trial by the sublingual route of immunotherapy with a standardized grass pollen extract. Allergy, 1994, Volume: 49, Issue:5 Topics: Administration, Sublingual; Adolescent; Adult; Aerosols; Betamethasone; Chlorpheniramine; Combined M	1994
The effect of antihistamines on the immediate allergic response: a comparative review. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 1993, Volume: 108, Issue:6 Topics: Capillary Permeability; Cetirizine; Cyproheptadine; Diphenhydramine; Double-Blind Method; Histamine	1993
Topical levocabastine compared with orally administered terfenadine for the prophylaxis and treatment of seasonal rhinoconjunctivitis. The Journal of allergy and clinical immunology, 1993, Volume: 92, Issue:1 Pt 1 Topics: Administration, Oral; Adult; Aerosols; Conjunctivitis, Allergic; Double-Blind Method; Drug Tolerance	1993
[Sublingual specific immunotherapy for rhinoconjunctivitis caused by grass pollens]. Allergie et immunologie, 1993, Volume: 25, Issue:6 Topics: Administration, Sublingual; Adolescent; Adult; Allergens; Betamethasone; Chlorpheniramine; Combined	1993
Prevention of pollen rhinitis symptoms: comparison of fluticasone propionate aqueous nasal spray and disodium cromoglycate aqueous nasal spray. A multicenter, double-blind, double-dummy, parallel-group study. Allergy, 1993, Volume: 48, Issue:5 Topics: Administration, Intranasal; Adolescent; Adult; Aged; Androstadienes; Anti-Inflammatory Agents; Child	1993
Effects of cetirizine versus terfenadine in seasonal allergic rhinitis. Annals of allergy, 1993, Volume: 70, Issue:4 Topics: Adult; Cetirizine; Female; Humans; Male; Middle Aged; Patient Satisfaction; Rhinitis, Allergic, Seas	1993
Safety and efficacy of terfenadine/pseudoephedrine versus clemastine/phenylpropanolamine in the treatment of seasonal allergic rhinitis. Annals of allergy, 1993, Volume: 70, Issue:5 Topics: Adolescent; Adult; Child; Clemastine; Drug Combinations; Ephedrine; Female; Humans; Male; Middle Age	1993
Terfenadine exerts antiallergic activity reducing ICAM-1 expression on nasal epithelial cells in patients with pollen allergy. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1995, Volume: 25, Issue:9 Topics: Adolescent; Adult; Anti-Allergic Agents; Cell Communication; Conjunctivitis, Allergic; Double-Blind	1995
Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5 Topics: Adolescent; Adult; Aged; Cetirizine; Child; Double-Blind Method; Ephedrine; Female; Humans; Male; Mi	1996
Model for outcomes assessment of antihistamine use for seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1996, Volume: 97, Issue:6 Topics: Adolescent; Adult; Cetirizine; Chlorpheniramine; Decision Making; Female; Formularies as Topic; Hist	1996
Fluticasone propionate aqueous nasal spray compared with terfenadine tablets in the treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1996, Volume: 97, Issue:4 Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Androstadienes; Anti-Alle	1996
Effect of systemically administered H1- and H2-receptor antagonists on nasal blood flow as measured with laser Doppler flowmetry in a provoked allergic reaction. Rhinology, 1996, Volume: 34, Issue:1 Topics: Adult; Allergens; Cimetidine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagoni	1996
Brompheniramine, terfenadine, and placebo in allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 77, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Brompheniramine; Delayed-Action Preparations; Double-Bli	1996
Hypoglycemic effect of terfenadine in patients of allergic rhinitis. Indian journal of physiology and pharmacology, 1996, Volume: 40, Issue:2 Topics: Adult; Anti-Allergic Agents; Blood Glucose; Female; Humans; Male; Middle Aged; Rhinitis, Allergic, S	1996
First-line treatment of seasonal (ragweed) rhinoconjunctivitis. A randomized management trial comparing a nasal steroid spray and a nonsedating antihistamine. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1997, Apr-15, Volume: 156, Issue:8 Topics: Administration, Inhalation; Administration, Oral; Adult; Androstadienes; Anti-Allergic Agents; Conju	1997
Can an antihistamine delay appearance of hay fever symptoms when given prior to pollen season? Allergy, 1997, Volume: 52, Issue:4 Topics: Adult; Benzimidazoles; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antag	1997
Onset of action and efficacy of terfenadine, astemizole, cetirizine, and loratadine for the relief of symptoms of allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:2 Topics: Adolescent; Adult; Anti-Allergic Agents; Astemizole; Cetirizine; Double-Blind Method; Environmental	1997
Treatment of hay fever. The Journal of family practice, 1997, Volume: 45, Issue:3 Topics: Adolescent; Adult; Aged; Androstadienes; Anti-Allergic Agents; Drug Therapy, Combination; Fluticason	1997
Efficacy and safety of fexofenadine hydrochloride for treatment of seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:5 Topics: Adolescent; Adult; Aged; Child; Drug Evaluation; Female; Histamine Antagonists; Humans; Male; Middle	1997
Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance. The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3 Topics: Adult; Alcohol Drinking; Anti-Allergic Agents; Automobile Driving; Clemastine; Cross-Over Studies; D	1998
Comparison of the effects of terfenadine with fexofenadine on nasal provocation tests with allergen. The Journal of allergy and clinical immunology, 1999, Volume: 103, Issue:6 Topics: Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Ma	1999
The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:1 Topics: Adolescent; Adrenergic beta-Agonists; Adult; Aged; Child; Delayed-Action Preparations; Double-Blind	1999
Cardiovascular safety of fexofenadine HCl. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3 Topics: Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Electrocardiography; Hista	1999
Once-daily fexofenadine HCl improves quality of life and reduces work and activity impairment in patients with seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1999, Volume: 83, Issue:4 Topics: Activities of Daily Living; Adolescent; Aged; Anti-Allergic Agents; Child; Double-Blind Method; Drug	1999
Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1999, Volume: 104, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Cetirizine; Child; Double-Blind Method; Drug Administ	1999
Effects of fexofenadine, diphenhydramine, and alcohol on driving performance. A randomized, placebo-controlled trial in the Iowa driving simulator. Annals of internal medicine, 2000, Mar-07, Volume: 132, Issue:5 Topics: Adult; Automobile Driving; Cross-Over Studies; Diphenhydramine; Double-Blind Method; Ethanol; Female	2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:6 Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 An	2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:6 Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 An	2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:6 Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 An	2000
Comparison of the efficacy, safety and quality of life provided by fexofenadine hydrochloride 120 mg, loratadine 10 mg and placebo administered once daily for the treatment of seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2000, Volume: 30, Issue:6 Topics: Adolescent; Adult; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 An	2000
Efficacy and tolerability of loratadine versus fexofenadine in the treatment of seasonal allergic rhinitis: a double-blind comparison with crossover treatment of nonresponders. Clinical therapeutics, 2000, Volume: 22, Issue:6 Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Child; Cross-Over Studies; Double-Blind Method; Femal	2000
The changing face of antihistamines and cardiac adverse drug reactions: a clinical perspective. Journal of the Indian Medical Association, 2000, Volume: 98, Issue:7 Topics: Cardiovascular Diseases; Drug Interactions; Electrocardiography; Erythromycin; Female; Histamine H1	2000
Absence of nasal mucosal atrophy with fluticasone aqueous nasal spray. Archives of otolaryngology--head & neck surgery, 2001, Volume: 127, Issue:2 Topics: Administration, Intranasal; Administration, Oral; Adult; Androstadienes; Anti-Allergic Agents; Anti-	2001
Controlled comparison of the efficacy and safety of cetirizine 10 mg o.d. and fexofenadine 120 mg o.d. in reducing symptoms of seasonal allergic rhinitis. International archives of allergy and immunology, 2001, Volume: 125, Issue:1 Topics: Adult; Anti-Allergic Agents; Bronchial Provocation Tests; Cetirizine; Cross-Over Studies; Double-Bli	2001
Safety of fexofenadine in children treated for seasonal allergic rhinitis. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2001, Volume: 87, Issue:1 Topics: Asthma; Child; Double-Blind Method; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Therapeutic E	2001
Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen. Pharmacological research, 2001, Volume: 44, Issue:6 Topics: Adult; Allergens; Astemizole; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; P	2001
A comparison of once daily fexofenadine versus the combination of montelukast plus loratadine on domiciliary nasal peak flow and symptoms in seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2002, Volume: 32, Issue:1 Topics: Acetates; Adult; Anti-Allergic Agents; Cross-Over Studies; Cyclopropanes; Double-Blind Method; Drug	2002
Suppression of epicutaneous reactivity by terfenadine and loratadine. Annals of allergy, 1992, Volume: 68, Issue:1 Topics: Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Lor	1992
Combined treatment of allergic rhinitis with terfenadine and nimesulide, a non-steroidal antiinflammatory drug. Allergie et immunologie, 1992, Volume: 24, Issue:8 Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Drug Therapy, Combi	1992
Protective effect of different doses of terfenadine on the conjunctival provocation test. Allergy, 1992, Volume: 47, Issue:4 Pt 1 Topics: Adolescent; Adult; Allergens; Cell Count; Conjunctiva; Conjunctivitis, Allergic; Female; Humans; Mal	1992
Onset and duration of the effects of three antihistamines in current use--astemizole, loratadine and terfenadine forte--studied during prolonged, controlled allergen challenges in volunteers. The Journal of international medical research, 1992, Volume: 20, Issue:5 Topics: Adult; Allergens; Astemizole; Double-Blind Method; Female; Humans; Loratadine; Male; Nasal Mucosa; P	1992
Comparison of loratadine and terfenadine in allergic seasonal rhinoconjunctivitis with emphasis on nasal stuffiness and peak flow. Arzneimittel-Forschung, 1992, Volume: 42, Issue:10 Topics: Adolescent; Adult; Aged; Conjunctivitis, Allergic; Double-Blind Method; Female; Humans; Loratadine;	1992
Does nasal provocation play a role in the diagnosis and management of ragweed-induced allergic rhinitis? Annals of allergy, 1992, Volume: 68, Issue:3 Topics: Double-Blind Method; Humans; Nasal Provocation Tests; Pollen; Rhinitis, Allergic, Seasonal; Terfenad	1992
Comparative effects of terfenadine and loratadine in the treatment of hay fever. Journal of investigational allergology & clinical immunology, 1991, Volume: 1, Issue:6 Topics: Adolescent; Adult; Double-Blind Method; Female; Humans; Loratadine; Male; Middle Aged; Rhinitis, All	1991
Multicenter, crossover study of the efficacy and tolerability of terfenadine, 120 mg, versus cetirizine, 10 mg, in perennial allergic rhinitis. Annals of allergy, 1991, Volume: 67, Issue:4 Topics: Adult; Cetirizine; Dose-Response Relationship, Drug; Female; Histamine H1 Antagonists; Humans; Hydro	1991
Terfenadine, an H1 antihistamine, inhibits histamine release in vivo in the human. The American review of respiratory disease, 1990, Volume: 142, Issue:1 Topics: Allergens; Benzhydryl Compounds; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine	1990
Multicentre, double-blind comparison of terfenadine and cetirizine in patients with seasonal allergic rhinitis. The British journal of clinical practice, 1990, Volume: 44, Issue:3 Topics: Adult; Benzhydryl Compounds; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Humans; Hydr	1990
Mequitazine in the treatment of hayfever. The British journal of clinical practice, 1990, Volume: 44, Issue:5 Topics: Adolescent; Adult; Benzhydryl Compounds; Bronchodilator Agents; Clinical Trials as Topic; Drug Admin	1990
Treatment of seasonal allergic rhinitis: a comparison of a combination tablet of terfenadine and pseudoephedrine with the individual ingredients. The British journal of clinical practice, 1990, Volume: 44, Issue:7 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Double-Blind Method; Drug Combinations; Ephedrine; Fe	1990
A comparative study of terfenadine at two dose levels in the management of hayfever. The British journal of clinical practice, 1990, Volume: 44, Issue:9 Topics: Adult; Benzhydryl Compounds; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1	1990
Allergen-induced increase in nonspecific nasal reactivity is blocked by antihistamines without a clear-cut relationship to eosinophil influx. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:4 Pt 1 Topics: Allergens; Benzhydryl Compounds; Cetirizine; Double-Blind Method; Eosinophils; Histamine H1 Antagoni	1990
The effects of antihistamines beyond H1 antagonism in allergic inflammation. The Journal of allergy and clinical immunology, 1990, Volume: 86, Issue:6 Pt 2 Topics: Benzhydryl Compounds; Cetirizine; Cyproheptadine; Dermatitis, Atopic; Histamine H1 Antagonists; Hist	1990
Profile of ragweed hay fever symptom control with terfenadine started before or after symptoms are established. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1990, Volume: 20, Issue:1 Topics: Adult; Benzhydryl Compounds; Double-Blind Method; Female; Humans; Male; Medical Records; Plants; Ran	1990
Antiallergic activity of H1-receptor antagonists assessed by nasal challenge. The Journal of allergy and clinical immunology, 1988, Volume: 82, Issue:5 Pt 1 Topics: Adult; Benzhydryl Compounds; Cyproheptadine; Double-Blind Method; Histamine H1 Antagonists; Histamin	1988
French multicentre double-blind study to evaluate the efficacy and safety of acrivastine as compared with terfenadine in seasonal allergic rhinitis. The Journal of international medical research, 1989, Volume: 17 Suppl 2 Topics: Adult; Benzhydryl Compounds; Clinical Trials as Topic; Double-Blind Method; Female; France; Histamin	1989
Efficacy and safety of loratadine (10 mg once daily), terfenadine (60 mg twice daily), and placebo in the treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1989, Volume: 84, Issue:5 Pt 1 Topics: Adolescent; Adult; Benzhydryl Compounds; Cyproheptadine; Double-Blind Method; Drug Administration Sc	1989
[Use of first and second generation antihistaminics in pediatric patients with allergic rhinitis]. Revista medica de Panama, 1989, Volume: 14, Issue:3 Topics: Adolescent; Benzhydryl Compounds; Child; Child, Preschool; Clemastine; Drug Evaluation; Histamine H1	1989
Once versus twice daily dosing of terfenadine in the treatment of seasonal allergic rhinitis: US and European studies. Annals of allergy, 1989, Volume: 63, Issue:6 Pt 2 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Dose-Response Relationship, Drug; Double-Blind	1989
Terfenadine with or without phenylpropanolamine in the treatment of seasonal allergic rhinitis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1989, Volume: 19, Issue:6 Topics: Benzhydryl Compounds; Double-Blind Method; Drug Therapy, Combination; Female; Histamine H1 Antagonis	1989
A placebo-controlled comparison of the efficacy and tolerability of picumast dihydrochloride and terfenadine in patients with seasonal allergic rhinitis. Arzneimittel-Forschung, 1989, Volume: 39, Issue:10A Topics: Adult; Aged; Benzhydryl Compounds; Coumarins; Drug Tolerance; Histamine H1 Antagonists; Humans; Midd	1989
[Comparison of astemizole and terfenadine in maintenance therapy of hay fever]. Zeitschrift fur Hautkrankheiten, 1985, Volume: 60 Suppl 1 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Clinical Trials as Topic	1985
[Hay fever therapy with 2 non-sedating antihistaminics]. Zeitschrift fur Hautkrankheiten, 1985, Volume: 60 Suppl 1 Topics: Arousal; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Conjunctivitis;	1985
Multicenter, double-blind, placebo-controlled trial of terfenadine in seasonal allergic rhinitis and conjunctivitis. Annals of allergy, 1985, Volume: 54, Issue:6 Topics: Adult; Benzhydryl Compounds; Child; Clinical Trials as Topic; Conjunctivitis; Double-Blind Method; F	1985
Terfenadine--a non-sedating antihistamine. The Medical letter on drugs and therapeutics, 1985, Aug-02, Volume: 27, Issue:693 Topics: Adult; Benzhydryl Compounds; Child; Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Hypn	1985
A comparative study of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in seasonal allergic rhinitis. Current medical research and opinion, 1985, Volume: 9, Issue:8 Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Beclomethasone; Benzhydryl Comp	1985
Terfenadine, a nonsedating H1-antihistamine. Iowa medicine : journal of the Iowa Medical Society, 1985, Volume: 75, Issue:12 Topics: Benzhydryl Compounds; Clinical Trials as Topic; Double-Blind Method; Histamine H1 Antagonists; Human	1985
Astemizole and terfenadine compared in hay fever. The Practitioner, 1986, Volume: 230, Issue:1411 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Female; Histamine H1 Antagonist	1986
Multicenter, double-blind, placebo-controlled trial of terfenadine suspension in the treatment of fall-allergic rhinitis in children. The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:1 Pt 1 Topics: Benzhydryl Compounds; Child; Clinical Trials as Topic; Double-Blind Method; Female; Histamine H1 Ant	1986
Treatment of seasonal allergic rhinitis--a double blind, group comparative study of terfenadine and dexchlorpheniramine. Rhinology, 1987, Volume: 25, Issue:1 Topics: Adolescent; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Me	1987
[Terfenadine in allergic respiratory tract diseases. General practice study on the effectiveness and tolerance in children]. Fortschritte der Medizin, 1987, Apr-20, Volume: 105, Issue:11 Topics: Adolescent; Asthma; Benzhydryl Compounds; Child; Clinical Trials as Topic; Female; Histamine H1 Anta	1987
Astemizole suspension in the maintenance treatment of paediatric hay fever: a comparison with terfenadine suspension. Pharmatherapeutica, 1986, Volume: 4, Issue:10 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Female; Histamine H1 Antagonists; Humans; M	1986
Antihistaminic treatment of allergic rhinitis: a double-blind study with terfenadine versus dexchlorpheniramine. Pharmatherapeutica, 1987, Volume: 5, Issue:2 Topics: Adolescent; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Me	1987
[Astemizole and terfenadine: comparison of their therapeutic effect in pollen rhinitis]. Revue medicale de la Suisse romande, 1987, Volume: 107, Issue:10 Topics: Adolescent; Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Clinical Trials as Topic; Doubl	1987
Effect of terfenadine and placebo on symptoms after nasal allergen provocation. Clinical allergy, 1988, Volume: 18, Issue:1 Topics: Adult; Benzhydryl Compounds; Female; Histamine H1 Antagonists; Humans; Male; Nasal Provocation Tests	1988
A multicenter, open study of the non-sedating antihistamine, terfenadine (Seldane), in the maintenance therapy of seasonal allergic rhinitis. Annals of allergy, 1988, Volume: 60, Issue:4 Topics: Adult; Benzhydryl Compounds; Clinical Trials as Topic; Female; Headache; Histamine H1 Antagonists; H	1988
A multicentric study of loratadine, terfenadine and placebo in patients with seasonal allergic rhinitis. Arzneimittel-Forschung, 1988, Volume: 38, Issue:1 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Child; Clinical Trials as Topic; Cyproheptadine; Doub	1988
Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1988, Volume: 81, Issue:5 Pt 1 Topics: Adolescent; Adult; Benzhydryl Compounds; Clinical Trials as Topic; Cyproheptadine; Double-Blind Meth	1988
Hay fever treatment with combined antihistamine and cyclooxygenase-inhibiting drugs. The Journal of allergy and clinical immunology, 1988, Volume: 81, Issue:6 Topics: Adult; Benzhydryl Compounds; Conjunctivitis; Cyclooxygenase Inhibitors; Drug Therapy, Combination; F	1988
Prophylaxis of whole season hay fever symptomatology: a comparison of terfenadine with chlorpheniramine. The British journal of clinical practice, 1987, Volume: 41, Issue:11 Topics: Adolescent; Adult; Aged; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-Bl	1987
Treatment of seasonal allergic rhinitis with flunisolide and terfenadine. The Journal of international medical research, 1986, Volume: 14, Issue:1 Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Aged; Benzhydryl Compounds; Cli	1986
A double-blind comparison of terfenadine and mequitazine in the symptomatic treatment of acute pollinosis. The Journal of international medical research, 1986, Volume: 14, Issue:3 Topics: Adult; Benzhydryl Compounds; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Ph	1986
Terfenadine reduces skin and conjunctival reactivity in grass pollen allergic children. Clinical allergy, 1986, Volume: 16, Issue:5 Topics: Benzhydryl Compounds; Child; Clinical Trials as Topic; Conjunctiva; Conjunctivitis, Allergic; Double	1986
Group comparative trial of cromolyn sodium and terfenadine in the treatment of seasonal allergic rhinitis. Annals of allergy, 1987, Volume: 58, Issue:1 Topics: Administration, Intranasal; Administration, Oral; Benzhydryl Compounds; Clinical Trials as Topic; Cr	1987
Terfenadine treatment of fall hay fever. Annals of allergy, 1988, Volume: 60, Issue:2 Topics: Adolescent; Adult; Benzhydryl Compounds; Child; Clinical Trials as Topic; Double-Blind Method; Femal	1988
Efficacy of continuous treatment with astemizole (Hismanal) and terfenadine (Seldane) in ragweed pollen-induced rhinoconjunctivitis. The Journal of allergy and clinical immunology, 1988, Volume: 82, Issue:4 Topics: Adult; Allergens; Astemizole; Benzhydryl Compounds; Benzimidazoles; Conjunctivitis, Allergic; Drug T	1988
[Administration of terfenadine in a single dose: comparison to standard treatment, as a double blind study, in patients presenting with allergic rhinitis]. Allergie et immunologie, 1988, Volume: 20, Issue:10 Topics: Benzhydryl Compounds; Double-Blind Method; Drug Administration Schedule; Drug Tolerance; Humans; Mul	1988
Double-blind comparison of astemizole, terfenadine and placebo in hay fever with special regard to onset of action. The Journal of international medical research, 1985, Volume: 13, Issue:2 Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Female; Humans; Male;	1985
Comparative study of the efficacy, tolerance and side-effects of dexchlorpheniramine maleate 6 mg b.i.d. with terfenadine 60 mg b.i.d. The Journal of international medical research, 1985, Volume: 13, Issue:5 Topics: Adolescent; Adult; Benzhydryl Compounds; Child; Chlorpheniramine; Clinical Trials as Topic; Drug Tol	1985
Treatment of allergic rhinitis with a new selective H1 antihistamine: terfenadine. New England and regional allergy proceedings, 1985,Winter, Volume: 6, Issue:1 Topics: Administration, Oral; Adult; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Doubl	1985

Article	Year
Nasal Symptoms Reduction and Decreased Neutrophilia in Japanese Cedar Pollinosis With Prophylactic Treatment With a Combination of Montelukast, Fexofenadine, and Fluticasone Nasal Spray. American journal of rhinology & allergy, 2019, Volume: 33, Issue:4 Topics: Acetates; Adult; Anti-Allergic Agents; Cetirizine; Cryptomeria; Cyclopropanes; Drug Therapy, Combina	2019
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniram	2008
Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats. Pharmacology, 2009, Volume: 84, Issue:5 Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Dibenzoxepins; Disease Models, Animal; Dr	2009
Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs, 2009, Volume: 69, Issue:18 Topics: Acetates; Administration, Oral; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Astemizole; Ceti	2009
Effects of fexofenadine on inflammatory mediators in nasal lavage fluid in intermittent allergic rhinitis. Journal of investigational allergology & clinical immunology, 2009, Volume: 19, Issue:6 Topics: Adult; Aged; Anti-Inflammatory Agents; Antigens, Plant; Artemisia; Betula; Disease Progression; Eosi	2009
Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. International archives of allergy and immunology, 2011, Volume: 155, Issue:1 Topics: Adult; Antigens, Plant; Cell Proliferation; Chemokine CCL17; Chemokine CCL22; Chlorpheniramine; Extr	2011
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen. Acta oto-laryngologica, 2012, Volume: 132, Issue:4 Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; I	2012
Enhancement of clara cell 10-kD protein (CC10) production from nasal epithelial cells by fexofenadine hydrochloride. Asian Pacific journal of allergy and immunology, 2012, Volume: 30, Issue:2 Topics: Adult; Cells, Cultured; Cryptomeria; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Histamine	2012
The use of antihistamines in safety-critical jobs: a meeting report. Current medical research and opinion, 2002, Volume: 18, Issue:6 Topics: Aviation; Cognition; Histamine H1 Antagonists; Humans; Occupational Diseases; Occupations; Rhinitis,	2002
Decongestant effects of antihistamines: a class effect? The Journal of allergy and clinical immunology, 2003, Volume: 111, Issue:3 Topics: Controlled Clinical Trials as Topic; Histamine H1 Antagonists; Humans; Loratadine; Nasal Decongestan	2003
Assessing satisfaction with desloratadine and fexofenadine in allergy patients who report dissatisfaction with loratadine. BMC family practice, 2003, Aug-13, Volume: 4 Topics: Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Patient Satisf	2003
Is 3-mm less drowsiness important? Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2003, Volume: 91, Issue:4 Topics: Anti-Allergic Agents; Automobile Driving; Cetirizine; Humans; Rhinitis, Allergic, Seasonal; Severity	2003
Suppressive activity of fexofenadine hydrochloride on thymus- and activation-regulated chemokine production from human peripheral blood leukocytes in response to antigenic stimulation in vitro. International archives of allergy and immunology, 2004, Volume: 133, Issue:3 Topics: Adult; Allergens; Antigens, Plant; Cell Division; Chemokine CCL17; Chemokines, CC; Dose-Response Rel	2004
The utility of mixed-effects covariate analysis in rapid selection of doses in pediatric subjects: a case study with fexofenadine hydrochloride. Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:9 Topics: Administration, Oral; Adult; Age Factors; Analysis of Variance; Body Weight; Child; Child, Preschool	2004
Treatment of ear pain in pilots in flight. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 95, Issue:4 Topics: Aerospace Medicine; Anti-Allergic Agents; Humans; Loratadine; Pain; Rhinitis, Allergic, Seasonal; St	2005
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs. European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:10 Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunct	2006
[Treatment of allergic rhinitis associated with hypothyroidism]. Vestnik otorinolaringologii, 2006, Issue:6 Topics: Adult; Anti-Allergic Agents; Female; Humans; Hypothyroidism; Immunoglobulins; Male; Middle Aged; Rhi	2006
Non-interventional study comparing treatment satisfaction in patients treated with antihistamines. Clinical drug investigation, 2008, Volume: 28, Issue:4 Topics: Activities of Daily Living; Administration, Oral; Adult; Aged; Aged, 80 and over; Cetirizine; Child;	2008
Sedation and antihistaminics. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Benzhydryl Compounds; Diphenhydramine; Electroencephalography; Electromyography; Electrooculography;	1982
Prophylaxis of seasonal allergic rhinitis with a new antihistaminic drug. Arzneimittel-Forschung, 1982, Volume: 32, Issue:9a Topics: Adolescent; Adult; Benzhydryl Compounds; Female; Histamine H1 Antagonists; Humans; Immunoglobulin E;	1982
Practical therapeutics: the use of histamine receptor antagonists in contemporary times. East African medical journal, 1984, Volume: 61, Issue:7 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Child; Cimetidine; Conjunctivitis, Allergic; Hista	1984
[Present status and therapeutic prospectives on allergic rhinitis]. Giornale di clinica medica, 1983, Volume: 64, Issue:12 Topics: Benzhydryl Compounds; Humans; Immunotherapy; Isoquinolines; Rhinitis, Allergic, Perennial; Rhinitis,	1983
Effect of terfenadine on substance P and vasoactive intestinal polypeptide concentrations in nasal secretions from patients with nasal allergy. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:1 Topics: Adolescent; Adult; Chromatography, High Pressure Liquid; Humans; Immunoenzyme Techniques; Nasal Muco	1994
Hay fever drug to be banned by the FDA. BMJ (Clinical research ed.), 1997, Jan-25, Volume: 314, Issue:7076 Topics: Anti-Allergic Agents; Humans; Legislation, Medical; Rhinitis, Allergic, Seasonal; Terfenadine; Unite	1997
First-line treatment of hay fever: what is the best option? CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1997, Apr-15, Volume: 156, Issue:8 Topics: Administration, Inhalation; Administration, Oral; Administration, Topical; Androstadienes; Anti-Alle	1997
Hay fever drug to become prescription only. BMJ (Clinical research ed.), 1997, May-03, Volume: 314, Issue:7090 Topics: Drug Prescriptions; Histamine H1 Antagonists; Humans; Legislation, Drug; Rhinitis, Allergic, Seasona	1997
[Syncopes during simultaneous use of terfenadine and itraconazole]. Nederlands tijdschrift voor geneeskunde, 1997, May-10, Volume: 141, Issue:19 Topics: Adult; Anti-Allergic Agents; Antifungal Agents; Cardiotonic Agents; Female; Humans; Isoproterenol; I	1997
Non-sedating antihistamines and cardiac arrhythmia. Lancet (London, England), 1997, Oct-18, Volume: 350, Issue:9085 Topics: Drug Interactions; Histamine H1 Antagonists; Humans; Nonprescription Drugs; Rhinitis, Allergic, Seas	1997
Effect of fexofenadine on eosinophil-induced changes in epithelial permeability and cytokine release from nasal epithelial cells of patients with seasonal allergic rhinitis. The Journal of allergy and clinical immunology, 1998, Volume: 101, Issue:3 Topics: Cell Adhesion; Cell Membrane Permeability; Cells, Cultured; Chemokine CCL5; Chemotaxis, Leukocyte; C	1998
Effective treatment for ragweed allergy. Canadian family physician Medecin de famille canadien, 1998, Volume: 44 Topics: Androstadienes; Anti-Allergic Agents; Fluticasone; Humans; Pollen; Randomized Controlled Trials as T	1998
The clinical efficacy of H1 antagonists in urticaria and rhinitis. The Journal of allergy and clinical immunology, 1998, Volume: 102, Issue:2 Topics: Anti-Allergic Agents; Cetirizine; Histamine H1 Antagonists; Humans; Loratadine; Mathematical Computi	1998
Fexofenadine: new preparation. Terfenadine, without cardiotoxicity. Prescrire international, 1999, Volume: 8, Issue:39 Topics: Cetirizine; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Histamine Antagonists; Human	1999
Fexofenadine: a review of its use in the management of seasonal allergic rhinitis and chronic idiopathic urticaria. Drugs, 2000, Volume: 59, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Anti-Allergic Agents; Chronic Disease; Dose-Response Relati	2000
[Multiple prevention. On the way to an ideal antihistamine?]. MMW Fortschritte der Medizin, 2000, Jan-13, Volume: 142, Issue:1-2 Topics: Histamine H1 Antagonists; Humans; Mast Cells; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment O	2000
Newer antihistamines. The Medical letter on drugs and therapeutics, 2001, Apr-30, Volume: 43, Issue:1103 Topics: Administration, Oral; Anti-Allergic Agents; Cetirizine; Chlorpheniramine; Conscious Sedation; Diphen	2001
[Seasonal allergic rhinitis. Nasal obstruction can also beh improved]. MMW Fortschritte der Medizin, 2001, May-03, Volume: 143, Issue:18 Topics: Anti-Allergic Agents; Double-Blind Method; Humans; Loratadine; Multicenter Studies as Topic; Nasal O	2001
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:9 Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chrom	2001
Pharmacological characterization of the leukocyte kinetics after intranasal antigen challenge in a guinea pig model of allergic rhinitis. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:9 Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory	2001
[Hay fever and asthma. Many of your patients have both]. MMW Fortschritte der Medizin, 2002, Apr-25, Volume: 144, Issue:17 Topics: Asthma; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Terfenadine; Treatment Outco	2002
Patient hair loss. North Carolina medical journal, 1992, Volume: 53, Issue:8 Topics: Alopecia; Female; Humans; Middle Aged; Rhinitis, Allergic, Seasonal; Terfenadine	1992
Torsades de Pointes after treatment with terfenadine and ketoconazole. European heart journal, 1992, Volume: 13, Issue:7 Topics: Adult; Cardiac Pacing, Artificial; Dermatomycoses; Drug Therapy, Combination; Electrocardiography, A	1992
A double-blind comparative trial of astemizole and terfenadine for the treatment of hay fever. Allergie et immunologie, 1989, Volume: 21, Issue:10 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Double-Blind Method; Histamine H1 Antagonists; Hum	1989
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1985, Volume: 40, Issue:5 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Histamine H1 Antagonists; Humans; Rhinitis, Allerg	1985
Choice of antihistamines for allergic rhinitis. The Medical letter on drugs and therapeutics, 1987, Nov-20, Volume: 29, Issue:753 Topics: Benzhydryl Compounds; Clemastine; Histamine H1 Antagonists; Humans; Rhinitis, Allergic, Seasonal; Te	1987
The use of antihistamines for the treatment of airway disease. Cutis, 1988, Oct-27, Volume: 42, Issue:4A Topics: Astemizole; Asthma; Benzhydryl Compounds; Benzimidazoles; Child; Chlorpheniramine; Double-Blind Meth	1988
Comparative trial of two non-sedative H1 antihistamines, terfenadine and astemizole, for hay fever. Thorax, 1986, Volume: 41, Issue:8 Topics: Astemizole; Benzhydryl Compounds; Benzimidazoles; Biological Availability; Humans; Rhinitis, Allergi	1986

terfenadine and Rhinitis, Allergic, Seasonal