terfenadine has been researched along with Nasal Obstruction in 11 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Nasal Obstruction: Any hindrance to the passage of air into and out of the nose. The obstruction may be unilateral or bilateral, and may involve any part of the NASAL CAVITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of the thromboxane (TX) A2 antagonist seratrodast, the peptide leukotriene (p-LT) antagonist pranlukast, the antihistaminic drug terfenadine and the glucocorticoid dexamethasone on antigen-induced sneezing, biphasic nasal blockage and nasal hyperresponsiveness to histamine using a guinea pig model of allergic rhinitis." | 3.71 | Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis. ( Ashida, Y; Kohno, S; Matsumoto, T; Mizutani, N; Nabe, T; Sasaki, K; Yamasaki, M, 2001) |
| "Terfenadine was more efficient than budesonide against histamine-mediated symptoms such as sneezing and itching." | 2.68 | Effect of terfenadine and budesonide on nasal symptoms, olfaction, and nasal airway patency following allergen challenge. ( Hilberg, O, 1995) |
| "Cetirizine is a new antihistamine with greater selectivity for the histamine H1 receptor and a low rate of hepatic metabolism." | 2.68 | Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis. ( Dockhorn, R; Grossman, J; Lockey, RF; Lumry, W; Mitchell, DQ; Widlitz, MD; Woehler, T, 1996) |
| " Recommended dosage of loratadine (CAS 79794-75-5) is 10 mg once daily, whereas terfenadine (CAS 50679-08-8) until recently has been recommended as 60 mg twice daily." | 2.67 | Comparison of loratadine and terfenadine in allergic seasonal rhinoconjunctivitis with emphasis on nasal stuffiness and peak flow. ( Hindberg Rasmussen, W; Høi, L; Lorentzen, KA; Nüchel Petersen, L; Olsen, OT; Svendsen, UG, 1992) |
| "Fexofenadine was associated with significantly lower nasal congestion scores compared with placebo in 4 studies (P <- 0." | 2.45 | A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis. ( Bachert, C, 2009) |
| "Nasal obstruction is one of the most bothersome symptoms of allergic rhinitis (AR) affecting sleep-related quality of life in AR patients." | 1.56 | Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis. ( Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Aoyagi, H | 1 |
| Kajiwara, D | 1 |
| Tsunekuni, K | 1 |
| Tanaka, K | 1 |
| Miyoshi, K | 1 |
| Hirasawa, N | 1 |
| Sawatsubashi, M | 1 |
| Bachert, C | 1 |
| Mösges, R | 2 |
| Lehmacher, W | 1 |
| Pasch, N | 1 |
| Vent, J | 1 |
| Koop, A | 1 |
| Hilberg, O | 1 |
| Lockey, RF | 1 |
| Widlitz, MD | 1 |
| Mitchell, DQ | 1 |
| Lumry, W | 1 |
| Dockhorn, R | 1 |
| Woehler, T | 1 |
| Grossman, J | 1 |
| Yamasaki, M | 1 |
| Mizutani, N | 1 |
| Sasaki, K | 1 |
| Nabe, T | 1 |
| Matsumoto, T | 1 |
| Ashida, Y | 1 |
| Kohno, S | 1 |
| Olsen, OT | 1 |
| Nüchel Petersen, L | 1 |
| Høi, L | 1 |
| Lorentzen, KA | 1 |
| Hindberg Rasmussen, W | 1 |
| Svendsen, UG | 1 |
| Dijkman, JH | 1 |
| Hekking, PR | 1 |
| Molkenboer, JF | 1 |
| Nierop, G | 1 |
| Vanderschueren, R | 1 |
| Bernheim, J | 1 |
| Van Ganse, EH | 1 |
2 reviews available for terfenadine and Nasal Obstruction
| Article | Year |
|---|---|
[Clinical Management of Japanese Cedar Pollinosis].
Topics: Administration, Inhalation; Cedrus; Desensitization, Immunologic; Disorders of Excessive Somnolence; | 2016 |
A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cetirizine; Child; Clinical Trials as Topic; Female; His | 2009 |
6 trials available for terfenadine and Nasal Obstruction
| Article | Year |
|---|---|
Assessment of the antiobstructive effect of fexofenadine on nasal allergy challenge in patients with seasonal allergic rhinitis.
Topics: Administration, Oral; Antigens, Plant; Double-Blind Method; Histamine H1 Antagonists, Non-Sedating; | 2009 |
The use of handheld computers in clinical trials.
Topics: Adult; Anti-Allergic Agents; Data Collection; Databases, Factual; Double-Blind Method; Humans; Mathe | 2002 |
Effect of terfenadine and budesonide on nasal symptoms, olfaction, and nasal airway patency following allergen challenge.
Topics: Administration, Inhalation; Administration, Topical; Adult; Allergens; Anti-Inflammatory Agents; Bro | 1995 |
Comparative study of cetirizine and terfenadine versus placebo in the symptomatic management of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Cetirizine; Child; Double-Blind Method; Ephedrine; Female; Humans; Male; Mi | 1996 |
Comparison of loratadine and terfenadine in allergic seasonal rhinoconjunctivitis with emphasis on nasal stuffiness and peak flow.
Topics: Adolescent; Adult; Aged; Conjunctivitis, Allergic; Double-Blind Method; Female; Humans; Loratadine; | 1992 |
Prophylactic treatment of grass pollen-induced asthma with cetirizine.
Topics: Adolescent; Adult; Aged; Asthma; Benzhydryl Compounds; Cetirizine; Child; Double-Blind Method; Femal | 1990 |
3 other studies available for terfenadine and Nasal Obstruction
| Article | Year |
|---|---|
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Syne | 2020 |
[Seasonal allergic rhinitis. Nasal obstruction can also beh improved].
Topics: Anti-Allergic Agents; Double-Blind Method; Humans; Loratadine; Multicenter Studies as Topic; Nasal O | 2001 |
Involvement of thromboxane A2 and peptide leukotrienes in early and late phase nasal blockage in a guinea pig model of allergic rhinitis.
Topics: Animals; Anti-Allergic Agents; Anti-Asthmatic Agents; Anti-Inflammatory Agents; Benzoquinones; Chrom | 2001 |