terfenadine has been researched along with Melanoma in 3 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previously we found that terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca(2+) homeostasis." | 7.77 | Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. ( Alonso-Tejerina, E; Apraiz, A; Arroyo-Berdugo, Y; Asumendi, A; Boyano, MD; Careaga, JM; Díaz-Ramón, JL; Gardeazabal, J; Jangi, SM; Nicolau-Galmés, F; Pérez-Yarza, G, 2011) |
| "In our previous works, we have demonstrated that terfenadine (TEF) induces DNA damage and apoptosis in human melanoma cell lines." | 7.74 | Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors. ( Andollo, N; Arroyo-Berdugo, Y; Boyano, MD; Díaz-Pérez, JL; Jangi, SM; Nicolau-Galmés, F; Ortega-Martínez, I; Ruiz-Larrea, MB, 2008) |
| "Previously we found that terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca(2+) homeostasis." | 3.77 | Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. ( Alonso-Tejerina, E; Apraiz, A; Arroyo-Berdugo, Y; Asumendi, A; Boyano, MD; Careaga, JM; Díaz-Ramón, JL; Gardeazabal, J; Jangi, SM; Nicolau-Galmés, F; Pérez-Yarza, G, 2011) |
| "In our previous works, we have demonstrated that terfenadine (TEF) induces DNA damage and apoptosis in human melanoma cell lines." | 3.74 | Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors. ( Andollo, N; Arroyo-Berdugo, Y; Boyano, MD; Díaz-Pérez, JL; Jangi, SM; Nicolau-Galmés, F; Ortega-Martínez, I; Ruiz-Larrea, MB, 2008) |
| "Histamine has been demonstrated to be involved in cell proliferation, embryonic development, and tumour growth." | 2.46 | Histamine and histamine receptor antagonists in cancer biology. ( Alonso-Tejerina, E; Asumendi, A; Blaya, B; Boyano, MD; Burgos-Bretones, J; Jangi, SM; Nicolau-Galmés, F; Ortega-Martínez, I; Pérez-Yarza, G, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blaya, B | 1 |
| Nicolau-Galmés, F | 3 |
| Jangi, SM | 3 |
| Ortega-Martínez, I | 2 |
| Alonso-Tejerina, E | 2 |
| Burgos-Bretones, J | 1 |
| Pérez-Yarza, G | 2 |
| Asumendi, A | 2 |
| Boyano, MD | 3 |
| Gardeazabal, J | 1 |
| Arroyo-Berdugo, Y | 2 |
| Careaga, JM | 1 |
| Díaz-Ramón, JL | 1 |
| Apraiz, A | 1 |
| Ruiz-Larrea, MB | 1 |
| Andollo, N | 1 |
| Díaz-Pérez, JL | 1 |
1 review available for terfenadine and Melanoma
| Article | Year |
|---|---|
Histamine and histamine receptor antagonists in cancer biology.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Histamine; Histamine Antagonists; Histamin | 2010 |
2 other studies available for terfenadine and Melanoma
| Article | Year |
|---|---|
Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms.
Topics: Apoptosis; Autophagy; Caspases; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Me | 2011 |
Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors.
Topics: Apoptosis; Base Sequence; Calcium; Cell Line, Tumor; Cyclic AMP; Cyclic GMP; DNA Primers; Egtazic Ac | 2008 |