terfenadine has been researched along with Heart Diseases in 14 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Heart Diseases: Pathological conditions involving the HEART including its structural and functional abnormalities.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 7.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| "Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias." | 4.81 | Cardiotoxicity of new antihistamines and cisapride. ( Paakkari, I, 2002) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 3.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| "The risk of serious ventricular arrhythmias with terfenadine using epidemiologic data is the same or less than that associated with traditional first-generation antihistamines." | 2.67 | Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. ( Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 9 (64.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, JJ | 1 |
| Xu, YQ | 1 |
| He, JH | 1 |
| Yu, HP | 1 |
| Huang, CJ | 1 |
| Gao, JM | 1 |
| Dong, QX | 1 |
| Xuan, YX | 1 |
| Li, CQ | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Camelo-Nunes, IC | 1 |
| Crumb, WJ | 2 |
| Wible, B | 1 |
| Arnold, DJ | 1 |
| Payne, JP | 1 |
| Brown, AM | 2 |
| Morganroth, J | 1 |
| Critz, S | 1 |
| Kunze, DL | 1 |
| Lacerda, AE | 1 |
| Lopez, H | 1 |
| Marchiando, RJ | 1 |
| Cook, MD | 1 |
| Jue, SG | 1 |
| Hey, JA | 1 |
| del Prado, M | 1 |
| Kreutner, W | 1 |
| Egan, RW | 1 |
| Clark, S | 1 |
| Li, AP | 1 |
| Jurima-Romet, M | 2 |
| Roberts, DJ | 2 |
| Paakkari, I | 1 |
| Davies, AJ | 1 |
| Harindra, V | 1 |
| McEwan, A | 1 |
| Ghose, RR | 1 |
5 reviews available for terfenadine and Heart Diseases
| Article | Year |
|---|---|
New antihistamines: a critical view.
Topics: Anti-Allergic Agents; Blood-Brain Barrier; Central Nervous System Diseases; Cetirizine; Child; Cypro | 2006 |
Overview: pharmacokinetic drug-drug interactions.
Topics: Arabinofuranosyluracil; Contraceptives, Oral; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 E | 1997 |
Drug interactions: perspectives of the Canadian Drugs Directorate.
Topics: Canada; Drug Approval; Drug Interactions; Guidelines as Topic; Heart Diseases; Humans; Pharmaceutica | 1997 |
Towards the optimal antihistamine: studies with ebastine.
Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; | 1998 |
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Disea | 2002 |
1 trial available for terfenadine and Heart Diseases
| Article | Year |
|---|---|
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.
Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; H | 1993 |
8 other studies available for terfenadine and Heart Diseases
| Article | Year |
|---|---|
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Blockade of multiple human cardiac potassium currents by the antihistamine terfenadine: possible mechanism for terfenadine-associated cardiotoxicity.
Topics: Atrial Function; Carboxylic Acids; Cells, Cultured; Heart; Heart Atria; Heart Diseases; Humans; Kine | 1995 |
Probable terfenadine-fluoxetine-associated cardiac toxicity.
Topics: Adult; Anti-Allergic Agents; Antidepressive Agents, Second-Generation; Drug Interactions; Female; Fl | 1995 |
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; | 1996 |
Dangers of non-sedating antihistamines.
Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legi | 1997 |
Cardiotoxicity of second-generation antihistamines.
Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadi | 1999 |
Cardiotoxic effect with convulsions in terfenadine overdose.
Topics: Adult; Arrhythmias, Cardiac; Benzhydryl Compounds; Female; Heart Diseases; Histamine H1 Antagonists; | 1989 |