terfenadine has been researched along with Disease Models, Animal in 33 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 7.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 7.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 5.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Fexofenadine treatment of sensitized mice prevented the development of airway hyperresponsiveness in both the primary sensitization and challenge, as well as in the adoptive transfer experiments." | 5.31 | Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness. ( Cui, ZH; Gelfand, EW; Joetham, A; Kanehiro, A; Takeda, K, 2002) |
| "It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes." | 3.96 | Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes. ( Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Izumi-Nakaseko, H; Kambayashi, R; Matsumoto, A; Nunoi, Y; Sakamoto, K; Sugiyama, A, 2020) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 3.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| " Enzalutamide also induced bradycardia and death in zebrafish embryos in a dose-dependent manner and strongly synergized with the potassium-channel blocking agent, terfenadine, known to induce long QT syndrome and cardiac arrhythmia." | 3.85 | Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia. ( Berman, JN; Collins, CC; Dellaire, G; Holly, A; MacDonald, M; Melong, N; Steele, S; Zoubeidi, A, 2017) |
| " In this study, taking advantage of the transparency of larval zebrafish, Danio rerio, we assessed cardiovascular toxicity of seven known human cardiotoxic drugs (aspirin, clomipramine hydrochloride, cyclophosphamide, nimodipine, quinidine, terfenadine and verapamil hydrochloride) and two non-cardiovascular toxicity drugs (gentamicin sulphate and tetracycline hydrochloride) in zebrafish using six specific phenotypic endpoints: heart rate, heart rhythm, pericardial edema, circulation, hemorrhage and thrombosis." | 3.80 | Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish. ( Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ, 2014) |
| " This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K(+) channel blocking drug that can induce torsade de pointes." | 3.71 | Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes. ( Batey, AJ; Coker, SJ, 2002) |
| " Allergic bronchial eosinophilia in guinea pigs was inhibited by orally administered dexamethasone and methylprednisolone." | 3.68 | Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs. ( Chand, N; De Vine, CL; Diamantis, W; Harrison, JE; Jakubicki, RG; Nolan, KW; Pillar, J; Rooney, SM; Sofia, RD, 1993) |
| "Nasal obstruction is one of the most bothersome symptoms of allergic rhinitis (AR) affecting sleep-related quality of life in AR patients." | 1.56 | Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis. ( Aoyagi, H; Hirasawa, N; Kajiwara, D; Miyoshi, K; Tanaka, K; Tsunekuni, K, 2020) |
| "Olopatadine hydrochloride (olopatadine) is an antiallergic agent with histamine H(1) receptor antagonistic action." | 1.35 | Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats. ( Kimoto, N; Tamura, T, 2009) |
| "In search of suitable arrhythmia models, we isolated the zebrafish mutation reggae (reg), which displays clinical features of the malignant human short-QT syndrome such as accelerated cardiac repolarization accompanied by cardiac fibrillation." | 1.35 | Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. ( Fishman, MC; Friedrich, O; Hassel, D; Just, S; Karle, CA; Katus, HA; Marquart, S; Meder, B; Rottbauer, W; Scholz, EP; Seemann, G; Trano, N; Vogel, B; Weiss, DL; Zitron, E, 2008) |
| "Allergic rhinitis is an inflammatory disease of the nasal mucosa, induced by histamine, leukotrienes, and other substances released from mast cells." | 1.33 | Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis. ( Makita, S; Sakairi, T; Shakuto, S; Suzuki, K; Wajima, T; Yaguchi, M; Yoshida, Y, 2005) |
| "Fexofenadine treatment of sensitized mice prevented the development of airway hyperresponsiveness in both the primary sensitization and challenge, as well as in the adoptive transfer experiments." | 1.31 | Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness. ( Cui, ZH; Gelfand, EW; Joetham, A; Kanehiro, A; Takeda, K, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (21.21) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 4 (12.12) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zhao, X | 1 |
| Liu, R | 1 |
| Chen, Y | 1 |
| Hettinghouse, A | 1 |
| Liu, C | 1 |
| Goto, A | 1 |
| Sakamoto, K | 1 |
| Hagiwara-Nagasawa, M | 1 |
| Kambayashi, R | 1 |
| Chiba, K | 1 |
| Nunoi, Y | 1 |
| Izumi-Nakaseko, H | 2 |
| Matsumoto, A | 1 |
| Sugiyama, A | 4 |
| Aoyagi, H | 1 |
| Kajiwara, D | 1 |
| Tsunekuni, K | 1 |
| Tanaka, K | 1 |
| Miyoshi, K | 1 |
| Hirasawa, N | 1 |
| Cao, X | 1 |
| Wada, T | 1 |
| Nakamura, Y | 1 |
| Matsukura, S | 1 |
| Ando, K | 1 |
| Naito, AT | 1 |
| Matsubara, R | 1 |
| Kumagai, K | 1 |
| Shigematsu, H | 1 |
| Kitaura, K | 1 |
| Nakasone, Y | 1 |
| Suzuki, S | 1 |
| Hamada, Y | 2 |
| Suzuki, R | 1 |
| Melong, N | 1 |
| Steele, S | 1 |
| MacDonald, M | 1 |
| Holly, A | 1 |
| Collins, CC | 1 |
| Zoubeidi, A | 1 |
| Berman, JN | 1 |
| Dellaire, G | 1 |
| Raveendran, VV | 1 |
| Kassel, KM | 1 |
| Smith, DD | 1 |
| Luyendyk, JP | 1 |
| Williams, KJ | 1 |
| Cherian, R | 1 |
| Reed, GA | 1 |
| Flynn, CA | 1 |
| Csanaky, IL | 1 |
| Lickteig, AL | 1 |
| Pratt-Hyatt, MJ | 1 |
| Klaassen, CD | 1 |
| Dileepan, KN | 1 |
| Tang, C | 1 |
| Xie, D | 1 |
| Feng, B | 1 |
| Hawkes, N | 1 |
| Akiyama, K | 1 |
| Karaki, M | 1 |
| Kobayshi, R | 1 |
| Dobashi, H | 1 |
| Ishida, T | 1 |
| Mori, N | 1 |
| Tamura, T | 1 |
| Kimoto, N | 1 |
| Andoh, T | 1 |
| Sakai, K | 1 |
| Urashima, M | 1 |
| Kitazawa, K | 1 |
| Honma, A | 1 |
| Kuraishi, Y | 1 |
| Zhu, JJ | 1 |
| Xu, YQ | 1 |
| He, JH | 1 |
| Yu, HP | 1 |
| Huang, CJ | 1 |
| Gao, JM | 1 |
| Dong, QX | 1 |
| Xuan, YX | 1 |
| Li, CQ | 1 |
| Gelfand, EW | 2 |
| Cui, ZH | 2 |
| Takeda, K | 2 |
| Kanehiro, A | 2 |
| Joetham, A | 2 |
| Fossa, AA | 1 |
| DePasquale, MJ | 1 |
| Raunig, DL | 1 |
| Avery, MJ | 1 |
| Leishman, DJ | 1 |
| Sakairi, T | 1 |
| Suzuki, K | 1 |
| Makita, S | 1 |
| Wajima, T | 1 |
| Shakuto, S | 1 |
| Yoshida, Y | 1 |
| Yaguchi, M | 1 |
| Shiotani, M | 1 |
| Harada, T | 1 |
| Abe, J | 1 |
| Sawada, Y | 1 |
| Hashimoto, K | 2 |
| Horii, I | 1 |
| Aiba, T | 1 |
| Shimizu, W | 1 |
| Hidaka, I | 1 |
| Uemura, K | 1 |
| Noda, T | 1 |
| Zheng, C | 1 |
| Kamiya, A | 1 |
| Inagaki, M | 1 |
| Sugimachi, M | 1 |
| Sunagawa, K | 1 |
| Yamashita, H | 1 |
| Makino, T | 1 |
| Mizukami, H | 1 |
| Nose, M | 1 |
| Hassel, D | 1 |
| Scholz, EP | 1 |
| Trano, N | 1 |
| Friedrich, O | 1 |
| Just, S | 1 |
| Meder, B | 1 |
| Weiss, DL | 1 |
| Zitron, E | 1 |
| Marquart, S | 1 |
| Vogel, B | 1 |
| Karle, CA | 1 |
| Seemann, G | 1 |
| Fishman, MC | 1 |
| Katus, HA | 1 |
| Rottbauer, W | 1 |
| Yakuo, I | 1 |
| Ishii, K | 1 |
| Seto, Y | 1 |
| Imano, K | 1 |
| Takeyama, K | 1 |
| Nakamura, H | 1 |
| Karasawa, T | 1 |
| Chand, N | 1 |
| Harrison, JE | 1 |
| Rooney, SM | 1 |
| Nolan, KW | 1 |
| De Vine, CL | 1 |
| Jakubicki, RG | 1 |
| Pillar, J | 1 |
| Diamantis, W | 1 |
| Sofia, RD | 1 |
| Song, C | 1 |
| Earley, B | 1 |
| Leonard, BE | 1 |
| Roberts, DJ | 1 |
| Llenas, J | 1 |
| Hey, JA | 1 |
| del Prado, M | 1 |
| Sherwood, J | 1 |
| Kreutner, W | 1 |
| Egan, RW | 1 |
| Chow, JY | 1 |
| Ma, L | 1 |
| Cho, CH | 1 |
| Usui, T | 1 |
| Ishida, Y | 1 |
| Satoh, Y | 1 |
| Sasaki, Y | 1 |
| Musoh, K | 1 |
| Maeda, Y | 1 |
| Tanaka, H | 1 |
| Inagaki, N | 1 |
| Nagai, H | 1 |
| Batey, AJ | 1 |
| Coker, SJ | 1 |
1 review available for terfenadine and Disease Models, Animal
| Article | Year |
|---|---|
[Effects of clinically available drugs on the repolarization process of the heart assessed by the in vivo canine models].
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Antitubercular Agents; Cat | 2003 |
32 other studies available for terfenadine and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Cytosolic Phospholipase A2 Is Required for Fexofenadine's Therapeutic Effects against Inflammatory Bowel Disease in Mice.
Topics: Animals; Biomarkers, Pharmacological; Disease Models, Animal; Inflammatory Bowel Diseases; Mice; Mic | 2021 |
Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes.
Topics: Animals; Atrioventricular Block; Chronic Disease; Disease Models, Animal; Drug Synergism; Ketoconazo | 2020 |
Potential synergistic effects of novel hematopoietic prostaglandin D synthase inhibitor TAS-205 and different types of anti-allergic medicine on nasal obstruction in a Guinea pig model of experimental allergic rhinitis.
Topics: Acetates; Animals; Anti-Allergic Agents; Cell Line; Cyclopropanes; Disease Models, Animal; Drug Syne | 2020 |
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose | 2017 |
Fexofenadine Suppresses Delayed-Type Hypersensitivity in the Murine Model of Palladium Allergy.
Topics: Allergens; Animals; Anti-Allergic Agents; Antigen-Presenting Cells; Biomarkers; Cytokines; Disease M | 2017 |
Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.
Topics: Animals; Antineoplastic Agents; Benzamides; Bradycardia; Cell Line, Tumor; Cell Proliferation; Disea | 2017 |
H1-antihistamines exacerbate high-fat diet-induced hepatic steatosis in wild-type but not in apolipoprotein E knockout mice.
Topics: Animals; Apolipoproteins E; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Ca | 2014 |
Zebrafish as a new model for phenotype-based screening of positive inotropic agents.
Topics: Animals; Blood Pressure; Cardiotonic Agents; Digoxin; Disease Models, Animal; Embryo, Nonmammalian; | 2015 |
Dogs died in studies of drug that killed man in French trial.
Topics: Animals; Brain; Brain Diseases; Clinical Trials as Topic; Death; Disease Models, Animal; Disease Pro | 2016 |
IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model.
Topics: Animals; Anti-Allergic Agents; Carbazoles; Disease Models, Animal; Eosinophils; Female; Immunoglobul | 2009 |
Efficacy of repeated pretreatment with olopatadine hydrochloride on rhinitis induced by intranasal instillation of toluene-2,4-diisocyanate in rats.
Topics: Administration, Intranasal; Animals; Anti-Allergic Agents; Dibenzoxepins; Disease Models, Animal; Dr | 2009 |
Involvement of leukotriene B4 in itching in a mouse model of ocular allergy.
Topics: Allergens; Ambrosia; Animals; Conjunctivitis, Allergic; Disease Models, Animal; Glucocorticoids; His | 2012 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease | 2014 |
Fexofenadine modulates T-cell function, preventing allergen-induced airway inflammation and hyperresponsiveness.
Topics: Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Bronchial Hyperreactivity; Bronchoalveo | 2002 |
The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.
Topics: Animals; Anti-Arrhythmia Agents; Butylamines; Cisapride; Disease Models, Animal; Dogs; Female; Heart | 2002 |
Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.
Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Antibody Sp | 2003 |
Effects of fexofenadine hydrochloride in a guinea pig model of antigen-induced rhinitis.
Topics: Airway Resistance; Animals; Anti-Allergic Agents; Area Under Curve; Carbazoles; Disease Models, Anim | 2005 |
Practical application of guinea pig telemetry system for QT evaluation.
Topics: Animals; Anti-Arrhythmia Agents; Antipsychotic Agents; Bepridil; Cisapride; Disease Models, Animal; | 2005 |
Cellular basis for trigger and maintenance of ventricular fibrillation in the Brugada syndrome model: high-resolution optical mapping study.
Topics: Action Potentials; Animals; Cardiovascular Agents; Disease Models, Animal; Dogs; Electrocardiography | 2006 |
Pharmacological characterization of a chronic pruritus model induced by multiple application of 2,4,6-trinitrochlorobenzene in NC mice.
Topics: Animals; Antipruritics; Cell Degranulation; Chronic Disease; Cromolyn Sodium; Cyproheptadine; Dermat | 2007 |
Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Topics: Action Potentials; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Dise | 2008 |
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, D | 1994 |
Allergic bronchial eosinophilia: a therapeutic approach for the selection of potential bronchial anti-inflammatory drugs.
Topics: Albuterol; Allergens; Animals; Anti-Inflammatory Agents; Asthma; Bronchial Hyperreactivity; Bronchoa | 1993 |
Behavioural and immunological effects of the antihistamine terfenadine in olfactory bulbectomized rats.
Topics: Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Leukocytes; Lymphocytes; Mal | 1996 |
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig.
Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardio | 1996 |
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea | 1996 |
Involvement of free radicals and histamine in the potentiating action of cigarette smoke exposure on ethanol-induced gastric mucosal damage in rats.
Topics: Animals; Disease Models, Animal; Ethanol; Free Radicals; Gastric Mucosa; Histamine; Histamine H1 Ant | 1998 |
Simultaneous assessment of the hemodynamic, cardiomechanical, and electrophysiological effects of terfenadine on the in vivo canine model.
Topics: Analysis of Variance; Animals; Cardiovascular Physiological Phenomena; Cardiovascular System; Diseas | 1998 |
Effect of a novel anti-allergic agent, HSR-609, on antigen-induced airway hyperresponsiveness in mice.
Topics: Acetylcholine; Animals; Anti-Allergic Agents; Anti-Inflammatory Agents; Benzoxepins; Bronchial Hyper | 2000 |
Proarrhythmic potential of halofantrine, terfenadine and clofilium in a modified in vivo model of torsade de pointes.
Topics: Animals; Antimalarials; Disease Models, Animal; Electrocardiography; Histamine Antagonists; Male; Ph | 2002 |