terfenadine has been researched along with Death, Sudden, Cardiac in 5 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Death, Sudden, Cardiac: Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 7.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 7.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 3.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 3.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Radnic, B | 1 |
| Radojevic, N | 1 |
| Vucinic, J | 1 |
| Duborija-Kovacevic, N | 1 |
| Brown, AM | 1 |
| Hanrahan, JP | 1 |
| Choo, PW | 1 |
| Carlson, W | 1 |
| Greineder, D | 1 |
| Faich, GA | 1 |
| Platt, R | 1 |
| Pratt, CM | 1 |
| Hertz, RP | 1 |
| Ellis, BE | 1 |
| Crowell, SP | 1 |
| Louv, W | 1 |
| Moyé, L | 1 |
| Flockhart, DA | 1 |
1 review available for terfenadine and Death, Sudden, Cardiac
| Article | Year |
|---|---|
Drugs, hERG and sudden death.
Topics: Death, Sudden, Cardiac; Drug Evaluation, Preclinical; ERG1 Potassium Channel; Ether-A-Go-Go Potassiu | 2004 |
4 other studies available for terfenadine and Death, Sudden, Cardiac
| Article | Year |
|---|---|
The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?
Topics: Adult; Amitriptyline; Aortic Valve Stenosis; Arrhythmias, Cardiac; Autopsy; Caffeine; Death, Sudden, | 2017 |
Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Boston; Cohort Studies; Death, | 1995 |
Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Clemastine; Cohort Studies; Death, Sudden, Cardiac; | 1994 |
Drug interactions, cardiac toxicity, and terfenadine: from bench to clinic?
Topics: Death, Sudden, Cardiac; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome | 1996 |