terfenadine has been researched along with Cough in 8 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twelve healthy volunteers and 12 subjects with URI underwent pulmonary function testing and capsaicin cough challenge on two separate days, 2 h after ingesting 180 mg fexofenadine or matched placebo." | 9.10 | Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function. ( Dicpinigaitis, PV; Gayle, YE, 2003) |
| "Antihistamines have been reported to have antitussive actions in allergic rhinitis which may be due to an effect of the drug on the cough reflex." | 9.07 | The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers. ( Fuller, RW; Studham, J, 1992) |
| "We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes." | 7.73 | Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. ( Kamei, J; Takahashi, Y, 2006) |
| "The goal of the study was to determine if pranlukast has effects on the upper and lower airways through a comparison of the effects of fexofenadine and pranlukast on airway hyperresponsiveness in non-asthmatic patients with cedar pollinosis before the Japanese cedar pollen season and during the peak pollen season." | 5.14 | Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis. ( Fukuda, T; Kashima, R; Okada, T; Sagara, H; Yukawa, T, 2009) |
| "Twelve healthy volunteers and 12 subjects with URI underwent pulmonary function testing and capsaicin cough challenge on two separate days, 2 h after ingesting 180 mg fexofenadine or matched placebo." | 5.10 | Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function. ( Dicpinigaitis, PV; Gayle, YE, 2003) |
| "Antihistamines have been reported to have antitussive actions in allergic rhinitis which may be due to an effect of the drug on the cough reflex." | 5.07 | The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers. ( Fuller, RW; Studham, J, 1992) |
| "We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes." | 3.73 | Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. ( Kamei, J; Takahashi, Y, 2006) |
| " Before the amendment, assessments included physical examination, vital signs reporting (oral temperature, heart rate, and respiratory rate), and adverse event (AE) reporting." | 2.73 | Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old. ( Hampel, FC; Kittner, B; Lanier, R; Milgrom, H, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sagara, H | 1 |
| Yukawa, T | 1 |
| Kashima, R | 1 |
| Okada, T | 1 |
| Fukuda, T | 1 |
| Dicpinigaitis, PV | 1 |
| Gayle, YE | 1 |
| Kamei, J | 2 |
| Takahashi, Y | 2 |
| Milgrom, H | 1 |
| Kittner, B | 1 |
| Lanier, R | 1 |
| Hampel, FC | 1 |
| Itabashi, T | 1 |
| Hayashi, S | 1 |
| Kawai, K | 1 |
| Gorton, B | 1 |
| Ciprandi, G | 1 |
| Tosca, MA | 1 |
| Iudice, A | 1 |
| Buscaglia, S | 1 |
| Fasce, L | 1 |
| Canonica, GW | 1 |
| Studham, J | 1 |
| Fuller, RW | 1 |
4 trials available for terfenadine and Cough
| Article | Year |
|---|---|
Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.
Topics: Acetylcholine; Activities of Daily Living; Adult; Anti-Allergic Agents; Anti-Asthmatic Agents; Antig | 2009 |
Effect of the second-generation antihistamine, fexofenadine, on cough reflex sensitivity and pulmonary function.
Topics: Adolescent; Adult; Capsaicin; Cough; Cross-Over Studies; Double-Blind Method; Female; Forced Expirat | 2003 |
Safety and tolerability of fexofenadine for the treatment of allergic rhinitis in children 2 to 5 years old.
Topics: Age Factors; Anti-Allergic Agents; Body Temperature; Child, Preschool; Cough; Double-Blind Method; E | 2007 |
The effect of oral terfenadine on the sensitivity of the cough reflex in normal volunteers.
Topics: Administration, Oral; Adult; Capsaicin; Cough; Dose-Response Relationship, Drug; Double-Blind Method | 1992 |
4 other studies available for terfenadine and Cough
| Article | Year |
|---|---|
Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Citric Acid; Cough; Dose-Response Relat | 2006 |
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hy | 2008 |
Advice on medications for coughs and colds.
Topics: Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Child, Preschool; Common Col | 1997 |
Terfenadine in allergic chronic cough in children.
Topics: Asthma; Child; Chronic Disease; Cough; Female; Humans; Hypersensitivity; Male; Pilot Projects; Terfe | 1992 |