terfenadine has been researched along with Bronchospasm in 9 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effect of terfenadine, a selective H1-receptor antagonist devoid of central nervous system side effects, was evaluated on hyperventilation-induced bronchospasm in 11 adult subjects with asthma in a double-blind, placebo-controlled, crossover study." | 9.06 | Attenuation of hyperventilation-induced bronchospasm by terfenadine: a new antihistamine. ( Badier, M; Beaumont, D; Orehek, J, 1988) |
| " To investigate this further we have determined that, in eight mild atopic asthmatic subjects, terfenadine (180 mg), administered 3 hr pre-challenge, increases the geometric mean PC20 for histamine from 0." | 7.67 | The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma. ( Holgate, ST; Phillips, GD; Polosa, R, 1989) |
| " These effects on exercise-induced bronchospasm followed a dose-response curve; 180 mg had the most significant effect." | 6.66 | Terfenadine blockade of exercise-induced bronchospasm. ( Altman, LC; Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1989) |
| "The effect of terfenadine, a selective H1-receptor antagonist devoid of central nervous system side effects, was evaluated on hyperventilation-induced bronchospasm in 11 adult subjects with asthma in a double-blind, placebo-controlled, crossover study." | 5.06 | Attenuation of hyperventilation-induced bronchospasm by terfenadine: a new antihistamine. ( Badier, M; Beaumont, D; Orehek, J, 1988) |
| "In vivo antihistaminic activity experiments consisted of measurement of: inhibition of increase in capillary permeability and reduction in microvascular extravasation and bronchospasm in rats and guinea pigs induced by histamine and other inflammatory mediators; and protection against lethality induced by histamine and other inflammatory mediators in rats." | 3.73 | In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist. ( Berisa, A; Corcóstegui, R; Innerárity, A; Labeaga, L; Orjales, A, 2006) |
| " The present studies compared loratadine and terfenadine, another non-sedating antihistamine, for their ability to inhibit the bronchial response to histamine and other autacoids which have been implicated as contributing to the symptoms of an allergic reaction." | 3.67 | Antiallergic activity of loratadine, a non-sedating antihistamine. ( Chapman, RW; Gulbenkian, A; Kreutner, W; Siegel, MI, 1987) |
| " To investigate this further we have determined that, in eight mild atopic asthmatic subjects, terfenadine (180 mg), administered 3 hr pre-challenge, increases the geometric mean PC20 for histamine from 0." | 3.67 | The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma. ( Holgate, ST; Phillips, GD; Polosa, R, 1989) |
| " These effects on exercise-induced bronchospasm followed a dose-response curve; 180 mg had the most significant effect." | 2.66 | Terfenadine blockade of exercise-induced bronchospasm. ( Altman, LC; Bierman, CW; Furukawa, CT; Pierson, WE; Shapiro, GG, 1989) |
| "012) when the areas under the dose-response curves were compared." | 1.27 | Effect of terfenadine on the bronchoconstriction induced by ultrasonically nebulized distilled water. ( Bewtra, AK; Hopp, RJ; Nair, NM; Townley, RG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Corcóstegui, R | 1 |
| Labeaga, L | 1 |
| Innerárity, A | 1 |
| Berisa, A | 1 |
| Orjales, A | 1 |
| Kreutner, W | 1 |
| Chapman, RW | 1 |
| Gulbenkian, A | 1 |
| Siegel, MI | 1 |
| Badier, M | 1 |
| Beaumont, D | 1 |
| Orehek, J | 1 |
| Bewtra, AK | 2 |
| Hopp, RJ | 2 |
| Nair, NM | 2 |
| Townley, RG | 2 |
| Chanez, P | 1 |
| Bousquet, J | 1 |
| Mauboussin, JM | 1 |
| Godard, P | 1 |
| Michel, FB | 1 |
| Phillips, GD | 1 |
| Polosa, R | 1 |
| Holgate, ST | 1 |
| Pierson, WE | 1 |
| Furukawa, CT | 1 |
| Shapiro, GG | 1 |
| Altman, LC | 1 |
| Bierman, CW | 1 |
| Rafferty, P | 1 |
| Beasley, R | 1 |
| Southgate, P | 1 |
| Holgate, S | 1 |
3 trials available for terfenadine and Bronchospasm
| Article | Year |
|---|---|
Attenuation of hyperventilation-induced bronchospasm by terfenadine: a new antihistamine.
Topics: Adolescent; Adult; Asthma, Exercise-Induced; Benzhydryl Compounds; Bronchial Spasm; Clinical Trials | 1988 |
Terfenadine blockade of exercise-induced bronchospasm.
Topics: Adolescent; Adult; Benzhydryl Compounds; Bronchial Spasm; Bronchodilator Agents; Child; Female; Hist | 1989 |
The role of histamine in allergen and adenosine-induced bronchoconstriction.
Topics: Adenosine Monophosphate; Allergens; Astemizole; Benzhydryl Compounds; Benzimidazoles; Bronchial Prov | 1987 |
6 other studies available for terfenadine and Bronchospasm
| Article | Year |
|---|---|
In vivo pharmacological characterisation of bilastine, a potent and selective histamine H1 receptor antagonist.
Topics: Animals; Benzimidazoles; Bradykinin; Bronchial Spasm; Capillary Permeability; Cetirizine; Dermatitis | 2006 |
Antiallergic activity of loratadine, a non-sedating antihistamine.
Topics: Animals; Benzhydryl Compounds; Bronchial Spasm; Calcium; Cyproheptadine; Guinea Pigs; Histamine Anta | 1987 |
Effect of terfenadine on cold air-induced bronchospasm.
Topics: Air; Asthma; Benzhydryl Compounds; Bronchial Spasm; Cold Temperature; Dose-Response Relationship, Dr | 1989 |
Bronchoconstriction and pentamidine.
Topics: Amidines; Benzhydryl Compounds; Bronchial Spasm; Histamine H1 Antagonists; Humans; Pentamidine; Skin | 1989 |
The effect of histamine-H1 receptor antagonism with terfenadine on concentration-related AMP-induced bronchoconstriction in asthma.
Topics: Adult; Asthma; Benzhydryl Compounds; Bronchial Spasm; Cyclic AMP; Double-Blind Method; Female; Force | 1989 |
Effect of terfenadine on the bronchoconstriction induced by ultrasonically nebulized distilled water.
Topics: Adolescent; Adult; Benzhydryl Compounds; Bronchial Provocation Tests; Bronchial Spasm; Female; Force | 1988 |