terfenadine has been researched along with Bradycardia in 4 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Enzalutamide also induced bradycardia and death in zebrafish embryos in a dose-dependent manner and strongly synergized with the potassium-channel blocking agent, terfenadine, known to induce long QT syndrome and cardiac arrhythmia." | 3.85 | Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia. ( Berman, JN; Collins, CC; Dellaire, G; Holly, A; MacDonald, M; Melong, N; Steele, S; Zoubeidi, A, 2017) |
| "The effects of epinastine hydrochloride and terfenadine on electrocardiographic (ECG) parameters in rats were investigated from a pharmacokinetic and pharmacodynamic perspective." | 1.30 | A comparative pharmacokinetic-pharmacodynamic study of the electrocardiographic effects of epinastine and terfenadine in rats. ( Iga, T; Kotaki, H; Ohtani, H; Sawada, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melong, N | 1 |
| Steele, S | 1 |
| MacDonald, M | 1 |
| Holly, A | 1 |
| Collins, CC | 1 |
| Zoubeidi, A | 1 |
| Berman, JN | 1 |
| Dellaire, G | 1 |
| Takahara, A | 1 |
| Sugiyama, A | 1 |
| Ishida, Y | 1 |
| Satoh, Y | 1 |
| Wang, K | 1 |
| Nakamura, Y | 1 |
| Hashimoto, K | 1 |
| Crane, JK | 1 |
| Shih, HT | 1 |
| Ohtani, H | 1 |
| Kotaki, H | 1 |
| Sawada, Y | 1 |
| Iga, T | 1 |
4 other studies available for terfenadine and Bradycardia
| Article | Year |
|---|---|
Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.
Topics: Animals; Antineoplastic Agents; Benzamides; Bradycardia; Cell Line, Tumor; Cell Proliferation; Disea | 2017 |
Long-term bradycardia caused by atrioventricular block can remodel the canine heart to detect the histamine H1 blocker terfenadine-induced torsades de pointes arrhythmias.
Topics: Animals; Atrioventricular Node; Bradycardia; Catheter Ablation; Dogs; Dose-Response Relationship, Dr | 2006 |
Syncope and cardiac arrhythmia due to an interaction between itraconazole and terfenadine.
Topics: Bradycardia; Drug Interactions; Humans; Itraconazole; Male; Middle Aged; Syncope; Terfenadine | 1993 |
A comparative pharmacokinetic-pharmacodynamic study of the electrocardiographic effects of epinastine and terfenadine in rats.
Topics: Animals; Bradycardia; Chromatography, High Pressure Liquid; Dibenzazepines; Dose-Response Relationsh | 1997 |