terfenadine has been researched along with Atopic Hypersensitivity in 31 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fourteen atopic patients with mild-to-moderate asthma (forced expiratory volume in 1 second of 76%) completed a double-blind, randomized, crossover study consisting of 3-week treatment blocks of either fluticasone propionate-salmeterol, 250 microg twice daily, or fluticasone propionate alone, 250 microg twice daily, in conjunction with either fexofenadine, 180 mg once daily, or matched placebo." | 9.11 | Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma. ( Fardon, TC; Hodge, MR; Lee, DK; Lipworth, BJ, 2005) |
| "We have attempted to use a potent and selective histamine H1-receptor antagonist terfenadine to allow a larger dose of allergen to be administered to previous single early responders to investigate if an increased dose of allergen could induce a late asthmatic response." | 7.67 | The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response. ( Beasley, R; Holgate, ST; Lai, CK, 1989) |
| "Fourteen atopic patients with mild-to-moderate asthma (forced expiratory volume in 1 second of 76%) completed a double-blind, randomized, crossover study consisting of 3-week treatment blocks of either fluticasone propionate-salmeterol, 250 microg twice daily, or fluticasone propionate alone, 250 microg twice daily, in conjunction with either fexofenadine, 180 mg once daily, or matched placebo." | 5.11 | Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma. ( Fardon, TC; Hodge, MR; Lee, DK; Lipworth, BJ, 2005) |
| "Pretreatment with fexofenadine during venom immunotherapy reduces local allergic reactions and generalized symptoms of the urticaria and angioedema type." | 5.09 | Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial. ( Hari, Y; Müller, U; Reimers, A, 2000) |
| "We have attempted to use a potent and selective histamine H1-receptor antagonist terfenadine to allow a larger dose of allergen to be administered to previous single early responders to investigate if an increased dose of allergen could induce a late asthmatic response." | 3.67 | The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response. ( Beasley, R; Holgate, ST; Lai, CK, 1989) |
| "Diphenhydramine is often the treatment of choice for acute urticarial or allergic reactions despite its adverse effects of sedation and impairment." | 2.73 | Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine. ( Casale, TB; Jones, DH; Romero, FA, 2008) |
| " In conclusion, this study shows that, at the end of the conventional dosing interval, ebastine 10 mg and cetirizine 10 mg once daily in repeated doses suppressed the histamine wheal more effectively than did loratadine 10 mg once daily or fexofenadine 60 mg twice daily." | 2.70 | Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state. ( Boyce, M; Carey, W; Luria, X; Warrington, S, 2002) |
| "Erythromycin was started to treat presumed bacterial infection in children with complete radiologic opacification of the maxillary sinus(es)." | 2.69 | Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children. ( Delgado, LF; Naspitz, CK; Pferferman, A; Solé, D, 1998) |
| "Ebastine was no better than placebo until 4 h, but was efficacious thereafter until 24 h." | 2.69 | A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects. ( Danielson, L; DeVos, C; Grant, JA; Rihoux, JP, 1999) |
| "5." | 2.68 | Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers. ( Cabanis, MJ; Caplain, H; Chaufour, S; Rosenzweig, P; Thebault, JJ; Ulliac, N, 1995) |
| "Terfenadine is a selective histamine H1 receptor antagonist which binds preferentially to peripheral receptors in vivo and is devoid of central nervous system depressant activity and thus has an improved adverse effect profile (1)." | 2.67 | Pharmacodynamic bioequivalence: evaluation of different brands of terfenadine hydrochloride. ( Gupta, U; Mehta, VL; Tekur, U, 1993) |
| "Histamine was administered intradermally one hour prior to dosing for baseline measurements." | 2.66 | Evaluation of inhibition of wheal response to histamine by multiple doses of terfenadine. ( Ryan, WM, 1989) |
| " She subsequently received maintenance dosing in the outpatient clinic weekly for 4 weeks and bimonthly for 8 weeks, and she continues monthly maintenance VIT." | 1.33 | Ultrarush venom desensitization after systemic reactions during conventional venom immunotherapy. ( Chegini, S; Hamilos, DL; Oren, E, 2006) |
| " Pretreatment with antihistamines diminishes the incidence of adverse reactions (AR) such as large local and mild systemic reactions but it is suggested that it may mask a development of serious allergic reactions." | 1.33 | [Safety of venom immunotherapy in patients pretreated with antihistamines--a retrospective study]. ( Bocheńska-Marciniak, M; Kuna, P; Kupczyk, M; Kupryś-Lipińska, I; Tworek, D, 2006) |
| "Cetirizine also inhibited the immediate hypersensitivity reaction induced by Ascaris extract in dogs." | 1.27 | Inhibition of histamine and allergen skin wheal by cetirizine in four animal species. ( Baltes, E; De Vos, C; Gobert, J; Maleux, MR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (19.35) | 18.7374 |
| 1990's | 16 (51.61) | 18.2507 |
| 2000's | 8 (25.81) | 29.6817 |
| 2010's | 1 (3.23) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunawardena, MD | 1 |
| Weerasinghe, A | 1 |
| Herath, J | 1 |
| Amarasena, N | 1 |
| Jones, DH | 1 |
| Romero, FA | 1 |
| Casale, TB | 1 |
| Inoue, T | 1 |
| Katoh, N | 1 |
| Kishimoto, S | 1 |
| Matsunaga, K | 1 |
| Carey, W | 1 |
| Warrington, S | 1 |
| Boyce, M | 1 |
| Luria, X | 1 |
| Fardon, TC | 1 |
| Lee, DK | 1 |
| Hodge, MR | 1 |
| Lipworth, BJ | 1 |
| Oren, E | 1 |
| Chegini, S | 1 |
| Hamilos, DL | 1 |
| Tworek, D | 1 |
| Bocheńska-Marciniak, M | 1 |
| Kupczyk, M | 1 |
| Kupryś-Lipińska, I | 1 |
| Kuna, P | 1 |
| Maier, T | 1 |
| Herzinger, T | 1 |
| de Weck, AL | 1 |
| Derer, T | 1 |
| Bischoff, SC | 1 |
| Takafuji, S | 1 |
| Christensen, M | 1 |
| Moelby, L | 1 |
| Svendsen, F | 1 |
| Scott, DW | 1 |
| Miller, WH | 1 |
| Cayatte, SM | 1 |
| Decker, GA | 1 |
| Tekur, U | 1 |
| Gupta, U | 1 |
| Mehta, VL | 1 |
| Chhabra, SK | 1 |
| Singh, P | 1 |
| Jhamb, S | 1 |
| Agarwal, MK | 1 |
| Rosenzweig, P | 1 |
| Caplain, H | 1 |
| Chaufour, S | 1 |
| Ulliac, N | 1 |
| Cabanis, MJ | 1 |
| Thebault, JJ | 1 |
| Paul, E | 1 |
| Merk, HF | 1 |
| Delgado, LF | 1 |
| Pferferman, A | 1 |
| Solé, D | 1 |
| Naspitz, CK | 1 |
| Grant, JA | 1 |
| Danielson, L | 1 |
| Rihoux, JP | 2 |
| DeVos, C | 1 |
| Reimers, A | 1 |
| Hari, Y | 1 |
| Müller, U | 1 |
| Kaliner, MA | 1 |
| Ghys, L | 1 |
| Mühlethaler, K | 1 |
| Wüthrich, B | 1 |
| Shall, L | 1 |
| Thompson, DA | 1 |
| Barkley, AS | 1 |
| Millard, LG | 1 |
| Sciberras, DG | 1 |
| Jordan, S | 1 |
| Gill, D | 1 |
| Baber, NS | 1 |
| James, I | 1 |
| Hamid, M | 1 |
| Rafferty, P | 1 |
| Holgate, ST | 4 |
| Church, MM | 1 |
| Lai, C | 1 |
| Beasley, R | 2 |
| Featherstone, RL | 1 |
| Djukanovic, R | 1 |
| Finnerty, JP | 1 |
| Lai, CK | 1 |
| Ryan, WM | 1 |
| De Vos, C | 1 |
| Maleux, MR | 1 |
| Baltes, E | 1 |
| Gobert, J | 1 |
| Gendreau-Reid, L | 1 |
| Simons, KJ | 1 |
| Simons, FE | 1 |
1 review available for terfenadine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Nonsedating antihistamines: pharmacology, clinical efficacy and adverse effects.
Topics: Astemizole; Cyproheptadine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Loratadin | 1992 |
18 trials available for terfenadine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine.
Topics: Administration, Oral; Adolescent; Adult; Child; Cross-Over Studies; Diphenhydramine; Double-Blind Me | 2008 |
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Hist | 2002 |
Addition of fexofenadine to inhaled corticosteroid therapy to reduce inflammatory biomarkers in atopic asthma.
Topics: Adenosine Monophosphate; Administration, Inhalation; Adolescent; Adrenal Cortex Hormones; Adult; Alb | 2005 |
The effect of terfenadine on the immediate and late-phase reactions mediated by immunoglobulin E.
Topics: Administration, Oral; Allergens; Antibodies, Anti-Idiotypic; Basophils; Candida albicans; Complement | 1993 |
Reliability of skin prick tests during terfenadine treatment in adults with pollen rhinitis. A clinical study.
Topics: Adolescent; Adult; Allergens; Cross-Over Studies; Double-Blind Method; Drug Hypersensitivity; Humans | 1994 |
Failure of terfenadine as an antipruritic agent in atopic dogs: results of a double-blinded, placebo-controlled study.
Topics: Administration, Oral; Animals; Dog Diseases; Dogs; Double-Blind Method; Female; Hypersensitivity, Im | 1994 |
Pharmacodynamic bioequivalence: evaluation of different brands of terfenadine hydrochloride.
Topics: Adult; Aged; Double-Blind Method; Histamine; Humans; Hypersensitivity, Immediate; Middle Aged; Terfe | 1993 |
Comparative wheal and flare study of mizolastine vs terfenadine, cetirizine, loratadine and placebo in healthy volunteers.
Topics: Adult; Benzimidazoles; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine H1 Antagonists | 1995 |
Evaluation of the potential cardiotoxicity of the antihistamines terfenadine, astemizole, loratadine, and cetirizine in atopic children.
Topics: Anti-Allergic Agents; Anti-Bacterial Agents; Astemizole; Cetirizine; Child; Child, Preschool; Drug I | 1998 |
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamin | 1999 |
Reduction of side-effects from ultrarush immunotherapy with honeybee venom by pretreatment with fexofenadine: a double-blind, placebo-controlled trial.
Topics: Adolescent; Adult; Angioedema; Anti-Allergic Agents; Bee Venoms; Double-Blind Method; Drug Therapy, | 2000 |
The skin as a target organ for the investigation of antiallergic drugs: comparison between cetirizine and terfenadine.
Topics: Adolescent; Adult; Antigens; Cetirizine; Dermatitis; Double-Blind Method; Female; Histamine; Histami | 1992 |
Comparative inhibition profiles of three non-sedating antihistamines assessed by an extended Lewis model.
Topics: Adult; Analysis of Variance; Cetirizine; Cyproheptadine; Female; Histamine Antagonists; Histamine H1 | 1992 |
The role of histamine in the acute inflammatory responses to intradermal platelet activating factor.
Topics: Benzhydryl Compounds; Double-Blind Method; Drug Hypersensitivity; Histamine; Histamine H1 Antagonist | 1991 |
The inhibitory effect of terfenadine and flurbiprofen on early and late-phase bronchoconstriction following allergen challenge in atopic asthma.
Topics: Adolescent; Adult; Allergens; Asthma; Benzhydryl Compounds; Bronchial Provocation Tests; Female; Flu | 1990 |
Wheal-and-flare responses to intradermally injected adenosine 5'-monophosphate, hypertonic saline, and histamine: comparison of atopic and nonatopic subjects.
Topics: Adenosine Monophosphate; Benzhydryl Compounds; Data Interpretation, Statistical; Dose-Response Relat | 1989 |
Evaluation of inhibition of wheal response to histamine by multiple doses of terfenadine.
Topics: Adolescent; Adult; Benzhydryl Compounds; Clinical Trials as Topic; Dose-Response Relationship, Drug; | 1989 |
Comparison of the suppressive effect of astemizole, terfenadine, and hydroxyzine on histamine-induced wheals and flares in humans.
Topics: Adult; Astemizole; Benzhydryl Compounds; Benzimidazoles; Dose-Response Relationship, Immunologic; Do | 1986 |
12 other studies available for terfenadine and Atopic Hypersensitivity
| Article | Year |
|---|---|
Myocardial infarction associated with eosinophilia and plasma extravasation at multiple sites. A variant of Kounis syndrome.
Topics: Adult; Anti-Allergic Agents; Anti-Inflammatory Agents; Eosinophilia; Humans; Hypersensitivity, Immed | 2015 |
Inhibitory effects of oral prednisolone and fexofenadine on skin responses by prick tests with histamine and compound 48/80.
Topics: Administration, Oral; Adult; Anti-Allergic Agents; Female; Glucocorticoids; Histamine; Humans; Hyper | 2002 |
Ultrarush venom desensitization after systemic reactions during conventional venom immunotherapy.
Topics: Adult; Anti-Allergic Agents; Desensitization, Immunologic; Female; Humans; Hypersensitivity, Immedia | 2006 |
[Safety of venom immunotherapy in patients pretreated with antihistamines--a retrospective study].
Topics: Adolescent; Adult; Aged; Anaphylaxis; Animals; Bee Venoms; Desensitization, Immunologic; Erythema; F | 2006 |
[Linear dermatitis due to shiitake mushrooms].
Topics: Administration, Oral; Administration, Topical; Adult; Androstadienes; Anti-Allergic Agents; Dermatit | 2007 |
Duration of inhibitory effect of terfenadine on histamine-induced skin wheals.
Topics: Adult; Dose-Response Relationship, Immunologic; Drug Administration Schedule; Female; Histamine; His | 1996 |
[Introduction of a new antihistamine generation].
Topics: Histamine Antagonists; Histamine H1 Antagonists; Humans; Hypersensitivity; Hypersensitivity, Immedia | 1997 |
[Further development of terfenadine].
Topics: Clinical Trials as Topic; Histamine Antagonists; Histamine H1 Antagonists; Humans; Hypersensitivity, | 1997 |
[Fexofenadine--progress in antihistamine therapy].
Topics: Histamine H1 Antagonists; Humans; Hypersensitivity; Hypersensitivity, Immediate; Terfenadine | 1997 |
The mediator and cellular basis of the allergic response.
Topics: Animals; Asthma; Benzhydryl Compounds; Cromolyn Sodium; Eosinophils; Guinea Pigs; Histamine H1 Antag | 1988 |
The effect of an increase in inhaled allergen dose after terfenadine on the occurrence and magnitude of the late asthmatic response.
Topics: Administration, Inhalation; Adult; Aged; Allergens; Asthma; Benzhydryl Compounds; Female; Forced Exp | 1989 |
Inhibition of histamine and allergen skin wheal by cetirizine in four animal species.
Topics: Allergens; Animals; Benzhydryl Compounds; Cetirizine; Clemastine; Dogs; Female; Guinea Pigs; Histami | 1987 |