terfenadine has been researched along with Arrhythmia in 48 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 7.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 7.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 7.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| "Although the new second-generation nonsedative antihistamines terfenadine and astemizole were launched as highly selective and specific H(1)-receptor antagonists, they were later found to cause prolongation of the QT-interval and severe cardiac arrhythmias." | 4.81 | Cardiotoxicity of new antihistamines and cisapride. ( Paakkari, I, 2002) |
| "Using moxifloxacin and terfenadine, which are known to induce benign and malignant QT interval prolongation, respectively, we analysed whether halothane-anaesthetized microminipigs are an appropriate model for assessing the risk of drug-induced long QT syndrome." | 3.85 | Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome. ( Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Naito, AT; Nakamura, Y; Sugiyama, A; Wada, T, 2017) |
| "This study compared the occurrence of syncope, ventricular arrhythmias, and corrected QT interval (QTc) prolongation over a 2 1/2-year period in persons prescribed terfenadine versus other prescription antihistamines among 265,000 members of the Harvard Community Health Plan (HCHP), the largest staff-model health maintenance organization in New England." | 3.69 | Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. ( Carlson, W; Choo, PW; Faich, GA; Greineder, D; Hanrahan, JP; Platt, R, 1995) |
| "Terfenadine and astemizole are widely prescribed nonsedating antihistamines that have been associated with QT-interval prolongation and ventricular arrhythmias." | 3.69 | Regulation of potassium channels by nonsedating antihistamines. ( Berul, CI; Morad, M, 1995) |
| "Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially fatal ventricular arrhythmias." | 3.69 | Possible interactions with terfenadine or astemizole. ( Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD, 1994) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 3.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| "The risk of serious ventricular arrhythmias with terfenadine using epidemiologic data is the same or less than that associated with traditional first-generation antihistamines." | 2.67 | Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. ( Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J, 1993) |
| "In order to better understand the variability of pharmacodynamic and pharmacokinetic profiles of terfenadine between the previous studies as well as to qualitatively and quantitatively examine the proarrhythmic potential of its major active metabolite fexofenadine in comparison with that of terfenadine, we directly compared their electropharmacological effects with halothane-anesthetized dogs (n = 3)." | 1.48 | Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsa ( Ando, K; Chiba, K; Goto, A; Hagiwara-Nagasawa, M; Harada, H; Inamura, N; Izumi-Nakaseko, H; Lubna, NJ; Miyamoto, H; Naito, AT; Nakamura, Y; Sugiyama, A; Takagi, K, 2018) |
| "In search of suitable arrhythmia models, we isolated the zebrafish mutation reggae (reg), which displays clinical features of the malignant human short-QT syndrome such as accelerated cardiac repolarization accompanied by cardiac fibrillation." | 1.35 | Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. ( Fishman, MC; Friedrich, O; Hassel, D; Just, S; Karle, CA; Katus, HA; Marquart, S; Meder, B; Rottbauer, W; Scholz, EP; Seemann, G; Trano, N; Vogel, B; Weiss, DL; Zitron, E, 2008) |
| "Cisapride (Propulsid) is a gastrointestinal prokinetic agent commonly used to treat nocturnal heartburn as well as a variety of other gastrointestinal disorders." | 1.30 | A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG. ( Brown, AM; Dennis, A; Rampe, D; Roy, ML, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.08) | 18.7374 |
| 1990's | 28 (58.33) | 18.2507 |
| 2000's | 11 (22.92) | 29.6817 |
| 2010's | 6 (12.50) | 24.3611 |
| 2020's | 2 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Rampe, D | 1 |
| Roy, ML | 1 |
| Dennis, A | 1 |
| Brown, AM | 2 |
| Jia, L | 1 |
| Sun, H | 1 |
| Brinkwirth, N | 1 |
| Takasuna, K | 1 |
| Doi, M | 1 |
| Becker, N | 1 |
| Obergrussberger, A | 1 |
| Friis, S | 1 |
| Furukawa, H | 1 |
| Hasegawa, Y | 1 |
| Oka, T | 1 |
| Ohtsuki, A | 1 |
| Fertig, N | 1 |
| Stoelzle-Feix, S | 1 |
| Kimura, A | 1 |
| Murakami, S | 1 |
| Cao, X | 1 |
| Wada, T | 1 |
| Nakamura, Y | 2 |
| Matsukura, S | 1 |
| Izumi-Nakaseko, H | 2 |
| Ando, K | 2 |
| Naito, AT | 2 |
| Sugiyama, A | 2 |
| Polak, S | 2 |
| Wiśniowska, B | 2 |
| Mendyk, A | 1 |
| Pacławski, A | 1 |
| Szlęk, J | 1 |
| Hagiwara-Nagasawa, M | 1 |
| Harada, H | 1 |
| Miyamoto, H | 1 |
| Inamura, N | 1 |
| Takagi, K | 1 |
| Goto, A | 1 |
| Chiba, K | 1 |
| Lubna, NJ | 1 |
| Badyra, B | 1 |
| Lisowski, B | 1 |
| Kudolo, J | 1 |
| Radnic, B | 1 |
| Radojevic, N | 1 |
| Vucinic, J | 1 |
| Duborija-Kovacevic, N | 1 |
| Sintra Grilo, L | 1 |
| Carrupt, PA | 1 |
| Abriel, H | 1 |
| Daina, A | 1 |
| Di Diego, JM | 1 |
| Cordeiro, JM | 1 |
| Goodrow, RJ | 1 |
| Fish, JM | 3 |
| Zygmunt, AC | 1 |
| Pérez, GJ | 1 |
| Scornik, FS | 1 |
| Antzelevitch, C | 3 |
| Scherer, CR | 1 |
| Lerche, C | 1 |
| Decher, N | 1 |
| Dennis, AT | 1 |
| Maier, P | 1 |
| Ficker, E | 1 |
| Busch, AE | 1 |
| Wollnik, B | 1 |
| Steinmeyer, K | 1 |
| Welchons, DR | 1 |
| Kim, YS | 1 |
| Lee, SH | 1 |
| Ho, WK | 1 |
| Hove-Madsen, L | 1 |
| Llach, A | 1 |
| Molina, CE | 1 |
| Prat-Vidal, C | 1 |
| Farré, J | 1 |
| Roura, S | 1 |
| Cinca, J | 1 |
| Mikhail, A | 1 |
| Fischer, C | 1 |
| Patel, A | 1 |
| Long, MA | 1 |
| Limberis, JT | 1 |
| Martin, RL | 1 |
| Cox, BF | 1 |
| Gintant, GA | 1 |
| Su, Z | 1 |
| Darpö, B | 1 |
| Hassel, D | 1 |
| Scholz, EP | 1 |
| Trano, N | 1 |
| Friedrich, O | 1 |
| Just, S | 1 |
| Meder, B | 1 |
| Weiss, DL | 1 |
| Zitron, E | 1 |
| Marquart, S | 1 |
| Vogel, B | 1 |
| Karle, CA | 1 |
| Seemann, G | 1 |
| Fishman, MC | 1 |
| Katus, HA | 1 |
| Rottbauer, W | 1 |
| Hanrahan, JP | 1 |
| Choo, PW | 1 |
| Carlson, W | 1 |
| Greineder, D | 1 |
| Faich, GA | 1 |
| Platt, R | 1 |
| Berul, CI | 1 |
| Morad, M | 1 |
| Burkhart, GA | 1 |
| Freiman, J | 1 |
| Zechnich, AD | 2 |
| Hedges, JR | 1 |
| Eiselt-Proteau, D | 1 |
| Haxby, D | 1 |
| Marquardt, D | 1 |
| Pratt, CM | 1 |
| Hertz, RP | 1 |
| Ellis, BE | 1 |
| Crowell, SP | 1 |
| Louv, W | 1 |
| Moyé, L | 1 |
| Honig, PK | 2 |
| Cantilena, LR | 1 |
| Morganroth, J | 1 |
| Critz, S | 1 |
| Crumb, WJ | 1 |
| Kunze, DL | 1 |
| Lacerda, AE | 1 |
| Lopez, H | 1 |
| Sabbah, A | 1 |
| Haxby, DG | 1 |
| Ohtani, H | 2 |
| Hanada, E | 1 |
| Yamamoto, K | 1 |
| Sawada, Y | 2 |
| Iga, T | 2 |
| Usuda, K | 1 |
| Clark, S | 1 |
| Himmel, MH | 1 |
| Worobec, AS | 1 |
| Tafler, G | 1 |
| Sato, H | 1 |
| Kotaki, H | 1 |
| de Abajo, FJ | 1 |
| Rodríguez, LA | 1 |
| Giraud, T | 1 |
| Po, AL | 1 |
| Kendall, MJ | 1 |
| Ohmura, T | 1 |
| Chachin, M | 1 |
| Tarui, S | 1 |
| Nagakura, A | 1 |
| Igarashi, T | 1 |
| Ikeda, H | 1 |
| Ikegami, K | 1 |
| Kitagawa, H | 1 |
| Uchida, S | 1 |
| Kashyap, AS | 1 |
| Kashyap, S | 1 |
| Craig-McFeely, PM | 1 |
| Freemantle, SL | 1 |
| Pearce, GL | 1 |
| Shakir, SA | 1 |
| Paakkari, I | 1 |
| Feychting, K | 1 |
| Myrenfors, P | 1 |
| Krasner, LM | 1 |
| Venturini, E | 1 |
| Borghi, E | 1 |
| Maurini, V | 1 |
| Vecce, R | 1 |
| Carnicelli, A | 1 |
| Davies, AJ | 1 |
| Harindra, V | 1 |
| McEwan, A | 1 |
| Ghose, RR | 1 |
3 reviews available for terfenadine and Arrhythmia
| Article | Year |
|---|---|
Detection and reporting of drug-induced proarrhythmias: room for improvement.
Topics: Adverse Drug Reaction Reporting Systems; Arrhythmias, Cardiac; Cisapride; Drug Labeling; Gastrointes | 2007 |
[Drug induced arrhythmias].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digitalis Glycosides; Electrocardiography, Ambulatory; | 1996 |
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Disea | 2002 |
1 trial available for terfenadine and Arrhythmia
| Article | Year |
|---|---|
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.
Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; H | 1993 |
44 other studies available for terfenadine and Arrhythmia
| Article | Year |
|---|---|
A mechanism for the proarrhythmic effects of cisapride (Propulsid): high affinity blockade of the human cardiac potassium channel HERG.
Topics: Arrhythmias, Cardiac; Cation Transport Proteins; Cell Line; Cisapride; DNA-Binding Proteins; Electro | 1997 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment.
Topics: Animals; Arrhythmias, Cardiac; Astemizole; Benchmarking; Calibration; Cardiovascular Agents; Cell Li | 2020 |
Different voltage dependence of I
Topics: Action Potentials; Amiodarone; Arrhythmias, Cardiac; Bepridil; Calcium Channels, L-Type; Computer Si | 2021 |
Sensitivity and Reliability of Halothane-anaesthetized Microminipigs to Assess Risk of Drug-induced Long QT Syndrome.
Topics: Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Disease Models, Animal; Dose | 2017 |
Quantitative Assessment of the Physiological Parameters Influencing QT Interval Response to Medication: Application of Computational Intelligence Tools.
Topics: Action Potentials; Algorithms; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Artificial Intelligence | 2018 |
Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsa
Topics: Anesthesia; Animals; Arrhythmias, Cardiac; Blood Pressure; Cross-Over Studies; Dogs; Dose-Response R | 2018 |
How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Dextromethorphan; Dose-Response Relationshi | 2015 |
The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?
Topics: Adult; Amitriptyline; Aortic Valve Stenosis; Arrhythmias, Cardiac; Autopsy; Caffeine; Death, Sudden, | 2017 |
Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization.
Topics: Action Potentials; Anesthetics, Local; Anti-Allergic Agents; Arrhythmias, Cardiac; Binding Sites; Bu | 2011 |
Ionic and cellular basis for the predominance of the Brugada syndrome phenotype in males.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Cells, Cultured; Culture Techniques; Dogs; Female; | 2002 |
The antihistamine fexofenadine does not affect I(Kr) currents in a case report of drug-induced cardiac arrhythmia.
Topics: Aged; Amino Acid Sequence; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Base Sequence; Bl | 2002 |
Cellular and ionic basis for the sex-related difference in the manifestation of the Brugada syndrome and progressive conduction disease phenotypes.
Topics: Animals; Arrhythmias, Cardiac; Dogs; Electrocardiography; Female; Humans; In Vitro Techniques; Male; | 2003 |
Dimethyl lithospermate B, an extract of Danshen, suppresses arrhythmogenesis associated with the Brugada syndrome.
Topics: Animals; Arrhythmias, Cardiac; Biological Transport; Calcium Channel Blockers; Dogs; Drug Evaluation | 2006 |
The proarrhythmic antihistaminic drug terfenadine increases spontaneous calcium release in human atrial myocytes.
Topics: Arrhythmias, Cardiac; Calcium; Calcium Channels, L-Type; Cyproheptadine; Electrophysiology; Histamin | 2006 |
Hydroxypropyl beta-cyclodextrins: a misleading vehicle for the in vitro hERG current assay.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; beta-Cyclodextrins; | 2007 |
Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants.
Topics: Action Potentials; Amino Acid Substitution; Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Dise | 2008 |
Terfenadine-associated ventricular arrhythmias and QTc interval prolongation. A retrospective cohort comparison with other antihistamines among members of a health maintenance organization.
Topics: Administration, Oral; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Boston; Cohort Studies; Death, | 1995 |
Regulation of potassium channels by nonsedating antihistamines.
Topics: Animals; Arrhythmias, Cardiac; Astemizole; Cells, Cultured; Dose-Response Relationship, Drug; Electr | 1995 |
The risk of life-threatening cardiovascular events with terfenadine.
Topics: Arrhythmias, Cardiac; Clemastine; Humans; Ibuprofen; Risk Factors; Terfenadine; Ventricular Dysfunct | 1995 |
Possible interactions with terfenadine or astemizole.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescripti | 1994 |
Antihistamines and the heart.
Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Drug Interactions; Heart; Histamine H1 Antagonists; Hum | 1993 |
Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Clemastine; Cohort Studies; Death, Sudden, Cardiac; | 1994 |
Ketoconazole and fluconazole drug interactions.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketocon | 1994 |
[Teldane update. Interview with Dr. Alfred Sabbah, chief of the immuno-allergology laboratory of the C.H.U. d'Angers. Interview by Dr. Pierre Ceddaha].
Topics: Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Contraindications; Cytochrome P-450 Enzyme Inh | 1993 |
Drug interactions associated with terfenadine and related nonsedating antihistamines.
Topics: Arrhythmias, Cardiac; Astemizole; Drug Interactions; Histamine H1 Antagonists; Humans; Terfenadine | 1996 |
Pharmacokinetic-pharmacodynamic analysis of the electrocardiographic effects of terfenadine and quinidine in rats.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Interactions; Electrocardiography; Elect | 1996 |
Dangers of non-sedating antihistamines.
Topics: Arrhythmias, Cardiac; Astemizole; Cetirizine; Heart Diseases; Histamine H1 Antagonists; Humans; Legi | 1997 |
Dangers of non-sedating antihistamines.
Topics: Adverse Drug Reaction Reporting Systems; Arrhythmias, Cardiac; Astemizole; Histamine H1 Antagonists; | 1997 |
Terfenadine and SSRIs.
Topics: Arrhythmias, Cardiac; Drug Interactions; Histamine H1 Antagonists; Humans; Selective Serotonin Reupt | 1997 |
[Drug side effects and their prevention].
Topics: Arrhythmias, Cardiac; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Ele | 1997 |
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats.
Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; | 1999 |
Risk of ventricular arrhythmias associated with nonsedating antihistamine drugs.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Case-Control Studies; Cetirizine; Child; | 1999 |
QT lengthening and arrhythmias associated with fexofenadine.
Topics: Aged; Arrhythmias, Cardiac; Electrocardiography; Histamine Antagonists; Humans; Risk Factors; Terfen | 1999 |
Causality assessment of adverse drug effects: when is rechallenge ethically acceptable?
Topics: Arrhythmias, Cardiac; Ethics, Medical; Histamine H1 Antagonists; Humans; Terfenadine | 1999 |
Effects of terfenadine, astemizole and epinastine on electrocardiogram in conscious cynomolgus monkeys.
Topics: Animals; Arrhythmias, Cardiac; Astemizole; Dibenzazepines; Electrocardiography; Heart Block; Histami | 1999 |
Prolonged QTc time and ventricular arrhythmia with fexofenadine.
Topics: Arrhythmias, Cardiac; Heart Conduction System; Histamine H1 Antagonists; Humans; Terfenadine | 1999 |
QT lengthening and life-threatening arrhythmias associated with fexofenadine.
Topics: Arrhythmias, Cardiac; Clinical Trials as Topic; Cohort Studies; Histamine H1 Antagonists; Humans; Te | 2000 |
Special drug communication teleconference. August 7, 1992.
Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Dr | 1992 |
[Severe effects of terfenadine overdose on the heart].
Topics: Adolescent; Adult; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Female; Heart Rate; Human | 1992 |
Terfenadine use associated with ventricular dysrhythmias.
Topics: Arrhythmias, Cardiac; Electrocardiography; Humans; Terfenadine; Torsades de Pointes | 1992 |
[Prolongation of the Q-T interval and hyperkinetic ventricular arrhythmias probably induced by terfenadine use in liver cirrhosis patients].
Topics: Arrhythmias, Cardiac; Electrocardiography; Female; Heart Ventricles; Humans; Liver Cirrhosis; Middle | 1992 |
Safety of terfenadine and astemizole.
Topics: Arrhythmias, Cardiac; Astemizole; Humans; Terfenadine | 1992 |
Cardiotoxic effect with convulsions in terfenadine overdose.
Topics: Adult; Arrhythmias, Cardiac; Benzhydryl Compounds; Female; Heart Diseases; Histamine H1 Antagonists; | 1989 |