terfenadine has been researched along with Airway Hyper-Responsiveness in 9 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We elected to evaluate the effects of repeated dosing with fexofenadine (FEX) and montelukast (ML) at clinically recommended doses in ICS-treated asthmatic patients using adenosine monophosphate (AMP) bronchial challenge as the primary outcome." | 5.11 | Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients. ( Haggart, K; Jackson, CM; Lee, DK; Lipworth, BJ, 2004) |
| "Sixteen atopic patients with mild-to-moderate asthma of whom 10 were receiving inhaled corticosteroid therapy (all had positive results to house dust mite on skin prick testing) were randomized in a double-blind, placebo-controlled, cross-over fashion to receive single doses of 5 mg of desloratadine, 180 mg of fexofenadine hydrochloride (FEX), 5 mg of levocetirizine dihydrochloride (LEV), or placebo, with AMP challenge performed 12 hours after dosing." | 5.10 | Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma. ( Bates, CE; Currie, GP; Lee, DK; Lipworth, BJ, 2003) |
| " When compounds were administered intravenously, at a dosage (1 mg/kg) which fully abolished responses to intravenous histamine, the observed rank order for inhibition of PAF-induced hyperreactivity was: ketotifen greater than cetirizine greater than acrivastine greater than KB-2413 greater than oxatomide greater than azelastine greater than terfenadine = astemizole = clemastine = mepyramine = loratadine = saline." | 1.28 | Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig. ( Chapman, ID; Hoshiko, K; Morley, J, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 4 (44.44) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, DK | 2 |
| Bates, CE | 1 |
| Currie, GP | 1 |
| Lipworth, BJ | 2 |
| Gelfand, EW | 1 |
| Cui, ZH | 1 |
| Takeda, K | 1 |
| Kanehiro, A | 1 |
| Joetham, A | 1 |
| Jackson, CM | 1 |
| Haggart, K | 1 |
| Kamei, J | 1 |
| Takahashi, Y | 1 |
| Itabashi, T | 1 |
| Hayashi, S | 1 |
| Kawai, K | 1 |
| Melillo, G | 1 |
| D'Amato, G | 1 |
| Zanussi, C | 1 |
| Ortolani, C | 1 |
| Pastorello, E | 1 |
| Loy, M | 1 |
| Di Tucci, A | 1 |
| Locci, F | 1 |
| Del Giacco, GS | 1 |
| Lenzini, L | 1 |
| Sestini, P | 1 |
| Rottoli, P | 1 |
| Ciprandi, G | 1 |
| Ricca, V | 1 |
| Tosca, M | 1 |
| Landi, M | 1 |
| Passalacqua, G | 1 |
| Canonica, GW | 1 |
| Hoshiko, K | 1 |
| Chapman, ID | 1 |
| Morley, J | 1 |
| Chand, N | 1 |
| Pillar, J | 1 |
| Nolan, K | 1 |
| Diamantis, W | 1 |
| Sofia, RD | 1 |
| Togias, AG | 1 |
| Proud, D | 1 |
| Kagey-Sobotka, A | 1 |
| Freidhoff, L | 1 |
| Lichtenstein, LM | 1 |
| Naclerio, RM | 1 |
5 trials available for terfenadine and Airway Hyper-Responsiveness
| Article | Year |
|---|---|
Comparative in vivo bioactivity of modern H1-antihistamines on AMP challenge in atopic asthma.
Topics: Acetates; Adenosine Monophosphate; Adult; Aged; Asthma; Bronchial Provocation Tests; Cetirizine; Cro | 2003 |
Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients.
Topics: Acetates; Adenosine Monophosphate; Administration, Inhalation; Adrenal Cortex Hormones; Anti-Allergi | 2004 |
A multicentre controlled trial of terfenadine, dexchlorpheniramine, and placebo in allergic rhinitis.
Topics: Adolescent; Adult; Aging; Benzhydryl Compounds; Chlorpheniramine; Clinical Trials as Topic; Double-B | 1982 |
Continuous antihistamine treatment controls allergic inflammation and reduces respiratory morbidity in children with mite allergy.
Topics: Adolescent; Animals; Antigens, Dermatophagoides; Child; Child, Preschool; Double-Blind Method; Dust; | 1999 |
In vivo and in vitro effects of antihistamines on mast cell mediator release: a potentially important property in the treatment of allergic disease.
Topics: Administration, Intranasal; Administration, Oral; Administration, Topical; Adolescent; Adult; Benzhy | 1989 |
4 other studies available for terfenadine and Airway Hyper-Responsiveness
| Article | Year |
|---|---|
Effects of fexofenadine on T-cell function in a murine model of allergen-induced airway inflammation and hyperresponsiveness.
Topics: Administration, Inhalation; Adoptive Transfer; Allergens; Animals; Anti-Allergic Agents; Antibody Sp | 2003 |
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hy | 2008 |
Histamine(H1) antagonists and airway hyperreactivity in the guinea-pig.
Topics: Airway Resistance; Animals; Bronchoconstriction; Guinea Pigs; Histamine; Histamine H1 Antagonists; I | 1991 |
Inhibition of allergic and nonallergic leukotriene C4 formation and histamine secretion by azelastine: implication for its mechanism of action.
Topics: Animals; Benzhydryl Compounds; Benzoquinones; Guinea Pigs; Histamine Release; Immunosuppressive Agen | 1989 |