terfenadine has been researched along with Adverse Drug Event in 17 studies
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 7.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| " Enzalutamide also induced bradycardia and death in zebrafish embryos in a dose-dependent manner and strongly synergized with the potassium-channel blocking agent, terfenadine, known to induce long QT syndrome and cardiac arrhythmia." | 3.85 | Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia. ( Berman, JN; Collins, CC; Dellaire, G; Holly, A; MacDonald, M; Melong, N; Steele, S; Zoubeidi, A, 2017) |
| "An observational, historical cohort evaluation was performed to examine the hypothesis that terfenadine (Seldane) exposure increases the risk of developing life-threatening ventricular arrhythmias." | 3.69 | Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine. ( Crowell, SP; Ellis, BE; Hertz, RP; Louv, W; Moyé, L; Pratt, CM, 1994) |
| "Fexofenadine has a positive antihistamine effect, which is probably no worse than the second-generation antihistamines." | 2.61 | Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials. ( Huang, CZ; Jiang, ZH; Luo, Y; Peng, H; Wang, J, 2019) |
| " Cell lines have been selected and validated on automated electrophysiology systems to facilitate cost-effective screening for safe and selective compounds at earlier stages in the drug development process." | 1.35 | An ion channel library for drug discovery and safety screening on automated platforms. ( Brown, AM; Kuryshev, YA; Liu, Z; Smith, SS; Wible, BA, 2008) |
| " Collections of individual case safety reports (ICSRs) related to suspected ADR incidents in clinical practice have proven to be very useful in post-marketing surveillance for pairwise drug--ADR associations, but have yet to reach their full potential for drug-drug interaction surveillance." | 1.35 | A statistical methodology for drug-drug interaction surveillance. ( Bate, A; Edwards, IR; Norén, GN; Sundberg, R, 2008) |
| "5 million adverse drug reaction (ADR) reports for 8620 drugs/biologics that are listed for 1191 Coding Symbols for Thesaurus of Adverse Reaction (COSTAR) terms of adverse effects." | 1.32 | Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. ( Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 9 (52.94) | 29.6817 |
| 2010's | 4 (23.53) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pearlstein, R | 1 |
| Vaz, R | 1 |
| Rampe, D | 1 |
| Matthews, EJ | 1 |
| Kruhlak, NL | 1 |
| Weaver, JL | 1 |
| Benz, RD | 1 |
| Contrera, JF | 1 |
| Pedersen, JM | 1 |
| Matsson, P | 1 |
| Bergström, CA | 1 |
| Norinder, U | 1 |
| Hoogstraate, J | 1 |
| Artursson, P | 1 |
| Liu, Z | 2 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Huang, CZ | 1 |
| Jiang, ZH | 1 |
| Wang, J | 1 |
| Luo, Y | 1 |
| Peng, H | 1 |
| Melong, N | 1 |
| Steele, S | 1 |
| MacDonald, M | 1 |
| Holly, A | 1 |
| Collins, CC | 1 |
| Zoubeidi, A | 1 |
| Berman, JN | 1 |
| Dellaire, G | 1 |
| Vos, MA | 1 |
| Dabhi, J | 1 |
| Mehta, A | 1 |
| Wible, BA | 1 |
| Kuryshev, YA | 1 |
| Smith, SS | 1 |
| Brown, AM | 1 |
| Bate, A | 2 |
| Lindquist, M | 1 |
| Orre, R | 1 |
| Edwards, IR | 2 |
| Meyboom, RH | 1 |
| Takahara, A | 1 |
| Sugiyama, A | 1 |
| Hashimoto, K | 1 |
| Norén, GN | 1 |
| Sundberg, R | 1 |
| Ciummo, PE | 1 |
| Katz, NL | 1 |
| Neuvonen, P | 1 |
| Pratt, CM | 1 |
| Hertz, RP | 1 |
| Ellis, BE | 1 |
| Crowell, SP | 1 |
| Louv, W | 1 |
| Moyé, L | 1 |
| Offerhaus, L | 1 |
4 reviews available for terfenadine and Adverse Drug Event
| Article | Year |
|---|---|
Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
Topics: Cation Transport Proteins; DNA-Binding Proteins; Drug-Related Side Effects and Adverse Reactions; ER | 2003 |
Antihistamine effects and safety of fexofenadine: a systematic review and Meta-analysis of randomized controlled trials.
Topics: Cognition; Drug-Related Side Effects and Adverse Reactions; Histamine H1 Antagonists, Non-Sedating; | 2019 |
Literature-based evaluation of four 'hard endpoint' models for assessing drug-induced torsades de pointes liability.
Topics: Animals; Aza Compounds; Cisapride; Dogs; Drug Evaluation, Preclinical; Drug-Related Side Effects and | 2008 |
[Current hazardous drug interactions].
Topics: Anti-Infective Agents; Astemizole; Benzodiazepines; Calcium Channel Blockers; Cyclosporins; Drug Int | 1993 |
13 other studies available for terfenadine and Adverse Drug Event
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Dru | 2004 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Bi | 2008 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia.
Topics: Animals; Antineoplastic Agents; Benzamides; Bradycardia; Cell Line, Tumor; Cell Proliferation; Disea | 2017 |
QT prolongation and safety in the Indian population.
Topics: Astemizole; Cisapride; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Electroc | 2007 |
An ion channel library for drug discovery and safety screening on automated platforms.
Topics: Animals; Astemizole; Automation; Cell Line; CHO Cells; Cloning, Organism; Cricetinae; Cricetulus; DN | 2008 |
Data-mining analyses of pharmacovigilance signals in relation to relevant comparison drugs.
Topics: Adverse Drug Reaction Reporting Systems; Bayes Theorem; Captopril; Clozapine; Databases, Factual; Dr | 2002 |
Reduction of repolarization reserve by halothane anaesthesia sensitizes the guinea-pig heart for drug-induced QT interval prolongation.
Topics: Action Potentials; Adrenergic beta-Antagonists; Algorithms; Anesthetics, Inhalation; Animals; Chroma | 2005 |
A statistical methodology for drug-drug interaction surveillance.
Topics: Adverse Drug Reaction Reporting Systems; Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Or | 2008 |
Interactions and drug-metabolizing enzymes.
Topics: Adolescent; Adult; Anti-Allergic Agents; Antidepressive Agents, Second-Generation; Antifungal Agents | 1995 |
Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine.
Topics: Adult; Age Factors; Aged; Arrhythmias, Cardiac; Clemastine; Cohort Studies; Death, Sudden, Cardiac; | 1994 |
[Foreign reports on side effects of drugs].
Topics: Australia; Drug-Related Side Effects and Adverse Reactions; Humans; Indoles; Ranitidine; Sulfonamide | 1993 |