Page last updated: 2024-11-04

terbutaline and Premature Birth

terbutaline has been researched along with Premature Birth in 12 studies

Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
terbutaline : A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.

Premature Birth: CHILDBIRTH before 37 weeks of PREGNANCY (259 days from the first day of the mother's last menstrual period, or 245 days after FERTILIZATION).

Research Excerpts

ExcerptRelevanceReference
" Evidence of low strength from observational studies with risk of bias favored SQ terbutaline pump for the outcomes of delivery at <32 and <37 weeks, mean days of pregnancy prolongation, and neonatal death."8.88Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis. ( Ansari, MT; Gaudet, LM; Singh, K; Skidmore, B; Tsertsvadze, A; Weeks, L, 2012)
" We found no strong evidence that terbutaline maintenance therapy offered any advantages over saline placebo or oral terbutaline maintenance therapy in reducing adverse neonatal outcomes by prolonging pregnancy among women with arrested preterm labour."4.90Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes. ( Chawanpaiboon, S; Dowswell, T; Laopaiboon, M; Lumbiganon, P; Sangkomkamhang, US, 2014)
" No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies (ritodrine or terbutaline)."4.89Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour. ( Crowther, CA; Han, S; Moore, V, 2013)
" Evidence of low strength from observational studies with risk of bias favored SQ terbutaline pump for the outcomes of delivery at <32 and <37 weeks, mean days of pregnancy prolongation, and neonatal death."4.88Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis. ( Ansari, MT; Gaudet, LM; Singh, K; Skidmore, B; Tsertsvadze, A; Weeks, L, 2012)
" No differences in the incidence of preterm birth or perinatal mortality were seen when magnesium maintenance therapy was compared with placebo or no treatment; or alternative therapies (ritodrine or terbutaline)."4.86Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour. ( Crowther, CA; Han, S; Moore, V, 2010)
" Human myometrial strips from cesarean sections at full-term pregnancy and at preterm labor were stimulated with oxytocin, and the inhibitory effects of theophylline, rolipram and terbutaline were studied."3.79Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro. ( Ducza, E; Falkay, G; Gáspár, R; Hajagos-Tóth, J; Klukovits, A; Kormányos, Z; Seres, AB; Verli, J, 2013)
" Our aim was to study the effects of the non-selective phosphodiesterase (PDE) inhibitor theophylline and the selective PDE4 inhibitor rolipram on the uteri of intact late-pregnant female rats (on days 20 and 22 of pregnancy) and of pregnant rats treated with lipopolysaccharide (LPS) to evoke preterm labor (on day 20)."3.76Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro. ( Falkay, G; Gáspár, R; Klukovits, A; Verli, J, 2010)
"Preterm birth is a major contributor to perinatal mortality and morbidity worldwide."2.50Betamimetics for inhibiting preterm labour. ( Dowswell, T; Neilson, JP; West, HM, 2014)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (16.67)29.6817
2010's9 (75.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Buckley, VA1
Wu, J1
De Vries, B1
Han, S2
Crowther, CA2
Moore, V2
Neilson, JP1
West, HM1
Dowswell, T2
Chawanpaiboon, S1
Laopaiboon, M1
Lumbiganon, P3
Sangkomkamhang, US1
Yamasmit, W2
Chaithongwongwatthana, S2
Tolosa, JE2
Limpongsanurak, S2
Pereira, L2
Klukovits, A3
Márki, A1
Páldy, E1
Benyhe, S1
Gálik, M1
Falkay, G3
Gáspár, R3
Rebarber, A1
Cleary-Goldman, J1
Istwan, N1
Rhea, D1
Stanziano, G1
Saltzman, D1
Verli, J2
Gaudet, LM1
Singh, K1
Weeks, L1
Skidmore, B1
Tsertsvadze, A1
Ansari, MT1
Kormányos, Z1
Hajagos-Tóth, J1
Ducza, E1
Seres, AB1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Acute Tocolysis With Terbutaline vs Placebo Prior to Emergency Caesarean Delivery for Suspected Intrauterine Fetal Compromise[NCT05326269]100 participants (Actual)Interventional2017-04-23Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for terbutaline and Premature Birth

ArticleYear
Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour.
    The Cochrane database of systematic reviews, 2013, May-31, Issue:5

    Topics: Female; Humans; Magnesium Chloride; Magnesium Compounds; Magnesium Oxide; Magnesium Sulfate; Obstetr

2013
Betamimetics for inhibiting preterm labour.
    The Cochrane database of systematic reviews, 2014, Feb-05, Issue:2

    Topics: Adrenergic beta-Agonists; Female; Fenoterol; Hexoprenaline; Humans; Obstetric Labor, Premature; Preg

2014
Terbutaline pump maintenance therapy after threatened preterm labour for reducing adverse neonatal outcomes.
    The Cochrane database of systematic reviews, 2014, Mar-23, Issue:3

    Topics: Female; Gestational Age; Humans; Maintenance Chemotherapy; Obstetric Labor, Premature; Pregnancy; Pr

2014
Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy.
    The Cochrane database of systematic reviews, 2015, Dec-08, Issue:12

    Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Female; Fenoterol; Fetal Membranes

2015
Magnesium maintenance therapy for preventing preterm birth after threatened preterm labour.
    The Cochrane database of systematic reviews, 2010, Jul-07, Issue:7

    Topics: Female; Humans; Magnesium Chloride; Magnesium Compounds; Magnesium Oxide; Magnesium Sulfate; Obstetr

2010
Effectiveness of terbutaline pump for the prevention of preterm birth. A systematic review and meta-analysis.
    PloS one, 2012, Volume: 7, Issue:2

    Topics: Adult; Birth Weight; Delivery, Obstetric; Female; Gestational Age; Humans; Infant, Newborn; Infusion

2012
Prophylactic oral betamimetics for reducing preterm birth in women with a twin pregnancy.
    The Cochrane database of systematic reviews, 2012, Sep-12, Issue:9

    Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Albuterol; Female; Fenoterol; Gestational Age

2012

Other Studies

5 other studies available for terbutaline and Premature Birth

ArticleYear
Outcomes following acute tocolysis prior to emergency caesarean section.
    The Australian & New Zealand journal of obstetrics & gynaecology, 2020, Volume: 60, Issue:6

    Topics: Adult; Cesarean Section; Emergency Treatment; Female; Humans; Labor, Obstetric; Obstetric Labor, Pre

2020
Inflammatory processes enhance cAMP-mediated uterus relaxation in the pregnant rat: the role of TNF-alpha.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 379, Issue:5

    Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonists; Animals; Cyclic AMP; Disease Models,

2009
The association of elective cessation of tocolysis and preterm birth in singleton gestations.
    American journal of perinatology, 2009, Volume: 26, Issue:5

    Topics: Adolescent; Adult; Comorbidity; Female; Georgia; Gestational Age; Humans; Infant, Newborn; Marital S

2009
Improving the relaxing effect of terbutaline with phosphodiesterase inhibitors: studies on pregnant rat uteri in vitro.
    Life sciences, 2010, Dec-18, Volume: 87, Issue:23-26

    Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Drug Synergism; Female; Lipopolysaccharide

2010
Uterus-relaxing effect of β2-agonists in combination with phosphodiesterase inhibitors: studies on pregnant rat in vivo and on pregnant human myometrium in vitro.
    The journal of obstetrics and gynaecology research, 2013, Volume: 39, Issue:1

    Topics: Adrenergic beta-2 Receptor Agonists; Animals; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type

2013