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terbutaline and Hypokalemia

terbutaline has been researched along with Hypokalemia in 23 studies

Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
terbutaline : A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.

Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"Terbutaline, a beta 2-adrenergic agonist, has been shown to cause hypokalemia and an increase of plasma glucose and serum insulin concentrations."9.06Effects of somatostatin and oral potassium administration on terbutaline-induced hypokalemia. ( Burghuber, OC; Podolsky, A; Schernthaner, G; Schnack, C; Watzke, H, 1989)
"The time course and concentration-effect relationship of terbutaline-induced hypokalemia was studied, using computer-aided pharmacokinetic-dynamic modeling."9.06Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol. ( Jonkers, R; Oosterhuis, B; Van Boxtel, CJ, 1987)
"Chance observation of hypokalemia in a patient given intravenous terbutaline for management of premature labor led us to review retrospectively the medical records of all patients in whom terbutaline was similarly used as a tocolytic agent."7.66Hypokalemia associated with terbutaline administration in obstetrical patients. ( Hurlbert, BJ; Moravec, MA, 1980)
"In 83 women with preterm labor randomly assigned to ritodrine (N = 42) or terbutaline (N = 41), the maximum decrease in plasma potassium occurred after six hours of drug infusion."6.68Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. ( Braden, GL; Germain, MJ; Haag, BL; von Oeyen, PT; Watson, DJ, 1997)
"The time course and concentration-effect relationship of terbutaline-induced hypokalemia was studied, using computer-aided pharmacokinetic-dynamic modeling."5.06Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol. ( Jonkers, R; Oosterhuis, B; Van Boxtel, CJ, 1987)
"Chance observation of hypokalemia in a patient given intravenous terbutaline for management of premature labor led us to review retrospectively the medical records of all patients in whom terbutaline was similarly used as a tocolytic agent."3.66Hypokalemia associated with terbutaline administration in obstetrical patients. ( Hurlbert, BJ; Moravec, MA, 1980)
"terbutaline and there were no significant differences between Arg-16 and Gly-16 individuals in this respect."2.73The influence of the AA 16 beta 2-adrenoceptor polymorphism on systemic and airway responses in asthma. ( Jansen, HM; Jonkers, RE; van Veen, A; Weller, FR; Wierenga, EA, 2008)
"In 83 women with preterm labor randomly assigned to ritodrine (N = 42) or terbutaline (N = 41), the maximum decrease in plasma potassium occurred after six hours of drug infusion."2.68Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences. ( Braden, GL; Germain, MJ; Haag, BL; von Oeyen, PT; Watson, DJ, 1997)
" In this single blind placebo controlled study in six healthy male volunteers, we have compared the effects of chronic dosing with either oral terbutaline (5 mg three times daily for two weeks) or placebo on a number of these responses produced by an intravenous infusion of terbutaline (6 micrograms per kilogram over 1 hour)."2.66Downgrading of biochemical and cardiovascular responses to an intravenous infusion of terbutaline following chronic treatment with oral terbutaline. ( Kendall, MJ; Smith, SR, 1986)
"Treatment with terbutaline, a Na/K-ATPase-stimulating drug, resulted in attack-free periods of approximately 9 months, after which the attacks reoccurred."1.30Multiple anomalies, hypokalaemic paralysis and partial symptomatic relief by terbutaline. ( Andersen, PE; Djurhuus, MS; Jensen, BM; Klitgaard, NA; Schrøder, HD, 1998)
"Changes in beta 2-adrenoceptor function by chronic dosing of beta 2-mimetics and the possible influence of a single dose of prednisone have been studied as changes over time in the concentration-effect relationship of the beta 2-adrenoceptor agonist terbutaline."1.29Pharmacodynamic modelling of the drug-induced downregulation of a beta 2-adrenoceptor mediated response and lack of restoration of receptor function after a single high dose of prednisone. ( Braat, MC; Jonkers, RE; Koopmans, RP; van Boxtel, CJ, 1995)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-199010 (43.48)18.7374
1990's9 (39.13)18.2507
2000's2 (8.70)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Buhl, LF1
Pedersen, FN1
Andersen, MS1
Glintborg, D1
Tran, CT1
Kjeldsen, K1
Berger, WE1
van Veen, A1
Weller, FR1
Wierenga, EA1
Jansen, HM1
Jonkers, RE2
Moravec, MA1
Hurlbert, BJ2
Edelman, JD1
David, K1
Gross, TL1
Sokol, RJ1
Taylor, DR1
Herbison, GP1
Sears, MR1
Ingrams, GJ1
Morgan, FB1
Braat, MC1
Koopmans, RP1
van Boxtel, CJ2
Braden, GL1
von Oeyen, PT1
Germain, MJ1
Watson, DJ1
Haag, BL1
Djurhuus, MS1
Klitgaard, NA1
Jensen, BM1
Andersen, PE1
Schrøder, HD1
Rahman, AR1
McDevitt, DG2
Struthers, AD1
Lipworth, BJ2
Narang, NK1
Meratwal, S1
Toshniwal, GL1
Newnham, DM1
Clifton, GD1
Hunt, BA1
Patel, RC1
Burki, NK1
Schnack, C1
Podolsky, A1
Watzke, H1
Schernthaner, G1
Burghuber, OC1
Burgess, CD1
Flatt, A1
Siebers, R1
Crane, J1
Beasley, R1
Purdie, G1
Jonkers, R1
Oosterhuis, B1
Ingemarsson, I1
Arulkumaran, S1
Kottegoda, SR1
Deenstra, M1
Haalboom, JR1
Struyvenberg, A1
Smith, SR2
Kendall, MJ2

Reviews

2 reviews available for terbutaline and Hypokalemia

ArticleYear
The use of inhaled formoterol in the treatment of asthma.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:1

    Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonist

2006
Complications of beta-mimetic therapy in preterm labour.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1985, Volume: 25, Issue:3

    Topics: Adrenergic beta-Agonists; Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Coronary Disease; Fe

1985

Trials

9 trials available for terbutaline and Hypokalemia

ArticleYear
The influence of the AA 16 beta 2-adrenoceptor polymorphism on systemic and airway responses in asthma.
    Pulmonary pharmacology & therapeutics, 2008, Volume: 21, Issue:1

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Asthma; Cross-Over Studies; Double-Blin

2008
Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences.
    Kidney international, 1997, Volume: 51, Issue:6

    Topics: Adolescent; Adult; Aldosterone; Blood Glucose; Female; Heart Rate; Humans; Hypokalemia; Injections,

1997
The effects of enalapril and spironolactone on terbutaline-induced hypokalemia.
    Chest, 1992, Volume: 102, Issue:1

    Topics: Adult; Electrocardiography; Enalapril; Female; Hemodynamics; Humans; Hypokalemia; Magnesium; Male; P

1992
The effects of frusemide and triamterene on the hypokalaemic and electrocardiographic responses to inhaled terbutaline.
    British journal of clinical pharmacology, 1991, Volume: 32, Issue:5

    Topics: Administration, Inhalation; Administration, Oral; Adult; Drug Synergism; Electrocardiography; Furose

1991
Effects of sequential doses of parenteral terbutaline on plasma levels of potassium and related cardiopulmonary responses.
    The American review of respiratory disease, 1990, Volume: 141, Issue:3

    Topics: Adult; Asthma; Blood Glucose; Blood Pressure; Double-Blind Method; Drug Administration Schedule; Ele

1990
Effects of somatostatin and oral potassium administration on terbutaline-induced hypokalemia.
    The American review of respiratory disease, 1989, Volume: 139, Issue:1

    Topics: Administration, Oral; Adult; Blood Glucose; Blood Pressure; Female; Heart Rate; Humans; Hypokalemia;

1989
Beta-2-adrenoceptor-mediated hypokalemia and its abolishment by oxprenolol.
    Clinical pharmacology and therapeutics, 1987, Volume: 42, Issue:6

    Topics: Adult; Humans; Hypokalemia; Oxprenolol; Potassium; Receptors, Adrenergic, beta; Terbutaline

1987
Decrease of plasma potassium due to inhalation of beta-2-agonists: absence of an additional effect of intravenous theophylline.
    European journal of clinical investigation, 1988, Volume: 18, Issue:2

    Topics: Adrenergic beta-Agonists; Adult; Aerosols; Albuterol; Blood Pressure; Drug Interactions; Fenoterol;

1988
Downgrading of biochemical and cardiovascular responses to an intravenous infusion of terbutaline following chronic treatment with oral terbutaline.
    International journal of clinical pharmacology, therapy, and toxicology, 1986, Volume: 24, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Blood Pressure; Humans; Hypokalemia; Infusio

1986

Other Studies

12 other studies available for terbutaline and Hypokalemia

ArticleYear
Licorice-induced apparent mineralocorticoid excess compounded by excessive use of terbutaline and high water intake.
    BMJ case reports, 2018, Apr-19, Volume: 2018

    Topics: Aldosterone; Asthma; Bronchodilator Agents; Diagnosis, Differential; Glycyrrhiza; Humans; Hypertensi

2018
Protection against β adrenoceptor agonist reduction of plasma potassium in severe but not in moderate hypokalemia.
    Fundamental & clinical pharmacology, 2011, Volume: 25, Issue:4

    Topics: Adrenergic beta-Agonists; Animals; Blood; Female; Heart; Hypokalemia; Insulin; Muscle, Skeletal; Myo

2011
Hypokalemia associated with terbutaline administration in obstetrical patients.
    Anesthesia and analgesia, 1980, Volume: 59, Issue:12

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Anesthesia; Cell Membrane Permeability; Female; Humans;

1980
Serum potassium levels during and after terbutaline.
    Anesthesia and analgesia, 1981, Volume: 60, Issue:10

    Topics: Adult; Female; Humans; Hypokalemia; Infusions, Parenteral; Potassium; Pregnancy; Terbutaline; Time F

1981
Severe hypokalemia and acidosis: a potential complication of beta-adrenergic treatment.
    American journal of obstetrics and gynecology, 1980, Dec-15, Volume: 138, Issue:8

    Topics: Acidosis; Adult; Betamethasone; Female; Humans; Hypokalemia; Obstetric Labor, Premature; Pregnancy;

1980
Sex differences in hypokalaemic and electrocardiographic effects of inhaled terbutaline.
    Thorax, 1993, Volume: 48, Issue:7

    Topics: Administration, Inhalation; Asthma; Electrocardiography; Female; Fenoterol; Humans; Hypokalemia; Mal

1993
Transcutaneous overdose of terbutaline.
    BMJ (Clinical research ed.), 1993, Aug-21, Volume: 307, Issue:6902

    Topics: Administration, Cutaneous; Administration, Inhalation; Adolescent; Drug Overdose; Humans; Hypokalemi

1993
Pharmacodynamic modelling of the drug-induced downregulation of a beta 2-adrenoceptor mediated response and lack of restoration of receptor function after a single high dose of prednisone.
    European journal of clinical pharmacology, 1995, Volume: 49, Issue:1-2

    Topics: Adrenergic beta-Agonists; Adult; Down-Regulation; Female; Glucocorticoids; Humans; Hypokalemia; Male

1995
Multiple anomalies, hypokalaemic paralysis and partial symptomatic relief by terbutaline.
    Acta paediatrica (Oslo, Norway : 1992), 1998, Volume: 87, Issue:4

    Topics: Abnormalities, Multiple; Arrhythmias, Cardiac; Child; Fatal Outcome; Humans; Hypokalemia; Male; Mand

1998
Hypokalaemic effect of salbutamol and terbutaline in bronchial asthma.
    The Journal of the Association of Physicians of India, 1991, Volume: 39, Issue:3

    Topics: Adult; Aged; Albuterol; Asthma; Female; Forced Expiratory Volume; Humans; Hypokalemia; Male; Middle

1991
A comparison of the extent and duration of hypokalaemia following three nebulized beta 2-adrenoceptor agonists.
    European journal of clinical pharmacology, 1989, Volume: 36, Issue:4

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Fenoterol; Humans; Hypokalem

1989
Potentiation of the adverse effects of intravenous terbutaline by oral theophylline.
    British journal of clinical pharmacology, 1986, Volume: 21, Issue:4

    Topics: Administration, Oral; Adolescent; Adult; Blood Glucose; Blood Pressure; Drug Evaluation; Drug Synerg

1986