Page last updated: 2024-11-04

terbutaline and Fetal Hypoxia

terbutaline has been researched along with Fetal Hypoxia in 3 studies

Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
terbutaline : A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.

Fetal Hypoxia: Deficient oxygenation of FETAL BLOOD.

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19903 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lundell, KH1
Hedner, T1
Iversen, K1
Lewis, P1
Boylan, P1
Dagbjartsson, A1
Herbertsson, G1
Stefansson, TS1
Kjeld, M1
Lagercrantz, H1
Rosen, KG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized Trial of Fetal ECG ST Segment and T Wave Analysis as an Adjunct to Electronic Fetal Heart Rate Monitoring (STAN)[NCT01131260]11,108 participants (Actual)Interventional2010-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Median Apgar Score at 5 Minutes

The Apgar score is a simple method of quickly assessing the health and vital signs of a newborn baby created by and named after Dr. Virginia Apgar. Apgar testing assesses Appearance, Pulse, Grimace and Activity in a newborn and is typically done at one and five minutes after a baby is born, and it may be repeated at 10, 15, and 20 minutes if the score is low. The five criteria are each scored as 0, 1, or 2 (two being the best), and the total score is calculated by then adding the five values obtained. Agar scores of 0-3 are critically low, 4-6 are below normal, and indicate that the baby likely requires medical intervention, scores of 7+ are considered normal. The lower the Apgar score, the more alert the medical team should be to the possibility of the baby requiring intervention. Some components of the Apgar score are subjective, and there are cases in which a baby requires urgent medical treatment despite having a high Apgar score. (NCT01131260)
Timeframe: 5 minutes after Delivery

Interventionscore on a scale (Median)
Open Group9
Masked Group9

Median Duration of Labor Post-randomization

Duration of labor in hours after randomization through delivery (NCT01131260)
Timeframe: Onset of Labor through delivery

InterventionHours (Median)
Open Group3.8
Masked Group3.9

Median Length of Hospital Stay

Days of stay in the hospital (NCT01131260)
Timeframe: From admission to labor and delivery through hospital discharge

InterventionDays (Median)
Open Group2
Masked Group2

Number of Infants Admitted to Special Care Nursery

Intermediate care nursery or neonatal intensive care (anything more than well-baby nursery) (NCT01131260)
Timeframe: Delivery and 1 month of age

InterventionParticipants (Count of Participants)
Open Group498
Masked Group470

Number of Infants Experiencing Neonatal Encephalopathy (Primary Outcome Component)

Neonatal encephalopathy experienced between delivery and discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

InterventionParticipants (Count of Participants)
Open Group4
Masked Group5

Number of Infants Who Experienced Neonatal Seizure (Primary Outcome Component)

Number of infants who experienced Neonatal Seizure (NCT01131260)
Timeframe: Birth through hospital discharge

InterventionParticipants (Count of Participants)
Open Group3
Masked Group4

Number of Infants With a Major Congenital Malformation

Major congenital malformation (NCT01131260)
Timeframe: Delivery

InterventionParticipants (Count of Participants)
Open Group38
Masked Group23

Number of Infants With Apgar Score < = 3 at 5 Minutes (Primary Outcome Component)

The Apgar score is a simple method of quickly assessing the health and vital signs of a newborn baby created by and named after Dr. Virginia Apgar. Apgar testing assesses Appearance, Pulse, Grimace and Activity in a newborn and is typically done at one and five minutes after a baby is born, and it may be repeated at 10, 15, and 20 minutes if the score is low. The five criteria are each scored as 0, 1, or 2 (two being the best), and the total score is calculated by then adding the five values obtained. Agar scores of 0-3 are critically low, 4-6 are below normal, and indicate that the baby likely requires medical intervention, scores of 7+ are considered normal. The lower the Apgar score, the more alert the medical team should be to the possibility of the baby requiring intervention. Some components of the Apgar score are subjective, and there are cases in which a baby requires urgent medical treatment despite having a high Apgar score. The lowest score is 0, the highest score is 10. (NCT01131260)
Timeframe: 5 minutes after delivery

InterventionParticipants (Count of Participants)
Open Group17
Masked Group6

Number of Infants With Meconium Aspiration Syndrome

Meconium aspiration syndrome (NCT01131260)
Timeframe: Delivery through discharge

InterventionParticipants (Count of Participants)
Open Group20
Masked Group20

Number of Infants With Umbilical-artery Blood pH < = 7.05 and Base Deficit in Extracellular Fluid > = 12 mmol/Liter (Primary Outcome Component)

Umbilical-artery blood pH < = 7.05 and base deficit in extracellular fluid > = 12 mmol/liter (NCT01131260)
Timeframe: Delivery

InterventionParticipants (Count of Participants)
Open Group3
Masked Group8

Number of Intrapartum Fetal Deaths (Primary Outcome Component)

Death of the fetus during the intrapartum period. (NCT01131260)
Timeframe: During labor and through delivery of the baby

InterventionParticipants (Count of Participants)
Open Group0
Masked Group0

Number of Neonatal Deaths (Primary Outcome Component)

Death of the newborn between delivery and1 month of age (NCT01131260)
Timeframe: Delivery through1 month of age

InterventionParticipants (Count of Participants)
Open Group3
Masked Group1

Number of Neonates Intubated for Ventilation at Delivery (Primary Outcome Component)

Neonatal intubation for ventilation in the delivery room (NCT01131260)
Timeframe: Delivery

InterventionParticipants (Count of Participants)
Open Group42
Masked Group27

Number of Neonates With Shoulder Dystocia During Delivery

Presence of shoulder dystocia during delivery (NCT01131260)
Timeframe: Delivery

InterventionParticipants (Count of Participants)
Open Group141
Masked Group158

Number of Participants Experiencing Postpartum Endometritis

Postpartum endometritis (NCT01131260)
Timeframe: Delivery through hospital discharge

InterventionParticipants (Count of Participants)
Open Group71
Masked Group88

Number of Participants Who Had a Postpartum Blood Transfusion

Blood transfusion from delivery and through hospital stay until discharge (NCT01131260)
Timeframe: Delivery through hospital discharge

InterventionParticipants (Count of Participants)
Open Group80
Masked Group74

Number of Participants With Chorioamnionitis

Chorioamnionitis (NCT01131260)
Timeframe: Any time from Randomization through Delivery

InterventionParticipants (Count of Participants)
Open Group286
Masked Group269

Number of Participants With Primary Composite Outcome

Composite primary outcome of intrapartum fetal death, neonatal death, Apgar score <=3 at 5 minutes, neonatal seizure, umbilical artery blood pH <= 7.05 with base deficit >=12 mmol/L in extra-cellular fluid, intubation for ventilation at delivery, neonatal encelphalopathy (NCT01131260)
Timeframe: From Delivery through 1 month of age

InterventionParticipants (Count of Participants)
Open Group52
Masked Group40

Number of Participants With an Indication for Forceps or Vacuum Delivery

Indication for delivery by forceps or vacuum (NCT01131260)
Timeframe: During labor through delivery

,
InterventionParticipants (Count of Participants)
Fetal indicationDystociaOther
Masked Group2181018
Open Group225959

Other Studies

3 other studies available for terbutaline and Fetal Hypoxia

ArticleYear
Beta 2-adrenergic treatment of neonatal hypoxic disorders.
    European journal of respiratory diseases, 1981, Volume: 62, Issue:5

    Topics: Adrenergic beta-Agonists; Blood Gas Analysis; Blood Pressure Determination; Female; Fetal Hypoxia; H

1981
Fetal breathing: a review.
    American journal of obstetrics and gynecology, 1979, Jul-01, Volume: 134, Issue:5

    Topics: Amniocentesis; Animals; Barbiturates; Benzodiazepines; Betamethasone; Blood Glucose; Blood Pressure;

1979
Beta-adrenoceptor agonists and hypoxia in sheep fetuses.
    Acta physiologica Scandinavica, 1989, Volume: 137, Issue:2

    Topics: Animals; Blood Pressure; Female; Fetal Hypoxia; Heart Rate; Hemodynamics; Myocardial Contraction; Pr

1989