terbutaline and Asthma, Exercise-Induced studies

Terbutaline: A selective beta-2 adrenergic agonist used as a bronchodilator and tocolytic.
terbutaline : A member of the class of phenylethanolamines that is catechol substituted at position 5 by a 2-(tert-butylamino)-1-hydroxyethyl group.

Asthma, Exercise-Induced: Asthma attacks following a period of exercise. Usually the induced attack is short-lived and regresses spontaneously. The magnitude of postexertional airway obstruction is strongly influenced by the environment in which exercise is performed (i.e. inhalation of cold air during physical exertion markedly augments the severity of the airway obstruction; conversely, warm humid air blunts or abolishes it).

Research Excerpts

Excerpt	Relevance	Reference
"In fifteen patients with asthma tulobuterol, a new beta 2-adrenoceptor agonist, given by inhalation in 100 micrograms increments up to a cumulative dose of 600 micrograms produced dose related increases in both the FEV1 and FVC."	9.06	Bronchodilator activity of a new inhaled beta 2-adrenoceptor agonist, tulobuterol and its protective effect in exercise-induced asthma. ( Patel, KR, 1986)
"Eight asthmatic patients and two normal subjects performed two identical exercise tests 140 minutes apart (first test preceded by inhalation of saline and the second by terbutaline sulphate)."	9.05	Arterial plasma histamine levels at rest, and during and after exercise in patients with asthma: effects of terbutaline aerosol. ( Anderson, SD; Bye, PT; Ferris, L; Schoeffel, RE; Seale, JP; Taylor, KM, 1981)
"Terbutaline sulphate (Bricanyl; Keatings) aerosol or placebo aerosol was administered in a randomized fashion to 26 asthmatic children with proven exercise-induced asthma."	9.05	The effect of terbutaline sulphate on exercise-induced asthma in children. ( Weinberg, EG, 1982)
"0 mg of terbutaline or placebo disclosed that terbutaline produced a highly significant protective effect against exercise-induced asthma."	9.05	Effect of oral terbutaline on exercise-induced asthma. ( O'Brien, SR; Sly, RM, 1982)
"The protective effect of pre-exercise treatment with disodium cromoglycate (DC), terbutaline sulphate (TS) and thiazinamium methylsulphate (TM) on exercise-induced asthma (EIA) was investigated."	7.67	Comparison of disodium cromoglycate, terbutaline and thiazinamium in the prevention of exercise-induced asthma and its relation to non-specific bronchial responsiveness. ( Berg, WC; Gimeno, F; Steenhuis, EJ; van Veenen, R, 1985)
"In fifteen patients with asthma tulobuterol, a new beta 2-adrenoceptor agonist, given by inhalation in 100 micrograms increments up to a cumulative dose of 600 micrograms produced dose related increases in both the FEV1 and FVC."	5.06	Bronchodilator activity of a new inhaled beta 2-adrenoceptor agonist, tulobuterol and its protective effect in exercise-induced asthma. ( Patel, KR, 1986)
"Eight asthmatic patients and two normal subjects performed two identical exercise tests 140 minutes apart (first test preceded by inhalation of saline and the second by terbutaline sulphate)."	5.05	Arterial plasma histamine levels at rest, and during and after exercise in patients with asthma: effects of terbutaline aerosol. ( Anderson, SD; Bye, PT; Ferris, L; Schoeffel, RE; Seale, JP; Taylor, KM, 1981)
"Terbutaline sulphate (Bricanyl; Keatings) aerosol or placebo aerosol was administered in a randomized fashion to 26 asthmatic children with proven exercise-induced asthma."	5.05	The effect of terbutaline sulphate on exercise-induced asthma in children. ( Weinberg, EG, 1982)
"0 mg of terbutaline or placebo disclosed that terbutaline produced a highly significant protective effect against exercise-induced asthma."	5.05	Effect of oral terbutaline on exercise-induced asthma. ( O'Brien, SR; Sly, RM, 1982)
"In a single-blind, placebo-controlled, cross-over study, the effects of intravenous 20 micrograms NAB 365 (clenbuterol) and intravenous 250 microgram terbutaline were compared in nine asthmatic patients with bronchospasm induced by exercise."	5.04	Intravenous NAB 365 (clenbuterol) and terbutaline in exercise-induced bronchospasm (EIB). ( Del Bono, N; Quartieri, F; Vibelli, C, 1979)
"The protective effect of pre-exercise treatment with disodium cromoglycate (DC), terbutaline sulphate (TS) and thiazinamium methylsulphate (TM) on exercise-induced asthma (EIA) was investigated."	3.67	Comparison of disodium cromoglycate, terbutaline and thiazinamium in the prevention of exercise-induced asthma and its relation to non-specific bronchial responsiveness. ( Berg, WC; Gimeno, F; Steenhuis, EJ; van Veenen, R, 1985)
" The main outcome was EIB 24 h after the last dosing of study medication."	2.79	Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. ( Bjermer, L; Carlsen, KH; Dahlén, B; Ekström, T; Hedlin, G; Jørgensen, L; Larsson, K; Lazarinis, N; Pullerits, T, 2014)
" Inhaled beta-2-agonists were found to give better protection against EIA than intramuscular dosed beta-2-agonists."	2.65	Exercise-induced asthma - laboratory observations. ( Bundgaard, A, 1983)
"Both terbutaline treatments resulted in a significant increase in forced expiratory volume in one second, as compared with placebo (P less than 0."	2.65	Aerosol treatment of bronchoconstriction in children, with or without a tube spacer. ( Pedersen, S, 1983)
" Our findings suggest that the two effects have different dose-response relationships, with higher doses of adrenergic agonists needed to prevent EIA than to maintain bronchodilation."	2.65	Bronchodilation and inhibition of induced asthma by adrenergic agonists. ( Beasley, PP; Eggleston, PA, 1981)

Research

Studies (36)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Asthma Control Measured by a 5-item Asthma Control Questionnaire (ACQ5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	19 (52.78)	18.7374
1990's	11 (30.56)	18.2507
2000's	3 (8.33)	29.6817
2010's	3 (8.33)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Simpson, AJ	2
Tufvesson, E	1
Anderson, SD	4
Romer, LM	2
Bjermer, L	2
Kippelen, P	2
Lazarinis, N	1
Jørgensen, L	1
Ekström, T	1
Dahlén, B	1
Pullerits, T	1
Hedlin, G	1
Carlsen, KH	1
Larsson, K	1
Berger, WE	1
Bundgaard, A	4
Sly, RM	2
Bye, PT	1
Schoeffel, RE	1
Seale, JP	1
Taylor, KM	1
Ferris, L	1
Henriksen, JM	1
Dahl, R	3
Gimeno, F	2
Berg, WC	2
Steenhuis, EJ	2
Pedersen, S	1
Shapiro, GG	1
McPhillips, JJ	1
Smith, K	1
Furukawa, CT	1
Pierson, WE	1
Bierman, CW	1
Pedersen, JZ	1
Schmidt, A	1
Bach-Mortensen, N	1
Weinberg, EG	1
O'Brien, SR	1
Eggleston, PA	1
Beasley, PP	1
Hertz, B	2
Fuglsang, G	2
Holm, EB	2
Svenonius, E	1
Arborelius, M	1
Wiberg, R	1
Ståhl, E	3
Svensson, M	1
Pichaipat, V	1
Tongpenyai, Y	1
Nerntong, T	1
Sriprapachiranont, C	1
Packham, S	1
Ebden, P	1
Grönneröd, TA	1
von Berg, A	1
Schwabe, G	1
Soliman, S	1
Richter, K	1
Janicki, S	1
Jörres, RA	1
Magnussen, H	1
Póder, G	1
Kelemen, J	1
Romhányi, I	1
Cserháti, E	1
Erdös, Z	1
Tammivaara, R	1
Del Bono, N	1
Quartieri, F	1
Vibelli, C	1
Vilsvik, J	1
Schaanning, J	1
Holthe, S	1
Venge, P	2
Henriksen, J	2
dos Santos, JM	1
Costa, H	1
Wirén, JE	1
Woolley, M	1
Quigley, BM	1
Håkansson, L	1
van Veenen, R	1
Voy, RO	1
Patel, KR	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
"A Randomised, Double Blind, Placebo Controlled, Parallel-group Study With Use of Budesonide/Formoterol As-needed, or Terbutaline As-needed or Regular Use of Budesonide + Terbutaline As-needed, in Patients With Mild Intermittent Asthma"[NCT00989833]	Phase 2	66 participants (Actual)	Interventional	2009-09-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Change in overall ACQ5. ACQ5 measures asthma control and a lower values shows a better asthma control, a higher value is worse. A decrease in the ACQ5 shows an improvement during the treatment period. Range of ACQ5 is 0-5, with 0 as the best value and 5 as the worst value. Further information at www.qoltech.co.uk. (NCT00989833)
Timeframe: Baseline e and 6 weeks

Bronchial Responsiveness to Mannitol

Intervention	units on a scale (Mean)
Budesonide/Terbutaline	-0.3
Terbutaline	-0.2
Budesonide/Formoterol	-0.4

Change in cumulative Mannitol dose in mg in patients with a positive mannitol provocation test at baseline (PD15) (NCT00989833)
Timeframe: Baseline and 6 weeks

Concentration of Exhaled Nitric Oxide

Diary Recording of Asthma Symptoms

Number of Participants With an Adverse Event During the Study

Percent Change in Maximum Post-exercise FEV1 Fall After 3 Weeks

Percent Change in Maximum Post-exercise Forced Expiratory Volume in One Second (FEV1) Fall After 6 Weeks

Use of as Needed Medication

Intervention	mg (Mean)
Budesonide/Terbutaline	67.26
Terbutaline	-6.15
Budesonide/Formoterol	151.87

Intervention	ppb (Mean)
Budesonide/Terbutaline	25.9
Terbutaline	35.5
Budesonide/Formoterol	24.4

Intervention	Percent of exercise days (Mean)
Budesonide/Terbutaline	51.1
Terbutaline	50.9
Budesonide/Formoterol	49.8

Intervention	Participants (Number)
Budesonide/Terbutaline	13
Terbutaline	13
Budesonide/Formoterol	13

Intervention	Percent change (Mean)
Budesonide/Terbutaline	-4.07
Terbutaline	-1.19
Budesonide/Formoterol	-3.81

Intervention	Percent change (Mean)
Budesonide/Terbutaline	-5.85
Terbutaline	0.61
Budesonide/Formoterol	-5.24

Mean number of as needed inhalations taken before exercise (NCT00989833)
Timeframe: 6 weeks

Article	Year
The use of inhaled formoterol in the treatment of asthma. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:1 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adrenergic beta-Agonist	2006
Diagnosing and treating exercise-induced asthma. The Practitioner, 1999, Volume: 243, Issue:1604 Topics: Adrenal Cortex Hormones; Albuterol; Asthma, Exercise-Induced; Bronchodilator Agents; Exercise Test;	1999

Article	Year
Effect of terbutaline on hyperpnoea-induced bronchoconstriction and urinary club cell protein 16 in athletes. Journal of applied physiology (Bethesda, Md. : 1985), 2013, Volume: 115, Issue:10 Topics: Administration, Inhalation; Adolescent; Adult; Asthma, Exercise-Induced; Athletes; Bronchoconstricti	2013
Combination of budesonide/formoterol on demand improves asthma control by reducing exercise-induced bronchoconstriction. Thorax, 2014, Volume: 69, Issue:2 Topics: Administration, Inhalation; Adolescent; Adrenergic beta-2 Receptor Agonists; Adult; Asthma, Exercise	2014
Self-reported Symptoms after Induced and Inhibited Bronchoconstriction in Athletes. Medicine and science in sports and exercise, 2015, Volume: 47, Issue:10 Topics: Adrenergic beta-2 Receptor Agonists; Adult; Asthma, Exercise-Induced; Bronchial Provocation Tests; B	2015
Pretreatment of exercise-induced asthma with beta-2 agonists inhaled from RV to TLC or at TLC. A preliminary report. European journal of respiratory diseases. Supplement, 1983, Volume: 128 (Pt 2) Topics: Administration, Intranasal; Adult; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Gluco	1983
Arterial plasma histamine levels at rest, and during and after exercise in patients with asthma: effects of terbutaline aerosol. Thorax, 1981, Volume: 36, Issue:4 Topics: Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Cyclic AMP; Forced Expiratory Volume; Histamine;	1981
Exercise-induced asthma - laboratory observations. European journal of respiratory diseases. Supplement, 1983, Volume: 128 (Pt 1) Topics: Adult; Asthma; Asthma, Exercise-Induced; Bronchial Provocation Tests; Clinical Trials as Topic; Doub	1983
Effects of inhaled budesonide alone and in combination with low-dose terbutaline in children with exercise-induced asthma. The American review of respiratory disease, 1983, Volume: 128, Issue:6 Topics: Adolescent; Aerosols; Asthma; Asthma, Exercise-Induced; Budesonide; Child; Clinical Trials as Topic;	1983
Aerosol treatment of bronchoconstriction in children, with or without a tube spacer. The New England journal of medicine, 1983, Jun-02, Volume: 308, Issue:22 Topics: Aerosols; Asthma; Asthma, Exercise-Induced; Bronchial Spasm; Child; Double-Blind Method; Female; For	1983
Effectiveness of terbutaline and theophylline alone and in combination in exercise-induced bronchospasm. Pediatrics, 1981, Volume: 67, Issue:4 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic; Double-Blind M	1981
[Should stable asthma be treated with a nebulizer or spray?]. Ugeskrift for laeger, 1981, Oct-26, Volume: 143, Issue:44 Topics: Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic; Humans; Middle A	1981
The effect of terbutaline sulphate on exercise-induced asthma in children. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Apr-17, Volume: 61, Issue:16 Topics: Aerosols; Asthma; Asthma, Exercise-Induced; Child; Clinical Trials as Topic; Female; Humans; Male; P	1982
Effect of oral terbutaline on exercise-induced asthma. Annals of allergy, 1982, Volume: 48, Issue:3 Topics: Administration, Oral; Asthma; Asthma, Exercise-Induced; Blood Pressure; Child; Female; Forced Expira	1982
Bronchodilation and inhibition of induced asthma by adrenergic agonists. Clinical pharmacology and therapeutics, 1981, Volume: 29, Issue:4 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchodilator Agents; Forced Expiratory Volume	1981
[Exercise-induced asthma in children and oral terbutaline. A dose-response relationship study]. Ugeskrift for laeger, 1994, Sep-26, Volume: 156, Issue:39 Topics: Administration, Oral; Asthma, Exercise-Induced; Child; Cross-Sectional Studies; Delayed-Action Prepa	1994
A comparison of terbutaline inhaled by Turbuhaler and by a chlorofluorocarbon (CFC) inhaler in children with exercise-induced asthma. Allergy, 1994, Volume: 49, Issue:6 Topics: Adolescent; Asthma, Exercise-Induced; Child; Double-Blind Method; Female; Forced Expiratory Volume;	1994
No protection by oral terbutaline against exercise-induced asthma in children: a dose-response study. The European respiratory journal, 1993, Volume: 6, Issue:4 Topics: Administration, Oral; Asthma, Exercise-Induced; Child; Delayed-Action Preparations; Dose-Response Re	1993
The protective effect of inhaled terbutaline, sodium cromoglycate and budesonide on exercise-induced asthma in children. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1995, Volume: 78, Issue:10 Topics: Administration, Inhalation; Adolescent; Anti-Asthmatic Agents; Asthma, Exercise-Induced; Bronchodila	1995
Formoterol via Turbuhaler gave better protection than terbutaline against repeated exercise challenge for up to 12 hours in children and adolescents. Respiratory medicine, 2000, Volume: 94, Issue:7 Topics: Administration, Inhalation; Adolescent; Asthma, Exercise-Induced; Bronchodilator Agents; Child; Cros	2000
Acute protection against exercise-induced bronchoconstriction by formoterol, salmeterol and terbutaline. The European respiratory journal, 2002, Volume: 19, Issue:5 Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Albuterol; Asthma, Exercise-Induced; Br	2002
The efficacy of terbutaline and fenoterol aerosols on adult exercise-induced asthma [proceedings]. Scandinavian journal of respiratory diseases. Supplementum, 1979, Volume: 103 Topics: Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Clinical Trials as Topic; Drug Evaluation; Ethano	1979
Intravenous NAB 365 (clenbuterol) and terbutaline in exercise-induced bronchospasm (EIB). Clinical allergy, 1979, Volume: 9, Issue:3 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Blood Pressure; Clenbuterol; Ethanolamines; For	1979
Comparison between Bricanyl Turbuhaler and Ventolin metered dose inhaler in the treatment of exercise-induced asthma in adults. Annals of allergy, 1991, Volume: 67, Issue:3 Topics: Administration, Intranasal; Adolescent; Adult; Albuterol; Asthma, Exercise-Induced; Double-Blind Met	1991
Eosinophils in exercise-induced asthma. The Journal of allergy and clinical immunology, 1991, Volume: 88, Issue:5 Topics: Adolescent; Adult; Aerosols; Asthma, Exercise-Induced; Blood Proteins; Budesonide; Double-Blind Meth	1991
Bricanyl Turbuhaler and Ventolin Rotahaler in exercise-induced asthma in children. Allergy, 1991, Volume: 46, Issue:3 Topics: Acute Disease; Adolescent; Albuterol; Asthma, Exercise-Induced; Bronchoconstriction; Child; Double-B	1991
Exercise-induced asthma and the generation of neutrophil chemotactic activity. The Journal of allergy and clinical immunology, 1990, Volume: 85, Issue:2 Topics: Adult; Aerosols; Asthma; Asthma, Exercise-Induced; Budesonide; Chemotaxis, Leukocyte; Cromolyn Sodiu	1990
Bronchodilator activity of a new inhaled beta 2-adrenoceptor agonist, tulobuterol and its protective effect in exercise-induced asthma. British journal of clinical pharmacology, 1986, Volume: 21, Issue:2 Topics: Adult; Albuterol; Asthma; Asthma, Exercise-Induced; Blood Pressure; Bronchodilator Agents; Clinical	1986

Article	Year
Beta-adrenergic drugs in the management of asthma in athletes. The Journal of allergy and clinical immunology, 1984, Volume: 73, Issue:5 Pt 2 Topics: Adrenergic beta-Agonists; Albuterol; Asthma; Asthma, Exercise-Induced; Dose-Response Relationship, D	1984
[Modification of exercise-induced airway obstruction using a combination of 2 drugs]. Nederlands tijdschrift voor geneeskunde, 1983, Sep-03, Volume: 127, Issue:36 Topics: Adult; Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Drug Therapy, Combination; Heart Function	1983
Pretreatment of exercise-induced asthma with terbutaline administered from pressurized aerosols and nebulizers. European journal of respiratory diseases. Supplement, 1982, Volume: 119 Topics: Aerosols; Asthma; Asthma, Exercise-Induced; Humans; Pressure; Respiratory Therapy; Terbutaline	1982
Drugs and the control of exercise-induced asthma. The European respiratory journal, 1993, Volume: 6, Issue:8 Topics: Adult; Aerosols; Asthma, Exercise-Induced; Bronchodilator Agents; Child; Cromolyn Sodium; Dose-Respo	1993
[Effect of cromoglycate and terbutaline on exertion-produced bronchial spasm in asthmatic children]. Acta paediatrica Academiae Scientiarum Hungaricae, 1979, Volume: 20, Issue:2-3 Topics: Adolescent; Asthma; Asthma, Exercise-Induced; Bronchi; Child; Cromolyn Sodium; Female; Humans; Male;	1979
Duration of protective effect of terbutaline sulfate and cromolyn sodium alone and in combination on exercise-induced asthma. Chest, 1990, Volume: 97, Issue:1 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Drug Therapy, Combination; Exe	1990
Comparison of disodium cromoglycate, terbutaline and thiazinamium in the prevention of exercise-induced asthma and its relation to non-specific bronchial responsiveness. Respiration; international review of thoracic diseases, 1985, Volume: 48, Issue:2 Topics: Adolescent; Adult; Asthma; Asthma, Exercise-Induced; Bronchial Diseases; Cromolyn Sodium; Female; Fo	1985
The U.S. Olympic Committee experience with exercise-induced bronchospasm, 1984. Medicine and science in sports and exercise, 1986, Volume: 18, Issue:3 Topics: Adult; Albuterol; Asthma; Asthma, Exercise-Induced; Cromolyn Sodium; Female; Humans; Male; Sex Facto	1986

terbutaline and Asthma, Exercise-Induced