terbinafine and Tinea

terbinafine has been researched along with Tinea* in 2 studies

Other Studies

2 other study(ies) available for terbinafine and Tinea

Article	Year
Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10 Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations. Topics: Antifungal Agents; Calcineurin; Colony Count, Microbial; Culture Media; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Ergosterol; Fluconazole; Humans; Immunosuppressive Agents; Naphthalenes; Signal Transduction; Skin; Tacrolimus; Terbinafine; Tinea; Trichophyton	2007
Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphtha lenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 The allylamine derivatives are a new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. A new subclass, which features an acetylene group conjugated with the allylamine double bond, is characterized by enhanced antifungal activity, especially on oral treatment of guinea pig dermatophytoses. Increased branching of the alkyl group next to the triple bond led to the tert-butylacetylene derivative SF 86-327, a compound with strikingly increased activity in vitro and in vivo, which is now under clinical evaluation. Versatile synthetic routes, comparative biological data, and structure--activity relationships are presented. Topics: Administration, Oral; Animals; Antifungal Agents; Dermatomycoses; Fungi; Guinea Pigs; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Naphthalenes; Structure-Activity Relationship; Terbinafine; Tinea; Trichophyton	1984

Article

Year

Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.

Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:10

Fluconazole-FK506 or fluconazole-cyclosporine drug combinations were tested in an ex vivo Trichophyton mentagrophytes human skin infection model. Conidia colonization was monitored by scanning electron microscopy over a 7-day treatment period. The fluconazole-FK506 combination demonstrated the most obvious advantage over single-drug therapy by clearing conidia and protecting skin from damage at low drug concentrations.

Topics: Antifungal Agents; Calcineurin; Colony Count, Microbial; Culture Media; Cyclosporine; Drug Synergism; Drug Therapy, Combination; Ergosterol; Fluconazole; Humans; Immunosuppressive Agents; Naphthalenes; Signal Transduction; Skin; Tacrolimus; Terbinafine; Tinea; Trichophyton

2007

Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphtha lenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activity.

Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

The allylamine derivatives are a new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. A new subclass, which features an acetylene group conjugated with the allylamine double bond, is characterized by enhanced antifungal activity, especially on oral treatment of guinea pig dermatophytoses. Increased branching of the alkyl group next to the triple bond led to the tert-butylacetylene derivative SF 86-327, a compound with strikingly increased activity in vitro and in vivo, which is now under clinical evaluation. Versatile synthetic routes, comparative biological data, and structure--activity relationships are presented.

Topics: Administration, Oral; Animals; Antifungal Agents; Dermatomycoses; Fungi; Guinea Pigs; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Naphthalenes; Structure-Activity Relationship; Terbinafine; Tinea; Trichophyton

1984