terazosin has been researched along with Muscle Contraction in 19 studies
Terazosin: induces decreased blood pressure; used in the treatment of benign prostatic hyperplasia
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Terazosin was shown to have a four hundred-fold greater affinity for alpha-1 binding sites." | 6.66 | Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia. ( Baumann, M; Gup, DI; Lepor, H; Shapiro, E, 1988) |
| "Terazosin treatment, even 2 mg." | 5.31 | Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia. ( Furuya, S; Itoh, N; Masumori, N; Ogura, H; Sato, Y; Takahashi, A; Tanaka, Y; Tsukamoto, T, 2002) |
| "The adrenergic alpha-1 and -2 adrenoceptors in human hypertrophied and non-hypertrophied prostatic adenomas were measured in the saturation experiment using 3H-prazosin and 3H-yohimbine." | 3.68 | [Quantitative analyses of human prostatic alpha-adrenoceptors and effects of terazosin on the alpha-adrenoceptor activity]. ( Morita, T, 1991) |
| "Terazosin was shown to have a four hundred-fold greater affinity for alpha-1 binding sites." | 2.66 | Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia. ( Baumann, M; Gup, DI; Lepor, H; Shapiro, E, 1988) |
| "Terazosin treatment, even 2 mg." | 1.31 | Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia. ( Furuya, S; Itoh, N; Masumori, N; Ogura, H; Sato, Y; Takahashi, A; Tanaka, Y; Tsukamoto, T, 2002) |
| "Terazosin had lower affinity at various subtypes than tamsulosin, but showed relatively high selectivity to the alpha1D-subtype." | 1.30 | Tamsulosin: alpha1-adrenoceptor subtype-selectivity and comparison with terazosin. ( Muramatsu, I; Okada, K; Taniguchi, T, 1998) |
| "Medical management of benign prostatic hyperplasia (BPH) is an alternative to surgical treatment of this disease." | 1.29 | Medical management of benign prostatic hyperplasia: a canine model comparing the in vivo efficacy of alpha-1 adrenergic antagonists in the prostate. ( Breslin, D; Chou, TC; Felsen, D; Fields, DW; Kane, M; Marion, DN; Vaughan, ED, 1993) |
| "Terazosin was a more potent antagonist than rauwolscine against each of the agonists, except dopamine, in the mesenteric artery but rauwolscine was more potent than terazosin in the vein." | 1.27 | Pharmacological characterization of the postsynaptic alpha-adrenoceptors in isolated canine mesenteric arteries and veins. ( Itoh, H; Kohli, JD; Rajfer, SI, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 8 (42.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wong, WC | 1 |
| Chiu, G | 1 |
| Wetzel, JM | 2 |
| Marzabadi, MR | 1 |
| Nagarathnam, D | 2 |
| Wang, D | 1 |
| Fang, J | 1 |
| Miao, SW | 1 |
| Hong, X | 1 |
| Forray, C | 2 |
| Vaysse, PJ | 1 |
| Branchek, TA | 1 |
| Gluchowski, C | 2 |
| Tang, R | 1 |
| Lepor, H | 3 |
| Lagu, B | 1 |
| Tian, D | 1 |
| Jeon, Y | 1 |
| Li, C | 1 |
| Shen, Q | 1 |
| Chang, RS | 1 |
| Broten, TP | 1 |
| Ransom, RW | 1 |
| Chan, TB | 1 |
| O'Malley, SS | 1 |
| Schorn, TW | 1 |
| Rodrigues, AD | 1 |
| Kassahun, K | 1 |
| Pettibone, DJ | 1 |
| Freidinger, RO | 1 |
| Kobayashi, S | 1 |
| Tomiyama, Y | 1 |
| Maruyama, K | 1 |
| Hoyano, Y | 1 |
| Yamazaki, Y | 1 |
| Kusama, H | 1 |
| Pawar, A | 1 |
| Fahim, M | 1 |
| Tostes, RC | 1 |
| Giachini, FR | 1 |
| Carneiro, FS | 1 |
| Leite, R | 1 |
| Inscho, EW | 1 |
| Webb, RC | 1 |
| Colabufo, NA | 1 |
| Pagliarulo, V | 1 |
| Berardi, F | 1 |
| Contino, M | 1 |
| Perrone, R | 1 |
| Niso, M | 1 |
| Albo, G | 1 |
| de Rienzo, G | 1 |
| Pagliarulo, A | 1 |
| Onur, R | 1 |
| Tasdemir, C | 1 |
| Seckin, D | 1 |
| Ilhan, N | 1 |
| Kutlu, S | 1 |
| Akpolat, N | 1 |
| Somogyi, GT | 1 |
| Tanowitz, M | 1 |
| de Groat, WC | 1 |
| Breslin, D | 1 |
| Fields, DW | 1 |
| Chou, TC | 1 |
| Marion, DN | 1 |
| Kane, M | 1 |
| Vaughan, ED | 1 |
| Felsen, D | 1 |
| Mikuma, N | 1 |
| Furuya, S | 2 |
| Isomura, H | 1 |
| Yabu, H | 1 |
| Sawada, N | 1 |
| Tsukamoto, T | 2 |
| Muramatsu, I | 1 |
| Taniguchi, T | 1 |
| Okada, K | 1 |
| Amadesi, S | 1 |
| Varani, K | 1 |
| Spisani, L | 1 |
| Daniele, C | 1 |
| Turini, A | 1 |
| Agnello, G | 1 |
| Zamboni, P | 1 |
| Borea, PA | 1 |
| Geppetti, P | 1 |
| Tanaka, Y | 1 |
| Masumori, N | 1 |
| Itoh, N | 1 |
| Sato, Y | 1 |
| Takahashi, A | 1 |
| Ogura, H | 1 |
| Nishizawa, O | 1 |
| Sugaya, K | 1 |
| Takahashi, T | 1 |
| Shimoda, N | 1 |
| Satoh, K | 1 |
| Otomo, R | 1 |
| Noto, H | 1 |
| Harada, T | 1 |
| Tsuchida, S | 1 |
| Morita, T | 1 |
| Gup, DI | 1 |
| Baumann, M | 1 |
| Shapiro, E | 1 |
| Alver, JE | 1 |
| Mooppan, UM | 1 |
| Kester, RR | 1 |
| Gintautas, J | 1 |
| Abadir, AR | 1 |
| Kim, H | 1 |
| Itoh, H | 1 |
| Kohli, JD | 1 |
| Rajfer, SI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Medical Therapy of Prostatic Symptoms[NCT00021814] | Phase 3 | 3,407 participants (Actual) | Interventional | 1995-12-31 | Completed | ||
| A Multicenter, Randomized, Double-blind, Clinical Study to Investigate the Efficacy and Safety of Treatment With Tamsulosin 0.2mg Mono and Tamsulosin 0.2mg, Finasteride 5mg Combination Therapy in Patients With LUTS/BPH[NCT01736033] | Phase 4 | 545 participants (Actual) | Interventional | 2012-02-29 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for terazosin and Muscle Contraction
| Article | Year |
|---|---|
Role of alpha-adrenergic blockers in the treatment of benign prostatic hyperplasia.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Brimonidine Tartrate; Carbachol; Humans; Ma | 1990 |
1 trial available for terazosin and Muscle Contraction
| Article | Year |
|---|---|
Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Humans; Male; Multicenter Studies as Topic; Muscl | 1988 |
Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Humans; Male; Multicenter Studies as Topic; Muscl | 1988 |
Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Humans; Male; Multicenter Studies as Topic; Muscl | 1988 |
Laboratory assessment of terazosin and alpha-1 blockade in prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Double-Blind Method; Humans; Male; Multicenter Studies as Topic; Muscl | 1988 |
17 other studies available for terazosin and Muscle Contraction
| Article | Year |
|---|---|
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Animals; Brain; Ca | 1998 |
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Animals; Aorta; Binding, Competitive; Biological | 2000 |
Effects of four different alpha(1)-adrenoceptor antagonists on alpha-adrenoceptor agonist-induced contractions in isolated mouse and hamster ureters.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; An | 2009 |
Baroreceptor mediated blood pressure regulation is not affected during dose dependent inhibition of prostatic contractions by terazosin.
Topics: Animals; Baroreflex; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Male; Muscle Contractio | 2004 |
Determination of adenosine effects and adenosine receptors in murine corpus cavernosum.
Topics: 2-Chloroadenosine; Adenosine; Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Adr | 2007 |
Human epididymal and prostatic tracts of vas deferens: different contraction response to noradrenaline stimulation in isolated organ bath assay.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Aged; Dose-Response Relationship, D | 2007 |
Combined use of melatonin and terazosin restores bladder contractility in rabbits with partial outlet obstruction.
Topics: Adrenergic alpha-Antagonists; Animals; Antioxidants; Drug Therapy, Combination; Humans; Melatonin; M | 2008 |
Prejunctional facilitatory alpha 1-adrenoceptors in the rat urinary bladder.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Calcium; Dose-Response Relationship, Drug; Ele | 1995 |
Medical management of benign prostatic hyperplasia: a canine model comparing the in vivo efficacy of alpha-1 adrenergic antagonists in the prostate.
Topics: Adrenergic alpha-Antagonists; Animals; Dogs; Dose-Response Relationship, Drug; Epinephrine; Male; Mu | 1993 |
Morphological and pharmacological characterization of guinea-pig prostatic smooth muscle cells in vitro.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Dose-Response Rel | 1997 |
Tamsulosin: alpha1-adrenoceptor subtype-selectivity and comparison with terazosin.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Binding, Competitive; Dogs; Dose-Response Re | 1998 |
Comparison of prazosin, terazosin and tamsulosin: functional and binding studies in isolated prostatic and vascular human tissues.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Dose-Response Relationship, D | 2001 |
Urodynamic effects of terazosin treatment for Japanese patients with symptomatic benign prostatic hyperplasia.
Topics: Adrenergic alpha-Antagonists; Aged; Aged, 80 and over; Humans; Japan; Male; Middle Aged; Muscle Cont | 2002 |
[Effect of terazosin on lower urinary tract function in the male decerebrate dog].
Topics: Animals; Decerebrate State; Dogs; Dose-Response Relationship, Drug; Electromyography; Male; Muscle C | 1992 |
[Quantitative analyses of human prostatic alpha-adrenoceptors and effects of terazosin on the alpha-adrenoceptor activity].
Topics: Adenoma; Adrenergic alpha-Antagonists; Aged; Humans; Male; Muscle Contraction; Muscle, Smooth; Norep | 1991 |
The effects of the alpha 1-adrenergic antagonists terazosin and phentolamine on prostatic adenoma and urethra in vitro.
Topics: Adenoma; Adrenergic alpha-Antagonists; Humans; In Vitro Techniques; Male; Muscle Contraction; Phento | 1989 |
Pharmacological characterization of the postsynaptic alpha-adrenoceptors in isolated canine mesenteric arteries and veins.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Dogs; Dopamine | 1987 |