tenovin-1 and Neoplasms

tenovin-1 has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tenovin-1 and Neoplasms

ArticleYear
Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
    The Journal of biological chemistry, 2020, 12-25, Volume: 295, Issue:52

    The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also capable of inhibiting autophagic flux, demonstrating the ability of these compounds to engage with more than one target. In this study, we present two additional mechanisms by which tenovins are able to activate p53 and kill tumor cells in culture. These mechanisms are the inhibition of a key enzyme of the

    Topics: Acetanilides; Autophagy; Cell Proliferation; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Polypharmacology; Sirtuin 1; Thiourea; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2020