tenovin-1 and Neoplasms

The tenovins are a frequently studied class of compounds capable of inhibiting sirtuin activity, which is thought to result in increased acetylation and protection of the tumor suppressor p53 from degradation. However, as we and other laboratories have shown previously, certain tenovins are also capable of inhibiting autophagic flux, demonstrating the ability of these compounds to engage with more than one target. In this study, we present two additional mechanisms by which tenovins are able to activate p53 and kill tumor cells in culture. These mechanisms are the inhibition of a key enzyme of the

Topics: Acetanilides; Autophagy; Cell Proliferation; Dihydroorotate Dehydrogenase; Enzyme Inhibitors; Humans; Neoplasms; Oxidoreductases Acting on CH-CH Group Donors; Polypharmacology; Sirtuin 1; Thiourea; Tumor Cells, Cultured; Tumor Suppressor Protein p53