Compounds > tenofovir
Page last updated: 2024-08-24

tenofovir and AIDS, Simian

tenofovir has been researched along with AIDS, Simian in 89 studies

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (12.36)18.2507
2000's44 (49.44)29.6817
2010's33 (37.08)24.3611
2020's1 (1.12)2.80

Authors

AuthorsStudies
Del Prete, GQ; Fennessey, CM; Gorelick, RJ; Keele, BF; Li, Y; Lifson, JD; Long, S; Newman, L; O'Brien, SP; Reid, C1
Anderson, DM; Beck, IA; Frenkel, LM; Hu, SL; Joy, JP; Kuller, L; Montefiori, DC; Mulvania, TM; Tsai, CC1
Apetrei, C; Dunsmore, T; Haret-Richter, G; Pandrea, I; Policicchio, BB; Ribeiro, RM; Sette, P; Xu, C1
Dinh, C; Dobard, CW; Garcia-Lerma, G; Heneine, W; Khalil, G; Lipscomb, J; Makarova, N; Martin, A; Mitchell, J; Taylor, A; West-Deadwyler, R1
Doyle-Meyers, L; Foley, BT; Gao, Y; Li, Q; Ling, B; Perez, S; Siddiqui, S1
Bachman, S; Cong, ME; García-Lerma, JG; Hanson, DL; Heneine, W; Mitchell, J; Sweeney, E1
Amancha, PK; Ansari, AA; Hong, JJ; Rogers, K; Villinger, F1
Anderson, PL; Bushman, LR; Chuong, D; Dobard, CW; Garcia-Lerma, JG; Hanson, D; Heneine, W; McGowan, I; Pau, CP; Rohan, L; Sharma, S; Taylor, A; Wang, L1
Del Prete, GQ; Geleziunas, R; Hattersley, J; Hesselgesser, J; Jones, GS; Keele, BF; Li, B; Lifson, JD; Macallister, R; Piatak, M; Smedley, J; Zheng, J1
Cong, ME; Dobard, CW; Garcia-Lerma, JG; Hanson, DL; Heneine, W; Holder, A; Makarova, N; Novembre, FJ; Pau, CP; Sharma, S; West, R1
Brenchley, JM; Calantone, N; Carmack, K; DiNapoli, SR; Estes, JD; Gallagher, J; Klase, ZA; Klatt, NR; McCune, JM; Ortiz, AM; Paiardini, M; Perkins, MR; Riddick, NE; Vinton, CL; Vujkovic-Cvijin, I1
Chen, J; Li, L; Qin, C; Ren, Y; Wan, Y; Wang, J; Wang, W; Wei, Q; Xu, J; Zhang, X1
Barnable, P; Clark, MR; Cooney, ML; Doncel, GF; Fernández-Romero, JA; Jean-Pierre, N; Kizima, L; Robbiani, M; Rodríguez, A; Seidor, S; Teleshova, N; Zydowsky, TM1
Barnett, SW; Cope, A; Dereuddre-Bosquet, N; Desjardins, D; Dispinseri, S; Gosse, L; Le Grand, R; Ochsenbauer, C; Prague, M; Saidi, H; Scarlatti, G; Shattock, RJ; Shen, X; Thiebaut, R; Tolazzi, M; Tomaras, G1
Baum, MM; Butkyavichene, I; Churchman, SA; Dinh, CT; Fanter, R; Gunawardana, M; McNicholl, JM; Miller, CS; Mitchell, JM; Moss, JA; Smith, JM; Smith, TJ; Srinivasan, P; Yang, F; Zhang, J1
Babusis, D; Deyounks, F; García-Lerma, JG; Heneine, W; Massud, I; Miller, MD; Mitchell, J; Ray, AS; Rooney, JF1
Aubert, R; Dinh, C; Dobard, C; Garcia-Lerma, GJ; Hanson, D; Heneine, W; Henning, T; Kersh, E; Lipscomb, J; Makarova, N; McNicholl, J; Mitchell, J; Papp, J; Phillips, C; Taylor, A1
Abel, K; Bischofberger, N; Brignolo, LL; Cihlar, T; Durand-Gasselin, L; Jerome, C; Kearney, BP; Marthas, ML; Moore, J; Ray, AS; Reiser, H; Spinner, A; Van Rompay, KK1
Anton, P; Berry, N; Cope, A; Cranage, M; Dennis, M; Ham, C; Heeney, J; Herrera, C; Kashuba, A; McGowan, I; Rezk, N; Sharpe, S; Shattock, R1
Brenchley, J; Buckler-White, A; Igarashi, T; Kubo, M; Lafont, B; Lee, W; Martin, MA; Nishimura, Y; Shingai, M1
Cong, ME; Dobard, C; Folks, T; Garcia-Lerma, JG; Guenthner, P; Hanson, DL; Heneine, W; Jia, H; Kersh, E; Martin, A; Novembre, FJ; Otten, R; Parikh, UM; Pau, CP; Sharma, S; Smith, J1
Barreca, ML; Chirullo, B; Collins, M; Garaci, E; Greenhouse, J; Iraci, N; Lewis, MG; Norelli, S; Savarino, A; Titti, F; Yalley-Ogunro, J1
Barr, JR; Cong, ME; Folks, TM; García-Lerma, JG; Hanson, DL; Heneine, W; Holder, A; Kuklenyik, Z; Lipscomb, J; Martin, A; Masciotra, S; Mitchell, J; Otten, R; Pau, CP; Paxton, L; Youngpairoj, AS; Zheng, Q1
Assouline, B; Axthelm, MK; Legasse, A; Leone, A; Lifson, JD; Morre, M; Okoye, A; Piatak, M; Picker, LJ; Rohankhedkar, M; Sodora, DL; Villinger, F1
Aung, W; Cong, ME; Dobard, C; Garcia-Lerma, JG; Heneine, W; Mitchell, J; Sharma, S; Youngpairoj, AS1
Aung, W; Cong, ME; García-Lerma, JG; Hanson, DL; Heneine, W; Holder, A; Kersh, E; Kuklenyik, S; Lee, WA; Lin, CY; Luo, W; Martin, A; Mitchell, J; Pau, CP; Ray, AS; Rooney, JF; Youngpairoj, AS; Zheng, Q1
Cong, ME; Curtis, KA; García-Lerma, JG; Hanson, D; Heneine, W; Kennedy, MS; Luckay, A; Owen, SM; Smith, J; Youngpairoj, AS; Zheng, Q1
Katsikis, PD; Lewis, MG; Lugli, E; Mueller, YM; Roederer, M; Villinger, F1
Allen, P; Kashuba, A; Nuttall, J; Roberts, J; Romano, J; Wang, R; White, N1
Dobard, C; García-Lerma, JG; Hanson, DL; Heneine, W; Holder, A; Kuklenyik, Z; Lipscomb, J; Martin, A; Novembre, FJ; Pau, CP; Sharma, S; Smith, J1
Didier, PJ; Michael, H; Mitsuya, H; Murphey-Corb, M; Nyaundi, J; Parniak, MA; Rajakumar, P; Reeve, AB; Sarafianos, SG1
Acosta, EP; Barreca, ML; Chirullo, B; Collins, M; Della Corte, A; Greenhouse, J; Iraci, N; Lewis, MG; Norelli, S; Savarino, A; Shytaj, IL; Yalley-Ogunro, J1
Adams, DR; Butler, K; Cong, ME; Garcia-Lerma, JG; Hanson, D; Hendry, RM; Heneine, W; Kersh, EN; Luo, W; McNicholl, JM; Youngpairoj, AS; Zheng, Q1
Abbott, Z; Abel, K; Babusis, D; Geng, Y; Heneine, W; Jayashankar, K; Johnson, JA; Lipscomb, J; Ray, AS; Van Rompay, KK1
Abel, K; Canfield, DR; Forthal, DN; Geng, Y; Heneine, W; Jayashankar, K; Johnson, JA; LaBranche, CC; Landucci, G; Lipscomb, J; Montefiori, D; Tarara, RP; Trott, KA; Van Rompay, KK1
Murakami, T; Nakasone, T; Yamamoto, N1
Aravantinou, M; Blanchard, JL; Frank, I; Geer, S; Gettie, A; Jasny, E; Lifson, JD; Piatak, M; Robbiani, M; Salazar, AM; Vagenas, P1
Bischofberger, N; Lawson, JR; Marthas, ML; Schmidt, KA; Singh, R; Van Rompay, KK1
Castillo, AB; Martin, RB; Tarantal, AF; Watnik, MR1
Bischofberger, N; Blanchard, J; Cline, AN; Lifson, JD; Pandrea, I; Piatak, M; Purcell, J; Rossio, JL; Veazey, RS1
Cohen, J4
Bischofberger, N; Lawson, JR; Marthas, ML; Pahar, B; Singh, RP; Sodora, DL; Van Rompay, KK; Wingfield, C1
Bischofberger, N; Brignolo, LL; Canfield, DR; Lawson, JR; Marthas, ML; Pahar, B; Schmidt, KA; Singh, RP; Sodora, DL; Tarara, RP; Van Rompay, KK1
Chen, ZW; Du, GZ; Huang, D; Letvin, NL; Miller, MD; Qiu, L; Sehgal, P; Shen, L; Shen, Y1
Dandekar, S; George, MD; Reay, E; Sankaran, S1
Carruth, LM; Clements, JE; Li, M; Mankowski, JL; Miller, MD; Queen, LA; Shen, A; Siliciano, RF; Tarwater, PM; Zink, MC1
Bullock, B; Carruth, LM; Clements, JE; Gama, L; Li, M; Mankowski, JL; Zink, MC1
Allen, TM; Bazmi, A; Fuller, DH; Fuller, JT; Haynes, JR; McMahon, CW; Mothe, B; Murphey-Corb, M; Rajakumar, PA; Shipley, T; Trichel, AM; Watkins, DI; Wu, MS1
Bischofberger, N; Heneine, W; Johnson, JA; Marthas, ML; Montefiori, DC; Singh, RP; Van Rompay, KK1
Bischofberger, N; Blackwood, EJ; Colón, R; Kearney, BP; Lawson, JR; Lee, WA; Marthas, ML; Sexton, JJ; Van Rompay, KK1
Amedee, A; Dowling, P; Fuller, DH; Meleason, D; Murphey-Corb, M; Rajakumar, PA; Taber, R; Trichel, AM1
Grant, RM; Wainberg, MA1
Adams, DR; Bashirian, S; Butera, S; Folks, TM; Greenberg, AE; Hudgens, MG; Jackson, E; Janssen, R; Johnson, J; Kim, C; Monsour, M; Otten, RA; Paxton, L; Ramos, A; Rendon, A; Soriano, V; Subbarao, S1
Cervasi, B; Engram, J; Fraternale, A; Lawson, B; Magnani, M; Menotta, M; Paiardini, M; Perno, CF; Piedimonte, G; Serafini, S; Silvestri, G; Staprans, SI1
Binley, JM; Connor, RI; Gettie, A; Marx, P; Metzner, KJ; Nixon, DF1
Erfle, V; Heeney, J; Rosenwirth, B; Sutter, G; Ten Haaft, P; Uberla, K1
Bischofberger, N; Blackwood, EJ; Heneine, W; Johnson, JA; Lipscomb, J; Marthas, ML; Matthews, TB; North, TW; Pedersen, NC; Singh, RP; Van Rompay, KK1
Dandekar, S; Sankaran, S; Verhoeven, D1
Adams, D; Butera, S; Folks, T; Kim, C; Monsour, M; Otten, RA; Ramos, A; Subbarao, S1
Adams, DR; Cong, ME; Delinsky, D; Folks, TM; García-Lerma, JG; Heneine, W; Jackson, E; Janssen, R; Johnson, JA; Kim, C; Lipscomb, J; Luo, W; Masciotra, S; Monsour, M; Otten, RA; Qari, SH; Schinazi, RF1
Adams, DR; Butera, S; Folks, TM; Garcia-Lerma, JG; Heneine, W; Kersh, EN; Luo, W; Mitchell, J; Otten, RA1
McCarthy, M1
Beck, TW; Benveniste, RE; Bischofberger, N; Black, R; Follis, KE; Grant, RF; Sabo, A; Tsai, CC1
Berardi, CJ; Bischofberger, N; Canfield, DR; Cherrington, JM; Marthas, ML; Mulato, AS; Pedersen, NC; Spinner, A; Tarara, RP; Telm, S; Van Rompay, KK1
Beck, TW; Benveniste, RE; Bischofberger, N; Emau, P; Follis, KE; Lifson, JD; Morton, WR; Tsai, CC1
Agatep, E; Berardi, CJ; Bischofberger, N; Cundy, KC; Dehqanzada, ZA; Lifson, JD; Marthas, ML; Pedersen, NC; Van Rompay, KK; Vasquez, GM1
Aguirre, NL; Berardi, CJ; Bischofberger, N; Lietman, PS; Marthas, ML; Pedersen, NC; Van Rompay, KK1
Aguirre, NL; Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Lamy, PD; Marthas, ML; Pedersen, NC; Tarara, RP; van Rompay, KK1
Bischofberger, N; Cundy, K; Marthas, ML; Shaw, JP; Tarantal, AF1
Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Lamy, PD; Marthas, ML; Pedersen, NC; Tarara, RP; Van Rompay, KK1
Dailey, P; Dandekar, S; Mattapallil, JJ; Smit-McBride, Z1
Bischofberger, N; Bogers, WM; Heeney, JL; Kuhn, EM; Nieuwenhuis, IG; Niphuis, H; Rosenwirth, B; ten Haaft, P; Uberla, K1
Aguirre, NL; Bischofberger, N; Canfield, DR; Cherrington, JM; Dailey, PJ; Margot, NA; Marthas, ML; Miller, MD; Pedersen, NC; Tarara, RP; Van Rompay, KK1
Arnaout, R; Bischofberger, N; Coalter, VJ; Fisher, B; Flynn, BM; Hirsch, VM; Imming, RJ; Kiser, RF; Li, L; Lifson, JD; Nowak, MA; Parks, TL; Piatak, M; Rossio, JL; Schneider, DK; Walsh, G; Wodarz, D1
Bischofberger, N; Crabbs, C; Greenhouse, J; Jiang, JB; Lewis, MG; Racz, K; Racz, P; Silvera, P; Yalley-Ogunro, J1
Self, SG; Wick, D1
Adany, I; Bischofberger, N; Buch, S; Foresman, L; Li, Z; Lifson, JD; Lopez, GJ; Narayan, O; Page, A; Smith, MS; Tsay, J; Wang, C; Wodarz, D1
Beck, TW; Bischofberger, N; Emau, P; Follis, KE; Morton, WR; Sun, JC; Tran, CA; Tsai, CC1
Crabbs, C; Greenhouse, J; Lewis, MG; Lisziewicz, J; Lori, F; Silvera, P; Tinelli, C; Varga, G; Wagner, W; Xu, J; Yalley-Ogunro, J; Zinn, DE1
Bischofberger, N; Buch, S; Foresman, L; Kumar, A; Lifson, JD; Narayan, O1
Bischofberger, N; Dittmer, U; Heeney, J; Hunsmann, G; Lorenzen, D; Ràcz, P; Spring, M; Stahl-Hennig, C; Stolte, N; Tenner-Ràcz, K1
Aguirre, NL; Bischofberger, N; Marthas, ML; McChesney, MB; Schmidt, KA; Van Rompay, KK1
Chalifoux, L; Chen, ZW; Enimi, EA; Gastron, M; Henckler, B; Letvin, NL; Miller, M; Sehgal, N; Sehgal, P; Shen, L; Shen, Y; Simon, M; Zhou, D1
Bischofberger, N; Coalter, V; Czajak, S; Desrosiers, RC; Fisher, B; Flynn, BM; Ghrayeb, J; Hirsch, VM; Kiser, R; Li, L; Lifson, JD; Nowak, MA; Parks, T; Piatak, M; Reimann, KA; Rossio, JL; Schmitz, JE; Wodarz, D1
Ansari, AA; Bostik, P; Brice, GT; June, CH; Mayne, AE; Mori, K; Villinger, F1

Other Studies

89 other study(ies) available for tenofovir and AIDS, Simian

ArticleYear
Evaluating the Intactness of Persistent Viral Genomes in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Initiating Antiretroviral Therapy within One Year of Infection.
    Journal of virology, 2019, 12-12, Volume: 94, Issue:1

    Topics: Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4-Positive T-Lymphocytes; DNA, Viral; Emtricitabine; Genome, Viral; Genomics; Macaca mulatta; Mutation; Raltegravir Potassium; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Viremia; Virus Replication; Whole Genome Sequencing

2019
Immunization by exposure to live virus (SIVmne/HIV-2287) during antiretroviral drug prophylaxis may reduce risk of subsequent viral challenge.
    PloS one, 2021, Volume: 16, Issue:4

    Topics: Animals; Anti-Retroviral Agents; Disease Models, Animal; Female; HIV Infections; HIV-2; Humans; Immunization; Macaca nemestrina; Pre-Exposure Prophylaxis; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2021
Emergence of resistance mutations in simian immunodeficiency virus (SIV)-infected rhesus macaques receiving non-suppressive antiretroviral therapy (ART).
    PloS one, 2018, Volume: 13, Issue:2

    Topics: Animals; Anti-Retroviral Agents; Disease Models, Animal; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; Emtricitabine; Genes, Viral; Humans; Integrases; Macaca mulatta; Mutation; Raltegravir Potassium; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load

2018
Efficacy of Vaginally Administered Gel Containing Emtricitabine and Tenofovir Against Repeated Rectal Simian Human Immunodeficiency Virus Exposures in Macaques.
    The Journal of infectious diseases, 2018, 09-08, Volume: 218, Issue:8

    Topics: Administration, Intravaginal; Administration, Topical; Animals; Anti-HIV Agents; Drug Therapy, Combination; Emtricitabine; Female; Macaca mulatta; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vaginal Creams, Foams, and Jellies

2018
Persistent Viral Reservoirs in Lymphoid Tissues in SIV-Infected Rhesus Macaques of Chinese-Origin on Suppressive Antiretroviral Therapy.
    Viruses, 2019, 01-27, Volume: 11, Issue:2

    Topics: Animals; Anti-Retroviral Agents; China; Emtricitabine; Lymphoid Tissue; Macaca mulatta; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Virus Latency; Virus Replication

2019
Prophylactic efficacy of oral emtricitabine and tenofovir disoproxil fumarate combination therapy against a tenofovir-resistant simian/human immunodeficiency virus containing the K65R mutation in macaques.
    The Journal of infectious diseases, 2013, Aug-01, Volume: 208, Issue:3

    Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Deoxycytidine; Disease Transmission, Infectious; Drug Resistance, Viral; Emtricitabine; HIV; Macaca; Mutation, Missense; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome

2013
In vivo blockade of the programmed cell death-1 pathway using soluble recombinant PD-1-Fc enhances CD4+ and CD8+ T cell responses but has limited clinical benefit.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Dec-15, Volume: 191, Issue:12

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antibodies, Monoclonal; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Combined Modality Therapy; Drug Evaluation, Preclinical; Emtricitabine; Histocompatibility Antigens Class I; Immunity, Cellular; Immunoglobulin Fc Fragments; Immunotherapy; Lymphokines; Macaca mulatta; Organophosphonates; Programmed Cell Death 1 Receptor; Recombinant Proteins; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Solubility; Tenofovir; Viremia; Zalcitabine

2013
Protection Against Rectal Chimeric Simian/Human Immunodeficiency Virus Transmission in Macaques by Rectal-Specific Gel Formulations of Maraviroc and Tenofovir.
    The Journal of infectious diseases, 2015, Dec-15, Volume: 212, Issue:12

    Topics: Administration, Topical; Animals; Anti-HIV Agents; Cross-Over Studies; Cyclohexanes; Disease Models, Animal; Disease Transmission, Infectious; Gels; Macaca; Maraviroc; Placebos; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Treatment Outcome; Triazoles

2015
Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques.
    AIDS research and human retroviruses, 2016, Volume: 32, Issue:2

    Topics: Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Drug Combinations; Drug Resistance, Viral; Emtricitabine; Heterocyclic Compounds, 3-Ring; HIV Integrase Inhibitors; Macaca mulatta; Oxazines; Piperazines; Pyridones; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load

2016
Efficacy of topical tenofovir against transmission of a tenofovir-resistant SHIV in macaques.
    Retrovirology, 2015, Aug-08, Volume: 12

    Topics: Administration, Intravaginal; Animals; Disease Models, Animal; Drug Resistance, Viral; Female; Gels; HIV; HIV Infections; Humans; Macaca radiata; Pre-Exposure Prophylaxis; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vagina

2015
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques.
    Mucosal immunology, 2016, Volume: 9, Issue:2

    Topics: Animals; Anti-Retroviral Agents; Bacterial Translocation; Cell Proliferation; Combined Modality Therapy; Dysbiosis; Emtricitabine; Gastrointestinal Microbiome; Gastrointestinal Tract; Immunity, Mucosal; Interleukins; Macaca nemestrina; Probiotics; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Th17 Cells

2016
Mucosal Topical Microbicide Candidates Exert Influence on the Subsequent SIV Infection and Survival by Regulating SIV-Specific T-Cell Immune Responses.
    Journal of acquired immune deficiency syndromes (1999), 2016, Feb-01, Volume: 71, Issue:2

    Topics: Administration, Rectal; Animals; Anti-Infective Agents, Local; CD4-Positive T-Lymphocytes; Cyclohexanes; Disease Progression; Gene Expression Profiling; Humans; Immunity, Cellular; Macaca mulatta; Maraviroc; Mucous Membrane; Oligonucleotide Array Sequence Analysis; Peptides; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Rate; Tenofovir; Triazoles; Viral Load

2016
Multipurpose Prevention Approaches with Antiretroviral-Based Formulations.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:2

    Topics: Administration, Intravaginal; Animals; Anti-Retroviral Agents; Carrageenan; Drug Combinations; Female; Gels; Herpesvirus 2, Human; HIV-1; Macaca mulatta; Mice, Inbred BALB C; Pyridines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Urea; Vagina; Zinc Acetate

2016
Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates.
    Journal of virology, 2016, 06-01, Volume: 90, Issue:11

    Topics: AIDS Vaccines; Animals; Anti-HIV Agents; Antibodies, Viral; Drug Synergism; Female; HIV Antibodies; HIV Infections; HIV-1; Humans; Macaca fascicularis; Models, Animal; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vaccination

2016
Topical Delivery of Tenofovir Disoproxil Fumarate and Emtricitabine from Pod-Intravaginal Rings Protects Macaques from Multiple SHIV Exposures.
    PloS one, 2016, Volume: 11, Issue:6

    Topics: Administration, Intravaginal; Administration, Topical; Animals; Contraceptive Devices, Female; Emtricitabine; Female; Macaca nemestrina; Retroviruses, Simian; Simian Acquired Immunodeficiency Syndrome; Tenofovir

2016
Chemoprophylaxis With Oral Emtricitabine and Tenofovir Alafenamide Combination Protects Macaques From Rectal Simian/Human Immunodeficiency Virus Infection.
    The Journal of infectious diseases, 2016, 10-01, Volume: 214, Issue:7

    Topics: Adenine; Alanine; Animals; Anti-HIV Agents; Chemoprevention; Emtricitabine; Macaca; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Treatment Outcome

2016
Topical tenofovir protects against vaginal simian HIV infection in macaques coinfected with Chlamydia trachomatis and Trichomonas vaginalis.
    AIDS (London, England), 2017, 03-27, Volume: 31, Issue:6

    Topics: Administration, Topical; Animals; Anti-HIV Agents; Chlamydia Infections; Coinfection; Disease Transmission, Infectious; Female; Macaca; Placebos; Plasma; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Trichomonas Vaginitis; Vagina; Vaginal Creams, Foams, and Jellies

2017
Chronic administration of tenofovir to rhesus macaques from infancy through adulthood and pregnancy: summary of pharmacokinetics and biological and virological effects.
    Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:9

    Topics: Adenine; Age Factors; Animals; Anti-HIV Agents; Disease Models, Animal; Female; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Pregnancy; Pregnancy Complications, Infectious; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome

2008
Prevention of SIV rectal transmission and priming of T cell responses in macaques after local pre-exposure application of tenofovir gel.
    PLoS medicine, 2008, Aug-05, Volume: 5, Issue:8

    Topics: Adenine; Animals; Anti-Infective Agents, Local; Antibody Formation; Cross-Priming; Gels; HeLa Cells; HIV-1; Humans; Interferon-gamma; Macaca; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Treatment Outcome; Virus Replication

2008
Initiation of antiretroviral therapy 48 hours after infection with simian immunodeficiency virus potently suppresses acute-phase viremia and blocks the massive loss of memory CD4+ T cells but fails to prevent disease.
    Journal of virology, 2009, Volume: 83, Issue:14

    Topics: Adenine; Amino Acid Sequence; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cells, Cultured; Disease Models, Animal; Drug Administration Schedule; HIV Antibodies; HIV Infections; Humans; Injections; Macaca mulatta; Molecular Sequence Data; Organophosphonates; Sequence Alignment; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viremia; Virus Replication

2009
Complete protection from repeated vaginal simian-human immunodeficiency virus exposures in macaques by a topical gel containing tenofovir alone or with emtricitabine.
    Journal of virology, 2009, Volume: 83, Issue:20

    Topics: Adenine; Administration, Intravaginal; Animals; Anti-HIV Agents; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Female; Gels; Humans; Macaca nemestrina; Organophosphonates; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Vagina

2009
Response of a simian immunodeficiency virus (SIVmac251) to raltegravir: a basis for a new treatment for simian AIDS and an animal model for studying lentiviral persistence during antiretroviral therapy.
    Retrovirology, 2010, Mar-16, Volume: 7

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cell Line; Cells, Cultured; Deoxycytidine; DNA, Viral; Emtricitabine; Humans; Macaca mulatta; Organophosphonates; Proviruses; Pyrrolidinones; Raltegravir Potassium; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load

2010
Intermittent prophylaxis with oral truvada protects macaques from rectal SHIV infection.
    Science translational medicine, 2010, Jan-13, Volume: 2, Issue:14

    Topics: Adenine; Administration, Oral; Animals; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Kinetics; Leukocytes, Mononuclear; Macaca; Organophosphonates; Organophosphorus Compounds; Proportional Hazards Models; Rectum; Research Design; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome; Viral Load

2010
Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Aug-01, Volume: 185, Issue:3

    Topics: Adenine; Animals; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; Cell Proliferation; CHO Cells; Cricetinae; Cricetulus; Deoxycytidine; Emtricitabine; Interleukin-7; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Tenofovir

2010
More research needed to find new HIV-suppressive functions of cytotoxic T cells.
    Immunotherapy, 2010, Volume: 2, Issue:2

    Topics: Adenine; Animals; Combined Modality Therapy; Deoxycytidine; Emtricitabine; HIV Infections; Humans; Lymphocyte Depletion; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Tenofovir; Viral Load; Viremia

2010
Generation and mucosal transmissibility of emtricitabine- and tenofovir-resistant SHIV162P3 mutants in macaques.
    Virology, 2011, Apr-10, Volume: 412, Issue:2

    Topics: Adenine; Animals; Anti-HIV Agents; Deoxycytidine; Disease Models, Animal; Drug Resistance, Viral; Emtricitabine; HIV; Humans; Macaca; Mutation; Organophosphonates; Recombination, Genetic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Virus Cultivation

2011
Natural substrate concentrations can modulate the prophylactic efficacy of nucleotide HIV reverse transcriptase inhibitors.
    Journal of virology, 2011, Volume: 85, Issue:13

    Topics: Adenine; Animals; Anti-HIV Agents; Chemoprevention; Deoxyadenine Nucleotides; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Lymphocytes; Lymphoid Tissue; Macaca; Organophosphonates; Prodrugs; Rectum; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Substrate Specificity; Tenofovir

2011
Delayed maturation of antibody avidity but not seroconversion in rhesus macaques infected with simian HIV during oral pre-exposure prophylaxis.
    Journal of acquired immune deficiency syndromes (1999), 2011, Aug-15, Volume: 57, Issue:5

    Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Antibodies, Viral; Antibody Affinity; Deoxycytidine; Drug Combinations; Emtricitabine; HIV; HIV Antibodies; Human Immunodeficiency Virus Proteins; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load

2011
IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.
    Blood, 2011, Sep-01, Volume: 118, Issue:9

    Topics: Adaptive Immunity; Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Drug Evaluation, Preclinical; Drug Therapy, Combination; Emtricitabine; Immunity, Mucosal; Immunologic Factors; Immunotherapy; Interleukin-15; Lymphocyte Activation; Lymphoid Tissue; Macaca mulatta; Mucous Membrane; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Random Allocation; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Treatment Failure; Viral Load

2011
Pharmacokinetics of tenofovir following intravaginal and intrarectal administration of tenofovir gel to rhesus macaques.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:1

    Topics: Adenine; Administration, Intravaginal; Administration, Rectal; Animals; Antiviral Agents; Area Under Curve; Body Fluids; Dose-Response Relationship, Drug; Female; Gels; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vagina

2012
Durable protection from vaginal simian-human immunodeficiency virus infection in macaques by tenofovir gel and its relationship to drug levels in tissue.
    Journal of virology, 2012, Volume: 86, Issue:2

    Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; Drug Stability; Female; Half-Life; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Longitudinal Studies; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vagina; Vaginal Creams, Foams, and Jellies

2012
Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; Deoxyadenosines; Deoxycytidine; Emtricitabine; Leukocytes, Mononuclear; Macaca mulatta; Male; Mutation; Organophosphonates; Recurrence; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Zidovudine

2012
A highly intensified ART regimen induces long-term viral suppression and restriction of the viral reservoir in a simian AIDS model.
    PLoS pathogens, 2012, Volume: 8, Issue:6

    Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Cyclohexanes; Darunavir; Deoxycytidine; Drug Therapy, Combination; Emtricitabine; Flow Cytometry; Fluorescent Antibody Technique; Macaca mulatta; Maraviroc; Organophosphonates; Pyrrolidinones; Raltegravir Potassium; Ritonavir; Simian Acquired Immunodeficiency Syndrome; Sulfonamides; T-Lymphocyte Subsets; Tenofovir; Triazoles; Viral Load; Viremia

2012
Reduced inflammation and CD4 loss in acute SHIV infection during oral pre-exposure prophylaxis.
    The Journal of infectious diseases, 2012, Sep-01, Volume: 206, Issue:5

    Topics: Adenine; Alanine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cytokines; Deoxycytidine; Drug Combinations; Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination; Longitudinal Studies; Macaca mulatta; Male; Organophosphorus Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Statistics, Nonparametric; Tenofovir; Viremia

2012
Compared to subcutaneous tenofovir, oral tenofovir disoproxyl fumarate administration preferentially concentrates the drug into gut-associated lymphoid cells in simian immunodeficiency virus-infected macaques.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: Adenine; Administration, Oral; Animals; Antiviral Agents; Drug Administration Schedule; Injections, Subcutaneous; Intestines; Lymphocytes; Macaca mulatta; Male; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome

2012
Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal.
    Retrovirology, 2012, Jul-17, Volume: 9

    Topics: Adenine; Alleles; Animals; Antibodies, Viral; Antibody Formation; Antiviral Agents; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Disease Models, Animal; Genes, MHC Class I; Genotyping Techniques; Immunity, Cellular; Lymphocyte Activation; Macaca mulatta; Neutralization Tests; Organophosphonates; RNA-Directed DNA Polymerase; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Treatment Outcome; Viremia; Virus Replication

2012
Double oral administration of emtricitabine/tenofovir prior to virus exposure protects against highly pathogenic simian/human immunodeficiency virus infection in macaques.
    Japanese journal of infectious diseases, 2012, Volume: 65, Issue:4

    Topics: Adenine; Administration, Oral; Animals; Anti-HIV Agents; Antibiotic Prophylaxis; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Deoxycytidine; Disease Models, Animal; Emtricitabine; Humans; Macaca; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Viral Load

2012
Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.
    Journal of acquired immune deficiency syndromes (1999), 2012, Dec-01, Volume: 61, Issue:4

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antiretroviral Therapy, Highly Active; Deoxycytidine; Emtricitabine; Immunity, Mucosal; Immunophenotyping; Injections, Subcutaneous; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; T-Lymphocyte Subsets; Tenofovir

2012
Topical administration of low-dose tenofovir disoproxil fumarate to protect infant macaques against multiple oral exposures of low doses of simian immunodeficiency virus.
    The Journal of infectious diseases, 2002, Nov-15, Volume: 186, Issue:10

    Topics: Adenine; Administration, Topical; Animals; Anti-HIV Agents; Disease Models, Animal; Macaca; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2002
Tenofovir treatment at 30 mg/kg/day can inhibit cortical bone mineralization in growing rhesus monkeys (Macaca mulatta).
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2002, Volume: 20, Issue:6

    Topics: Adenine; Animals; Bone Remodeling; Calcification, Physiologic; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Tibia

2002
Transient early post-inoculation anti-retroviral treatment facilitates controlled infection with sparing of CD4+ T cells in gut-associated lymphoid tissues in SIVmac239-infected rhesus macaques, but not resistance to rechallenge.
    Journal of medical primatology, 2003, Volume: 32, Issue:4-5

    Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; DNA Primers; Gene Products, env; Gene Products, gag; Intestines; Lymphoid Tissue; Macaca mulatta; Male; Organophosphonates; Organophosphorus Compounds; Retroviridae Proteins, Oncogenic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Fusion Proteins; Viral Load; Viremia

2003
Cambodia: can a drug provide some protection?
    Science (New York, N.Y.), 2003, Sep-19, Volume: 301, Issue:5640

    Topics: Adenine; Animals; Anti-HIV Agents; Cambodia; Controlled Clinical Trials as Topic; Female; Haplorhini; HIV Infections; Humans; International Cooperation; Male; Organophosphonates; Organophosphorus Compounds; Sex Work; Simian Acquired Immunodeficiency Syndrome; Tenofovir

2003
CD8+-cell-mediated suppression of virulent simian immunodeficiency virus during tenofovir treatment.
    Journal of virology, 2004, Volume: 78, Issue:10

    Topics: Adenine; Animals; Antiviral Agents; CD8-Positive T-Lymphocytes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia; Virus Replication

2004
The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters.
    Journal of acquired immune deficiency syndromes (1999), 2004, Aug-01, Volume: 36, Issue:4

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Chronic Disease; Drug Evaluation, Preclinical; Female; Injections, Subcutaneous; Lymphocyte Count; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Analysis; Tenofovir; Viral Load

2004
Development of Vgamma2Vdelta2+ T cell responses during active mycobacterial coinfection of simian immunodeficiency virus-infected macaques requires control of viral infection and immune competence of CD4+ T cells.
    The Journal of infectious diseases, 2004, Oct-15, Volume: 190, Issue:8

    Topics: Adenine; Amino Acid Sequence; Animals; Cattle; CD4-Positive T-Lymphocytes; Disease Models, Animal; Drug Therapy, Combination; HIV Protease Inhibitors; Indinavir; Lung; Lymphocyte Count; Macaca mulatta; Macaca nemestrina; Molecular Sequence Data; Mycobacterium bovis; Organophosphonates; Receptors, Antigen, T-Cell, gamma-delta; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Tuberculosis, Bovine

2004
Early antiretroviral therapy for simian immunodeficiency virus infection leads to mucosal CD4+ T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration.
    Journal of virology, 2005, Volume: 79, Issue:5

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antibody Formation; Antigen Presentation; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Gene Expression; Gene Expression Profiling; Immunity, Mucosal; Intestinal Mucosa; Lymphocyte Activation; Lymphoid Tissue; Macaca mulatta; Male; Oligonucleotide Array Sequence Analysis; Organophosphonates; Regeneration; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2005
SIV-specific T lymphocyte responses in PBMC and lymphoid tissues of SIV-infected pigtailed macaques during suppressive combination antiretroviral therapy.
    Journal of medical primatology, 2005, Volume: 34, Issue:3

    Topics: Adenine; Animals; Anti-Retroviral Agents; Drug Therapy, Combination; Emtricitabine; Immunity, Cellular; Interferon-gamma; Linear Models; Macaca nemestrina; Organophosphonates; Primate Diseases; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Viremia; Zalcitabine

2005
The central nervous system is a viral reservoir in simian immunodeficiency virus--infected macaques on combined antiretroviral therapy: a model for human immunodeficiency virus patients on highly active antiretroviral therapy.
    Journal of neurovirology, 2005, Volume: 11, Issue:2

    Topics: Adenine; Animals; Anti-HIV Agents; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Disease Models, Animal; DNA, Viral; Drug Therapy, Combination; Histocompatibility Antigens Class II; Injections, Subcutaneous; Macaca nemestrina; Organophosphonates; Polymerase Chain Reaction; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Zalcitabine

2005
DNA immunization in combination with effective antiretroviral drug therapy controls viral rebound and prevents simian AIDS after treatment is discontinued.
    Virology, 2006, Apr-25, Volume: 348, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Cell Proliferation; Disease Progression; Epitopes, T-Lymphocyte; Gene Products, gag; Gene Products, tat; Immunotherapy, Active; Macaca mulatta; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Statistics as Topic; Tenofovir; Vaccines, DNA; Viremia; Withholding Treatment

2006
Retrovirus meeting. Novel attacks on HIV move closer to reality.
    Science (New York, N.Y.), 2006, Feb-17, Volume: 311, Issue:5763

    Topics: Adenine; Animals; Anti-HIV Agents; Evolution, Molecular; HIV Infections; HIV-1; Humans; Organic Chemicals; Organophosphonates; Primates; Pyrrolidinones; Raltegravir Potassium; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2006
Structured treatment interruptions with tenofovir monotherapy for simian immunodeficiency virus-infected newborn macaques.
    Journal of virology, 2006, Volume: 80, Issue:13

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Biomarkers; Drug Resistance, Viral; Immune Tolerance; Macaca mulatta; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Virus Replication

2006
Evaluation of oral tenofovir disoproxil fumarate and topical tenofovir GS-7340 to protect infant macaques against repeated oral challenges with virulent simian immunodeficiency virus.
    Journal of acquired immune deficiency syndromes (1999), 2006, Volume: 43, Issue:1

    Topics: Adenine; Administration, Oral; Administration, Topical; Alanine; Animals; Anti-HIV Agents; Genetic Predisposition to Disease; Macaca mulatta; Organophosphonates; Prodrugs; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Virulence

2006
Effects of monotherapy with (R)-9-(2-phosphonylmethoxypropyl)adenine (PMPA) on the evolution of a primary Simian immunodeficiency virus (SIV) isolate.
    Virology, 2006, Oct-10, Volume: 354, Issue:1

    Topics: Adenine; Amino Acid Sequence; Animals; Antiviral Agents; Drug Resistance, Viral; Evolution, Molecular; Genome, Viral; Genotype; Glycosylation; Heteroduplex Analysis; Humans; Macaca mulatta; Molecular Sequence Data; Organophosphonates; Sequence Homology; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Viral Load; Virus Replication

2006
Chemoprophylaxis of HIV infection: moving forward with caution.
    The Journal of infectious diseases, 2006, Oct-01, Volume: 194, Issue:7

    Topics: Adenine; Animals; Antiviral Agents; Chemoprevention; Disease Models, Animal; HIV Infections; HIV-1; Humans; Macaca mulatta; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2006
Chemoprophylaxis with tenofovir disoproxil fumarate provided partial protection against infection with simian human immunodeficiency virus in macaques given multiple virus challenges.
    The Journal of infectious diseases, 2006, Oct-01, Volume: 194, Issue:7

    Topics: Adenine; Animals; Anti-HIV Agents; Chemoprevention; Disease Models, Animal; Drug Resistance, Viral; HIV Infections; HIV Reverse Transcriptase; HIV-1; Humans; Macaca mulatta; Male; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2006
Administration of fludarabine-loaded autologous red blood cells in simian immunodeficiency virus-infected sooty mangabeys depletes pSTAT-1-expressing macrophages and delays the rebound of viremia after suspension of antiretroviral therapy.
    Journal of virology, 2006, Volume: 80, Issue:21

    Topics: Adenine; Animals; Antiretroviral Therapy, Highly Active; Antiviral Agents; Cercocebus atys; Drug Carriers; Erythrocytes; Female; Humans; Macrophages; Male; Myeloablative Agonists; Organophosphonates; Simian Acquired Immunodeficiency Syndrome; STAT1 Transcription Factor; T-Lymphocyte Subsets; Tenofovir; Vidarabine; Viremia; Virus Replication

2006
Tenofovir treatment augments anti-viral immunity against drug-resistant SIV challenge in chronically infected rhesus macaques.
    Retrovirology, 2006, Dec-21, Volume: 3

    Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; CD8-Positive T-Lymphocytes; Chronic Disease; Drug Resistance, Viral; Macaca mulatta; Organophosphonates; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Virus Replication

2006
Therapeutic immunization with Modified Vaccinia Virus Ankara (MVA) vaccines in SIV-infected rhesus monkeys undergoing antiretroviral therapy.
    Journal of medical primatology, 2007, Volume: 36, Issue:1

    Topics: Adenine; Animals; Anti-Retroviral Agents; Antibodies, Viral; Fusion Proteins, gag-pol; Genetic Vectors; Macaca mulatta; Organophosphonates; SAIDS Vaccines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Vaccines, DNA; Vaccinia virus

2007
Sequential emergence and clinical implications of viral mutants with K70E and K65R mutation in reverse transcriptase during prolonged tenofovir monotherapy in rhesus macaques with chronic RT-SHIV infection.
    Retrovirology, 2007, Apr-06, Volume: 4

    Topics: Adenine; Amino Acid Substitution; Animals; Anti-HIV Agents; CD8-Positive T-Lymphocytes; Disease Models, Animal; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Lymphocyte Depletion; Macaca; Mutation, Missense; Organophosphonates; RNA, Viral; Selection, Genetic; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Viremia

2007
Simian immunodeficiency virus infection induces severe loss of intestinal central memory T cells which impairs CD4+ T-cell restoration during antiretroviral therapy.
    Journal of medical primatology, 2007, Volume: 36, Issue:4-5

    Topics: Adenine; Animals; Anti-Retroviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; DNA, Viral; Emtricitabine; Flow Cytometry; Immunologic Memory; Lymphoid Tissue; Macaca mulatta; Organophosphonates; Polymerase Chain Reaction; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets; Tenofovir; Viral Load; Virus Replication; Zalcitabine

2007
Direct stringency comparison of two macaque models (single-high vs. repeat-low) for mucosal HIV transmission using an identical anti-HIV chemoprophylaxis intervention.
    Journal of medical primatology, 2007, Volume: 36, Issue:4-5

    Topics: Adenine; Administration, Rectal; Animals; Anti-HIV Agents; Antibodies, Viral; Chemoprevention; Disease Models, Animal; Macaca mulatta; Male; Organophosphonates; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2007
Prevention of rectal SHIV transmission in macaques by daily or intermittent prophylaxis with emtricitabine and tenofovir.
    PLoS medicine, 2008, Volume: 5, Issue:2

    Topics: Adenine; Animals; Deoxycytidine; Drug Administration Schedule; Emtricitabine; Macaca; Macaca mulatta; Organophosphonates; Rectum; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2008
Short communication: no evidence of occult SHIV infection as demonstrated by CD8+ cell depletion after chemoprophylaxis-induced protection from mucosal infection in rhesus macaques.
    AIDS research and human retroviruses, 2008, Volume: 24, Issue:4

    Topics: Adenine; Animals; Anti-HIV Agents; Antibodies; Antibody Specificity; Antiviral Agents; CD8-Positive T-Lymphocytes; Chemoprevention; Deoxycytidine; Drug Administration Schedule; Drug Evaluation, Preclinical; Emtricitabine; HIV-1; Injections, Intravenous; Injections, Subcutaneous; Lymphocyte Count; Macaca mulatta; Organophosphonates; Reassortant Viruses; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load; Viremia

2008
Drug prevents SIV infection.
    Lancet (London, England), 1995, Dec-02, Volume: 346, Issue:8988

    Topics: Adenine; Animals; Antiviral Agents; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir

1995
AIDS research. New drug shows promise in monkeys.
    Science (New York, N.Y.), 1995, Nov-17, Volume: 270, Issue:5239

    Topics: Adenine; Animals; Antiviral Agents; HIV; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

1995
Prevention of SIV infection in macaques by (R)-9-(2-phosphonylmethoxypropyl)adenine.
    Science (New York, N.Y.), 1995, Nov-17, Volume: 270, Issue:5239

    Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Base Sequence; Cells, Cultured; HIV Infections; Humans; Injections, Subcutaneous; Leukocytes, Mononuclear; Lymph Nodes; Macaca fascicularis; Molecular Sequence Data; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

1995
9-[2-(Phosphonomethoxy)propyl]adenine therapy of established simian immunodeficiency virus infection in infant rhesus macaques.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:11

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Drug Resistance; Immunoglobulin G; Macaca mulatta; Microbial Sensitivity Tests; Organophosphonates; Organophosphorus Compounds; Phenotype; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir

1996
Effectiveness of postinoculation (R)-9-(2-phosphonylmethoxypropyl) adenine treatment for prevention of persistent simian immunodeficiency virus SIVmne infection depends critically on timing of initiation and duration of treatment.
    Journal of virology, 1998, Volume: 72, Issue:5

    Topics: Adenine; Animals; Antiviral Agents; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Drug Administration Schedule; Drug Evaluation; Female; Humans; Macaca fascicularis; Male; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Tumor Cells, Cultured; Virus Latency

1998
Administration of 9-[2-(phosphonomethoxy)propyl]adenine (PMPA) for prevention of perinatal simian immunodeficiency virus infection in rhesus macaques.
    AIDS research and human retroviruses, 1998, Jun-10, Volume: 14, Issue:9

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Cesarean Section; Chimera; Drug Administration Schedule; Female; HIV; HIV Infections; Humans; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Pregnancy; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome

1998
Two doses of PMPA protect newborn macaques against oral simian immunodeficiency virus infection.
    AIDS (London, England), 1998, Jun-18, Volume: 12, Issue:9

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Antibodies, Viral; Dose-Response Relationship, Drug; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia

1998
Early short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine treatment favorably alters the subsequent disease course in simian immunodeficiency virus-infected newborn Rhesus macaques.
    Journal of virology, 1999, Volume: 73, Issue:4

    Topics: Adenine; Animals; Animals, Newborn; Anti-HIV Agents; Humans; Injections, Subcutaneous; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors

1999
Administration of 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) to gravid and infant rhesus macaques (Macaca mulatta): safety and efficacy studies.
    Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association, 1999, Apr-01, Volume: 20, Issue:4

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Biological Transport; Body Weight; Female; Immunophenotyping; Macaca mulatta; Maternal-Fetal Exchange; Organophosphonates; Organophosphorus Compounds; Placenta; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Viral Load

1999
9-[2-(Phosphonomethoxy)propyl]adenine (PMPA) therapy prolongs survival of infant macaques inoculated with simian immunodeficiency virus with reduced susceptibility to PMPA.
    Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:4

    Topics: Adenine; Animals; Animals, Newborn; Antiviral Agents; Macaca; Mutation; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Survival Analysis; Tenofovir

1999
Activated memory CD4(+) T helper cells repopulate the intestine early following antiretroviral therapy of simian immunodeficiency virus-infected rhesus macaques but exhibit a decreased potential to produce interleukin-2.
    Journal of virology, 1999, Volume: 73, Issue:8

    Topics: Adenine; Animals; Antiviral Agents; CD11 Antigens; CD4-Positive T-Lymphocytes; Cell Division; Immunologic Memory; Immunophenotyping; Integrin beta1; Interleukin-2; Intestinal Mucosa; Intestine, Small; Longitudinal Studies; Lymphocyte Activation; Lymphocyte Depletion; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load

1999
Antiretroviral therapy during primary immunodeficiency virus infection can induce persistent suppression of virus load and protection from heterologous challenge in rhesus macaques.
    Journal of virology, 2000, Volume: 74, Issue:4

    Topics: Adenine; Animals; Anti-HIV Agents; Cells, Cultured; HIV Envelope Protein gp120; HIV Reverse Transcriptase; HIV-1; Humans; Lymphocyte Subsets; Macaca mulatta; Membrane Glycoproteins; Organophosphonates; Organophosphorus Compounds; Recombination, Genetic; Reverse Transcriptase Inhibitors; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Envelope Proteins; Viral Load

2000
Prophylactic and therapeutic benefits of short-term 9-[2-(R)-(phosphonomethoxy)propyl]adenine (PMPA) administration to newborn macaques following oral inoculation with simian immunodeficiency virus with reduced susceptibility to PMPA.
    Journal of virology, 2000, Volume: 74, Issue:4

    Topics: Adenine; Administration, Oral; Animals; Animals, Newborn; Antiviral Agents; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Research Design; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2000
Containment of simian immunodeficiency virus infection: cellular immune responses and protection from rechallenge following transient postinoculation antiretroviral treatment.
    Journal of virology, 2000, Volume: 74, Issue:6

    Topics: Adenine; Animals; Antiviral Agents; Female; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viral Load

2000
Effect of PMPA and PMEA on the kinetics of viral load in simian immunodeficiency virus-infected macaques.
    AIDS research and human retroviruses, 2000, May-20, Volume: 16, Issue:8

    Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Antiviral Agents; Lymph Nodes; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Treatment Outcome; Viral Load

2000
Early HIV infection in vivo: branching-process model for studying timing of immune responses and drug therapy.
    Mathematical biosciences, 2000, Volume: 165, Issue:2

    Topics: Adenine; Animals; Anti-HIV Agents; Computer Simulation; Disease Progression; HIV; HIV Infections; Humans; Macaca; Macrophages; Models, Immunological; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Soman; Stochastic Processes; Tenofovir; Time Factors; Viral Load

2000
Lasting effects of transient postinoculation tenofovir [9-R-(2-Phosphonomethoxypropyl)adenine] treatment on SHIV(KU2) infection of rhesus macaques.
    Virology, 2000, Nov-25, Volume: 277, Issue:2

    Topics: Adenine; Animals; Anti-HIV Agents; CD4 Lymphocyte Count; Cerebrospinal Fluid; Disease Models, Animal; Kinetics; Lymph Nodes; Macaca mulatta; Male; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Time Factors; Viral Load

2000
Post-exposure chemoprophylaxis (PECP) against SIV infection of macaques as a model for protection from HIV infection.
    Journal of medical primatology, 2000, Volume: 29, Issue:3-4

    Topics: Adenine; Animals; Disease Models, Animal; DNA, Viral; HIV Infections; Humans; Infectious Disease Transmission, Vertical; Macaca fascicularis; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2000
Control of SIV rebound through structured treatment interruptions during early infection.
    Science (New York, N.Y.), 2000, Nov-24, Volume: 290, Issue:5496

    Topics: Adenine; Animals; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; CD8-Positive T-Lymphocytes; Didanosine; Drug Administration Schedule; Hydroxyurea; Lymphocyte Activation; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Random Allocation; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viral Load; Viremia; Virus Replication

2000
Development of virus-specific immune responses in SHIV(KU)-infected macaques treated with PMPA.
    Virology, 2001, Jan-05, Volume: 279, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; Disease Models, Animal; HIV Antibodies; HIV Infections; HIV-1; Humans; Macaca mulatta; Neutralization Tests; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes, Cytotoxic; T-Lymphocytes, Helper-Inducer; Tenofovir; Virus Replication

2001
Enhanced cellular immune response and reduced CD8(+) lymphocyte apoptosis in acutely SIV-infected Rhesus macaques after short-term antiretroviral treatment.
    Virology, 2001, Jan-05, Volume: 279, Issue:1

    Topics: Adenine; Animals; Anti-HIV Agents; Apoptosis; CD8-Positive T-Lymphocytes; Disease Models, Animal; Humans; Immunologic Memory; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes, Helper-Inducer; Tenofovir; Viral Load

2001
Two low doses of tenofovir protect newborn macaques against oral simian immunodeficiency virus infection.
    The Journal of infectious diseases, 2001, Aug-15, Volume: 184, Issue:4

    Topics: Adenine; Animals; Anti-HIV Agents; Antibodies, Viral; DNA, Viral; Humans; Lymphocyte Activation; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Proviruses; Reverse Transcriptase Inhibitors; RNA, Viral; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir

2001
Antiretroviral agents restore Mycobacterium-specific T-cell immune responses and facilitate controlling a fatal tuberculosis-like disease in Macaques coinfected with simian immunodeficiency virus and Mycobacterium bovis BCG.
    Journal of virology, 2001, Volume: 75, Issue:18

    Topics: Adenine; Animals; Antiviral Agents; Cells, Cultured; HIV Protease Inhibitors; Indinavir; Macaca mulatta; Macaca nemestrina; Mycobacterium bovis; Nelfinavir; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocytes; Tenofovir; Tuberculosis

2001
Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment.
    Journal of virology, 2001, Volume: 75, Issue:21

    Topics: Adenine; Animals; Anti-HIV Agents; CD8-Positive T-Lymphocytes; Female; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; Simian Acquired Immunodeficiency Syndrome; Tenofovir; Virus Replication

2001
Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status.
    Blood, 2002, Jan-15, Volume: 99, Issue:2

    Topics: Adenine; Animals; Antibodies, Viral; Antiviral Agents; Blood Transfusion, Autologous; CD4-Positive T-Lymphocytes; Combined Modality Therapy; Disease Progression; DNA, Viral; Immunotherapy, Adoptive; Leukocytes, Mononuclear; Macaca mulatta; Neutralization Tests; Organophosphonates; Organophosphorus Compounds; Proviruses; Reverse Transcriptase Inhibitors; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; T-Lymphocyte Subsets; T-Lymphocytes, Cytotoxic; Tenofovir; Viral Load

2002
Vaccines. Monkey puzzles.
    Science (New York, N.Y.), 2002, Jun-28, Volume: 296, Issue:5577

    Topics: Acquired Immunodeficiency Syndrome; Adenine; AIDS Vaccines; Animals; Anti-HIV Agents; Clinical Trials as Topic; Haplorhini; HIV; Humans; Killer Cells, Natural; Macaca mulatta; Organophosphonates; Organophosphorus Compounds; SAIDS Vaccines; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Tenofovir; Viremia

2002