temsirolimus and Pancreatic-Neoplasms

temsirolimus has been researched along with Pancreatic-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for temsirolimus and Pancreatic-Neoplasms

Article	Year
Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas. Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17 Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4 μM). Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pancreatic Neoplasms; Porifera; Sesterterpenes; Structure-Activity Relationship	2014
Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp. Bioorganic & medicinal chemistry letters, 2013, Apr-15, Volume: 23, Issue:8 Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM. Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Haplorhini; Humans; K562 Cells; Kidney Neoplasms; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms; Porifera; Sesterterpenes; Spectrophotometry, Infrared	2013

Article

Year

Phorbaketals L-N, cytotoxic sesterterpenoids isolated from the marine sponge of the genus Phorbas.

Bioorganic & medicinal chemistry letters, 2014, Sep-01, Volume: 24, Issue:17

Three new sesterterpenoids, phorbaketals L-N (1-3), were isolated from a marine sponge of the genus Phorbas and their complete structures were elucidated via analysis of HRFABMS and NMR spectroscopic data. Phorbaketal N (3) showed potent cytotoxicity against human pancreas cancer cells (IC50=11.4 μM).

Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Molecular Structure; Pancreatic Neoplasms; Porifera; Sesterterpenes; Structure-Activity Relationship

2014

Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.

Bioorganic & medicinal chemistry letters, 2013, Apr-15, Volume: 23, Issue:8

Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.

Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Drug Screening Assays, Antitumor; Haplorhini; Humans; K562 Cells; Kidney Neoplasms; Mass Spectrometry; Nuclear Magnetic Resonance, Biomolecular; Pancreatic Neoplasms; Porifera; Sesterterpenes; Spectrophotometry, Infrared

2013