tempo and Lung-Neoplasms
tempo has been researched along with Lung-Neoplasms* in 1 studies
Other Studies
1 other study(ies) available for tempo and Lung-Neoplasms
| Article | Year |
|---|---|
Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells.
Exposure to high levels of ozone (O(3)) damages respiratory tract epithelial cells. This research evaluated the ability of TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl), a stable nitroxide free radical, to decrease O(3)-mediated injury to a respiratory tract-derived cell line (A549 cells) by monitoring in this cell system the interleukine-8 (IL-8) production. TEMPO reduced O(3)-induced IL-8 production in A549 cells, as evidenced by PCR analysis, Western blot and ELISA assays. This behaviour is explainable on the basis of the reactivity between TEMPO with O(3) and/or O(3)-derived free radicals in biological systems. The study provides evidence that TEMPO reacts with O(3) and/or its cytotoxic products and may provide protections against O(3)-induced biotoxicities. Topics: Cell Line, Tumor; Cell Survival; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Gene Expression; Humans; Interleukin-8; Lung Neoplasms; Oxidants, Photochemical; Ozone; Respiratory Mucosa; RNA, Messenger | 2009 |