tempo and Lung-Neoplasms

tempo has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for tempo and Lung-Neoplasms

Article	Year
Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells. Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:3 Exposure to high levels of ozone (O(3)) damages respiratory tract epithelial cells. This research evaluated the ability of TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl), a stable nitroxide free radical, to decrease O(3)-mediated injury to a respiratory tract-derived cell line (A549 cells) by monitoring in this cell system the interleukine-8 (IL-8) production. TEMPO reduced O(3)-induced IL-8 production in A549 cells, as evidenced by PCR analysis, Western blot and ELISA assays. This behaviour is explainable on the basis of the reactivity between TEMPO with O(3) and/or O(3)-derived free radicals in biological systems. The study provides evidence that TEMPO reacts with O(3) and/or its cytotoxic products and may provide protections against O(3)-induced biotoxicities. Topics: Cell Line, Tumor; Cell Survival; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Gene Expression; Humans; Interleukin-8; Lung Neoplasms; Oxidants, Photochemical; Ozone; Respiratory Mucosa; RNA, Messenger	2009

Article

Year

Nitroxide radical TEMPO reduces ozone-induced chemokine IL-8 production in lung epithelial cells.

Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:3

Exposure to high levels of ozone (O(3)) damages respiratory tract epithelial cells. This research evaluated the ability of TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl), a stable nitroxide free radical, to decrease O(3)-mediated injury to a respiratory tract-derived cell line (A549 cells) by monitoring in this cell system the interleukine-8 (IL-8) production. TEMPO reduced O(3)-induced IL-8 production in A549 cells, as evidenced by PCR analysis, Western blot and ELISA assays. This behaviour is explainable on the basis of the reactivity between TEMPO with O(3) and/or O(3)-derived free radicals in biological systems. The study provides evidence that TEMPO reacts with O(3) and/or its cytotoxic products and may provide protections against O(3)-induced biotoxicities.

Topics: Cell Line, Tumor; Cell Survival; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Gene Expression; Humans; Interleukin-8; Lung Neoplasms; Oxidants, Photochemical; Ozone; Respiratory Mucosa; RNA, Messenger

2009