tempo has been researched along with Dry-Eye-Syndromes* in 1 studies
1 other study(ies) available for tempo and Dry-Eye-Syndromes
Article | Year |
---|---|
TEMPO-Oxidized Sacchachitin Nanofibers (TOSCNFs) Combined with Platelet-Rich Plasma (PRP) for Management of Dry Eye Syndrome.
In this study, the combination of TEMPO-oxidized sacchachitin nanofibers (TOSCNFs) with chitosan-activated platelet-rich plasma (cPRP) was evaluated for remedying dry eye syndrome (DES).. TOSCNFs, designated T050SC, were generated. T050SC combined with chitosan-activated (. Results showed that the optimal eye formulation contained PRP activated by 350 μg/mL of the low-molecular-weight chitosan group (L3) combined with 300 μg/mL TO50SC (L3+T050SC). In the WST-1 cell-proliferation assay, L3 and L3+TO50SC significantly increased Statens SIRC cell proliferation after 24 hrs of incubation. In the SIRC cell migration assay, the L3+TO50SC group showed a wound-healing efficiency of 89% after 24-hr treatment. After 5 days of treatment, Schirmer's test results did not simulate the dry eye animal model. Typical cornea appearance and eye fluorescein staining results showed that the L3 group had the best effect on improving cornea haze and epithelial damage.. This study has determined that TOSCNFs effectively promoted the healing effect on severe cases of corneal damage, and also might enhance the clinical application and medical potential of PRP in ophthalmology. Topics: Animals; Cell Survival; Chitin; Cornea; Cyclic N-Oxides; Disease Models, Animal; Dry Eye Syndromes; Epithelial Cells; Fibroblasts; Glucans; Nanofibers; Oxidation-Reduction; Platelet-Rich Plasma; Rabbits; Regeneration | 2020 |