tempo and Cardiovascular-Diseases

tempo has been researched along with Cardiovascular-Diseases* in 1 studies

Other Studies

1 other study(ies) available for tempo and Cardiovascular-Diseases

Article	Year
Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane. Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5 Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischemia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress at the cell membrane. Topics: Animals; Brain Ischemia; Cardiovascular Diseases; Cell Line; Cell Membrane; Cyclic N-Oxides; Drug Design; Endotoxins; Macrophages; Mice; Oxidative Stress; Spin Labels; Structure-Activity Relationship	2007

Article

Year

Novel membrane-localizing TEMPO derivatives for measurement of cellular oxidative stress at the cell membrane.

Bioorganic & medicinal chemistry letters, 2007, Mar-01, Volume: 17, Issue:5

Oxidative stress affecting lipid membranes is considered to be closely related to cardiovascular disease and brain ischemia. In this study, we designed and synthesized membrane-localizing TEMPO derivatives and demonstrated that one of these synthesized probes, compound 1, localized and detected oxidative stress in the cell membrane in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress at the cell membrane.

Topics: Animals; Brain Ischemia; Cardiovascular Diseases; Cell Line; Cell Membrane; Cyclic N-Oxides; Drug Design; Endotoxins; Macrophages; Mice; Oxidative Stress; Spin Labels; Structure-Activity Relationship

2007