temozolomide has been researched along with Spinal Cord Neoplasms in 27 studies
Spinal Cord Neoplasms: Benign and malignant neoplasms which occur within the substance of the spinal cord (intramedullary neoplasms) or in the space between the dura and spinal cord (intradural extramedullary neoplasms). The majority of intramedullary spinal tumors are primary CNS neoplasms including ASTROCYTOMA; EPENDYMOMA; and LIPOMA. Intramedullary neoplasms are often associated with SYRINGOMYELIA. The most frequent histologic types of intradural-extramedullary tumors are MENINGIOMA and NEUROFIBROMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients age 18 or older with histologically proven and progressive ependymoma or anaplastic ependymoma were eligible and received dose-dense TMZ and daily lapatinib." | 9.41 | A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. ( Aldape, K; Armstrong, TS; Gerstner, ER; Gilbert, MR; Lieberman, F; Mendoza, T; Mikkelsen, T; Omuro, A; Robins, HI; Vera, E; Wen, PY; Wu, J; Yuan, Y, 2021) |
| "Based on our findings in two paediatric patients, temozolomide may be a useful agent in the management of progressive recurrent low grade spinal cord astrocytomas." | 9.12 | Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients. ( Abboud, MR; Al Kutoubi, AO; Alaraj, AM; Chamoun, RB; Haddad, GF, 2006) |
| "Since virtually no trials have evaluated the effectiveness of temozolomide (TMZ) in the treatment of spinal cord (SC) glioblastoma multiforme (GBM), we conducted a systematic review to evaluate its efficacy." | 8.91 | Primary spinal cord glioblastoma multiforme treated with temozolomide. ( Bregy, A; Hanft, S; Hernández-Durán, S; Komotar, RJ; Manzano, GR; Shah, AH, 2015) |
| "We retrospectively analyzed the data of 5 adult patients treated with temozolomide between 2008 and 2015 for a grade II intramedullary astrocytoma with progression after surgery." | 7.85 | [Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience]. ( Chaskis, E; De Witte, O; Devriendt, D; Goldman, S; Lefranc, F; Luce, S; Minichini, V; Sadeghi, N, 2017) |
| "We report a case of prolonged survival in a patient with cervical intramedullary glioblastoma multiforme (GBM) treated with total resection, radiotherapy, and temozolomide." | 7.76 | Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide. ( Huang, CY; Kuo, LT; Lien, HC; Liu, KL; Liu, MT; Tseng, HM, 2010) |
| "Myxopapillary ependymomas are intradural tumors which grow from the terminal filum of the spinal cord." | 6.58 | Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. ( Adachi, N; Fujiwara, Y; Izumi, B; Manabe, H; Shima, T, 2018) |
| "Patients age 18 or older with histologically proven and progressive ependymoma or anaplastic ependymoma were eligible and received dose-dense TMZ and daily lapatinib." | 5.41 | A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. ( Aldape, K; Armstrong, TS; Gerstner, ER; Gilbert, MR; Lieberman, F; Mendoza, T; Mikkelsen, T; Omuro, A; Robins, HI; Vera, E; Wen, PY; Wu, J; Yuan, Y, 2021) |
| "Temozolomide was administered to three patients at initial diagnosis and five patients at recurrence after failing prior radiotherapy." | 5.38 | Temozolomide or bevacizumab for spinal cord high-grade gliomas. ( Gavrilovic, IT; Kaley, TJ; Mondesire-Crump, I, 2012) |
| "Histology revealed an anaplastic oligodendroglioma." | 5.37 | Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide. ( Lou, X; Qiao, G; Wang, F, 2011) |
| "Treatment with temozolomide resulted in relief of clinical symptoms and stabilization of tumour growth for 8 months." | 5.34 | Metastatic medulloblastoma in an adult; treatment with temozolomide. ( Bernsen, HJ; Poelen, J; Prick, MJ, 2007) |
| "Based on our findings in two paediatric patients, temozolomide may be a useful agent in the management of progressive recurrent low grade spinal cord astrocytomas." | 5.12 | Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients. ( Abboud, MR; Al Kutoubi, AO; Alaraj, AM; Chamoun, RB; Haddad, GF, 2006) |
| "Since virtually no trials have evaluated the effectiveness of temozolomide (TMZ) in the treatment of spinal cord (SC) glioblastoma multiforme (GBM), we conducted a systematic review to evaluate its efficacy." | 4.91 | Primary spinal cord glioblastoma multiforme treated with temozolomide. ( Bregy, A; Hanft, S; Hernández-Durán, S; Komotar, RJ; Manzano, GR; Shah, AH, 2015) |
| "We retrospectively analyzed the data of 5 adult patients treated with temozolomide between 2008 and 2015 for a grade II intramedullary astrocytoma with progression after surgery." | 3.85 | [Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience]. ( Chaskis, E; De Witte, O; Devriendt, D; Goldman, S; Lefranc, F; Luce, S; Minichini, V; Sadeghi, N, 2017) |
| "We report a case of prolonged survival in a patient with cervical intramedullary glioblastoma multiforme (GBM) treated with total resection, radiotherapy, and temozolomide." | 3.76 | Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide. ( Huang, CY; Kuo, LT; Lien, HC; Liu, KL; Liu, MT; Tseng, HM, 2010) |
| " There was no clear relationship between vorinostat dosage and drug exposure over the dose range studied." | 2.78 | A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study. ( Ahern, C; Ames, MM; Blaney, SM; Fouladi, M; Gilbertson, RJ; Horton, T; Hummel, TR; Ingle, AM; McGovern, RM; Reid, JM; Wagner, L; Weigel, B, 2013) |
| "Myxopapillary ependymomas are intradural tumors which grow from the terminal filum of the spinal cord." | 2.58 | Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. ( Adachi, N; Fujiwara, Y; Izumi, B; Manabe, H; Shima, T, 2018) |
| "Glioblastoma multiforme is one of the most common malignant types of tumor arising from the central nervous system known for its devastating intracranial progress and dismal prognosis." | 1.62 | FDG PET/CT in Recurrent Glioblastoma Multiforme With Leptomeningeal and Diffuse Spinal Cord Metastasis. ( Malik, D, 2021) |
| "Spinal cord oligodendrogliomas are rare tumors, with a reported incidence varying between 0." | 1.43 | Spinal Anaplastic Oligodendroglioma With Oligodendrogliomatosis: Molecular Markers and Management: Case Report. ( Cachia, D; Cykowski, MD; Jalali, A; Langford, LA; Li, J; Penas-Prado, M; Shah, K; Strickland, BA; Weinberg, JS, 2016) |
| "Temozolomide was administered to three patients at initial diagnosis and five patients at recurrence after failing prior radiotherapy." | 1.38 | Temozolomide or bevacizumab for spinal cord high-grade gliomas. ( Gavrilovic, IT; Kaley, TJ; Mondesire-Crump, I, 2012) |
| "Histological examination revealed anaplastic astrocytoma." | 1.38 | Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma. ( Hoshimaru, M; Kawanabe, Y; Kihara, S; Koizumi, T; Sasaki, N; Sawada, M; Ueda, S; Yukawa, H, 2012) |
| "Histology revealed an anaplastic oligodendroglioma." | 1.37 | Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide. ( Lou, X; Qiao, G; Wang, F, 2011) |
| "Intramedullary gangliogliomas are indolent tumors of the spine with rare cases of malignant transformation." | 1.34 | Malignant transformation of conus medullaris ganglioglioma: case report. ( Amini, A; Chin, SS; Schmidt, MH, 2007) |
| "Temozolomide was administered at a dose of 200 mg/m(2) daily for 5 days, in a 4-week cycle." | 1.34 | Temozolomide in pediatric low-grade glioma. ( Ashley, DM; Coleman, LT; Downie, PA; Heath, JA; Khaw, SL, 2007) |
| "Treatment with temozolomide resulted in relief of clinical symptoms and stabilization of tumour growth for 8 months." | 1.34 | Metastatic medulloblastoma in an adult; treatment with temozolomide. ( Bernsen, HJ; Poelen, J; Prick, MJ, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 16 (59.26) | 24.3611 |
| 2020's | 3 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, K | 1 |
| Man, W | 1 |
| Jing, L | 1 |
| Sun, Z | 1 |
| Liang, P | 1 |
| Wang, J | 1 |
| Wang, G | 1 |
| Gilbert, MR | 1 |
| Yuan, Y | 1 |
| Wu, J | 2 |
| Mendoza, T | 1 |
| Vera, E | 1 |
| Omuro, A | 1 |
| Lieberman, F | 1 |
| Robins, HI | 1 |
| Gerstner, ER | 1 |
| Wen, PY | 1 |
| Mikkelsen, T | 1 |
| Aldape, K | 1 |
| Armstrong, TS | 1 |
| Malik, D | 1 |
| Cheng, X | 1 |
| Lou, S | 1 |
| Huang, S | 1 |
| Chen, H | 1 |
| Liu, J | 1 |
| Takai, K | 1 |
| Tanaka, S | 1 |
| Sota, T | 1 |
| Mukasa, A | 1 |
| Komori, T | 1 |
| Taniguchi, M | 1 |
| Chaskis, E | 1 |
| Minichini, V | 1 |
| Luce, S | 1 |
| Devriendt, D | 1 |
| Goldman, S | 1 |
| De Witte, O | 1 |
| Sadeghi, N | 1 |
| Lefranc, F | 1 |
| van der Vlist, A | 1 |
| Snijders, TJ | 1 |
| Stades, AME | 1 |
| Spliet, WGM | 1 |
| De Vos, FYFL | 1 |
| Fujiwara, Y | 1 |
| Manabe, H | 1 |
| Izumi, B | 1 |
| Shima, T | 1 |
| Adachi, N | 1 |
| Grah, JJ | 1 |
| Katalinic, D | 1 |
| Stern-Padovan, R | 1 |
| Paladino, J | 1 |
| Santek, F | 1 |
| Juretic, A | 1 |
| Zarkovic, K | 1 |
| Plestina, S | 1 |
| Supe, M | 1 |
| Hummel, TR | 1 |
| Wagner, L | 1 |
| Ahern, C | 1 |
| Fouladi, M | 1 |
| Reid, JM | 1 |
| McGovern, RM | 1 |
| Ames, MM | 1 |
| Gilbertson, RJ | 1 |
| Horton, T | 1 |
| Ingle, AM | 1 |
| Weigel, B | 1 |
| Blaney, SM | 1 |
| Gwak, SJ | 1 |
| An, SS | 1 |
| Yang, MS | 1 |
| Joe, E | 1 |
| Kim, DH | 1 |
| Yoon, DH | 1 |
| Kim, KN | 1 |
| Ha, Y | 1 |
| Lau, PK | 1 |
| Lee, G | 1 |
| Bynevelt, M | 1 |
| Nowak, AK | 1 |
| Strickland, BA | 1 |
| Cachia, D | 1 |
| Jalali, A | 1 |
| Cykowski, MD | 1 |
| Penas-Prado, M | 1 |
| Langford, LA | 1 |
| Li, J | 1 |
| Shah, K | 1 |
| Weinberg, JS | 1 |
| Hernández-Durán, S | 1 |
| Bregy, A | 1 |
| Shah, AH | 1 |
| Hanft, S | 1 |
| Komotar, RJ | 1 |
| Manzano, GR | 1 |
| Chamberlain, MC | 1 |
| Kim, WH | 2 |
| Yoon, SH | 1 |
| Kim, CY | 1 |
| Kim, KJ | 1 |
| Lee, MM | 1 |
| Choe, G | 1 |
| Kim, IA | 1 |
| Kim, JH | 1 |
| Kim, YJ | 1 |
| Kim, HJ | 1 |
| Tseng, HM | 1 |
| Kuo, LT | 1 |
| Lien, HC | 1 |
| Liu, KL | 1 |
| Liu, MT | 1 |
| Huang, CY | 1 |
| Wang, F | 1 |
| Qiao, G | 1 |
| Lou, X | 1 |
| Kaley, TJ | 1 |
| Mondesire-Crump, I | 1 |
| Gavrilovic, IT | 1 |
| Kawanabe, Y | 1 |
| Sawada, M | 1 |
| Yukawa, H | 1 |
| Ueda, S | 1 |
| Sasaki, N | 1 |
| Koizumi, T | 1 |
| Kihara, S | 1 |
| Hoshimaru, M | 1 |
| Salmaggi, A | 1 |
| Silvani, A | 1 |
| Eoli, M | 1 |
| Lamperti, E | 1 |
| Boiardi, A | 1 |
| Chamoun, RB | 1 |
| Alaraj, AM | 1 |
| Al Kutoubi, AO | 1 |
| Abboud, MR | 1 |
| Haddad, GF | 1 |
| Amini, A | 1 |
| Chin, SS | 1 |
| Schmidt, MH | 1 |
| Rovin, RA | 1 |
| Winn, R | 1 |
| Khaw, SL | 1 |
| Coleman, LT | 1 |
| Downie, PA | 1 |
| Heath, JA | 1 |
| Ashley, DM | 1 |
| Poelen, J | 1 |
| Bernsen, HJ | 1 |
| Prick, MJ | 1 |
| Groves, MD | 1 |
| Katz, RL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors[NCT01076530] | Phase 1 | 27 participants (Actual) | Interventional | 2010-02-28 | Completed | ||
| Genomic Landscape of Intramedullary Astrocytoma[NCT04211974] | 50 participants (Anticipated) | Observational | 2019-12-10 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for temozolomide and Spinal Cord Neoplasms
| Article | Year |
|---|---|
Clinical Features and Outcomes of Primary Spinal Cord Glioblastoma: A Single-Center Experience and Literature Review.
Topics: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immu | 2020 |
Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review.
Topics: Adult; Antineoplastic Agents, Alkylating; Cauda Equina; Chemotherapy, Adjuvant; Combined Modality Th | 2018 |
Primary spinal cord glioblastoma multiforme treated with temozolomide.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Glioblastoma; Humans; Kaplan-Me | 2015 |
Temozolomide for malignant primary spinal cord glioma: an experience of six cases and a literature review.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarbazine; Female; Gliom | 2011 |
4 trials available for temozolomide and Spinal Cord Neoplasms
| Article | Year |
|---|---|
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Topics: Adolescent; Adult; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Ependymoma; Humans; Lapatini | 2021 |
A pediatric phase 1 trial of vorinostat and temozolomide in relapsed or refractory primary brain or spinal cord tumors: a Children's Oncology Group phase 1 consortium study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Child; Child, Pr | 2013 |
Temozolomide and cisplatin in the treatment of leptomeningeal metastatic involvement from melanoma: a case report.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dacarbazine; Humans; Magnetic Reso | 2002 |
Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Child; Dacarbazine; Disease Progression; | 2006 |
19 other studies available for temozolomide and Spinal Cord Neoplasms
| Article | Year |
|---|---|
FDG PET/CT in Recurrent Glioblastoma Multiforme With Leptomeningeal and Diffuse Spinal Cord Metastasis.
Topics: Adult; Brain Neoplasms; Female; Fluorodeoxyglucose F18; Glioblastoma; Humans; Meningeal Neoplasms; P | 2021 |
Primary Spinal Cord Glioblastoma Multiforme: A Retrospective Study of Patients at a Single Institution.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarbazine; Female | 2017 |
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Chemoradiotherapy, Adjuvant; Dacarbazine; Fat | 2017 |
[Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience].
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Chemotherapy, Adjuvant; Dacarbazine; Di | 2017 |
Successful treatment of leptomeningeally metastasised pituitary carcinoma with temozolomide.
Topics: Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Humans; Male; Meningeal Neoplasms; Pituitary N | 2017 |
Leptomeningeal and intramedullary metastases of glioblastoma multiforme in a patient reoperated during adjuvant radiochemotherapy.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy, Adjuvant; Combined Modality T | 2013 |
Effect of combined bevacizumab and temozolomide treatment on intramedullary spinal cord tumor.
Topics: Animals; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizu | 2014 |
Marked functional improvement after combined chemoradiotherapy for cervical spine glioblastoma causing quadriparesis in an adolescent.
Topics: Adolescent; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkyl | 2014 |
Spinal Anaplastic Oligodendroglioma With Oligodendrogliomatosis: Molecular Markers and Management: Case Report.
Topics: Aged; Antineoplastic Agents, Alkylating; Chemoradiotherapy; Dacarbazine; Humans; Magnetic Resonance | 2016 |
Temozolomide for recurrent low-grade spinal cord gliomas in adults.
Topics: Adult; Antineoplastic Agents, Alkylating; Dacarbazine; Disease-Free Survival; Drug Administration Sc | 2008 |
Prolonged survival of a patient with cervical intramedullary glioblastoma multiforme treated with total resection, radiation therapy, and temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Biopsy; Cervical Vertebrae; Chemotherapy, Adjuvant; Combin | 2010 |
Spinal cord anaplastic oligodendroglioma with 1p deletion: report of a relapsing case treated with temozolomide.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Chromosome Deletion; Chromosomes, Human, Pair 1; Daca | 2011 |
Temozolomide or bevacizumab for spinal cord high-grade gliomas.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating | 2012 |
Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma.
Topics: Antineoplastic Agents; Astrocytoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine; | 2012 |
Malignant transformation of conus medullaris ganglioglioma: case report.
Topics: Adult; Antineoplastic Agents; Combined Modality Therapy; Dacarbazine; Ganglioglioma; Glioblastoma; H | 2007 |
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Combined Modality Therapy; Dacarbazine; Femal | 2007 |
Temozolomide in pediatric low-grade glioma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplati | 2007 |
Metastatic medulloblastoma in an adult; treatment with temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Cerebellar Neoplasms; Dacarbazine; Female; Humans; Magneti | 2007 |
Low grade astrocytoma presenting with visual loss.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Daca | 2008 |