temozolomide has been researched along with Sarcoma in 16 studies
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based on the promising results of a Phase I study with a combination of gemcitabine and DTIC performed in advanced soft tissue sarcoma (ASTS) patients, and due to the limited efficacy of second or third line therapies in those patients, we designed a Phase II study to determine the activity of this new regimen." | 9.12 | Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas. ( Buesa, JM; Del Muro, JG; Escudero, P; Esteban, E; Fra, J; Gión, M; Goitia, A; López-Pousa, A; Losa, R; Maurel, J; Nadal, R; Sierra, M; Uña, E, 2007) |
| "The objective of this study was to evaluate the activity and toxicity of temozolomide given as an extended schedule in patients with advanced sarcoma." | 9.11 | A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas. ( Bover, I; Buesa, JM; Casado, A; Cruz, J; Garcia del Muro, X; Lopez-Pousa, A; Martin, J; Martinez-Trufero, J; Maurel, J; Poveda, A, 2005) |
| "Temozolomide at the dose schedule employed in the current study was tolerated well and had modest activity against previously treated unresectable or metastatic leiomyosarcoma of both uterine and nonuterine origin." | 9.10 | A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. ( Bagiella, E; Hesdorffer, M; Keohan, ML; Orrico, R; Talbot, SM; Taub, RN; Troxel, AB, 2003) |
| "The authors conducted a two-arm Phase II study of temozolomide to determine its efficacy and toxicity in patients with soft tissue sarcomas (STSs) who had received, had refused, or were not eligible for standard chemotherapy with doxorubicin and ifosfamide (Arm 1) and in patients with gastrointestinal stromal tumors (GISTs; Arm 2)." | 9.10 | A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas. ( Beach, J; Benjamin, RS; Burgess, MA; Chen, LL; Papadopolous, N; Patel, SR; Trent, JC, 2003) |
| "Temozolomide, an oral imidazotetrazine derivative, was given to 31 patients with advanced soft tissue sarcoma." | 9.09 | Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. ( Buesa, JM; Hermans, C; Judson, I; Lee, SM; Leyvraz, S; Lorigan, PC; Nielsen, OS; Rodenhuis, S; van Glabbeke, M; Verweij, J; Woll, PJ, 1999) |
| "To evaluate the anticancer effects of cabozantinib, temozolomide, and their combination in uterine sarcoma cell lines and mouse xenograft models." | 8.12 | Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma. ( Cho, YJ; Choi, JJ; Choi, JY; Hwang, JR; Lee, JW; Noh, JJ; Ryu, JY, 2022) |
| "We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide." | 7.85 | Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide. ( Boichuk, SV; Khusnutdinov, RR, 2017) |
| "We performed a retrospective case series to evaluate the feasibility of adding temozolomide to pazopanib in advanced sarcoma patients following single-agent pazopanib failure." | 7.85 | Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series. ( Bupathi, M; Chen, JL; Hays, JL, 2017) |
| "To evaluate the toxicity and efficacy of preoperative intensity-modulated radiotherapy (IMRT) combined with temozolomide to improve local tumor control in soft-tissue sarcoma (STS)." | 7.75 | Preoperative intensity-modulated radiotherapy combined with temozolomide for locally advanced soft-tissue sarcoma. ( Dinter, DJ; Hohenberger, P; Jakob, J; Ströbel, P; Wenz, F, 2009) |
| "A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting." | 5.36 | Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report. ( Arai, A; Itoh, T; Kanomata, N; Kawamura, A; Kohmura, E; Nishihara, M; Sasayama, T; Tanaka, H, 2010) |
| "Based on the promising results of a Phase I study with a combination of gemcitabine and DTIC performed in advanced soft tissue sarcoma (ASTS) patients, and due to the limited efficacy of second or third line therapies in those patients, we designed a Phase II study to determine the activity of this new regimen." | 5.12 | Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas. ( Buesa, JM; Del Muro, JG; Escudero, P; Esteban, E; Fra, J; Gión, M; Goitia, A; López-Pousa, A; Losa, R; Maurel, J; Nadal, R; Sierra, M; Uña, E, 2007) |
| "The objective of this study was to evaluate the activity and toxicity of temozolomide given as an extended schedule in patients with advanced sarcoma." | 5.11 | A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas. ( Bover, I; Buesa, JM; Casado, A; Cruz, J; Garcia del Muro, X; Lopez-Pousa, A; Martin, J; Martinez-Trufero, J; Maurel, J; Poveda, A, 2005) |
| "Temozolomide at the dose schedule employed in the current study was tolerated well and had modest activity against previously treated unresectable or metastatic leiomyosarcoma of both uterine and nonuterine origin." | 5.10 | A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. ( Bagiella, E; Hesdorffer, M; Keohan, ML; Orrico, R; Talbot, SM; Taub, RN; Troxel, AB, 2003) |
| "The authors conducted a two-arm Phase II study of temozolomide to determine its efficacy and toxicity in patients with soft tissue sarcomas (STSs) who had received, had refused, or were not eligible for standard chemotherapy with doxorubicin and ifosfamide (Arm 1) and in patients with gastrointestinal stromal tumors (GISTs; Arm 2)." | 5.10 | A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas. ( Beach, J; Benjamin, RS; Burgess, MA; Chen, LL; Papadopolous, N; Patel, SR; Trent, JC, 2003) |
| "Temozolomide, an oral imidazotetrazine derivative, was given to 31 patients with advanced soft tissue sarcoma." | 5.09 | Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group. ( Buesa, JM; Hermans, C; Judson, I; Lee, SM; Leyvraz, S; Lorigan, PC; Nielsen, OS; Rodenhuis, S; van Glabbeke, M; Verweij, J; Woll, PJ, 1999) |
| "Recent progress in the therapy of sarcomas is highlighted by the rapid development and approval of the molecularly targeted therapy imatinib mesylate (STI571, Gleevec) for advanced gastrointestinal stromal tumours." | 4.81 | Developing therapeutic pharmaceuticals for the treatment of soft-tissue sarcomas. ( Patel, SR, 2002) |
| "To evaluate the anticancer effects of cabozantinib, temozolomide, and their combination in uterine sarcoma cell lines and mouse xenograft models." | 4.12 | Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma. ( Cho, YJ; Choi, JJ; Choi, JY; Hwang, JR; Lee, JW; Noh, JJ; Ryu, JY, 2022) |
| "We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide." | 3.85 | Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide. ( Boichuk, SV; Khusnutdinov, RR, 2017) |
| "We performed a retrospective case series to evaluate the feasibility of adding temozolomide to pazopanib in advanced sarcoma patients following single-agent pazopanib failure." | 3.85 | Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series. ( Bupathi, M; Chen, JL; Hays, JL, 2017) |
| "To evaluate the toxicity and efficacy of preoperative intensity-modulated radiotherapy (IMRT) combined with temozolomide to improve local tumor control in soft-tissue sarcoma (STS)." | 3.75 | Preoperative intensity-modulated radiotherapy combined with temozolomide for locally advanced soft-tissue sarcoma. ( Dinter, DJ; Hohenberger, P; Jakob, J; Ströbel, P; Wenz, F, 2009) |
| "A 33-year-old woman presented with rare brain metastases from undifferentiated high-grade sarcoma manifesting as headache and vomiting." | 1.36 | Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report. ( Arai, A; Itoh, T; Kanomata, N; Kawamura, A; Kohmura, E; Nishihara, M; Sasayama, T; Tanaka, H, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 5 (31.25) | 2.80 |
| Authors | Studies |
|---|---|
| B, H | 1 |
| Canute Fernandes, S | 1 |
| Rastogi, S | 1 |
| Defachelles, AS | 1 |
| Bogart, E | 1 |
| Casanova, M | 1 |
| Merks, JHM | 1 |
| Bisogno, G | 1 |
| Calareso, G | 1 |
| Melcon, SG | 1 |
| Gatz, SA | 1 |
| Le Deley, MC | 1 |
| McHugh, K | 1 |
| Probst, A | 1 |
| Rocourt, N | 1 |
| van Rijn, RR | 1 |
| Minard-Colin, V | 1 |
| Chisholm, JC | 1 |
| Noh, JJ | 1 |
| Cho, YJ | 1 |
| Ryu, JY | 1 |
| Choi, JJ | 1 |
| Hwang, JR | 1 |
| Choi, JY | 1 |
| Lee, JW | 1 |
| Khokhar, MA | 1 |
| Akhtar, M | 1 |
| Shah Gillani, SFUH | 1 |
| Abdulsalaam, R | 1 |
| Qamar, S | 1 |
| Nguépy Keubo, FR | 1 |
| Mboua, PC | 1 |
| Djifack Tadongfack, T | 1 |
| Fokouong Tchoffo, E | 1 |
| Tasson Tatang, C | 1 |
| Ide Zeuna, J | 1 |
| Noupoue, EM | 1 |
| Tsoplifack, CB | 1 |
| Folefack, GO | 1 |
| Kettani, M | 1 |
| Bandelier, P | 1 |
| Huo, J | 1 |
| Li, H | 4 |
| Yu, D | 1 |
| Arulsamy, N | 1 |
| AlAbbad, S | 1 |
| Sardot, T | 1 |
| Lekashvili, O | 1 |
| Decato, D | 1 |
| Lelj, F | 1 |
| Alexander Ross, JB | 1 |
| Rosenberg, E | 1 |
| Nazir, H | 1 |
| Muthuswamy, N | 1 |
| Louis, C | 1 |
| Jose, S | 1 |
| Prakash, J | 1 |
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| Hahn, S | 3 |
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| Ling, J | 2 |
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| Kim, Y | 3 |
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| Olorunfemi, G | 1 |
| Rabiu, KA | 1 |
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| Xu, C | 2 |
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| Dong, X | 1 |
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| Anastassiadou, M | 1 |
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| Brancato, A | 1 |
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| Jarrah, S | 1 |
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| Li, J | 7 |
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| Hou, J | 1 |
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| Lv, B | 1 |
| Gao, C | 1 |
| Pang, D | 1 |
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| Ahmad, NH | 1 |
| Wang, L | 1 |
| Zhu, J | 2 |
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| Zhuang, T | 1 |
| Tu, J | 1 |
| Zhao, Z | 1 |
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| Yao, H | 1 |
| Wang, X | 5 |
| Lee, DF | 1 |
| Shen, J | 3 |
| Wen, L | 1 |
| Huang, G | 2 |
| Xie, X | 1 |
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| Hu, W | 1 |
| Zhang, Y | 4 |
| Wu, X | 1 |
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| Stefan-van Staden, RI | 1 |
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| Szodorai, R | 1 |
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| Hermans, C | 1 |
| van Glabbeke, M | 1 |
| Verweij, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study Investigating Neoadjuvant Temozolomide-based Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas[NCT00881595] | Phase 2 | 0 participants (Actual) | Interventional | 2009-02-28 | Withdrawn (stopped due to No patients accrued since study opened) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for temozolomide and Sarcoma
| Article | Year |
|---|---|
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Developing therapeutic pharmaceuticals for the treatment of soft-tissue sarcomas.
Topics: Antineoplastic Agents; Benzamides; Camptothecin; Dacarbazine; Deoxycytidine; Dioxoles; Gemcitabine; | 2002 |
Developing therapeutic pharmaceuticals for the treatment of soft-tissue sarcomas.
Topics: Antineoplastic Agents; Benzamides; Camptothecin; Dacarbazine; Deoxycytidine; Dioxoles; Gemcitabine; | 2002 |
7 trials available for temozolomide and Sarcoma
| Article | Year |
|---|---|
Radiotherapy alone with concurrent chemoradiotherapy plus temozolamide in locally advanced soft tissue sarcoma at Mayo Hospital Lahore: A randomized controlled trial.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chemoradio | 2020 |
Radiotherapy alone with concurrent chemoradiotherapy plus temozolamide in locally advanced soft tissue sarcoma at Mayo Hospital Lahore: A randomized controlled trial.
Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Chemoradio | 2020 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
Psychological distress among health care professionals of the three COVID-19 most affected Regions in Cameroon: Prevalence and associated factors.
Topics: 3' Untranslated Regions; 5'-Nucleotidase; A549 Cells; Accidental Falls; Acetylcholinesterase; Acryli | 2021 |
A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Leiomyosarcoma; Male; M | 2003 |
A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Leiomyosarcoma; Male; M | 2003 |
A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Gastroint | 2003 |
A two-arm phase II study of temozolomide in patients with advanced gastrointestinal stromal tumors and other soft tissue sarcomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Gastroint | 2003 |
A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administrati | 2005 |
A phase II trial of temozolomide as a 6-week, continuous, oral schedule in patients with advanced soft tissue sarcoma: a study by the Spanish Group for Research on Sarcomas.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administrati | 2005 |
Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas.
Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; | 2007 |
Phase II study with the combination of gemcitabine and DTIC in patients with advanced soft tissue sarcomas.
Topics: Adult; Aged; Alanine Transaminase; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; | 2007 |
Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Male; Middle Aged; Sarc | 1999 |
Temozolomide in adult patients with advanced soft tissue sarcoma: a phase II study of the EORTC Soft Tissue and Bone Sarcoma Group.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Male; Middle Aged; Sarc | 1999 |
8 other studies available for temozolomide and Sarcoma
| Article | Year |
|---|---|
VIT-0910: Need for Cautious Optimism?
Topics: Adult; Child; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Temozolomide; Therapies, Investigationa | 2022 |
VIT-0910: Need for Cautious Optimism?
Topics: Adult; Child; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Temozolomide; Therapies, Investigationa | 2022 |
Reply to H. B et al.
Topics: Child; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Temozolomide; Therapies, Investigational; Vinc | 2022 |
Reply to H. B et al.
Topics: Child; Humans; Irinotecan; Rhabdomyosarcoma; Sarcoma; Temozolomide; Therapies, Investigational; Vinc | 2022 |
Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma.
Topics: Anilides; Animals; Apoptosis; Cell Line, Tumor; Female; Humans; Leiomyosarcoma; Mice; Pyridines; Sar | 2022 |
Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma.
Topics: Anilides; Animals; Apoptosis; Cell Line, Tumor; Female; Humans; Leiomyosarcoma; Mice; Pyridines; Sar | 2022 |
Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide.
Topics: Cell Line, Tumor; Cellular Senescence; Dacarbazine; Gene Expression Regulation, Neoplastic; Humans; | 2017 |
Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide.
Topics: Cell Line, Tumor; Cellular Senescence; Dacarbazine; Gene Expression Regulation, Neoplastic; Humans; | 2017 |
Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series.
Topics: Adult; Aged; Antineoplastic Agents; Dacarbazine; Disease Progression; Female; High-Throughput Nucleo | 2017 |
Temozolomide post pazopanib treatment failure in patients with advanced sarcoma: A case series.
Topics: Adult; Aged; Antineoplastic Agents; Dacarbazine; Disease Progression; Female; High-Throughput Nucleo | 2017 |
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Dacarbazine; Diagnosis, Differential; Humans; Male; | 2013 |
Primary undifferentiated spindle-cell sarcoma of sella turcica: successful treatment with adjuvant temozolomide.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Dacarbazine; Diagnosis, Differential; Humans; Male; | 2013 |
Preoperative intensity-modulated radiotherapy combined with temozolomide for locally advanced soft-tissue sarcoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarb | 2009 |
Preoperative intensity-modulated radiotherapy combined with temozolomide for locally advanced soft-tissue sarcoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Combined Modality Therapy; Dacarb | 2009 |
Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; D | 2010 |
Brain metastasis of undifferentiated sarcoma and response to temozolomide treatment. Case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combined Modality Therapy; Dacarbazine; D | 2010 |