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temozolomide and Paraganglioma

temozolomide has been researched along with Paraganglioma in 10 studies

Paraganglioma: A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion, such as the carotid body, or medulla of the adrenal gland (usually called a chromaffinoma or pheochromocytoma). It is more common in women than in men. (Stedman, 25th ed; from Segen, Dictionary of Modern Medicine, 1992)

Research Excerpts

ExcerptRelevanceReference
"Cyclophosphamide-dacarbazine-vincristine regimen is recommended for the treatment of malignant pheochromocytoma and paraganglioma (MPP); however, dacarbazine is the only recognized active drug in neuroendocrine tumours."7.80SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma. ( Al Ghuzlan, A; Amar, L; Baudin, E; Bertherat, J; Borget, I; Caramella, C; Chougnet, C; Déandreis, D; Deschamps, F; Dumont, F; Favier, J; Gimenez-Roqueplo, AP; Hadoux, J; Leboulleux, S; Letouzé, E; Libé, R; Loriot, C; Schlumberger, M; Scoazec, JY; Young, J, 2014)
"We report on the efficacy and safety of short-term administration of temozolomide, an inhibitor of nucleoside incorporation, in a 60-year-old woman with widespread hepatic metastases from a malignant paraganglioma."7.75Clinical utility of temozolomide in the treatment of malignant paraganglioma: a preliminary report. ( Bravo, EL; Gill, I; Kalmadi, SR, 2009)
"Temozolomide (TMZ) has been shown to determine radiological and biochemical response in malignant PCC/PGLs."5.48Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma. ( Bertorelle, R; Ferrara, AM; Iacobone, M; Lombardi, G; Meringolo, D; Nardin, M; Opocher, G; Pambuku, A; Schiavi, F; Zagonel, V; Zovato, S, 2018)
"Ten percent of paragangliomas are malignant and one-third occurs in a genetic background."5.38A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine. ( Borson-Chazot, F; Giraud, S; Joly, MO; Lombard-Bohas, C; Nozières, C; Riou, JP; Scoazec, JY; Simon, C; Walter, T, 2012)
"The therapeutic options for metastatic pheochromocytomas/paragangliomas (mPPGLs) include chemotherapy with cyclophosphamide/vincristine/dacarbazine (CVD), temozolomide monotherapy, radionuclide therapies, and tyrosine kinase inhibitors such as sunitinib."4.31Responses to systemic therapy in metastatic pheochromocytoma/paraganglioma: a retrospective multicenter cohort study. ( Auernhammer, CJ; Bechmann, N; Beuschlein, F; Bornstein, SR; Dischinger, U; Fischer, A; Fliedner, SMJ; Grossman, AB; Hantel, C; Kloos, S; Kroiss, M; Maurer, J; Mohr, H; Nölting, S; Pacak, K; Pamporaki, C; Pellegata, NS; Reincke, M; Remde, H; Reul, A; Robledo, M; Timmers, HJLM; Wang, K, 2023)
"Cyclophosphamide-dacarbazine-vincristine regimen is recommended for the treatment of malignant pheochromocytoma and paraganglioma (MPP); however, dacarbazine is the only recognized active drug in neuroendocrine tumours."3.80SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma. ( Al Ghuzlan, A; Amar, L; Baudin, E; Bertherat, J; Borget, I; Caramella, C; Chougnet, C; Déandreis, D; Deschamps, F; Dumont, F; Favier, J; Gimenez-Roqueplo, AP; Hadoux, J; Leboulleux, S; Letouzé, E; Libé, R; Loriot, C; Schlumberger, M; Scoazec, JY; Young, J, 2014)
"We report on the efficacy and safety of short-term administration of temozolomide, an inhibitor of nucleoside incorporation, in a 60-year-old woman with widespread hepatic metastases from a malignant paraganglioma."3.75Clinical utility of temozolomide in the treatment of malignant paraganglioma: a preliminary report. ( Bravo, EL; Gill, I; Kalmadi, SR, 2009)
"Temozolomide (TMZ) has been shown to determine radiological and biochemical response in malignant PCC/PGLs."1.48Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma. ( Bertorelle, R; Ferrara, AM; Iacobone, M; Lombardi, G; Meringolo, D; Nardin, M; Opocher, G; Pambuku, A; Schiavi, F; Zagonel, V; Zovato, S, 2018)
"Ten percent of paragangliomas are malignant and one-third occurs in a genetic background."1.38A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine. ( Borson-Chazot, F; Giraud, S; Joly, MO; Lombard-Bohas, C; Nozières, C; Riou, JP; Scoazec, JY; Simon, C; Walter, T, 2012)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's4 (40.00)24.3611
2020's5 (50.00)2.80

Authors

AuthorsStudies
Perez, K1
Jacene, H1
Hornick, JL1
Ma, C1
Vaz, N1
Brais, LK1
Alexander, H1
Baddoo, W1
Astone, K1
Esplin, ED1
Garcia, J1
Halperin, DM1
Kulke, MH1
Chan, JA1
Wang, K2
Crona, J1
Beuschlein, F2
Grossman, AB2
Pacak, K2
Nölting, S2
Singh, C1
Bindra, RS1
Glazer, PM1
Vasquez, JC1
Pashankar, F1
Urquhart, C3
Fleming, B3
Harper, I3
Aloj, L3
Armstrong, R3
Hook, L3
Long, AM3
Jackson, C3
Gallagher, FA3
McLean, MA3
Tarpey, P3
Kosmoliaptsis, V3
Nicholson, J3
Hendriks, AEJ3
Casey, RT3
Fischer, A1
Kloos, S1
Remde, H1
Dischinger, U1
Pamporaki, C1
Timmers, HJLM1
Robledo, M1
Fliedner, SMJ1
Maurer, J1
Reul, A1
Bechmann, N1
Hantel, C1
Mohr, H1
Pellegata, NS1
Bornstein, SR1
Kroiss, M1
Auernhammer, CJ1
Reincke, M1
Ferrara, AM1
Lombardi, G1
Pambuku, A1
Meringolo, D1
Bertorelle, R1
Nardin, M1
Schiavi, F1
Iacobone, M1
Opocher, G1
Zagonel, V1
Zovato, S1
Hadoux, J1
Favier, J1
Scoazec, JY2
Leboulleux, S1
Al Ghuzlan, A1
Caramella, C1
Déandreis, D1
Borget, I1
Loriot, C1
Chougnet, C1
Letouzé, E1
Young, J1
Amar, L1
Bertherat, J1
Libé, R1
Dumont, F1
Deschamps, F1
Schlumberger, M1
Gimenez-Roqueplo, AP1
Baudin, E1
Sait, S1
Kobos, R1
LaQuaglia, MP1
Pandit-Taskar, N1
Modak, S1
Bravo, EL1
Kalmadi, SR1
Gill, I1
Nozières, C1
Walter, T1
Joly, MO1
Giraud, S1
Borson-Chazot, F1
Simon, C1
Riou, JP1
Lombard-Bohas, C1

Reviews

2 reviews available for temozolomide and Paraganglioma

ArticleYear
Targeted Therapies in Pheochromocytoma and Paraganglioma.
    The Journal of clinical endocrinology and metabolism, 2022, 11-23, Volume: 107, Issue:11

    Topics: Adrenal Gland Neoplasms; Humans; Paraganglioma; Pheochromocytoma; Randomized Controlled Trials as To

2022
The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adrenal Gland Neoplasms; Adult; Brain Neoplasms; Child; Female; Humans; Neoplasms, Second Primary; P

2022
The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adrenal Gland Neoplasms; Adult; Brain Neoplasms; Child; Female; Humans; Neoplasms, Second Primary; P

2022
The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adrenal Gland Neoplasms; Adult; Brain Neoplasms; Child; Female; Humans; Neoplasms, Second Primary; P

2022
The use of temozolomide in paediatric metastatic phaeochromocytoma/paraganglioma: A case report and literature review.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Adrenal Gland Neoplasms; Adult; Brain Neoplasms; Child; Female; Humans; Neoplasms, Second Primary; P

2022

Other Studies

8 other studies available for temozolomide and Paraganglioma

ArticleYear
SDHx mutations and temozolomide in malignant pheochromocytoma and paraganglioma.
    Endocrine-related cancer, 2022, 09-01, Volume: 29, Issue:9

    Topics: Adrenal Gland Neoplasms; Humans; Mutation; Paraganglioma; Pheochromocytoma; Retrospective Studies; S

2022
Metastatic and multiply relapsed SDH-deficient GIST and paraganglioma displays clinical response to combined poly ADP-ribose polymerase inhibition and temozolomide.
    Pediatric blood & cancer, 2023, Volume: 70, Issue:3

    Topics: Adenosine Diphosphate Ribose; DNA Repair; Gastrointestinal Stromal Tumors; Humans; Paraganglioma; Po

2023
Responses to systemic therapy in metastatic pheochromocytoma/paraganglioma: a retrospective multicenter cohort study.
    European journal of endocrinology, 2023, Nov-08, Volume: 189, Issue:5

    Topics: Adrenal Gland Neoplasms; Brain Neoplasms; Cardiovascular Diseases; Cohort Studies; Humans; Iodine Ra

2023
Temozolomide treatment of a malignant pheochromocytoma and an unresectable MAX-related paraganglioma.
    Anti-cancer drugs, 2018, Volume: 29, Issue:1

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Alkylating; Basic Helix-Loop-Helix Leucine Zipper Tr

2018
SDHB mutations are associated with response to temozolomide in patients with metastatic pheochromocytoma or paraganglioma.
    International journal of cancer, 2014, Dec-01, Volume: 135, Issue:11

    Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Biomarke

2014
Acute myeloid leukemia therapy elicits durable complete response in chemoradio-resistant metastatic paraganglioma.
    Pediatric blood & cancer, 2017, Volume: 64, Issue:5

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Chemoradiotherapy; Cytarabine; Dacarbazi

2017
Clinical utility of temozolomide in the treatment of malignant paraganglioma: a preliminary report.
    Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009, Volume: 41, Issue:9

    Topics: Adrenal Gland Neoplasms; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Middle Aged

2009
A SDHB malignant paraganglioma with dramatic response to temozolomide-capecitabine.
    European journal of endocrinology, 2012, Volume: 166, Issue:6

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Capecitabine; Dacarbazine;

2012