temozolomide has been researched along with Neurofibromatosis 1 in 3 studies
Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Low-grade gliomas (e." | 1.39 | Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature. ( Brokinkel, B; Ewelt, C; Hargus, G; Heindel, W; Holling, M; Schober, O; Stummer, W; Wölfer, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brokinkel, B | 1 |
| Schober, O | 1 |
| Ewelt, C | 1 |
| Heindel, W | 1 |
| Hargus, G | 1 |
| Stummer, W | 1 |
| Holling, M | 1 |
| Wölfer, J | 1 |
| Xu, DS | 1 |
| Rosenfeld, A | 1 |
| Ponce, FA | 1 |
| Nakaji, P | 1 |
| Bhardwaj, RD | 1 |
| Hsieh, MS | 1 |
| Ho, JT | 1 |
| Lin, LW | 1 |
| Tu, PH | 1 |
| Perry, A | 1 |
| Huang, AP | 1 |
3 other studies available for temozolomide and Neurofibromatosis 1
| Article | Year |
|---|---|
Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Combined Modality Therapy; Dac | 2013 |
Cerebral peduncle tumor ablated by novel 3-mm laser tip.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Camptothecin; Cerebral Ped | 2015 |
Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature.
Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Chemoradiotherapy; Dacarbazine | 2012 |