temozolomide has been researched along with Neuroectodermal Tumors, Primitive in 14 studies
Neuroectodermal Tumors, Primitive: A group of malignant tumors of the nervous system that feature primitive cells with elements of neuronal and/or glial differentiation. Use of this term is limited by some authors to central nervous system tumors and others include neoplasms of similar origin which arise extracranially (i.e., NEUROECTODERMAL TUMORS, PRIMITIVE, PERIPHERAL). This term is also occasionally used as a synonym for MEDULLOBLASTOMA. In general, these tumors arise in the first decade of life and tend to be highly malignant. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2059)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study was to assess the objective response rate (ORR) of children and young adults with recurrent medulloblastoma/primitive neuroectodermal tumor (MB/PNET) treated with temozolomide (TMZ)." | 9.19 | Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: an Italian multi-institutional phase II trial. ( Abate, ME; Barone, G; Cefalo, G; Colosimo, C; Garrè, ML; Madon, E; Mascarin, M; Massimino, M; Perilongo, G; Potepan, P; Riccardi, R; Ridola, V; Ruggiero, A; Spreafico, F, 2014) |
| "There is no standard treatment for glioblastoma with elements of PNET (GBM-PNET)." | 5.43 | Craniospinal irradiation with concomitant and adjuvant temozolomide--a feasibility assessment of toxicity in patients with glioblastoma with a PNET component. ( Fersht, N; Mandeville, HC; Mycroft, J; O'Leary, B; Saran, F; Solda, F; Vaidya, S; Zacharoulis, S, 2016) |
| "The aim of this study was to assess the objective response rate (ORR) of children and young adults with recurrent medulloblastoma/primitive neuroectodermal tumor (MB/PNET) treated with temozolomide (TMZ)." | 5.19 | Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: an Italian multi-institutional phase II trial. ( Abate, ME; Barone, G; Cefalo, G; Colosimo, C; Garrè, ML; Madon, E; Mascarin, M; Massimino, M; Perilongo, G; Potepan, P; Riccardi, R; Ridola, V; Ruggiero, A; Spreafico, F, 2014) |
| "Although overall objective responses were limited, further exploration of temozolomide may be warranted in children with medulloblastoma and other PNETs, or in patients with low-grade astrocytoma, perhaps in a setting of less pretreatment than the patients in the current study, or in the context of multiagent therapy." | 5.12 | Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. ( Bernstein, M; Fort, D; Friedman, H; Harris, MB; Kadota, R; Krailo, M; Kretschmar, CS; Mazewski, C; Nicholson, HS; Reaman, GH; Sato, J; Tedeschi-Blok, N, 2007) |
| " The observed adverse effects of temozolomide included nausea, vomiting, headache, constipation, mild marrow suppression, and decreased activity; none of them was severe enough to discontinue the treatment." | 3.75 | Efficacy of temozolomide for recurrent embryonal brain tumors in children. ( Chang, KP; Hsu, TR; Wang, CH; Wong, TT, 2009) |
| "Angiocentric gliomas have recently been reclassified as a separate central nervous system tumor." | 2.48 | Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature. ( Aguilar, HN; Hung, RW; Kotylak, T; Mehta, V, 2012) |
| "Central nervous system primitive neuroectodermal tumors (CNS PNETs) mostly occur in children and present as cerebellar medulloblastoma." | 1.48 | A primitive neuroectodermal tumor in an adult: Case report of a unique location and MRI characteristics. ( Chen, Z; Dong, Y; He, X; Tong, D, 2018) |
| "Peripheral primitive neuroectodermal tumors of the lumbar paraspinal region with diffuse and strong glial differentiation have never been reported before." | 1.48 | Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide. ( Botros, J; El Ahmadieh, TY; Gluf, W; Kabangu, JL; Pan, E; Raisanen, JM, 2018) |
| "There is no standard treatment for glioblastoma with elements of PNET (GBM-PNET)." | 1.43 | Craniospinal irradiation with concomitant and adjuvant temozolomide--a feasibility assessment of toxicity in patients with glioblastoma with a PNET component. ( Fersht, N; Mandeville, HC; Mycroft, J; O'Leary, B; Saran, F; Solda, F; Vaidya, S; Zacharoulis, S, 2016) |
| "In seven MB/PNET cell lines investigated, MGMT promoter methylation was detected only in D425 human MB cells as assayed by the qualitative methylation-specific PCR and the more quantitative pyrosequencing assay." | 1.37 | Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma. ( Arnold, L; Faoro, D; Gerber, NU; Grotzer, MA; Haybaeck, J; Hegi, M; Hürlimann, ML; Mittelbronn, M; Rutkowski, S; Sciuscio, D; Shalaby, T; von Bueren, AO, 2011) |
| "Primitive neuroectodermal tumors (PNET) originating within the spinal cord are extraordinarily rare." | 1.37 | Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse. ( Anson, J; Gollard, RP; Khoury, J; Mason, J; Rosen, L, 2011) |
| "We studied 53 MG-PNETs in patients from 12 to 80 years of age (median = 54 years)." | 1.35 | Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases. ( Burger, PC; Cochran, EJ; Gujrati, M; Holland, EC; Huse, JT; Jost, SC; Miller, CR; Perry, A; Qian, J; Raghavan, R; Rosenblum, MK; Scheithauer, BW; Zambrano, SC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| He, X | 1 |
| Chen, Z | 1 |
| Dong, Y | 1 |
| Tong, D | 1 |
| El Ahmadieh, TY | 1 |
| Raisanen, JM | 1 |
| Botros, J | 1 |
| Kabangu, JL | 1 |
| Pan, E | 2 |
| Gluf, W | 1 |
| Khwaja, R | 1 |
| Mantilla, E | 1 |
| Fink, K | 1 |
| Cefalo, G | 1 |
| Massimino, M | 1 |
| Ruggiero, A | 1 |
| Barone, G | 1 |
| Ridola, V | 1 |
| Spreafico, F | 1 |
| Potepan, P | 1 |
| Abate, ME | 1 |
| Mascarin, M | 1 |
| Garrè, ML | 1 |
| Perilongo, G | 1 |
| Madon, E | 1 |
| Colosimo, C | 1 |
| Riccardi, R | 1 |
| O'Leary, B | 1 |
| Mandeville, HC | 1 |
| Fersht, N | 1 |
| Solda, F | 1 |
| Mycroft, J | 1 |
| Zacharoulis, S | 1 |
| Vaidya, S | 1 |
| Saran, F | 1 |
| Wang, CH | 1 |
| Hsu, TR | 1 |
| Wong, TT | 1 |
| Chang, KP | 1 |
| Oh, J | 1 |
| Bilbao, JM | 1 |
| Tsao, MN | 1 |
| Fazl, M | 1 |
| Guiot, MC | 1 |
| Del Maestro, RF | 1 |
| Perry, JR | 1 |
| Faoro, D | 1 |
| von Bueren, AO | 1 |
| Shalaby, T | 1 |
| Sciuscio, D | 1 |
| Hürlimann, ML | 1 |
| Arnold, L | 1 |
| Gerber, NU | 1 |
| Haybaeck, J | 1 |
| Mittelbronn, M | 1 |
| Rutkowski, S | 1 |
| Hegi, M | 1 |
| Grotzer, MA | 1 |
| Gollard, RP | 1 |
| Rosen, L | 1 |
| Anson, J | 1 |
| Mason, J | 1 |
| Khoury, J | 1 |
| Aguilar, HN | 1 |
| Hung, RW | 1 |
| Mehta, V | 1 |
| Kotylak, T | 1 |
| Terheggen, F | 1 |
| Troost, D | 1 |
| Majoie, CB | 1 |
| Leenstra, S | 1 |
| Richel, DJ | 1 |
| Nicholson, HS | 1 |
| Kretschmar, CS | 1 |
| Krailo, M | 1 |
| Bernstein, M | 1 |
| Kadota, R | 1 |
| Fort, D | 1 |
| Friedman, H | 1 |
| Harris, MB | 1 |
| Tedeschi-Blok, N | 1 |
| Mazewski, C | 1 |
| Sato, J | 1 |
| Reaman, GH | 1 |
| Perry, A | 1 |
| Miller, CR | 1 |
| Gujrati, M | 1 |
| Scheithauer, BW | 1 |
| Zambrano, SC | 1 |
| Jost, SC | 1 |
| Raghavan, R | 1 |
| Qian, J | 1 |
| Cochran, EJ | 1 |
| Huse, JT | 1 |
| Holland, EC | 1 |
| Burger, PC | 1 |
| Rosenblum, MK | 1 |
| Rao, RD | 1 |
| Robins, HI | 1 |
| Mehta, MP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Temozolomide in the Treatment of Children With High Grade Glioma[NCT00028795] | Phase 2 | 170 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| An International, Randomized, Open-label Phase I/II Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Adult Patients With Recurrent or Refractory Medulloblastomas Presenting an Activation of the Sonic Hedgehog (SHH) Pathway[NCT01601184] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2012-06-30 | Terminated (stopped due to The number of successes is not reached at the end of first stage of the phase II. The study is stopped.) | ||
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862] | Phase 1/Phase 2 | 36 participants (Anticipated) | Interventional | 2013-10-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for temozolomide and Neuroectodermal Tumors, Primitive
| Article | Year |
|---|---|
Imaging characteristics of an unusual, high-grade angiocentric glioma: a case report and review of the literature.
Topics: Adolescent; Brain Neoplasms; Combined Modality Therapy; Cranial Nerve Diseases; Dacarbazine; Diagnos | 2012 |
2 trials available for temozolomide and Neuroectodermal Tumors, Primitive
| Article | Year |
|---|---|
Temozolomide is an active agent in children with recurrent medulloblastoma/primitive neuroectodermal tumor: an Italian multi-institutional phase II trial.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Cerebellar Neoplasms; Child; Child, Preschool; | 2014 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
11 other studies available for temozolomide and Neuroectodermal Tumors, Primitive
| Article | Year |
|---|---|
A primitive neuroectodermal tumor in an adult: Case report of a unique location and MRI characteristics.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cerebral Ventricles; Chemotherapy, Adjuva | 2018 |
Successful Novel Treatment of a Paraspinal Primitive Neuroectodermal Tumor with Predominantly Glial Differentiation: A 3-Year Follow-Up After Surgery, Intensity-Modulated Radiation Therapy and Oral Temozolomide.
Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Brain Neoplasms; Female; Humans; Longitudin | 2018 |
Adult Primary Peripheral PNET/Ewing's Sarcoma of the Cervical and Thoracic Spine.
Topics: Adult; Aged; Humans; Male; Neck; Neuroectodermal Tumors, Primitive; RNA-Binding Protein EWS; Sarcoma | 2019 |
Craniospinal irradiation with concomitant and adjuvant temozolomide--a feasibility assessment of toxicity in patients with glioblastoma with a PNET component.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Chemoradiotherapy; Chemothera | 2016 |
Efficacy of temozolomide for recurrent embryonal brain tumors in children.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; D | 2009 |
Recurrent PNET with MGMT methylation responds to temozolomide.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Humans; Magnetic Resonance I | 2009 |
Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cell Proliferation; C | 2011 |
Intramedullary PNET of the spine: long-term survival after combined modality therapy and subsequent relapse.
Topics: Antineoplastic Combined Chemotherapy Protocols; Busulfan; Cerebellar Neoplasms; Chemotherapy, Adjuva | 2011 |
Local recurrence and distant metastasis of supratentorial primitive neuro-ectodermal tumor in an adult patient successfully treated with intensive induction chemotherapy and maintenance temozolomide.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Neoplasms; Cyclophosphamide; Daca | 2007 |
Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Brain Neoplasms; Comb | 2009 |
Late recurrence of a primitive neuro-ectodermal tumor.
Topics: Adult; Alkaline Phosphatase; Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Cerebellar Neopla | 2001 |