temozolomide has been researched along with Leiomyosarcoma in 9 studies
Leiomyosarcoma: A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Temozolomide at the dose schedule employed in the current study was tolerated well and had modest activity against previously treated unresectable or metastatic leiomyosarcoma of both uterine and nonuterine origin." | 9.10 | A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. ( Bagiella, E; Hesdorffer, M; Keohan, ML; Orrico, R; Talbot, SM; Taub, RN; Troxel, AB, 2003) |
| "After obtaining Institutional Review Board approval, we identified women with recurrent leiomyosarcoma treated with temozolomide at MSKCC from 9/2001 to 9/2004." | 8.82 | Temozolomide in uterine leiomyosarcomas. ( Aghajanian, C; Anderson, S, 2005) |
| "To evaluate the anticancer effects of cabozantinib, temozolomide, and their combination in uterine sarcoma cell lines and mouse xenograft models." | 8.12 | Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma. ( Cho, YJ; Choi, JJ; Choi, JY; Hwang, JR; Lee, JW; Noh, JJ; Ryu, JY, 2022) |
| "We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide." | 7.85 | Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide. ( Boichuk, SV; Khusnutdinov, RR, 2017) |
| "Our objective was to retrospectively review temozolomide in advanced and recurrent uterine leiomyosarcoma and to determine if tumor O-methylguanine DNA methyltransferase (MGMT) expression correlated with clinical response." | 7.76 | Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series. ( Atkins, KA; Ferriss, JS; Jazaeri, AA; Lachance, JA; Modesitt, SC, 2010) |
| "Temozolomide at the dose schedule employed in the current study was tolerated well and had modest activity against previously treated unresectable or metastatic leiomyosarcoma of both uterine and nonuterine origin." | 5.10 | A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma. ( Bagiella, E; Hesdorffer, M; Keohan, ML; Orrico, R; Talbot, SM; Taub, RN; Troxel, AB, 2003) |
| "After obtaining Institutional Review Board approval, we identified women with recurrent leiomyosarcoma treated with temozolomide at MSKCC from 9/2001 to 9/2004." | 4.82 | Temozolomide in uterine leiomyosarcomas. ( Aghajanian, C; Anderson, S, 2005) |
| "Dacarbazine is an important drug in the therapeutic landscape of leiomyosarcoma (LMS)." | 4.31 | The Impact of O6-Methylguanine-DNA Methyltransferase ( ( Badalamenti, G; Barretta, ML; Buonaiuto, M; Cannella, L; Chiariotti, L; Clemente, O; De Chiara, AR; Della Monica, R; Di Marzo, M; Di Mauro, A; Guida, M; Iervolino, D; Marretta, AL; Tafuto, S; Vincenzi, B, 2023) |
| "To evaluate the anticancer effects of cabozantinib, temozolomide, and their combination in uterine sarcoma cell lines and mouse xenograft models." | 4.12 | Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma. ( Cho, YJ; Choi, JJ; Choi, JY; Hwang, JR; Lee, JW; Noh, JJ; Ryu, JY, 2022) |
| "We studied the mechanisms of sensitivity of soft tissue sarcoma cells to alkylating agent temozolomide." | 3.85 | Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide. ( Boichuk, SV; Khusnutdinov, RR, 2017) |
| "Our objective was to retrospectively review temozolomide in advanced and recurrent uterine leiomyosarcoma and to determine if tumor O-methylguanine DNA methyltransferase (MGMT) expression correlated with clinical response." | 3.76 | Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series. ( Atkins, KA; Ferriss, JS; Jazaeri, AA; Lachance, JA; Modesitt, SC, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Noh, JJ | 1 |
| Cho, YJ | 1 |
| Ryu, JY | 1 |
| Choi, JJ | 1 |
| Hwang, JR | 1 |
| Choi, JY | 1 |
| Lee, JW | 1 |
| Cannella, L | 1 |
| Della Monica, R | 1 |
| Marretta, AL | 1 |
| Iervolino, D | 1 |
| Vincenzi, B | 1 |
| De Chiara, AR | 1 |
| Clemente, O | 1 |
| Buonaiuto, M | 1 |
| Barretta, ML | 1 |
| Di Mauro, A | 1 |
| Di Marzo, M | 1 |
| Guida, M | 1 |
| Badalamenti, G | 1 |
| Chiariotti, L | 1 |
| Tafuto, S | 1 |
| Ingham, M | 1 |
| Allred, JB | 1 |
| Chen, L | 1 |
| Das, B | 1 |
| Kochupurakkal, B | 1 |
| Gano, K | 1 |
| George, S | 1 |
| Attia, S | 1 |
| Burgess, MA | 1 |
| Seetharam, M | 1 |
| Boikos, SA | 1 |
| Bui, N | 1 |
| Chen, JL | 1 |
| Close, JL | 1 |
| Cote, GM | 1 |
| Thaker, PH | 1 |
| Ivy, SP | 1 |
| Bose, S | 1 |
| D'Andrea, A | 1 |
| Marino-Enriquez, A | 1 |
| Shapiro, GI | 1 |
| Schwartz, GK | 1 |
| Khusnutdinov, RR | 1 |
| Boichuk, SV | 1 |
| Ferriss, JS | 1 |
| Atkins, KA | 1 |
| Lachance, JA | 1 |
| Modesitt, SC | 1 |
| Jazaeri, AA | 1 |
| Takano, M | 1 |
| Kikuchi, Y | 1 |
| Susumu, N | 1 |
| Kudoh, K | 1 |
| Kita, T | 1 |
| Kouta, H | 1 |
| Goto, T | 1 |
| Furuya, K | 1 |
| Talbot, SM | 1 |
| Keohan, ML | 1 |
| Hesdorffer, M | 1 |
| Orrico, R | 1 |
| Bagiella, E | 1 |
| Troxel, AB | 1 |
| Taub, RN | 1 |
| Anderson, S | 1 |
| Aghajanian, C | 1 |
| Moreno Antón, F | 1 |
| Casado Herraez, A | 1 |
| Puente Vázquez, J | 1 |
| Gómez Díaz, R | 1 |
| Aragoncillo, P | 1 |
| Díaz-Rubio García, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study Investigating Neoadjuvant Temozolomide-based Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas[NCT00881595] | Phase 2 | 0 participants (Actual) | Interventional | 2009-02-28 | Withdrawn (stopped due to No patients accrued since study opened) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for temozolomide and Leiomyosarcoma
| Article | Year |
|---|---|
Temozolomide in uterine leiomyosarcomas.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; H | 2005 |
2 trials available for temozolomide and Leiomyosarcoma
| Article | Year |
|---|---|
Phase II Study of Olaparib and Temozolomide for Advanced Uterine Leiomyosarcoma (NCI Protocol 10250).
Topics: Antineoplastic Combined Chemotherapy Protocols; Clinical Trials, Phase II as Topic; Female; Humans; | 2023 |
A phase II trial of temozolomide in patients with unresectable or metastatic soft tissue sarcoma.
Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Leiomyosarcoma; Male; M | 2003 |
6 other studies available for temozolomide and Leiomyosarcoma
| Article | Year |
|---|---|
Anticancer Activity of the Combination of Cabozantinib and Temozolomide in Uterine Sarcoma.
Topics: Anilides; Animals; Apoptosis; Cell Line, Tumor; Female; Humans; Leiomyosarcoma; Mice; Pyridines; Sar | 2022 |
The Impact of O6-Methylguanine-DNA Methyltransferase (
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; DNA; DNA Methylation; DNA Modificat | 2023 |
Mechanisms of Sensitivity of Soft Tissue Sarcoma Cells to Temozolomide.
Topics: Cell Line, Tumor; Cellular Senescence; Dacarbazine; Gene Expression Regulation, Neoplastic; Humans; | 2017 |
Temozolomide in advanced and recurrent uterine leiomyosarcoma and correlation with o6-methylguanine DNA methyltransferase expression: a case series.
Topics: Adult; Antineoplastic Agents, Alkylating; Biomarkers, Pharmacological; Biomarkers, Tumor; Dacarbazin | 2010 |
Complete remission of recurrent and refractory uterine epithelioid leiomyosarcoma using weekly administration of bevacizumab and temozolomide.
Topics: Adult; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating | 2011 |
Cardiac metastasis from uterine leiomyosarcoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Dacarbazine; Deoxycytidin | 2006 |