Page last updated: 2024-11-04

temozolomide and Hypoxia

temozolomide has been researched along with Hypoxia in 18 studies

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks)."8.12Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats. ( Chen, JC; Hwang, JH, 2022)
"This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of these mutations in gliomas."7.80TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas. ( Chen, C; Han, S; Li, Z; Meng, L; Wu, A; Zhang, X, 2014)
" In contrast, the cytotoxic drug temozolomide, when used in combination with HIF-1alpha knockdown, exhibited a superadditive and likely synergistic therapeutic effect compared with the monotherapy of either treatment alone in the D54MG glioma model."5.33Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. ( Albert, DH; Fesik, SW; Li, L; Lin, X; Shen, Y; Shoemaker, AR, 2006)
"This study aims to investigate the role of hypoxia-induced long non-coding small nucleolar RNA host gene 14 (lncRNA SNHG14) in glioma temozolomide (TMZ) resistance and underlying mechanisms."4.12Mechanisms for hypoxia ( Gong, M; Liao, X; Liao, Y; Liu, Y; Meng, L; Mo, X; Zhao, H, 2022)
"Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks)."4.12Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats. ( Chen, JC; Hwang, JH, 2022)
"This study explored the effects of telomerase reverse transcriptase (TERT) promoter mutations on transcriptional activity of the TERT gene under hypoxic and temozolomide (TMZ) treatment conditions, and investigated the status and prognostic value of these mutations in gliomas."3.80TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas. ( Chen, C; Han, S; Li, Z; Meng, L; Wu, A; Zhang, X, 2014)
" This drug combination significantly impaired the sphere-forming ability of GSCs in vitro and tumor formation in vivo, leading to increase in the overall survival of mice bearing orthotopic inoculation of GSCs."1.39Effective elimination of cancer stem cells by a novel drug combination strategy. ( Chen, G; Colman, H; Feng, L; Huang, P; Keating, MJ; Li, X; Wang, F; Wang, J; Wang, L; Xu, RH; Yuan, S; Zhang, H, 2013)
" In contrast, the cytotoxic drug temozolomide, when used in combination with HIF-1alpha knockdown, exhibited a superadditive and likely synergistic therapeutic effect compared with the monotherapy of either treatment alone in the D54MG glioma model."1.33Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. ( Albert, DH; Fesik, SW; Li, L; Lin, X; Shen, Y; Shoemaker, AR, 2006)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (5.56)29.6817
2010's5 (27.78)24.3611
2020's12 (66.67)2.80

Authors

AuthorsStudies
Torres, JP1
Lin, Z1
Fenton, DS1
Leavitt, LU1
Niu, C1
Lam, PY1
Robes, JM1
Peterson, RT1
Concepcion, GP1
Haygood, MG1
Olivera, BM1
Schmidt, EW1
Zhao, H1
Meng, L2
Liao, X1
Liu, Y1
Mo, X1
Gong, M1
Liao, Y2
Zhang, G1
Tao, X1
Ji, B1
Gong, J1
Su, X1
Xie, Y2
Zhang, J2
Li, M1
Zhang, Q1
Jin, G1
Liu, F1
Wu, P1
Guo, J1
Yang, H1
Yuan, D1
Wang, C1
Wang, Z2
Lu, X1
Liu, M1
Liu, L1
Wang, R1
Yang, K1
Xiao, H1
Li, J2
Tang, X1
Liu, H1
Li, T1
Fu, X1
Wang, J2
Shang, W1
Wang, X2
Zhang, L2
Lickliter, JD1
Ruben, J1
Kichenadasse, G1
Jennens, R1
Gzell, C1
Mason, RP1
Zhou, H1
Becker, J1
Unger, E1
Stea, B1
Liu, J1
Gao, L1
Zhan, N1
Xu, P1
Yang, J1
Yuan, F1
Xu, Y1
Cai, Q1
Geng, R1
Chen, Q1
Yin, J1
Ge, X2
Shi, Z2
Yu, C1
Lu, C1
Wei, Y1
Zeng, A1
Yan, W1
You, Y1
Cheng, HS1
Marvalim, C1
Zhu, P1
Law, CLD1
Low, ZYJ1
Chong, YK1
Ang, BT1
Tang, C1
Tan, NS1
Chen, JC1
Hwang, JH1
Bielecka-Wajdman, AM1
Lesiak, M1
Ludyga, T1
Sieroń, A1
Obuchowicz, E1
Pan, MH1
Wang, L2
Li, W1
Jiang, C1
He, J1
Abouzid, K1
Liu, LZ1
Jiang, BH1
Wei, M1
Ma, R1
Huang, S1
Ding, Y1
Li, Z2
Guo, Q1
Tan, R1
Zhao, L1
Chen, C1
Han, S1
Zhang, X1
Wu, A1
Yuan, S1
Wang, F1
Chen, G1
Zhang, H1
Feng, L1
Colman, H1
Keating, MJ1
Li, X1
Xu, RH1
Huang, P1
Li, L1
Lin, X1
Shoemaker, AR1
Albert, DH1
Fesik, SW1
Shen, Y1

Other Studies

18 other studies available for temozolomide and Hypoxia

ArticleYear
Boholamide A, an APD-Class, Hypoxia-Selective Cyclodepsipeptide.
    Journal of natural products, 2020, 04-24, Volume: 83, Issue:4

    Topics: Antineoplastic Agents; Biological Products; Calcium; Cytotoxins; Depsipeptides; Hypoxia; Molecular S

2020
Mechanisms for hypoxia
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2022, Jul-28, Volume: 47, Issue:7

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Glioma; Humans; Hypoxia;

2022
Hypoxia-Driven M2-Polarized Macrophages Facilitate Cancer Aggressiveness and Temozolomide Resistance in Glioblastoma.
    Oxidative medicine and cellular longevity, 2022, Volume: 2022

    Topics: Brain Neoplasms; Cell Line, Tumor; Endothelial Cells; Glioblastoma; Humans; Hypoxia; Macrophages; Ph

2022
HIF-α activation by the prolyl hydroxylase inhibitor roxadustat suppresses chemoresistant glioblastoma growth by inducing ferroptosis.
    Cell death & disease, 2022, 10-08, Volume: 13, Issue:10

    Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Line, Tumor; Ferr

2022
Exosomes Derived from Hypoxic Glioma Cells Reduce the Sensitivity of Glioma Cells to Temozolomide Through Carrying miR-106a-5p.
    Drug design, development and therapy, 2022, Volume: 16

    Topics: Apoptosis; bcl-2-Associated X Protein; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neopla

2022
A hypoxia-dissociable siRNA nanoplatform for synergistically enhanced chemo-radiotherapy of glioblastoma.
    Biomaterials science, 2022, Nov-22, Volume: 10, Issue:23

    Topics: Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; Chemoradiotherapy; DNA; Drug Resistanc

2022
Mechanism of NURP1 in temozolomide resistance in hypoxia-treated glioma cells via the KDM3A/TFEB axis.
    Oncology research, 2023, Volume: 31, Issue:3

    Topics: Animals; Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Disease Models, Ani

2023
Dodecafluoropentane Emulsion as a Radiosensitizer in Glioblastoma Multiforme.
    Cancer research communications, 2023, Volume: 3, Issue:8

    Topics: Emulsions; Glioblastoma; Humans; Hypoxia; Oxygen; Radiation-Sensitizing Agents; Temozolomide

2023
Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma.
    Journal of experimental & clinical cancer research : CR, 2020, Jul-16, Volume: 39, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoferritins; Apoptosis; Biomarkers, Tumor; Cell Movemen

2020
Extracellular vesicles derived from hypoxic glioma stem-like cells confer temozolomide resistance on glioblastoma by delivering miR-30b-3p.
    Theranostics, 2021, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents, Alkylating; Apoptosis; Biomarkers, Tumor; Brain Neoplasms; Cell Prol

2021
Kinomic profile in patient-derived glioma cells during hypoxia reveals c-MET-PI3K dependency for adaptation.
    Theranostics, 2021, Volume: 11, Issue:11

    Topics: Animals; Antioxidants; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Glioblastoma; Glioma; Humans; H

2021
Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats.
    Nutrition and cancer, 2022, Volume: 74, Issue:3

    Topics: Animals; Apoptosis; Autophagy; Brain Neoplasms; Caffeine; Cell Line, Tumor; Endoplasmic Reticulum St

2022
Reversing glioma malignancy: a new look at the role of antidepressant drugs as adjuvant therapy for glioblastoma multiforme.
    Cancer chemotherapy and pharmacology, 2017, Volume: 79, Issue:6

    Topics: Antidepressive Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Line, Tumor; Cell Su

2017
Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis.
    Cell death & disease, 2018, 11-13, Volume: 9, Issue:11

    Topics: Animals; Antagomirs; Antineoplastic Agents, Alkylating; Apoptosis; bcl-2-Associated X Protein; bcl-A

2018
Oroxylin A increases the sensitivity of temozolomide on glioma cells by hypoxia-inducible factor 1α/hedgehog pathway under hypoxia.
    Journal of cellular physiology, 2019, Volume: 234, Issue:10

    Topics: Animals; Brain Neoplasms; Cell Movement; Cell Proliferation; Flavonoids; Gene Expression Regulation,

2019
TERT promoter mutations lead to high transcriptional activity under hypoxia and temozolomide treatment and predict poor prognosis in gliomas.
    PloS one, 2014, Volume: 9, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; Female; Follow-U

2014
Effective elimination of cancer stem cells by a novel drug combination strategy.
    Stem cells (Dayton, Ohio), 2013, Volume: 31, Issue:1

    Topics: Adenosine Triphosphate; Animals; Brain Neoplasms; Carmustine; Cell Line, Tumor; Cell Survival; Dacar

2013
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Aug-01, Volume: 12, Issue:15

    Topics: Administration, Oral; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Aryl Hydrocarbon Rece

2006