temozolomide has been researched along with Fanconi Anemia in 3 studies
Fanconi Anemia: Congenital disorder affecting all bone marrow elements, resulting in ANEMIA; LEUKOPENIA; and THROMBOPENIA, and associated with cardiac, renal, and limb malformations as well as dermal pigmentary changes. Spontaneous CHROMOSOME BREAKAGE is a feature of this disease along with predisposition to LEUKEMIA. There are at least 7 complementation groups in Fanconi anemia: FANCA, FANCB, FANCC, FANCD1, FANCD2, FANCE, FANCF, FANCG, and FANCL. (from Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227650, August 20, 2004)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nimustine (ACNU) and temozolomide (TMZ) are DNA alkylating agents which are commonly used in chemotherapy for glioblastomas." | 3.77 | FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. ( Hasegawa, M; Helleday, T; Kinashi, Y; Kondo, N; Masunaga, S; Mori, E; Noda, T; Ohnishi, T; Ono, K; Suzuki, M; Takahashi, A; Thompson, LH; Zdzienicka, MZ, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Voter, AF | 1 |
| Manthei, KA | 1 |
| Keck, JL | 1 |
| Patil, AA | 1 |
| Sayal, P | 1 |
| Depondt, ML | 1 |
| Beveridge, RD | 1 |
| Roylance, A | 1 |
| Kriplani, DH | 1 |
| Myers, KN | 1 |
| Cox, A | 1 |
| Jellinek, D | 1 |
| Fernando, M | 1 |
| Carroll, TA | 1 |
| Collis, SJ | 1 |
| Kondo, N | 1 |
| Takahashi, A | 1 |
| Mori, E | 1 |
| Noda, T | 1 |
| Zdzienicka, MZ | 1 |
| Thompson, LH | 1 |
| Helleday, T | 1 |
| Suzuki, M | 1 |
| Kinashi, Y | 1 |
| Masunaga, S | 1 |
| Ono, K | 1 |
| Hasegawa, M | 1 |
| Ohnishi, T | 1 |
3 other studies available for temozolomide and Fanconi Anemia
| Article | Year |
|---|---|
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
Topics: Antineoplastic Agents; DNA Damage; DNA Helicases; DNA Repair; Drug Screening Assays, Antitumor; Fanc | 2016 |
FANCD2 re-expression is associated with glioma grade and chemical inhibition of the Fanconi Anaemia pathway sensitises gliomas to chemotherapeutic agents.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Carmustine; Cell Line, Tumor; Curcumin; Dacarbaz | 2014 |
FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ.
Topics: Animals; BRCA2 Protein; Cell Line; Dacarbazine; DNA Damage; DNA Repair; Down-Regulation; Fanconi Ane | 2011 |