temozolomide has been researched along with Ependymoma in 17 studies
Ependymoma: Glioma derived from EPENDYMOGLIAL CELLS that tend to present as malignant intracranial tumors in children and as benign intraspinal neoplasms in adults. It may arise from any level of the ventricular system or central canal of the spinal cord. Intracranial ependymomas most frequently originate in the FOURTH VENTRICLE and histologically are densely cellular tumors which may contain ependymal tubules and perivascular pseudorosettes. Spinal ependymomas are usually benign papillary or myxopapillary tumors. (From DeVita et al., Principles and Practice of Oncology, 5th ed, p2018; Escourolle et al., Manual of Basic Neuropathology, 2nd ed, pp28-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients age 18 or older with histologically proven and progressive ependymoma or anaplastic ependymoma were eligible and received dose-dense TMZ and daily lapatinib." | 9.41 | A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. ( Aldape, K; Armstrong, TS; Gerstner, ER; Gilbert, MR; Lieberman, F; Mendoza, T; Mikkelsen, T; Omuro, A; Robins, HI; Vera, E; Wen, PY; Wu, J; Yuan, Y, 2021) |
| "Few data are available on temozolomide (TMZ) in ependymomas." | 7.83 | Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study. ( Bosa, C; Cassoni, P; Fiano, V; Franchino, F; Magistrello, M; Pellerino, A; Rudà, R; Soffietti, R; Trevisan, M, 2016) |
| "Ependymoma SC lines were highly sensitive to temozolomide and etoposide in vitro, but only temozolomide impaired tumor-initiation properties." | 7.80 | Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models. ( Arena, V; Binda, E; Lamorte, G; Meco, D; Riccardi, R; Servidei, T, 2014) |
| "Myxopapillary ependymomas are intradural tumors which grow from the terminal filum of the spinal cord." | 6.58 | Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. ( Adachi, N; Fujiwara, Y; Izumi, B; Manabe, H; Shima, T, 2018) |
| "Apatinib is a multitarget tyrosine kinase inhibitor, which has been reported to exhibit broad antitumor profiles." | 5.72 | Apatinib and temozolomide in children with recurrent ependymoma: A case report. ( Li, J; Shen, Z; Shi, L; Zhang, N; Zhao, S, 2022) |
| "Patients age 18 or older with histologically proven and progressive ependymoma or anaplastic ependymoma were eligible and received dose-dense TMZ and daily lapatinib." | 5.41 | A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma. ( Aldape, K; Armstrong, TS; Gerstner, ER; Gilbert, MR; Lieberman, F; Mendoza, T; Mikkelsen, T; Omuro, A; Robins, HI; Vera, E; Wen, PY; Wu, J; Yuan, Y, 2021) |
| "Anaplastic ependymomas are rare tumors in adult patients." | 5.39 | Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma. ( Bellu, L; Della Puppa, A; Gardiman, MP; Lombardi, G; Pambuku, A; Pomerri, F; Rumanò, L; Zagonel, V, 2013) |
| "Intracranial anaplastic ependymomas are a very rare entity within the group of adult CNS neoplasms." | 5.37 | Response to temozolomide in supratentorial multifocal recurrence of malignant ependymoma. ( Freyschlag, CF; Lohr, F; Schmieder, K; Seiz, M; Thomé, C; Tuettenberg, J, 2011) |
| "Although overall objective responses were limited, further exploration of temozolomide may be warranted in children with medulloblastoma and other PNETs, or in patients with low-grade astrocytoma, perhaps in a setting of less pretreatment than the patients in the current study, or in the context of multiagent therapy." | 5.12 | Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. ( Bernstein, M; Fort, D; Friedman, H; Harris, MB; Kadota, R; Krailo, M; Kretschmar, CS; Mazewski, C; Nicholson, HS; Reaman, GH; Sato, J; Tedeschi-Blok, N, 2007) |
| "Using data from the German multi-center E-HIT-REZ-2005 study, we examined the role of local therapy and the efficacy of chemotherapy with blockwise temozolomide (TMZ) in children and adolescents with recurrent ependymomas." | 4.02 | Local and systemic therapy of recurrent ependymoma in children and adolescents: short- and long-term results of the E-HIT-REZ 2005 study. ( Adolph, JE; Bison, B; Bode, U; Faldum, A; Fleischhack, G; Frühwald, MC; Kortmann, RD; Krauß, J; Kwiecien, R; Mikasch, R; Mynarek, M; Obrecht, D; Pajtler, KW; Pfister, SM; Pietsch, T; Rutkowski, S; Schüller, U; Timmermann, B; Tippelt, S; von Hoff, K; Warmuth-Metz, M; Witt, H; Witt, O; Zeller, J, 2021) |
| "Few data are available on temozolomide (TMZ) in ependymomas." | 3.83 | Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study. ( Bosa, C; Cassoni, P; Fiano, V; Franchino, F; Magistrello, M; Pellerino, A; Rudà, R; Soffietti, R; Trevisan, M, 2016) |
| "Ependymoma SC lines were highly sensitive to temozolomide and etoposide in vitro, but only temozolomide impaired tumor-initiation properties." | 3.80 | Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models. ( Arena, V; Binda, E; Lamorte, G; Meco, D; Riccardi, R; Servidei, T, 2014) |
| "Myxopapillary ependymomas are intradural tumors which grow from the terminal filum of the spinal cord." | 2.58 | Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review. ( Adachi, N; Fujiwara, Y; Izumi, B; Manabe, H; Shima, T, 2018) |
| "Apatinib is a multitarget tyrosine kinase inhibitor, which has been reported to exhibit broad antitumor profiles." | 1.72 | Apatinib and temozolomide in children with recurrent ependymoma: A case report. ( Li, J; Shen, Z; Shi, L; Zhang, N; Zhao, S, 2022) |
| "Anaplastic ependymomas are rare tumors in adult patients." | 1.39 | Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma. ( Bellu, L; Della Puppa, A; Gardiman, MP; Lombardi, G; Pambuku, A; Pomerri, F; Rumanò, L; Zagonel, V, 2013) |
| "Intracranial anaplastic ependymomas are a very rare entity within the group of adult CNS neoplasms." | 1.37 | Response to temozolomide in supratentorial multifocal recurrence of malignant ependymoma. ( Freyschlag, CF; Lohr, F; Schmieder, K; Seiz, M; Thomé, C; Tuettenberg, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 9 (52.94) | 24.3611 |
| 2020's | 3 (17.65) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, S | 1 |
| Shen, Z | 1 |
| Li, J | 1 |
| Shi, L | 1 |
| Zhang, N | 1 |
| Gilbert, MR | 1 |
| Yuan, Y | 1 |
| Wu, J | 2 |
| Mendoza, T | 1 |
| Vera, E | 1 |
| Omuro, A | 1 |
| Lieberman, F | 1 |
| Robins, HI | 1 |
| Gerstner, ER | 1 |
| Wen, PY | 1 |
| Mikkelsen, T | 1 |
| Aldape, K | 1 |
| Armstrong, TS | 1 |
| Adolph, JE | 1 |
| Fleischhack, G | 1 |
| Mikasch, R | 1 |
| Zeller, J | 1 |
| Warmuth-Metz, M | 1 |
| Bison, B | 1 |
| Mynarek, M | 1 |
| Rutkowski, S | 1 |
| Schüller, U | 1 |
| von Hoff, K | 1 |
| Obrecht, D | 1 |
| Pietsch, T | 1 |
| Pfister, SM | 1 |
| Pajtler, KW | 1 |
| Witt, O | 1 |
| Witt, H | 1 |
| Kortmann, RD | 1 |
| Timmermann, B | 1 |
| Krauß, J | 1 |
| Frühwald, MC | 1 |
| Faldum, A | 1 |
| Kwiecien, R | 1 |
| Bode, U | 1 |
| Tippelt, S | 1 |
| Fujiwara, Y | 1 |
| Manabe, H | 1 |
| Izumi, B | 1 |
| Shima, T | 1 |
| Adachi, N | 1 |
| Lombardi, G | 1 |
| Pambuku, A | 1 |
| Bellu, L | 1 |
| Della Puppa, A | 1 |
| Rumanò, L | 1 |
| Gardiman, MP | 1 |
| Pomerri, F | 1 |
| Zagonel, V | 1 |
| Meco, D | 1 |
| Servidei, T | 1 |
| Lamorte, G | 1 |
| Binda, E | 1 |
| Arena, V | 1 |
| Riccardi, R | 1 |
| Komori, K | 1 |
| Yanagisawa, R | 1 |
| Miyairi, Y | 1 |
| Sakashita, K | 1 |
| Shiohara, M | 1 |
| Fujihara, I | 1 |
| Morita, D | 1 |
| Nakamura, T | 1 |
| Ogiso, Y | 1 |
| Sano, K | 1 |
| Shirahata, M | 1 |
| Fukuoka, K | 1 |
| Ichimura, K | 1 |
| Shigeta, H | 1 |
| Rudà, R | 1 |
| Bosa, C | 1 |
| Magistrello, M | 1 |
| Franchino, F | 1 |
| Pellerino, A | 1 |
| Fiano, V | 1 |
| Trevisan, M | 1 |
| Cassoni, P | 1 |
| Soffietti, R | 1 |
| Gramatzki, D | 1 |
| Roth, P | 1 |
| Felsberg, J | 1 |
| Hofer, S | 1 |
| Rushing, EJ | 1 |
| Hentschel, B | 1 |
| Westphal, M | 1 |
| Krex, D | 1 |
| Simon, M | 1 |
| Schnell, O | 1 |
| Wick, W | 1 |
| Reifenberger, G | 1 |
| Weller, M | 1 |
| Chamberlain, MC | 1 |
| Johnston, SK | 1 |
| Freyschlag, CF | 1 |
| Tuettenberg, J | 1 |
| Lohr, F | 1 |
| Thomé, C | 1 |
| Schmieder, K | 1 |
| Seiz, M | 1 |
| Salameire, D | 1 |
| Khoo, HM | 1 |
| Kishima, H | 1 |
| Kinoshita, M | 1 |
| Goto, Y | 1 |
| Kagawa, N | 1 |
| Hashimoto, N | 1 |
| Maruno, M | 1 |
| Yoshimine, T | 1 |
| Vos, MJ | 1 |
| Uitdehaag, BM | 1 |
| Barkhof, F | 1 |
| Heimans, JJ | 1 |
| Baayen, HC | 1 |
| Boogerd, W | 1 |
| Castelijns, JA | 1 |
| Elkhuizen, PH | 1 |
| Postma, TJ | 1 |
| Rojas-Marcos, I | 1 |
| Calvet, D | 1 |
| Janoray, P | 1 |
| Delattre, JY | 1 |
| Rehman, S | 1 |
| Brock, C | 1 |
| Newlands, ES | 1 |
| Nicholson, HS | 1 |
| Kretschmar, CS | 1 |
| Krailo, M | 1 |
| Bernstein, M | 1 |
| Kadota, R | 1 |
| Fort, D | 1 |
| Friedman, H | 1 |
| Harris, MB | 1 |
| Tedeschi-Blok, N | 1 |
| Mazewski, C | 1 |
| Sato, J | 1 |
| Reaman, GH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase II Study of Temozolomide in the Treatment of Children With High Grade Glioma[NCT00028795] | Phase 2 | 170 participants (Actual) | Interventional | 2002-12-31 | Completed | ||
| An International, Randomized, Open-label Phase I/II Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Adult Patients With Recurrent or Refractory Medulloblastomas Presenting an Activation of the Sonic Hedgehog (SHH) Pathway[NCT01601184] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2012-06-30 | Terminated (stopped due to The number of successes is not reached at the end of first stage of the phase II. The study is stopped.) | ||
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862] | Phase 1/Phase 2 | 36 participants (Anticipated) | Interventional | 2013-10-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for temozolomide and Ependymoma
| Article | Year |
|---|---|
Remarkable efficacy of temozolomide for relapsed spinal myxopapillary ependymoma with multiple recurrence and cerebrospinal dissemination: a case report and literature review.
Topics: Adult; Antineoplastic Agents, Alkylating; Cauda Equina; Chemotherapy, Adjuvant; Combined Modality Th | 2018 |
2 trials available for temozolomide and Ependymoma
| Article | Year |
|---|---|
A phase II study of dose-dense temozolomide and lapatinib for recurrent low-grade and anaplastic supratentorial, infratentorial, and spinal cord ependymoma.
Topics: Adolescent; Adult; Brain Neoplasms; Dacarbazine; Disease-Free Survival; Ependymoma; Humans; Lapatini | 2021 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl | 2007 |
14 other studies available for temozolomide and Ependymoma
| Article | Year |
|---|---|
Apatinib and temozolomide in children with recurrent ependymoma: A case report.
Topics: Antineoplastic Agents; Brain Neoplasms; Child; Child, Preschool; Cisplatin; Ependymoma; Humans; Male | 2022 |
Local and systemic therapy of recurrent ependymoma in children and adolescents: short- and long-term results of the E-HIT-REZ 2005 study.
Topics: Adolescent; Brain Neoplasms; Child; Ependymoma; Humans; Neoplasm Recurrence, Local; Radiotherapy, Ad | 2021 |
Cisplatin and temozolomide combination in the treatment of supratentorial anaplastic ependymoma.
Topics: Antineoplastic Agents; Brain Neoplasms; Cisplatin; Dacarbazine; Drug Therapy, Combination; Ependymom | 2013 |
Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models.
Topics: Animals; Antineoplastic Agents, Alkylating; Dacarbazine; Disease Models, Animal; DNA Modification Me | 2014 |
Temozolomide Treatment for Pediatric Refractory Anaplastic Ependymoma with Low MGMT Protein Expression.
Topics: Antineoplastic Agents, Alkylating; Brain Neoplasms; Child, Preschool; Dacarbazine; DNA Modification | 2016 |
Temozolomide as salvage treatment for recurrent intracranial ependymomas of the adult: a retrospective study.
Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Ependymoma; Fema | 2016 |
Chemotherapy for intracranial ependymoma in adults.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Dacarbazine; Dis | 2016 |
Temozolomide for recurrent intracranial supratentorial platinum-refractory ependymoma.
Topics: Adult; Antineoplastic Agents, Alkylating; Carboplatin; Cisplatin; Dacarbazine; Disease-Free Survival | 2009 |
Response to temozolomide in supratentorial multifocal recurrence of malignant ependymoma.
Topics: Adult; Antineoplastic Agents; Brain Neoplasms; Dacarbazine; Disease Progression; Ependymoma; Female; | 2011 |
[Cutaneous neutrophils infiltrates. Case 4. Pseudo-tumoral cutaneous alternariosis].
Topics: Aged, 80 and over; Alternaria; Antifungal Agents; Antineoplastic Agents, Alkylating; Brain Neoplasms | 2011 |
Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report.
Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Dacarbazine; Ependymoma | 2013 |
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat | 2003 |
Response of recurrent anaplastic ependymoma to a combination of tamoxifen and isotretinoin.
Topics: Adrenal Cortex Hormones; Adult; Antineoplastic Combined Chemotherapy Protocols; Brain; Brain Neoplas | 2003 |
A case report of a recurrent intracranial ependymoma treated with temozolomide in remission 10 years after completing chemotherapy.
Topics: Adult; Antineoplastic Agents, Alkylating; Brain Neoplasms; Dacarbazine; Ependymoma; Female; Humans; | 2006 |