Page last updated: 2024-11-04

temozolomide and EHS Tumor

temozolomide has been researched along with EHS Tumor in 1 studies

Research Excerpts

ExcerptRelevanceReference
" The half-life of CCRG 81045 at 37 degrees C in 0."1.27Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. ( Baig, G; Chubb, D; Gibson, NW; Goddard, C; Hickman, JA; Langdon, SP; Slack, JA; Stevens, MF; Stone, R; Vickers, L, 1987)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Stevens, MF1
Hickman, JA1
Langdon, SP1
Chubb, D1
Vickers, L1
Stone, R1
Baig, G1
Goddard, C1
Gibson, NW1
Slack, JA1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Study of Gamma Knife Radiosurgery and Temozolomide (Temodar) for Newly Diagnosed Brain Metastases[NCT00582075]Phase 225 participants (Actual)Interventional2002-07-31Completed
A Pilot Study Investigating Neoadjuvant Temozolomide-based Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas[NCT00881595]Phase 20 participants (Actual)Interventional2009-02-28Withdrawn (stopped due to No patients accrued since study opened)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival

(NCT00582075)
Timeframe: 2 years

Interventionweeks (Median)
Radiosurgery 15-24 Gy + Adjuvant Temozolomide31

Percentage of Participants With Distant Brain Failure (DBF) at One Year

Patients developing distant brain failure (DBF) at one year. An approximation method was used to arrive at the reported percentage. (NCT00582075)
Timeframe: 1 years

Interventionpercentage of participants (Number)
Radiosurgery 15-24 Gy + Adjuvant Temozolomide37

Other Studies

1 other study available for temozolomide and EHS Tumor

ArticleYear
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.
    Cancer research, 1987, Nov-15, Volume: 47, Issue:22

    Topics: Animals; Antineoplastic Agents; Dacarbazine; Imidazoles; Lung Neoplasms; Male; Melanoma, Experimenta

1987
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.
    Cancer research, 1987, Nov-15, Volume: 47, Issue:22

    Topics: Animals; Antineoplastic Agents; Dacarbazine; Imidazoles; Lung Neoplasms; Male; Melanoma, Experimenta

1987
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.
    Cancer research, 1987, Nov-15, Volume: 47, Issue:22

    Topics: Animals; Antineoplastic Agents; Dacarbazine; Imidazoles; Lung Neoplasms; Male; Melanoma, Experimenta

1987
Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine.
    Cancer research, 1987, Nov-15, Volume: 47, Issue:22

    Topics: Animals; Antineoplastic Agents; Dacarbazine; Imidazoles; Lung Neoplasms; Male; Melanoma, Experimenta

1987