temozolomide has been researched along with Ataxia Telangiectasia in 1 studies
Ataxia Telangiectasia: An autosomal recessive inherited disorder characterized by choreoathetosis beginning in childhood, progressive CEREBELLAR ATAXIA; TELANGIECTASIS of CONJUNCTIVA and SKIN; DYSARTHRIA; B- and T-cell immunodeficiency, and RADIOSENSITIVITY to IONIZING RADIATION. Affected individuals are prone to recurrent sinobronchopulmonary infections, lymphoreticular neoplasms, and other malignancies. Serum ALPHA-FETOPROTEINS are usually elevated. (Menkes, Textbook of Child Neurology, 5th ed, p688) The gene for this disorder (ATM) encodes a cell cycle checkpoint protein kinase and has been mapped to chromosome 11 (11q22-q23).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clinical efficacy of DNA-damaging anticancer drugs can be influenced by the DNA damage response in tumor cells." | 1.91 | Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs. ( Coussens, NP; Dexheimer, TS; Doroshow, JH; Morris, J; Silvers, T; Teicher, BA; Wright, J, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dexheimer, TS | 1 |
| Coussens, NP | 1 |
| Silvers, T | 1 |
| Wright, J | 1 |
| Morris, J | 1 |
| Doroshow, JH | 1 |
| Teicher, BA | 1 |
1 other study available for temozolomide and Ataxia Telangiectasia
| Article | Year |
|---|---|
Multicellular Complex Tumor Spheroid Response to DNA Repair Inhibitors in Combination with DNA-damaging Drugs.
Topics: Ataxia Telangiectasia; DNA; DNA Repair; DNA-Activated Protein Kinase; Endothelial Cells; Humans; Neo | 2023 |