Page last updated: 2024-11-04

temozolomide and Astrocytoma

temozolomide has been researched along with Astrocytoma in 197 studies

Astrocytoma: Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082)

Research Excerpts

ExcerptRelevanceReference
"In a post hoc analysis of the CATNON trial (NCT00626990), we explored whether adding temozolomide to radiotherapy improves outcome in patients with IDH1/2 wildtype (wt) anaplastic astrocytomas with molecular features of glioblastoma [redesignated as glioblastoma, isocitrate dehydrogenase-wildtype (IDH-wt) in the 2021 World Health Organization (WHO) classification of central nervous system tumors]."9.51Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial. ( Aldape, K; Atmodimedjo, PN; Baumert, BG; Baurain, JF; Brandes, AA; Brouwer, RWW; Cheung, KJ; Chinot, OL; Clement, PM; de Heer, I; Dubbink, HJ; Erridge, SC; French, PJ; Gill, S; Golfinopoulos, V; Gorlia, T; Griffin, M; Hoogstrate, Y; Jenkins, RB; Kros, JM; Mason, WP; McBain, C; Nowak, AK; Rogers, L; Rudà, R; Sanson, M; Taal, W; Tesileanu, CMS; van den Bent, MJ; van IJcken, WFJ; van Linde, ME; Vogelbaum, MA; von Deimling, A; Weller, M; Wesseling, P; Wheeler, H; Wick, W, 2022)
"To investigate the toxicity profile and establish an optimal dosing schedule of zotiraciclib with temozolomide in patients with recurrent high-grade astrocytoma."9.41Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas. ( Aboud, O; Ahmad, S; Antony, R; Armstrong, TS; Boris, L; Bryla, C; Burton, EM; Butler, MK; Calvo, KR; Cordova, C; Figg, WD; Fink, D; Gallin, JI; Garren, N; Gilbert, MR; Gonzales, J; Grajkowska, E; Kuhns, DB; Leeper, H; Lindsley, M; Lollo, N; Long Priel, DA; Mendoza, TR; Mentges, K; Pang, Y; Peer, CJ; Penas-Prado, M; Siegel, C; Sissung, TM; Su, YT; Theeler, BJ; Vera, E; Wu, J; Yu, G; Yuan, Y, 2021)
"The primary objective of this study was to compare the overall survival (OS) of patients with anaplastic astrocytoma (AA) treated with radiotherapy (RT) and either temozolomide (TMZ) or a nitrosourea (NU)."9.24Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813. ( Aldape, KD; Bahary, JP; Barger, GR; Belanger, K; Bell, EH; Brachman, D; Brown, PD; Cairncross, JG; Chakravarti, A; Chang, S; Dolinskas, CA; Gilbert, MR; Hunter, G; Jaeckle, K; Mehta, M; Penas-Prado, M; Robins, HI; Schiff, D; Schultz, C; Shih, H; Werner-Wasik, M; Zhang, P, 2017)
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."9.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
"To evaluate the efficacy and safety of temozolomide (TMZ) versus semustine (Me-CCNU) in the treatment of recurrent glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA)."9.17[Multicenter randomized controlled study of temozolomide versus semustine in the treatment of recurrent malignant glioma]. ( Sun, J; Yang, SY; Yang, XJ, 2013)
" We did a randomised trial to compare the efficacy and safety of dose-dense temozolomide alone versus radiotherapy alone in elderly patients with anaplastic astrocytoma or glioblastoma."9.16Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. ( Braun, C; Combs, SE; Felsberg, J; Ketter, R; Mayer-Steinacker, R; Meisner, C; Meixensberger, J; Nikkhah, G; Papsdorf, K; Platten, M; Reifenberger, G; Sabel, M; Simon, M; Steinbach, JP; Tabatabai, G; Vesper, J; Weller, M; Wick, W, 2012)
"The primary objectives of this phase II study were to evaluate the use of preirradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma (MOA)."9.14Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. ( Berkey, B; Biggs, C; Blumenthal, DT; Brown, P; Giannini, C; Herman, J; Jenkins, R; Macdonald, D; Mehta, M; Peereboom, D; Schultz, C; Suh, JH; Vogelbaum, MA, 2009)
"We retrospectively investigated the correlation of IDH1 and IDH2 mutations with overall survival and response to temozolomide in a cohort of patients with dedifferentiated low-grade astrocytomas treated with temozolomide at the time of progression after radiotherapy."9.14IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide. ( Boogerd, W; Bromberg, JE; Dinjens, WN; Dubbink, HJ; Gijtenbeek, JM; Groenendijk, FH; Kros, JM; Postma, TJ; Smitt, PA; Taal, W; van den Bent, MJ; van Heuvel, I; van Marion, R; Zonnenberg, BA; Zonnenberg, CB, 2009)
"The primary objective of this prospective phase 2 study of CPT-11 in adult patients with recurrent temozolomide-refractory anaplastic astrocytoma (AA) was to evaluate 6-month progression-free survival (PFS)."9.13Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma. ( Blumenthal, DT; Chamberlain, MC; Glantz, MJ; Wei-Tsao, DD, 2008)
"A prospective Phase II study of cyclophosphamide (CYC) was conducted in adult patients with recurrent temozolomide-refractory anaplastic astrocytoma (AA) with a primary objective of evaluating 6-month progression-free survival (PFS)."9.12Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma. ( Chamberlain, MC; Groshen, S; Tsao-Wei, DD, 2006)
"Temozolomide (TMZ) a recent, oral, second generation alkylating agent is a chemotherapeutic with demonstrated efficacy for the treatment of high-grade gliomas."9.12Surgery, radiotherapy and temozolomide in treating high-grade gliomas. ( Barbarisi, M; Moraci, A; Moraci, M; Parlato, C, 2006)
"Based on our findings in two paediatric patients, temozolomide may be a useful agent in the management of progressive recurrent low grade spinal cord astrocytomas."9.12Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients. ( Abboud, MR; Al Kutoubi, AO; Alaraj, AM; Chamoun, RB; Haddad, GF, 2006)
"The efficacy and safety of temozolomide were evaluated in 32 patients with anaplastic astrocytoma at first relapse."9.12[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study]. ( Aoki, T; Fujimaki, T; Hori, T; Ikeda, J; Kochi, M; Maruno, M; Matsutani, M; Nakamura, H; Nishikawa, R; Sato, S; Sawamura, Y; Shibui, S; Sugiyama, K; Takahashi, H; Takahashi, J; Wakabayashi, T, 2006)
"To determine the safety and toxicity of carmustine (BCNU) and temozolomide (TMZ) with radiotherapy (RT) in newly diagnosed anaplastic astrocytoma."9.11Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors. ( Atkins, J; Bahary, JP; Barger, G; Buckner, J; Bushunow, P; Cairncross, G; Chang, SM; Choucair, A; Curran, W; Dolinskas, C; Gilbert, M; Kresl, J; Louis, DN; Mehta, M; Seiferheld, W; Share, R; Thoron, L, 2004)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."9.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"Seventy-five consecutive patients with recurrent malignant astrocytomas and glioblastomas had been treated at our institute with per os temozolomide for five days every month."9.11Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas. ( Afra, D; Sipos, L; Vitanovics, D, 2004)
"Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma."9.10Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas. ( Foster, T; Newlands, ES; Zaknoen, S, 2003)
"To determine the antitumor efficacy and safety profile of temozolomide in patients with malignant astrocytoma at first relapse."9.09Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. ( Albright, R; Brada, M; Bruner, J; Chang, SM; Dugan, M; Friedman, AH; Friedman, HS; Levin, VA; O'Neill, AM; Olson, J; Prados, MD; Rosenfeld, SS; Yaya-Tur, R; Yue, N; Yung, WK; Zaknoen, S, 1999)
"One of the objectives of this phase II study was to determine whether temozolomide (TMZ) improved the health-related quality of life (HRQL) of patients with recurrent anaplastic astrocytoma (AA)."9.09Health-related quality of life in patients with anaplastic astrocytoma during treatment with temozolomide. ( Brada, M; Osoba, D; Prados, MD; Yung, WK, 2000)
" A novel second-generation alkylating agent, temozolomide, has recently demonstrated efficacy and safety in patients with recurrent glioblastoma multiforme and anaplastic astrocytoma."9.09Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. ( Barrie, M; Braguer, D; Chinot, OL; Dufour, H; Figarella-Branger, D; Grisoli, F; Honore, S; Martin, PM; Muracciole, X, 2001)
"To report the long-term outcomes in adult patients with grade 2 IDH-mutant astrocytoma treated with temozolomide (TMZ)-based chemoradiation."8.31Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma. ( Antonelli, M; Arcella, A; Bozzao, A; Capone, L; De Pietro, R; Esposito, V; Gianno, F; Giraffa, M; Lanzetta, G; Minniti, G; Paolini, S; Romano, A; Tini, P, 2023)
"The role of temozolomide chemotherapy alone in isocitrate dehydrogenase (IDH)-mutant astrocytomas has not been conclusively determined."8.12Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3. ( Becker, H; Blobner, J; Egensperger, R; Katzendobler, S; Niyazi, M; Quach, S; Suchorska, B; Thiele, F; Thon, N; Tonn, JC; Weller, J; Weller, M, 2022)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."8.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
"To report clinical outcomes of temozolomide (TMZ)-based radio-chemotherapy and adjuvant chemotherapy in patients with aggressive/high-risk low-grade glioma (LGG)."8.02Upfront Therapy of Aggressive/High-Risk Low-Grade Glioma: Single-Institution Outcome Analysis of Temozolomide-Based Radio-Chemotherapy and Adjuvant Chemotherapy. ( Anand, S; Chatterjee, A; Epari, S; Goda, JS; Gupta, T; Jalali, R; Krishnatry, R; Moiyadi, A; Panda, P; Patil, V, 2021)
"This is the long-term update of NOA-08 (NCT01502241), which compared efficacy and safety of radiotherapy (RT, n = 176) and temozolomide (TMZ, n = 193) at 7/14 days in patients >65 years old with anaplastic astrocytoma or glioblastoma."7.96Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma. ( Bamberg, M; Bölting, H; Debus, J; Felsberg, J; Herrlinger, U; Hertler, C; Kessler, T; Ketter, R; Mayer-Steinacker, R; Meisner, C; Meixensberger, J; Papsdorf, K; Platten, M; Reifenberger, G; Reuss, D; Sabel, M; Sahm, F; Steinbach, JP; Vesper, J; von Deimling, A; Weisang, S; Weller, M; Weyerbrock, A; Wick, A; Wick, W, 2020)
"A standard post-concomitant radiochemotherapy involving adjuvant temozolomide (TMZ) was stopped after 6 cycles for high-grade gliomas (HGG)."7.88Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV). ( Ho, JT; Ho, RW; Lin, WC; Lin, YJ; Lin, YT; Lu, CH; Tsai, NW; Wang, HC, 2018)
"Postoperative management of anaplastic glioma remains without a clear standard of care-in this study we report outcomes for patients treated with radiotherapy (RT) with and without temozolomide (TMZ)."7.88Outcomes for Anaplastic Glioma Treated With Radiation Therapy With or Without Concurrent Temozolomide. ( Chan, MD; Debinski, W; Farris, M; Helis, C; Laxton, AW; Lesser, GJ; Lo, HW; Lucas, JT; McTyre, E; Mott, R; Soike, M; Strowd, RE; Tatter, SB, 2018)
"Temozolomide (TMZ) for malignant gliomas is traditionally dosed in 5 out of a 28-day cycle, however alternative regimens exist, including dose-dense."7.85Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. ( Howard, TA; Villano, JL; Zhou, Z, 2017)
"We retrospectively analyzed the data of 5 adult patients treated with temozolomide between 2008 and 2015 for a grade II intramedullary astrocytoma with progression after surgery."7.85[Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience]. ( Chaskis, E; De Witte, O; Devriendt, D; Goldman, S; Lefranc, F; Luce, S; Minichini, V; Sadeghi, N, 2017)
"To explore the efficacy and toxicity of an extended schedule of temozolomide (50 mg/mq 1 week on/1 week off) in a population of newly diagnosed low-grade gliomas (LGG)."7.85Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up. ( Carapella, CM; Carosi, M; Fabi, A; Giannarelli, D; Marucci, L; Maschio, M; Merola, R; Pace, A; Vidiri, A; Villani, V, 2017)
"It is currently unclear whether adjuvant therapy for WHO grade III anaplastic astrocytomas (AA) should be carried out as combined chemoradiotherapy with temozolomide (TMZ)--analogous to the approach for glioblastoma multiforme--or as radiotherapy (RT) alone."7.81Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience. ( Giese, A; Mayer, A; Renovanz, M; Schmidberger, H; Schwanbeck, C; Sommer, C; Stockinger, M; Vaupel, P, 2015)
" We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2004 and March 2012."7.80IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy. ( Arcella, A; Bozzao, A; Di Stefano, D; Enrici, RM; Esposito, V; Giangaspero, F; Lanzetta, G; Minniti, G; Pace, A; Salvati, M; Scaringi, C; Scarpino, S; Villani, V, 2014)
"This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA)."7.80The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma. ( Buckner, JC; Decker, PA; Giannini, C; Hardie, J; Jenkins, RB; Kizilbash, SH; Laack, NN; Parney, IF; Uhm, JH; Voss, JS, 2014)
" honey (ESH), beebread (EBB), and royal jelly (ERJ) with and without temozolomide (TMZ) on cell lines derived from a patient with diffuse astrocytoma (DASC), human glioblastoma multiforme (U87MG), and normal human astroglia (SVGp12)."7.80The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines. ( Bartosiuk, E; Borawska, MH; Kochanowicz, J; Mariak, Z; Markiewicz-Żukowska, R; Moskwa, J; Naliwajko, SK; Socha, K; Surażyński, A, 2014)
"Only a few studies examined the effect of temozolomide (TMZ) in recurrent low-grade astrocytoma (LGA) after surgery, none of which included a homogeneous and sufficiently sized group of patients with progression after radiotherapy (RT)."7.77First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response. ( Boogerd, W; Bromberg, JE; Dinjens, WN; Dubbink, HJ; Gijtenbeek, JM; Groenendijk, FH; Kouwenhoven, MC; Kros, JM; Postma, TJ; Sillevis Smitt, PA; Taal, W; van den Bent, MJ; van der Holt, B; van Heuvel, I; van Marion, R; Zonnenberg, BA; Zonnenberg, CB, 2011)
"The aim of the present study was to investigate the kinetics of the effects exerted by Temodal and quercetin on the survival of the human astrocytoma MOGGCCM cell line."7.77Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells. ( Jakubowicz-Gil, J; Langner, E; Rzeski, W, 2011)
"The aim of the present study was to investigate the effect of Temozolomide (an alkylating chemotherapeutic agent) and quercetin (natural flavonoid) on cell death in the human astrocytoma cell line MOGGCCM (WHO grade III)."7.76Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line. ( Jakubowicz-Gil, J; Langner, E; Piersiak, T; Rzeski, W; Wertel, I, 2010)
"We present a case of a 12-year-old female with a germline TP53 mutation who presented with anaplastic astrocytoma and subsequent acute lymphoblastic leukemia (ALL) 13 months after starting treatment with temozolomide (TMZ)."7.76Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. ( Hosono, A; Makimoto, A; Miyakita, Y; Momota, H; Nariata, Y; Narita, Y; Shibui, S, 2010)
"Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently under clinical investigation for the treatment of brain metastases from a variety of cancers."7.76Urticarial hypersensitivity reaction caused by temozolomide. ( Hsu, MY; Ibrahimi, OA; Kesari, S; Pothiawala, S; Yang, C, 2010)
"Temozolomide (TMZ) is an alkylating agent used in the management of gliomas."7.75Long-term use of temozolomide: could you use temozolomide safely for life in gliomas? ( Bell, D; Khasraw, M; Wheeler, H, 2009)
" In this study, the authors investigate the nature of the SP phenotype in 2 glioma cell lines, U87MG and T98G, and their response to temozolomide."7.74Characterization of a side population of astrocytoma cells in response to temozolomide. ( Ang, BT; Chong, KH; Chua, C; See, SJ; Tang, C; Wong, MC; Zaiden, N, 2008)
"Following the resection of newly diagnosed or recurrent glioblastomas, local implantation of carmustine-impregnated biodegradable wafers (Gliadel) in the resection cavity constitutes an adjuvant therapy that can improve the possibilities of survival."7.74Fatal outcome related to carmustine implants in glioblastoma multiforme. ( Barcia, JA; Barcia-Mariño, C; Gallego, JM, 2007)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."7.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"To assess whether the survival of patients with recurrent malignant glioma receiving temozolomide in everyday practice is comparable to that reported in previous studies."7.72Survival of patients with recurrent malignant glioma treated with temozolomide: a retrospective observational study. ( Maltoni, S; Messori, A; Pelagotti, F; Trippoli, S; Vacca, F; Vaiani, M, 2003)
"Patients with newly diagnosed anaplastic astrocytoma (AA) or anaplastic oligo-astrocytoma (AOA) were treated with concurrent radiotherapy (60 Gy over 6 weeks) and temozolomide (75 mg/m(2)), and six adjuvant 28-day cycles of either dose-dense (150 mg/m(2), days 1-7, 15-21) or metronomic (50 mg/m(2), days 1-28) temozolomide."6.80Radiotherapy and temozolomide for anaplastic astrocytic gliomas. ( Abrey, LE; Braunthal, SG; DeAngelis, LM; Huse, JT; Lassman, AB; Nayak, L; Panageas, KS; Pentsova, E; Reiner, AS, 2015)
"We conducted a study to determine the dose-limiting toxicity of an extended dosing schedule of temozolomide (TMZ) when used with a fixed dose of BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine), taking advantage of TMZ's ability to deplete O6-alkylguanine-DNA-alkyltransferase and the synergistic activity of these two agents."6.71Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy. ( Abrey, LE; Kleber, M; Malkin, MG; Raizer, JJ, 2004)
"Temozolomide is a novel, oral, second-generation alkylating agent."6.41Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis. ( Friedman, HS, 2000)
"Temozolomide, a new drug, has shown promise in treating malignant gliomas and other difficult-to-treat tumors."6.41Temozolomide and treatment of malignant glioma. ( Calvert, H; Friedman, HS; Kerby, T, 2000)
" For patients with recurrent malignant glioma, temozolomide provides a therapeutic option with a predictable safety profile, clinical efficacy, and convenient dosing that can provide important quality-of-life benefits."6.41Temozolomide for recurrent high-grade glioma. ( Macdonald, DR, 2001)
"In a post hoc analysis of the CATNON trial (NCT00626990), we explored whether adding temozolomide to radiotherapy improves outcome in patients with IDH1/2 wildtype (wt) anaplastic astrocytomas with molecular features of glioblastoma [redesignated as glioblastoma, isocitrate dehydrogenase-wildtype (IDH-wt) in the 2021 World Health Organization (WHO) classification of central nervous system tumors]."5.51Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial. ( Aldape, K; Atmodimedjo, PN; Baumert, BG; Baurain, JF; Brandes, AA; Brouwer, RWW; Cheung, KJ; Chinot, OL; Clement, PM; de Heer, I; Dubbink, HJ; Erridge, SC; French, PJ; Gill, S; Golfinopoulos, V; Gorlia, T; Griffin, M; Hoogstrate, Y; Jenkins, RB; Kros, JM; Mason, WP; McBain, C; Nowak, AK; Rogers, L; Rudà, R; Sanson, M; Taal, W; Tesileanu, CMS; van den Bent, MJ; van IJcken, WFJ; van Linde, ME; Vogelbaum, MA; von Deimling, A; Weller, M; Wesseling, P; Wheeler, H; Wick, W, 2022)
"A 43-year-old man with an anaplastic astrocytoma received radiation therapy synchronized with ranimustine and adjuvant TMZ chemotherapy for 15 cycles."5.46A Case of Therapy-Related Acute Myeloid Leukemia Associated with Adjuvant Temozolomide Chemotherapy for Anaplastic Astrocytoma. ( Kosugi, K; Saito, K; Takahashi, W; Tokuda, Y; Tomita, H, 2017)
"Patients with grade IV astrocytoma or glioblastoma multiforme (GBM) have a median survival of <12 months, increased to 14."5.43Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam. ( Ajit, NE; Burton, GV; El-Osta, H; Peddi, P, 2016)
"To investigate the toxicity profile and establish an optimal dosing schedule of zotiraciclib with temozolomide in patients with recurrent high-grade astrocytoma."5.41Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas. ( Aboud, O; Ahmad, S; Antony, R; Armstrong, TS; Boris, L; Bryla, C; Burton, EM; Butler, MK; Calvo, KR; Cordova, C; Figg, WD; Fink, D; Gallin, JI; Garren, N; Gilbert, MR; Gonzales, J; Grajkowska, E; Kuhns, DB; Leeper, H; Lindsley, M; Lollo, N; Long Priel, DA; Mendoza, TR; Mentges, K; Pang, Y; Peer, CJ; Penas-Prado, M; Siegel, C; Sissung, TM; Su, YT; Theeler, BJ; Vera, E; Wu, J; Yu, G; Yuan, Y, 2021)
"The treatment of anaplastic astrocytoma (AA) is controversial."5.40Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination. ( Canpinar, H; Castresana, JS; Ilgaz, S; Rey, JA; Sert, F; Sunguroglu, A; Taspinar, M; Ugur, HC, 2014)
"Temozolomide was used almost exclusively during CRT (94."5.39Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide. ( Cahill, D; Gilbert, MR; Lei, X; Shonka, NA; Smith, L; Theeler, B; Yung, A, 2013)
"Temozolomide (TMZ) is an alkylating agent primarily used to treat tumors of the central nervous system."5.39Central diabetes insipidus: a previously unreported side effect of temozolomide. ( Faje, AT; Klibanski, A; Makimura, H; Miller, KK; Nachtigall, L; Wexler, D, 2013)
"The tumor was partially resected and anaplastic astrocytoma was diagnosed."5.38Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis. ( Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Miyazaki, Y; Takehara, T; Tanaka, S; Yakushijin, T; Yoshimine, T, 2012)
"The primary objective of this study was to compare the overall survival (OS) of patients with anaplastic astrocytoma (AA) treated with radiotherapy (RT) and either temozolomide (TMZ) or a nitrosourea (NU)."5.24Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813. ( Aldape, KD; Bahary, JP; Barger, GR; Belanger, K; Bell, EH; Brachman, D; Brown, PD; Cairncross, JG; Chakravarti, A; Chang, S; Dolinskas, CA; Gilbert, MR; Hunter, G; Jaeckle, K; Mehta, M; Penas-Prado, M; Robins, HI; Schiff, D; Schultz, C; Shih, H; Werner-Wasik, M; Zhang, P, 2017)
"Cabozantinib inhibits mesenchymal-epithelial transition factor (MET) and vascular endothelial growth factor receptor 2 (VEGFR2) and has demonstrated activity in patients with recurrent glioblastoma, warranting evaluation of the addition of cabozantinib to radiotherapy (RT) and temozolomide (TMZ) for patients with newly diagnosed high-grade glioma."5.22Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas. ( Chamberlain, MC; Cloughesy, T; Desjardins, A; Glantz, M; Mikkelsen, T; Reardon, DA; Schiff, D; Wen, PY, 2016)
"Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage."5.22The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide. ( Abuali, I; Grossman, SA; Lu, Y; Strowd, RE; Ye, X, 2016)
"To evaluate the efficacy and safety of temozolomide (TMZ) versus semustine (Me-CCNU) in the treatment of recurrent glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA)."5.17[Multicenter randomized controlled study of temozolomide versus semustine in the treatment of recurrent malignant glioma]. ( Sun, J; Yang, SY; Yang, XJ, 2013)
" We did a randomised trial to compare the efficacy and safety of dose-dense temozolomide alone versus radiotherapy alone in elderly patients with anaplastic astrocytoma or glioblastoma."5.16Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial. ( Braun, C; Combs, SE; Felsberg, J; Ketter, R; Mayer-Steinacker, R; Meisner, C; Meixensberger, J; Nikkhah, G; Papsdorf, K; Platten, M; Reifenberger, G; Sabel, M; Simon, M; Steinbach, JP; Tabatabai, G; Vesper, J; Weller, M; Wick, W, 2012)
"The primary objectives of this phase II study were to evaluate the use of preirradiation temozolomide followed by concurrent temozolomide and radiotherapy (RT) in patients with newly diagnosed anaplastic oligodendroglioma (AO) and mixed anaplastic oligoastrocytoma (MOA)."5.14Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131. ( Berkey, B; Biggs, C; Blumenthal, DT; Brown, P; Giannini, C; Herman, J; Jenkins, R; Macdonald, D; Mehta, M; Peereboom, D; Schultz, C; Suh, JH; Vogelbaum, MA, 2009)
"We retrospectively investigated the correlation of IDH1 and IDH2 mutations with overall survival and response to temozolomide in a cohort of patients with dedifferentiated low-grade astrocytomas treated with temozolomide at the time of progression after radiotherapy."5.14IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide. ( Boogerd, W; Bromberg, JE; Dinjens, WN; Dubbink, HJ; Gijtenbeek, JM; Groenendijk, FH; Kros, JM; Postma, TJ; Smitt, PA; Taal, W; van den Bent, MJ; van Heuvel, I; van Marion, R; Zonnenberg, BA; Zonnenberg, CB, 2009)
"Temozolomide (TMZ) is an oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM)."5.14The outcomes of concomitant radiation plus temozolomide followed by adjuvant temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study. ( Abo Hamar, AH; El-Shorbagy, D; Galal, S; Shawky, H; Zakaria, F, 2009)
"The primary objective of this prospective phase 2 study of CPT-11 in adult patients with recurrent temozolomide-refractory anaplastic astrocytoma (AA) was to evaluate 6-month progression-free survival (PFS)."5.13Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma. ( Blumenthal, DT; Chamberlain, MC; Glantz, MJ; Wei-Tsao, DD, 2008)
"A prospective Phase II study of cyclophosphamide (CYC) was conducted in adult patients with recurrent temozolomide-refractory anaplastic astrocytoma (AA) with a primary objective of evaluating 6-month progression-free survival (PFS)."5.12Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma. ( Chamberlain, MC; Groshen, S; Tsao-Wei, DD, 2006)
"Temozolomide (TMZ) a recent, oral, second generation alkylating agent is a chemotherapeutic with demonstrated efficacy for the treatment of high-grade gliomas."5.12Surgery, radiotherapy and temozolomide in treating high-grade gliomas. ( Barbarisi, M; Moraci, A; Moraci, M; Parlato, C, 2006)
"Based on our findings in two paediatric patients, temozolomide may be a useful agent in the management of progressive recurrent low grade spinal cord astrocytomas."5.12Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients. ( Abboud, MR; Al Kutoubi, AO; Alaraj, AM; Chamoun, RB; Haddad, GF, 2006)
"The efficacy and safety of temozolomide were evaluated in 32 patients with anaplastic astrocytoma at first relapse."5.12[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study]. ( Aoki, T; Fujimaki, T; Hori, T; Ikeda, J; Kochi, M; Maruno, M; Matsutani, M; Nakamura, H; Nishikawa, R; Sato, S; Sawamura, Y; Shibui, S; Sugiyama, K; Takahashi, H; Takahashi, J; Wakabayashi, T, 2006)
"Although overall objective responses were limited, further exploration of temozolomide may be warranted in children with medulloblastoma and other PNETs, or in patients with low-grade astrocytoma, perhaps in a setting of less pretreatment than the patients in the current study, or in the context of multiagent therapy."5.12Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. ( Bernstein, M; Fort, D; Friedman, H; Harris, MB; Kadota, R; Krailo, M; Kretschmar, CS; Mazewski, C; Nicholson, HS; Reaman, GH; Sato, J; Tedeschi-Blok, N, 2007)
"To determine the safety and toxicity of carmustine (BCNU) and temozolomide (TMZ) with radiotherapy (RT) in newly diagnosed anaplastic astrocytoma."5.11Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors. ( Atkins, J; Bahary, JP; Barger, G; Buckner, J; Bushunow, P; Cairncross, G; Chang, SM; Choucair, A; Curran, W; Dolinskas, C; Gilbert, M; Kresl, J; Louis, DN; Mehta, M; Seiferheld, W; Share, R; Thoron, L, 2004)
"The authors investigated the results of PCV chemotherapy within a cohort of 24 patients treated within the EORTC study 26971 on temozolomide chemotherapy in recurrent oligodendroglioma."5.11Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas. ( Allgeier, A; Brandes, AA; Enting, RH; Frenay, M; Kros, JM; Menten, J; Stege, EB; Taphoorn, MJ; Tosoni, A; Triebels, VH; van den Bent, MJ; van Heuvel, I, 2004)
"Seventy-five consecutive patients with recurrent malignant astrocytomas and glioblastomas had been treated at our institute with per os temozolomide for five days every month."5.11Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas. ( Afra, D; Sipos, L; Vitanovics, D, 2004)
"Temozolomide (TMZ) is an oral alkylating agent with a good safety profile and proven efficacy in the treatment of malignant glioma."5.10Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas. ( Foster, T; Newlands, ES; Zaknoen, S, 2003)
"To determine the antitumor efficacy and safety profile of temozolomide in patients with malignant astrocytoma at first relapse."5.09Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group. ( Albright, R; Brada, M; Bruner, J; Chang, SM; Dugan, M; Friedman, AH; Friedman, HS; Levin, VA; O'Neill, AM; Olson, J; Prados, MD; Rosenfeld, SS; Yaya-Tur, R; Yue, N; Yung, WK; Zaknoen, S, 1999)
"One of the objectives of this phase II study was to determine whether temozolomide (TMZ) improved the health-related quality of life (HRQL) of patients with recurrent anaplastic astrocytoma (AA)."5.09Health-related quality of life in patients with anaplastic astrocytoma during treatment with temozolomide. ( Brada, M; Osoba, D; Prados, MD; Yung, WK, 2000)
" A novel second-generation alkylating agent, temozolomide, has recently demonstrated efficacy and safety in patients with recurrent glioblastoma multiforme and anaplastic astrocytoma."5.09Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy. ( Barrie, M; Braguer, D; Chinot, OL; Dufour, H; Figarella-Branger, D; Grisoli, F; Honore, S; Martin, PM; Muracciole, X, 2001)
" Temozolomide, a monofunctional alkylator, was the first chemotherapeutic agent to definitively improve survival in adults with newly diagnosed glioblastoma used in combination with radiation therapy with the most pronounced effect being in a subgroup of tumors with MGMT promoter methylation."4.98Chemotherapy of High-Grade Astrocytomas in Adults. ( Hoang, N; Puduvalli, VK, 2018)
" Temozolomide is a novel second-generation alkylating agent that has shown efficacy for the treatment of high-grade gliomas."4.84[Glioma therapy up-date]. ( Dalmau, J; de la Fuente, BP; Rosenfeld, M, 2007)
" We report a 44-year-old woman with t-MDS (refractory anemia with excess blasts) following treatment of recurrent anaplastic astrocytoma with temozolomide (TMZ)."4.82Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma. ( Chang, MC; Chiang, MF; Hsieh, RK; Su, YW, 2005)
"To report the long-term outcomes in adult patients with grade 2 IDH-mutant astrocytoma treated with temozolomide (TMZ)-based chemoradiation."4.31Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma. ( Antonelli, M; Arcella, A; Bozzao, A; Capone, L; De Pietro, R; Esposito, V; Gianno, F; Giraffa, M; Lanzetta, G; Minniti, G; Paolini, S; Romano, A; Tini, P, 2023)
"The role of temozolomide chemotherapy alone in isocitrate dehydrogenase (IDH)-mutant astrocytomas has not been conclusively determined."4.12Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3. ( Becker, H; Blobner, J; Egensperger, R; Katzendobler, S; Niyazi, M; Quach, S; Suchorska, B; Thiele, F; Thon, N; Tonn, JC; Weller, J; Weller, M, 2022)
"IDH-mutant anaplastic astrocytomas (AAs) are chemosensitive tumors for which the best choice of adjuvant chemotherapy between procarbazine, lomustine, and vincristine (PCV) or temozolomide (TMZ) after radiotherapy (RT) remains unclear."4.02Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort. ( Bronniman, C; Carpentier, C; Ciron, DL; Dehais, C; Ducray, F; Esteyrie, V; Figarella-Branger, D; Martin, E; Moyal, EC; Network, P; Pouessel, D; Uro-Coste, E, 2021)
"To report clinical outcomes of temozolomide (TMZ)-based radio-chemotherapy and adjuvant chemotherapy in patients with aggressive/high-risk low-grade glioma (LGG)."4.02Upfront Therapy of Aggressive/High-Risk Low-Grade Glioma: Single-Institution Outcome Analysis of Temozolomide-Based Radio-Chemotherapy and Adjuvant Chemotherapy. ( Anand, S; Chatterjee, A; Epari, S; Goda, JS; Gupta, T; Jalali, R; Krishnatry, R; Moiyadi, A; Panda, P; Patil, V, 2021)
"This is the long-term update of NOA-08 (NCT01502241), which compared efficacy and safety of radiotherapy (RT, n = 176) and temozolomide (TMZ, n = 193) at 7/14 days in patients >65 years old with anaplastic astrocytoma or glioblastoma."3.96Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma. ( Bamberg, M; Bölting, H; Debus, J; Felsberg, J; Herrlinger, U; Hertler, C; Kessler, T; Ketter, R; Mayer-Steinacker, R; Meisner, C; Meixensberger, J; Papsdorf, K; Platten, M; Reifenberger, G; Reuss, D; Sabel, M; Sahm, F; Steinbach, JP; Vesper, J; von Deimling, A; Weisang, S; Weller, M; Weyerbrock, A; Wick, A; Wick, W, 2020)
" Here, diffusion MRI data were acquired in a GL261 glioma mouse model before and during treatment with Temozolomide."3.96Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response. ( Agliardi, G; Alexander, DC; Atkinson, D; Brandner, S; Breen-Norris, JO; d'Esposito, A; Hipwell, B; Hyare, H; Ianus, A; Lythgoe, MF; Panagiotaki, E; Punwani, S; Ramasawmy, R; Rees, J; Roberts, TA; Siow, B; Taylor, V; Walker-Samuel, S, 2020)
"Oxygen 6-methylguanine-DNA methyltransferase (MGMT) promoter methylation is a significant prognostic biomarker in astrocytomas, especially for temozolomide (TMZ) chemotherapy."3.91A multi-sequence and habitat-based MRI radiomics signature for preoperative prediction of MGMT promoter methylation in astrocytomas with prognostic implication. ( Dong, D; Gu, D; Hao, X; Tan, Y; Tian, J; Wang, L; Wang, X; Wei, J; Yang, G; Zhang, H; Zhang, S, 2019)
" However, a randomized controlled study (RTOG 9802) showed that adding of procarbazine, CCNU, and vincristine (PCV) chemotherapy to fractionated radiotherapy (FRT) in patients with "high-risk" WHO grade II gliomas, including DA, has significant positive impact on both progression-free survival and overall survival."3.88Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults. ( Narita, Y, 2018)
"A standard post-concomitant radiochemotherapy involving adjuvant temozolomide (TMZ) was stopped after 6 cycles for high-grade gliomas (HGG)."3.88Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV). ( Ho, JT; Ho, RW; Lin, WC; Lin, YJ; Lin, YT; Lu, CH; Tsai, NW; Wang, HC, 2018)
"Postoperative management of anaplastic glioma remains without a clear standard of care-in this study we report outcomes for patients treated with radiotherapy (RT) with and without temozolomide (TMZ)."3.88Outcomes for Anaplastic Glioma Treated With Radiation Therapy With or Without Concurrent Temozolomide. ( Chan, MD; Debinski, W; Farris, M; Helis, C; Laxton, AW; Lesser, GJ; Lo, HW; Lucas, JT; McTyre, E; Mott, R; Soike, M; Strowd, RE; Tatter, SB, 2018)
"MOGGCCM (anaplastic astrocytoma) and T98G (glioblastoma multiforme) cell lines incubated with sorafenib and/or Temozolomide were used in the experiments."3.85Temozolomide and sorafenib as programmed cell death inducers of human glioma cells. ( Bądziul, D; Jakubowicz-Gil, J; Langner, E; Rzeski, W; Wertel, I; Zając, A, 2017)
"Temozolomide (TMZ) for malignant gliomas is traditionally dosed in 5 out of a 28-day cycle, however alternative regimens exist, including dose-dense."3.85Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma. ( Howard, TA; Villano, JL; Zhou, Z, 2017)
"We retrospectively analyzed the data of 5 adult patients treated with temozolomide between 2008 and 2015 for a grade II intramedullary astrocytoma with progression after surgery."3.85[Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience]. ( Chaskis, E; De Witte, O; Devriendt, D; Goldman, S; Lefranc, F; Luce, S; Minichini, V; Sadeghi, N, 2017)
"To explore the efficacy and toxicity of an extended schedule of temozolomide (50 mg/mq 1 week on/1 week off) in a population of newly diagnosed low-grade gliomas (LGG)."3.85Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up. ( Carapella, CM; Carosi, M; Fabi, A; Giannarelli, D; Marucci, L; Maschio, M; Merola, R; Pace, A; Vidiri, A; Villani, V, 2017)
"It is currently unclear whether adjuvant therapy for WHO grade III anaplastic astrocytomas (AA) should be carried out as combined chemoradiotherapy with temozolomide (TMZ)--analogous to the approach for glioblastoma multiforme--or as radiotherapy (RT) alone."3.81Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience. ( Giese, A; Mayer, A; Renovanz, M; Schmidberger, H; Schwanbeck, C; Sommer, C; Stockinger, M; Vaupel, P, 2015)
" We report a retrospective multicenter study of 97 consecutive adult patients with anaplastic astrocytoma (AA) treated with radiation therapy (RT) plus concomitant and adjuvant temozolomide (TMZ) between October 2004 and March 2012."3.80IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy. ( Arcella, A; Bozzao, A; Di Stefano, D; Enrici, RM; Esposito, V; Giangaspero, F; Lanzetta, G; Minniti, G; Pace, A; Salvati, M; Scaringi, C; Scarpino, S; Villani, V, 2014)
"This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA)."3.80The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma. ( Buckner, JC; Decker, PA; Giannini, C; Hardie, J; Jenkins, RB; Kizilbash, SH; Laack, NN; Parney, IF; Uhm, JH; Voss, JS, 2014)
" honey (ESH), beebread (EBB), and royal jelly (ERJ) with and without temozolomide (TMZ) on cell lines derived from a patient with diffuse astrocytoma (DASC), human glioblastoma multiforme (U87MG), and normal human astroglia (SVGp12)."3.80The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines. ( Bartosiuk, E; Borawska, MH; Kochanowicz, J; Mariak, Z; Markiewicz-Żukowska, R; Moskwa, J; Naliwajko, SK; Socha, K; Surażyński, A, 2014)
"The aim of the present study was to investigate whether silencing of Hsp27 or Hsp72 expression in glioblastoma multiforme T98G and anaplastic astrocytoma MOGGCCM cells increases their sensitivity to programmed cell death induction upon temozolomide and/or quercetin treatment."3.79Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment. ( Bądziul, D; Jakubowicz-Gil, J; Langner, E; Rzeski, W; Wertel, I, 2013)
"Few studies have assessed the presentation, management, and outcome of anaplastic astrocytoma (AA) in elderly patients in the temozolomide era."3.78Presentation, management, and outcome of elderly patients with newly-diagnosed anaplastic astrocytoma. ( Buckner, JC; Meyer, FB; Parney, IF; Tanaka, S; Uhm, JH; Yan, ES, 2012)
"To test the effect of starvation on glioma cells in vitro, we treated primary mouse glia, murine GL26, rat C6 and human U251, LN229 and A172 glioma cells with Temozolomide in ad lib and STS mimicking conditions."3.78Fasting enhances the response of glioma to chemo- and radiotherapy. ( Brandhorst, S; Chen, TC; Conti, PS; Hwang, S; Lee, C; Longo, VD; Safdie, F; Wang, W; Wei, M, 2012)
" Here, we report on celecoxib desensitization after a celecoxib-induced skin reaction, thereby allowing the continuation of temozolomide/celecoxib chemotherapy in a young patient with recurrent astrocytoma."3.78Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity reaction. ( Burbach, GJ; Vajkoczy, P; Zuberbier, T, 2012)
"Only a few studies examined the effect of temozolomide (TMZ) in recurrent low-grade astrocytoma (LGA) after surgery, none of which included a homogeneous and sufficiently sized group of patients with progression after radiotherapy (RT)."3.77First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response. ( Boogerd, W; Bromberg, JE; Dinjens, WN; Dubbink, HJ; Gijtenbeek, JM; Groenendijk, FH; Kouwenhoven, MC; Kros, JM; Postma, TJ; Sillevis Smitt, PA; Taal, W; van den Bent, MJ; van der Holt, B; van Heuvel, I; van Marion, R; Zonnenberg, BA; Zonnenberg, CB, 2011)
"The aim of the present study was to investigate the kinetics of the effects exerted by Temodal and quercetin on the survival of the human astrocytoma MOGGCCM cell line."3.77Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells. ( Jakubowicz-Gil, J; Langner, E; Rzeski, W, 2011)
"Temozolomide, an oral alkylating agent, is a commonly used medicine in the treatment of anaplastic astrocytoma and glioblastoma multiforme."3.76Temozolomide (Temodar). ( Mukherji, SK; Rajdev, P; Wesolowski, JR, 2010)
"The aim of the present study was to investigate the effect of Temozolomide (an alkylating chemotherapeutic agent) and quercetin (natural flavonoid) on cell death in the human astrocytoma cell line MOGGCCM (WHO grade III)."3.76Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line. ( Jakubowicz-Gil, J; Langner, E; Piersiak, T; Rzeski, W; Wertel, I, 2010)
"We present a case of a 12-year-old female with a germline TP53 mutation who presented with anaplastic astrocytoma and subsequent acute lymphoblastic leukemia (ALL) 13 months after starting treatment with temozolomide (TMZ)."3.76Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation. ( Hosono, A; Makimoto, A; Miyakita, Y; Momota, H; Nariata, Y; Narita, Y; Shibui, S, 2010)
"Temozolomide is an oral alkylating agent approved for the treatment of glioblastoma and anaplastic astrocytoma, and is currently under clinical investigation for the treatment of brain metastases from a variety of cancers."3.76Urticarial hypersensitivity reaction caused by temozolomide. ( Hsu, MY; Ibrahimi, OA; Kesari, S; Pothiawala, S; Yang, C, 2010)
"Temozolomide (TMZ) is an alkylating agent used in the management of gliomas."3.75Long-term use of temozolomide: could you use temozolomide safely for life in gliomas? ( Bell, D; Khasraw, M; Wheeler, H, 2009)
" In this study, the authors investigate the nature of the SP phenotype in 2 glioma cell lines, U87MG and T98G, and their response to temozolomide."3.74Characterization of a side population of astrocytoma cells in response to temozolomide. ( Ang, BT; Chong, KH; Chua, C; See, SJ; Tang, C; Wong, MC; Zaiden, N, 2008)
"Following the resection of newly diagnosed or recurrent glioblastomas, local implantation of carmustine-impregnated biodegradable wafers (Gliadel) in the resection cavity constitutes an adjuvant therapy that can improve the possibilities of survival."3.74Fatal outcome related to carmustine implants in glioblastoma multiforme. ( Barcia, JA; Barcia-Mariño, C; Gallego, JM, 2007)
"To develop a valid treatment strategy for recurrent high-grade gliomas using stereotactic hypofractionated reirradiation based on biologic imaging and temozolomide."3.73Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy. ( Franz, M; Grosu, AL; Gumprecht, H; Molls, M; Nieder, C; Piert, M; Schwaiger, M; Stärk, S; Thamm, R; Weber, WA, 2005)
"p53 inactivation sensitizes U87MG astrocytic glioma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and temozolomide (TMZ), drugs used clinically to treat high-grade astrocytomas."3.73Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin. ( Cairncross, JG; Mymryk, JS; Xu, GW, 2005)
"We compared survival in patients with anaplastic astrocytoma (AA) treated with adjuvant procarbazine, lomustine, and vincristine (PCV) with survival in patients treated with temozolomide."3.73Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma. ( Brandes, AA; Ermani, M; Gardiman, M; Ghimenton, C; Iuzzolino, P; Nicolardi, L; Reni, M; Rotilio, A; Sotti, G; Tosoni, A, 2006)
"To assess whether the survival of patients with recurrent malignant glioma receiving temozolomide in everyday practice is comparable to that reported in previous studies."3.72Survival of patients with recurrent malignant glioma treated with temozolomide: a retrospective observational study. ( Maltoni, S; Messori, A; Pelagotti, F; Trippoli, S; Vacca, F; Vaiani, M, 2003)
"Patients with newly diagnosed anaplastic astrocytoma (AA) or anaplastic oligo-astrocytoma (AOA) were treated with concurrent radiotherapy (60 Gy over 6 weeks) and temozolomide (75 mg/m(2)), and six adjuvant 28-day cycles of either dose-dense (150 mg/m(2), days 1-7, 15-21) or metronomic (50 mg/m(2), days 1-28) temozolomide."2.80Radiotherapy and temozolomide for anaplastic astrocytic gliomas. ( Abrey, LE; Braunthal, SG; DeAngelis, LM; Huse, JT; Lassman, AB; Nayak, L; Panageas, KS; Pentsova, E; Reiner, AS, 2015)
"Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity."2.71Initial chemotherapy in gliomatosis cerebri. ( Carpentier, A; Cartalat-Carel, S; Chinot, O; Cougnard, J; Delattre, JY; Djafari, L; Duffau, H; Gervais, H; Hoang-Xuan, K; Honnorat, J; Laigle, F; Mokhtari, K; Napolitano, M; Sanson, M; Taillandier, L; Taillibert, S, 2004)
"The optimal therapy for gliomatosis cerebri is unclear, and the rate of response to chemotherapy is not known."2.71Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide. ( Gomori, JM; Levin, N; Siegal, T, 2004)
"We conducted a study to determine the dose-limiting toxicity of an extended dosing schedule of temozolomide (TMZ) when used with a fixed dose of BCNU, or 1,3-bis(2-chloroethyl)-1-nitrosourea (carmustine), taking advantage of TMZ's ability to deplete O6-alkylguanine-DNA-alkyltransferase and the synergistic activity of these two agents."2.71Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy. ( Abrey, LE; Kleber, M; Malkin, MG; Raizer, JJ, 2004)
" The recommended dosage for TEMO for a phase II study of this combination is 200 mg/m2 per day for 5 days."2.70Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas. ( Affronti, ML; Cokgor, L; Early, M; Edwards, S; Friedman, AH; Friedman, HS; Gururangan, S; Herndon, JE; McLendon, RE; Provenzale, JM; Quinn, JA; Rich, JN; Sampson, JH; Stafford-Fox, V; Tourt-Uhlig, S; Zaknoen, S, 2001)
"Temozolomide was well tolerated with little subjective toxicity and usually predictable myelosuppression and is a promising new drug in the treatment of primary brain tumours."2.67Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. ( Brampton, M; Colquhoun, IR; Glaser, MG; Illingworth, RD; Kennard, C; Lewis, P; Newlands, ES; O'Reilly, SM; Rice-Edwards, JM; Richards, PG, 1993)
"Glioblastoma multiforme is the most common and most lethal pri- mary malignant tumor of the central nervous system."2.50Astrocytoma malignum in glioblastoma multiforme vertens with long term survival--case report and a literature review. ( Bochenek-Cibor, J; Krupa, M; Moskała, M; Trojanowski, T, 2014)
"Temozolomide is a new drug which has shown promise in treating malignant gliomas and other difficult-to-treat tumors."2.45Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article. ( Beli, I; Chaldeopoulos, D; Fotineas, A; Koukourakis, GV; Kouloulias, V; Kouvaris, J; Maravelis, G; Pantelakos, P; Papadimitriou, C; Zacharias, G, 2009)
"Temozolomide is an oral alkylating cytotoxic agent of second generation, used in the treatment of high-grade gliomas."2.45[Prescription guidebook for temozolomide usage in brain tumors]. ( Borget, I; Brignone, M; Cartalat-Carel, S; Chinot, O; Hassani, Y; Taillandier, L; Taillibert, S; Tilleul, P, 2009)
"High-grade gliomas (WHO grade III anaplastic astrocytoma and grade IV glioblastoma multiforme) are the most common primary tumors in the central nervous system in adults."2.45High-grade glioma mouse models and their applicability for preclinical testing. ( Beijnen, JH; de Vries, NA; van Tellingen, O, 2009)
"Anaplastic astrocytoma is an uncommon disease in the adult population."2.44Anaplastic astrocytoma in adults. ( Gatta, G; Mazza, E; Reni, M; Stupp, R; Vecht, C, 2007)
"Leptomeningeal dissemination of juvenile pilocytic astrocytoma (JPA) is a rare event."2.43Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature. ( Aryan, HE; Bruce, DA; Levy, ML; Lu, DC; Meltzer, HS; Ozgur, BM, 2005)
"Astrocytomas are the most common primary brain tumors."2.43Treatment of astrocytomas. ( Gilbert, MR; Gonzalez, J, 2005)
"Temozolomide was effective in delaying disease progression and maintaining health-related quality of life."2.41Temozolomide in malignant gliomas. ( Yung, WK, 2000)
"Temozolomide is a novel, oral, second-generation alkylating agent."2.41Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis. ( Friedman, HS, 2000)
"Temozolomide, a new drug, has shown promise in treating malignant gliomas and other difficult-to-treat tumors."2.41Temozolomide and treatment of malignant glioma. ( Calvert, H; Friedman, HS; Kerby, T, 2000)
" For patients with recurrent malignant glioma, temozolomide provides a therapeutic option with a predictable safety profile, clinical efficacy, and convenient dosing that can provide important quality-of-life benefits."2.41Temozolomide for recurrent high-grade glioma. ( Macdonald, DR, 2001)
"Temozolomide appears to produce few serious adverse effects and may also have a positive impact on health-related quality of life."2.41A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma. ( Cave, C; Dinnes, J; Huang, S; Milne, R, 2002)
"Diffuse gliomas are a heterogeneous category of primary central nervous system tumors."1.91Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences. ( Baird, L; Beadling, C; Corless, C; Harrington, CA; Moore, S; Neff, T; Wood, MD, 2023)
"Temozolomide (TMZ) was given to 24 patients and 11 patients received TMZ plus other chemotherapies."1.91The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma. ( Alkhayyat, S; Alkhotani, A; Almansouri, M; Alshanqiti, M; Alsinani, T; Baeesa, S; Bamaga, AK; Butt, N; Enani, M; Fadul, MM; Faizo, E; Hassan, A; Karami, MM; Kurdi, M, 2023)
"Glioblastoma is the most common brain tumor."1.72 ( Balkanov, AS; Belyaev, AY; Glazkov, AA; Kobyakov, GL; Rozanov, ID; Shmakov, PN; Strunina, YV; Telysheva, EN; Usachev, DY, 2022)
"Human glioblastoma is a malignant and aggressive primary human brain solid tumor characterized by severe hypoxia."1.51The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma. ( He, X; Huang, S; Li, F; Qi, P; Zhang, T, 2019)
"Tremor is the most prevalent movement disorder."1.48Tremor Secondary to a Thalamic Glioma: A Case Report. ( Elias, WJ; Fadul, CE; Wang, TR, 2018)
"Glioblastoma (GBM) is a grade IV astrocytoma."1.46Glioblastoma entities express subtle differences in molecular composition and response to treatment. ( Balça-Silva, J; Canedo, NHS; Correia, AH; De Souza, JM; Do Carmo, A; Dubois, LG; Girão, H; Gonçalves, AC; Lopes, MC; Matias, D; Moura-Neto, V; Sarmento-Ribeiro, AB, 2017)
"A 43-year-old man with an anaplastic astrocytoma received radiation therapy synchronized with ranimustine and adjuvant TMZ chemotherapy for 15 cycles."1.46A Case of Therapy-Related Acute Myeloid Leukemia Associated with Adjuvant Temozolomide Chemotherapy for Anaplastic Astrocytoma. ( Kosugi, K; Saito, K; Takahashi, W; Tokuda, Y; Tomita, H, 2017)
"The study included 26 patients with anaplastic astrocytoma and 37 patients with glioblastoma; all patients were aged ≤18 years."1.43High-grade glioma in children and adolescents: a single-center experience. ( Akalan, N; Akyuz, C; Cengiz, M; Eren, G; Gurkaynak, M; Ozyigit, G; Varan, A; Yazici, G; Yüce, D; Zorlu, F, 2016)
"Patients with grade IV astrocytoma or glioblastoma multiforme (GBM) have a median survival of <12 months, increased to 14."1.43Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam. ( Ajit, NE; Burton, GV; El-Osta, H; Peddi, P, 2016)
"The treatment of anaplastic astrocytoma (AA) is controversial."1.40Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination. ( Canpinar, H; Castresana, JS; Ilgaz, S; Rey, JA; Sert, F; Sunguroglu, A; Taspinar, M; Ugur, HC, 2014)
"One patient with anaplastic ganglioglioma experienced confirmed partial tumor response and significant clinical improvement and she is alive 20 months after start of treatment."1.40Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas. ( Bautista, F; Dufour, C; Geoerger, B; Grill, J; Lacroix, L; Minard-Colin, V; Paci, A; Valteau-Couanet, D; Varlet, P, 2014)
"Temozolomide was used almost exclusively during CRT (94."1.39Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide. ( Cahill, D; Gilbert, MR; Lei, X; Shonka, NA; Smith, L; Theeler, B; Yung, A, 2013)
"Low-grade gliomas (e."1.39Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature. ( Brokinkel, B; Ewelt, C; Hargus, G; Heindel, W; Holling, M; Schober, O; Stummer, W; Wölfer, J, 2013)
"Temozolomide (TMZ) is an alkylating agent primarily used to treat tumors of the central nervous system."1.39Central diabetes insipidus: a previously unreported side effect of temozolomide. ( Faje, AT; Klibanski, A; Makimura, H; Miller, KK; Nachtigall, L; Wexler, D, 2013)
"The tumor was partially resected and anaplastic astrocytoma was diagnosed."1.38Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis. ( Fujimoto, Y; Hashimoto, N; Kagawa, N; Kinoshita, M; Miyazaki, Y; Takehara, T; Tanaka, S; Yakushijin, T; Yoshimine, T, 2012)
"Compared with pilocytic astrocytoma, PMA is more aggressive, has a higher rate of local recurrence, and often disseminates to the leptomeninges."1.38Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy. ( Bouffet, E; Maeda, M; Morioka, M; Sawamura, Y; Sugita, Y; Terasaki, M, 2012)
"Histological examination revealed anaplastic astrocytoma."1.38Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma. ( Hoshimaru, M; Kawanabe, Y; Kihara, S; Koizumi, T; Sasaki, N; Sawada, M; Ueda, S; Yukawa, H, 2012)
"Temozolomide is an effective treatment for seizure control in patients with brain tumors."1.37Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients. ( Hu, A; Kesari, S; Kim, RY; Lee, JW; Nguyen, A; Xu, Z, 2011)
" The aim of the present study was to evaluate the efficacy and side effects of nimotuzumab in combination with chemotherapy for patients with malignant gliomas."1.37[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas]. ( Chen, ZP; Jiang, XB; Mu, YG; Sai, K; Shen, D; Yang, QY; Zhang, XH, 2011)
"Temozolomide is a relatively new chemotherapeutic agent frequently associated with selective CD4+ T-lymphocytopenia."1.35Disseminated salmonellosis in a patient treated with temozolomide. ( Adachi, J; Georgescu, G; Isola, IM; Rolston, K; Youssef, S, 2008)
"For patients with anaplastic astrocytoma, the 12-month survival rate was 73%."1.34Salvage chemotherapy in progressive high-grade astrocytoma. ( See, SJ; Ty, A; Wong, MC, 2007)
"Temozolomide was administered at a dose of 200 mg/m(2) daily for 5 days, in a 4-week cycle."1.34Temozolomide in pediatric low-grade glioma. ( Ashley, DM; Coleman, LT; Downie, PA; Heath, JA; Khaw, SL, 2007)
"At the time of the initial disease recurrence, 13 patients were readministered TMZ."1.33Salvage temozolomide for prior temozolomide responders. ( Abrey, LE; Demopoulos, A; Franceschi, E; Lassman, AB; Nolan, C; Omuro, AM, 2005)
"Grosstotal resection of an anaplastic astrocytoma was followed by chemotherapy with temozolomide and vincristine."1.33A congenital brain tumor associated with assisted in vitro fertilization. Case report. ( Danielpour, M; Das, A; Simmons, C, 2005)

Research

Studies (197)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (3.55)18.2507
2000's74 (37.56)29.6817
2010's91 (46.19)24.3611
2020's25 (12.69)2.80

Authors

AuthorsStudies
Tesileanu, CMS2
Gorlia, T2
Golfinopoulos, V2
French, PJ2
van den Bent, MJ7
Sanson, M3
Wick, W4
Brandes, AA3
Clement, PM1
Erridge, SC1
Vogelbaum, MA2
Nowak, AK1
Baurain, JF1
Mason, WP1
Wheeler, H3
Chinot, OL3
Gill, S1
Griffin, M1
Rogers, L1
Taal, W3
Rudà, R1
Weller, M4
McBain, C1
van Linde, ME1
Aldape, K1
Jenkins, RB2
Kros, JM5
Wesseling, P1
von Deimling, A2
Hoogstrate, Y1
de Heer, I1
Atmodimedjo, PN1
Dubbink, HJ3
Brouwer, RWW1
van IJcken, WFJ1
Cheung, KJ1
Baumert, BG1
Tom, MC1
Milano, MT1
Chao, ST1
Soltys, SG1
Knisely, JPS1
Sahgal, A1
Nagpal, S1
Lo, SS1
Jabbari, S1
Wang, TJC1
Ahluwalia, MS1
Simonson, M1
Palmer, JD1
Gephart, MH1
Halasz, LM1
Garg, AK1
Chiang, VLS1
Chang, EL1
Feldheim, J1
Kessler, AF1
Feldheim, JJ1
Schulz, E1
Wend, D1
Lazaridis, L1
Kleinschnitz, C1
Glas, M2
Ernestus, RI1
Brandner, S2
Monoranu, CM1
Löhr, M1
Hagemann, C1
Jo, J1
Schiff, D3
Weller, J1
Katzendobler, S1
Blobner, J1
Thiele, F1
Becker, H1
Quach, S1
Egensperger, R1
Niyazi, M1
Suchorska, B1
Thon, N1
Tonn, JC1
Balkanov, AS1
Rozanov, ID1
Glazkov, AA1
Belyaev, AY1
Kobyakov, GL1
Shmakov, PN1
Telysheva, EN1
Strunina, YV1
Usachev, DY1
Minniti, G2
Paolini, S1
Antonelli, M1
Gianno, F1
Tini, P1
Lanzetta, G2
Arcella, A2
De Pietro, R1
Giraffa, M1
Capone, L1
Romano, A1
Bozzao, A2
Esposito, V2
Wood, MD1
Beadling, C1
Neff, T1
Moore, S1
Harrington, CA1
Baird, L1
Corless, C1
Butt, N1
Enani, M1
Alshanqiti, M1
Alkhotani, A1
Alsinani, T1
Karami, MM1
Fadul, MM1
Almansouri, M1
Hassan, A1
Baeesa, S1
Bamaga, AK1
Alkhayyat, S1
Faizo, E1
Kurdi, M1
Rautajoki, KJ1
Jaatinen, S1
Hartewig, A1
Tiihonen, AM1
Annala, M1
Salonen, I1
Valkonen, M1
Simola, V1
Vuorinen, EM1
Kivinen, A1
Rauhala, MJ1
Nurminen, R1
Maass, KK1
Lahtela, SL1
Jukkola, A1
Yli-Harja, O1
Helén, P1
Pajtler, KW1
Ruusuvuori, P1
Haapasalo, J1
Zhang, W1
Haapasalo, H2
Nykter, M2
Vaz Salgado, MA1
Torres, J1
Esteban, J1
Gutiérrez, JA1
Ley, L1
Carrato, A1
Wick, A1
Kessler, T1
Platten, M2
Meisner, C2
Bamberg, M1
Herrlinger, U2
Felsberg, J2
Weyerbrock, A1
Papsdorf, K2
Steinbach, JP3
Sabel, M2
Vesper, J2
Debus, J2
Meixensberger, J2
Ketter, R2
Hertler, C1
Mayer-Steinacker, R2
Weisang, S1
Bölting, H1
Reuss, D1
Reifenberger, G2
Sahm, F1
Candido, MF1
Baldissera, GC1
Medeiros, M1
Umezawa, K1
Brassesco, MS1
Roberts, TA1
Hyare, H1
Agliardi, G1
Hipwell, B1
d'Esposito, A1
Ianus, A1
Breen-Norris, JO1
Ramasawmy, R1
Taylor, V1
Atkinson, D1
Punwani, S1
Lythgoe, MF1
Siow, B1
Rees, J1
Panagiotaki, E1
Alexander, DC1
Walker-Samuel, S1
Yang, D1
Cheng, X1
Bu, X1
Yan, Z1
Wu, T1
Zhang, Y2
Bhawe, K1
Felty, Q1
Yoo, C1
Ehtesham, NZ1
Hasnain, SE1
Singh, VP1
Mohapatra, I1
Roy, D1
White, ML1
Kazmi, SAJ1
Aizenberg, M1
Shonka, N1
Yu, F1
Appiah, AK1
Esteyrie, V1
Dehais, C1
Martin, E1
Carpentier, C1
Uro-Coste, E1
Figarella-Branger, D2
Bronniman, C1
Pouessel, D1
Ciron, DL1
Ducray, F1
Moyal, EC1
Network, P1
Wu, J1
Yuan, Y1
Long Priel, DA1
Fink, D1
Peer, CJ1
Sissung, TM1
Su, YT1
Pang, Y1
Yu, G1
Butler, MK1
Mendoza, TR1
Vera, E1
Ahmad, S1
Bryla, C1
Lindsley, M1
Grajkowska, E1
Mentges, K1
Boris, L1
Antony, R1
Garren, N1
Siegel, C1
Lollo, N1
Cordova, C1
Aboud, O1
Theeler, BJ1
Burton, EM1
Penas-Prado, M2
Leeper, H1
Gonzales, J1
Armstrong, TS1
Calvo, KR1
Figg, WD1
Kuhns, DB1
Gallin, JI1
Gilbert, MR4
Guo, Z1
Li, D1
Xie, Y1
Qian, J1
Zhao, B1
Filppu, P1
Tanjore Ramanathan, J1
Granberg, KJ1
Gucciardo, E1
Lehti, K1
Le Joncour, V1
Laakkonen, P1
Sasaki, H1
Anand, S1
Chatterjee, A1
Gupta, T1
Panda, P1
Moiyadi, A1
Epari, S1
Patil, V1
Krishnatry, R1
Goda, JS1
Jalali, R1
Marucci, G1
Chang, SM4
Chakavarti, A1
Bell, EH2
Carroll, KT1
Hirshman, B1
Ali, MA1
Alattar, AA1
Brandel, MG1
Lochte, B1
Lanman, T1
Carter, B1
Chen, CC1
Trogrlić, I1
Trogrlić, D1
Trogrlić, Z1
Jakubowicz-Gil, J4
Bądziul, D2
Langner, E4
Wertel, I3
Zając, A1
Rzeski, W4
Balça-Silva, J1
Matias, D1
Do Carmo, A1
Dubois, LG1
Gonçalves, AC1
Girão, H1
Canedo, NHS1
Correia, AH1
De Souza, JM1
Sarmento-Ribeiro, AB1
Lopes, MC1
Moura-Neto, V1
Zhou, Z1
Howard, TA1
Villano, JL1
Takai, K1
Tanaka, S3
Sota, T1
Mukasa, A1
Komori, T1
Taniguchi, M1
Chaskis, E1
Minichini, V1
Luce, S1
Devriendt, D1
Goldman, S1
De Witte, O1
Sadeghi, N1
Lefranc, F1
Wang, TR1
Fadul, CE1
Elias, WJ1
Hayashi, S1
Akao, N1
Nakazato, Y1
Okamoto, K1
Puduvalli, VK1
Hoang, N1
Narita, Y2
Wang, HC1
Lin, YT1
Lin, WC1
Ho, RW1
Lin, YJ1
Tsai, NW1
Ho, JT2
Lu, CH1
Wei, J1
Yang, G1
Hao, X1
Gu, D1
Tan, Y1
Wang, X1
Dong, D1
Zhang, S1
Wang, L1
Zhang, H1
Tian, J1
Fortunato, JT1
Reys, B1
Singh, P1
Pan, E1
Thompson, EM1
Landi, D1
Ashley, D1
Keir, ST1
Bigner, D1
Huang, S2
Qi, P1
Zhang, T1
Li, F1
He, X1
Aghajan, Y1
Malicki, DM1
Levy, ML2
Crawford, JR1
Back, M1
Jayamanne, D1
Brazier, D1
Newey, A1
Bailey, D1
Schembri, G1
Hsiao, E1
Khasraw, M2
Wong, M1
Kastelan, M1
Brown, C1
Carabenciov, ID1
Bhargav, AG1
Uhm, JH3
Ruff, MW1
Katayama, K1
Asano, K1
Shimamura, N1
Ogasawara, Y1
Naraoka, M1
Ohkuma, H1
Kurose, A1
Shonka, NA1
Theeler, B1
Cahill, D1
Yung, A1
Smith, L1
Lei, X1
Sun, J1
Yang, XJ1
Yang, SY1
Brokinkel, B1
Schober, O1
Ewelt, C1
Heindel, W1
Hargus, G1
Stummer, W1
Holling, M1
Wölfer, J1
Faje, AT1
Nachtigall, L1
Wexler, D1
Miller, KK1
Klibanski, A1
Makimura, H1
Takeshi, N1
Kazuhiko, S1
Koji, I1
Toshikazu, H1
Kaoru, K1
Habets, EJ1
Taphoorn, MJ2
Nederend, S1
Klein, M1
Delgadillo, D1
Hoang-Xuan, K3
Bottomley, A1
Allgeier, A2
Seute, T1
Gijtenbeek, AM1
de Gans, J1
Enting, RH3
Tijssen, CC1
Reijneveld, JC1
Ugur, HC1
Taspinar, M1
Ilgaz, S1
Sert, F1
Canpinar, H1
Rey, JA1
Castresana, JS1
Sunguroglu, A1
Bautista, F1
Paci, A1
Minard-Colin, V1
Dufour, C1
Grill, J1
Lacroix, L1
Varlet, P1
Valteau-Couanet, D1
Geoerger, B1
Capdevila, L1
Cros, S1
Ramirez, JL1
Sanz, C1
Carrato, C1
Romeo, M1
Etxaniz, O1
Hostalot, C1
Massuet, A1
Cuadra, JL1
Villà, S1
Balañà, C1
Scaringi, C1
Di Stefano, D1
Scarpino, S1
Pace, A2
Villani, V2
Salvati, M1
Giangaspero, F1
Enrici, RM1
Kizilbash, SH1
Giannini, C2
Voss, JS1
Decker, PA1
Hardie, J1
Laack, NN2
Parney, IF2
Buckner, JC3
Voellger, B1
Tapia-Perez, JH1
Rupa, R1
Karagiannis, D1
Mawrin, C1
Kirches, E1
Schneider, T1
Aiken, RD1
Byrne, RW1
Ajlan, A1
Recht, L1
Lee, SY1
Slagle-Webb, B1
Rizk, E1
Patel, A1
Miller, PA1
Sung, SS1
Connor, JR1
Borawska, MH1
Markiewicz-Żukowska, R1
Naliwajko, SK1
Moskwa, J1
Bartosiuk, E1
Socha, K1
Surażyński, A1
Kochanowicz, J1
Mariak, Z1
Bochenek-Cibor, J1
Krupa, M1
Moskała, M1
Trojanowski, T1
Chamberlain, MC5
Xu, DS1
Rosenfeld, A1
Ponce, FA1
Nakaji, P1
Bhardwaj, RD1
Kazda, T1
Pospisil, P1
Vrzal, M1
Sevela, O1
Prochazka, T1
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Clinical Trials (19)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase III Trial on Concurrent and Adjuvant Temozolomide Chemotherapy in Non-1p/19q Deleted Anaplastic Glioma. The CATNON Intergroup Trial.[NCT00626990]Phase 3751 participants (Actual)Interventional2007-12-31Active, not recruiting
Temozolomid (One Week on/One Week Off) Versus Strahlentherapie in Der Primärtherapie Anaplastischer Astrozytome Und Glioblastome Bei älteren Patienten: Eine Randomisierte Phase III-Studie (Methvsalem)[NCT01502241]Phase 3412 participants (Actual)Interventional2005-01-31Completed
A Phase I/II Study of Zotiraciclib for Recurrent High-Grade Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations[NCT05588141]Phase 1/Phase 296 participants (Anticipated)Interventional2023-05-16Recruiting
A Phase II Trial Of Pre-Irradiation And Concurrent Temozolomide In Patients With Newly Diagnosed Anaplastic Oligodendrogliomas And Mixed Anaplastic Oligoastrocytomas[NCT00033280]Phase 242 participants (Actual)Interventional2002-07-31Completed
Temozolomide Plus Bevacizumab Chemotherapy in Supratentorial Glioblastoma in 70 Years and Older Patients With an Impaired Functional Status (KPS<70)[NCT02898012]Phase 270 participants (Actual)Interventional2010-10-31Completed
A Feasibility Pilot Trial Evaluating Caloric Restriction for Oncology Research in Early Stage Breast Cancer Patients[NCT01819233]38 participants (Actual)Interventional2013-03-08Completed
Can Fasting Decrease the Side Effects of Chemotherapy?[NCT04027478]39 participants (Anticipated)Interventional2019-09-01Enrolling by invitation
A Phase III Randomized Study (Phase I Closed) of Radiation Therapy and Temozolomide Versus Radiation Therapy and Nitrosourea for Anaplastic Astrocytoma And Mixed Anaplastic Oligoastrocytoma (Astrocytoma Dominant)[NCT00004259]Phase 3230 participants (Actual)Interventional2000-06-30Completed
A Phase 2a Study of the Addition of Temozolomide to a Standard Conditioning Regimen for Autologous Stem Cell Transplantation in Relapsed and Refractory Central Nervous System (CNS) Lymphoma[NCT01235793]Phase 211 participants (Actual)Interventional2010-10-14Terminated (stopped due to The clinical trial was terminated due to poor enrollment)
A Pilot Study Investigating Neoadjuvant Temozolomide-based Proton Chemoradiotherapy for High-Risk Soft Tissue Sarcomas[NCT00881595]Phase 20 participants (Actual)Interventional2009-02-28Withdrawn (stopped due to No patients accrued since study opened)
Amino-acid PET Versus MRI Guided Re-irradiation in Patients With Recurrent Glioblastoma Multiforme - a Randomised Phase II Trial[NCT01252459]Phase 2200 participants (Anticipated)Interventional2011-07-31Not yet recruiting
Role of Repeat Resection in Recurrent Glioblastoma (4rGBM) Trial: a Randomized Care Trial for Patients With Recurrent GBM[NCT04838782]250 participants (Anticipated)Interventional2021-08-26Recruiting
A Phase II Study in Relapsing Glioblastoma of Intraarterial Concurrent Chemoradiation Therapy Using IA Carboplatin[NCT03672721]Phase 1/Phase 235 participants (Anticipated)Interventional2018-07-10Recruiting
A Phase II Study of Temozolomide in the Treatment of Children With High Grade Glioma[NCT00028795]Phase 2170 participants (Actual)Interventional2002-12-31Completed
An International, Randomized, Open-label Phase I/II Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Adult Patients With Recurrent or Refractory Medulloblastomas Presenting an Activation of the Sonic Hedgehog (SHH) Pathway[NCT01601184]Phase 1/Phase 224 participants (Actual)Interventional2012-06-30Terminated (stopped due to The number of successes is not reached at the end of first stage of the phase II. The study is stopped.)
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas[NCT01837862]Phase 1/Phase 236 participants (Anticipated)Interventional2013-10-22Recruiting
Phase II Study of Gamma Knife Radiosurgery and Temozolomide (Temodar) for Newly Diagnosed Brain Metastases[NCT00582075]Phase 225 participants (Actual)Interventional2002-07-31Completed
A Phase I Study of ABT-888, an Oral Inhibitor of Poly(ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors[NCT00994071]Phase 19 participants (Actual)Interventional2009-09-22Completed
The Efficacy and Safety of Temozolomide in Patients With Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: a Multicenter, Single-arm, Phase II Trial[NCT01847235]Phase 223 participants (Actual)Interventional2013-05-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Overall Survival as Measured From the Day of Randomization

The duration of survival is the time interval between randomization and the date of death due to any cause. Patients not reported dead or lost to follow up will be censored at the date of the last follow up examination. (NCT00626990)
Timeframe: from date from enrollment till the date of death (time till death is up to 10.9 years after patient enrollment in the study)

InterventionMonths (Median)
Absence of Concomitant Temozolomide (TMZ)60.42
Presence of Concomitant Temozolomide (TMZ)66.92
Absence of Adjuvant Temozolomide (TMZ)46.92
Presence of Adjuvant Temozolomide (TMZ)82.33

Progression-free Survival

Disease progression is defined as radiological or neurological/clinical progression (whichever occurs first); progression free survival (PFS) is the time interval between the date of randomization and the date of disease progression or death whichever occurs first. If neither event has been observed, the patient is censored at the date of the last follow up examination. Radiological progression was defined as increase of contrast enhancing area on MRI or CT scans of more than 25% as measured by two perpendicular diameters compared to the smallest measurements ever recorded for the same lesion by the same technique. The appearance of new lesions with or without contrast enhancement Neurological/clinical progression was defined as:decrease in WHO performance status,deterioration of neurological functions,appearance of signs/symptoms of increased intracranial pressure,and/or start of corticosteroid or increase of corticosteroid dosage by 50% for control of neurological symptoms. (NCT00626990)
Timeframe: from randomization till the date of disease progression or death (time till death is up to 10.9 years after patient enrollment in the study)

InterventionMonths (Median)
Absence of Concomitant TMZ20.9
Presence of Concomitant TMZ33.02
Absence of Adjuvant TMZ19.09
Presence of Adjuvant TMZ42.81

Change in Body Fat Measurement

Analyzed via a paired t-test. Change in body fat measurement as determined by the Durnin-Womersley 4-fold technique (NCT01819233)
Timeframe: Baseline to 4 weeks after completion of study

Interventionpercentage of change in body fat (Mean)
Behavioral Dietary Intervention-3.1

Change in Body Mass Index (BMI)

Assessed via mixed-effects regression. Weight changes over time assessed by modeling BMI as a function of time (NCT01819233)
Timeframe: Baseline to 4 weeks after completion of study

Interventionpercentage of change in BMI (Mean)
Behavioral Dietary Intervention-1.2

Change in Heart Rate Over Time

Assessed via mixed-effects regression. (NCT01819233)
Timeframe: Baseline to 4 weeks after completion of study

Interventionbeats per minute (Mean)
Behavioral Dietary Intervention67.3

Distant Metastases

Analyzed via survival methods, specifically the Kaplan-Meier method and the logrank test. (NCT01819233)
Timeframe: Up to 4 weeks after completion of study

InterventionParticipants (Count of Participants)
Behavioral Dietary InterventionNA

Local Recurrence

Analyzed via survival methods, specifically the Kaplan-Meier method and the logrank test. (NCT01819233)
Timeframe: Up to 4 weeks after completion of study

InterventionParticipants (Count of Participants)
Behavioral Dietary InterventionNA

Number of Participants Who Are Adherent to the Diet Restriction

Computed along with a 95% exact confidence interval. Exact binomial test (with a one-sided alpha of 0.05) will be used to test whether adherence is greater than 60%. (NCT01819233)
Timeframe: Up to week 12

Interventionparticipants (Number)
Behavioral Dietary Intervention28

Overall Survival

Analyzed via survival methods, specifically the Kaplan-Meier method and the logrank test. (NCT01819233)
Timeframe: Up to 4 weeks after completion of study

InterventionParticipants (Count of Participants)
Behavioral Dietary InterventionNA

Patterns of Change Over Time in Psycho-social Outcomes Measured Using the Functional Assessment of Cancer Therapy-Breast (FACT-B)

Assessed via mixed-effects regression. The FACT-B is a questionnaire using a 5-point Likert scale (0-Not at all to 4-Very much) (NCT01819233)
Timeframe: Baseline to 4 weeks after completion of study

Interventionscore on a scale (Mean)
Behavioral Dietary Intervention0.8

Progression Free Survival

Analyzed via survival methods, specifically the Kaplan-Meier method and the logrank test. (NCT01819233)
Timeframe: Up to 4 weeks after completion of study

InterventionParticipants (Count of Participants)
Behavioral Dietary InterventionNA

(Phase III) Overall Survival (OS)

Survival time is defined as time from randomization to date of death from any cause and is estimated by the Kaplan-Meier method. Patients last known to be alive are censored at the date of last contact. Per the protocol, the pilot arms were not included in the Phase III analyses. (NCT00004259)
Timeframe: From randomization to date of death. Patients are followed until death. Analysis occurs after 155 deaths have been reported, estimated at 5.5 years from the study opening.

Interventionyears (Median)
Radiation Therapy + Temozolomide (TMZ)3.9
RT + BCNU/CCNU3.8

(Phase III) Progression-free Survival by MGMT Status

Progression is defined as a radiographic increase in size of the lesion by > 25%, recurrence of the study lesion, or the development of new lesions, confirmed by imaging. Progression-free survival time is defined as time from randomization to date of progression or death from any cause and is estimated by the Kaplan-Meier method. Patients last known to be alive are censored at the date of last contact. Tumor tissue samples were analyzed for methylation status of methyl guanine methyl transferase (MGMT), classified as methylated vs. unmethylated. (NCT00004259)
Timeframe: From randomization to date of death. Patients are followed until death. Analysis occurs after 155 deaths have been reported, estimated at 5.5 years from the study opening.

Interventionyears (Median)
Methylated MGMT4.0
Unmthylated MGMT2.1

(Phase III) Survival Time by MGMT Status

Survival time is defined as time from randomization to date of death from any cause and is estimated by the Kaplan-Meier method. Patients last known to be alive are censored at the date of last contact. Tumor tissue samples were analyzed for methylation status of methyl guanine methyl transferase (MGMT), classified as methylated vs. unmethylated. (NCT00004259)
Timeframe: From randomization to date of death. Patients are followed until death. Analysis occurs after 155 deaths have been reported, estimated at 5.5 years from the study opening.

Interventionyears (Median)
Methylated MGMT7.2
Unmthylated MGMT3.1

(Phase III) Time to Tumor Progression (TTP)

Three-year rate is reported. Progression is defined as a radiographic increase in size of the lesion by > 25%, recurrence of the study lesion, or the development of new lesions, confirmed by imaging. Time to tumor progression was estimated using the cumulative incidence function (CIF) on tumor progression, with death as a competing risk. Per the protocol, the pilot arms were not included in the Phase III analyses. (NCT00004259)
Timeframe: From randomization to date of death. Patients are followed until death. Analysis occurs after 155 deaths have been reported, estimated at 5.5 years from the study opening.

Interventionmonths (Median)
Radiation Therapy + Temozolomide (TMZ)45.4
RT + BCNU/CCNU54.7

(Phase I) Number of Subjects With Dose Limiting Toxicities (DLT) on the Two Pilot Arms

Adverse events were graded using CTCAE v2.0. Grade refers to the severity of the adverse event (AE). The CTCAE v2.0 assigns Grades 1 through 5 with unique clinical descriptions of severity for each AE based on this general guideline: Grade 1 Mild AE, Grade 2 Moderate AE, Grade 3 Severe AE, Grade 4 Life-threatening or disabling AE, Grade 5 Death related to AE. Dose limiting toxicity (DLT) was defined as grade 3+ pulmonary toxicity, grade 4+ thrombocytopenia (< 25,000 for 5 days), neutropenia (< 500/microl for 7 days), or neutropenia of any duration with fever requiring hospital admission after one dose reduction of 50% in BCNU. A 20% rate of grade 3+ pulmonary toxicities or a 40% rate of grade 4+ thrombocytopenia and neutropenia was considered unacceptable for a treatment arm combining RT, TMZ, and BCNU. (NCT00004259)
Timeframe: From start of treatment to 3 months

,
InterventionParticipants (Count of Participants)
Subjects with Pulmonary DLTSubjects with Hematologic DLT
Pilot Arm #1: RT+TMZ+BCNU14
Pilot Arm #2: RT+TMZ+BCNU03

(Phase III) Number of Patients With Grade 3 or Higher Toxicity

Adverse events were graded using CTCAE v2.0. Grade refers to the severity of the AE. The CTCAE v2.0 assigns Grades 1 through 5 with unique clinical descriptions of severity for each AE based on this general guideline: Grade 1 Mild AE, Grade 2 Moderate AE, Grade 3 Severe AE, Grade 4 Life-threatening or disabling AE, Grade 5 Death related to AE. The number of patients with grade or higher toxicity was calculated overall and for non-hematologic toxicity only. Per the protocol, the pilot arms were not included in the Phase III analyses. (NCT00004259)
Timeframe: From randomization to date of death. Patients are followed until death. Analysis occurs after 155 deaths have been reported, estimated at 5.5 years from the study opening.

,
Interventionparticipants (Number)
Overall toxicityNon-hematologic toxicity
Radiation Therapy + Temozolomide (TMZ)4631
RT + BCNU/CCNU7534

Safest Dose of Temozolomide for the DRBEAT Regimen

Safety will be assessed using a dose escalation design for temozolomide's use to determine the target dose and also to evaluate any and all acute treatment related toxicities. During the course of patient follow up and therapy, toxicities will be evaluated, particularly as the investigators will be determining the target dose of temozolomide. One of the major criteria for dose limiting toxicity for the study will be any Grade 3 or 4 nonhematologic toxicity from a list of commonly expected toxicities associated with autologous transplantation and temozolomide. (NCT01235793)
Timeframe: One Year

Interventiondose in mg/m^2 (Number)
DRBEAT Regimen773.25

One-year Progression-free Survival and Overall Survival

"Efficacy of the DRBEAT Regimen will be assessed by analysis of~one-year progression-free survival (PFS), defined as the time interval from maximal response from therapy to tumor regrowth, progression*, or death, (*Progression is defined as meeting the response criteria listed in Table 4: Response Criteria for Primary Central Nervous System Lymphoma according to Abrey LE, Batchelor TT, Ferreri AJM et al.)~and~Overall survival, defined as the time interval between the date of transplant and the date of death from any cause." (NCT01235793)
Timeframe: (1) One Year (2) Until date of death from any cause, assessed up to 2 years

InterventionDays (Median)
Progression Free SurvivalOverall Survival
DRBEAT Regimen132564

Overall Survival

(NCT00582075)
Timeframe: 2 years

Interventionweeks (Median)
Radiosurgery 15-24 Gy + Adjuvant Temozolomide31

Percentage of Participants With Distant Brain Failure (DBF) at One Year

Patients developing distant brain failure (DBF) at one year. An approximation method was used to arrive at the reported percentage. (NCT00582075)
Timeframe: 1 years

Interventionpercentage of participants (Number)
Radiosurgery 15-24 Gy + Adjuvant Temozolomide37

Reviews

30 reviews available for temozolomide and Astrocytoma

ArticleYear
Executive summary of American Radium Society's appropriate use criteria for the postoperative management of lower grade gliomas.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2022, Volume: 170

    Topics: Astrocytoma; Brain Neoplasms; Glioma; Humans; Oligodendroglioma; Radium; Temozolomide

2022
Executive summary of American Radium Society's appropriate use criteria for the postoperative management of lower grade gliomas.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2022, Volume: 170

    Topics: Astrocytoma; Brain Neoplasms; Glioma; Humans; Oligodendroglioma; Radium; Temozolomide

2022
Current Considerations in the Treatment of Grade 3 Gliomas.
    Current treatment options in oncology, 2022, Volume: 23, Issue:9

    Topics: Astrocytoma; Brain Neoplasms; Glioma; Humans; Isocitrate Dehydrogenase; Lymphoma, Follicular; Mutati

2022
Current Considerations in the Treatment of Grade 3 Gliomas.
    Current treatment options in oncology, 2022, Volume: 23, Issue:9

    Topics: Astrocytoma; Brain Neoplasms; Glioma; Humans; Isocitrate Dehydrogenase; Lymphoma, Follicular; Mutati

2022
Secondary cerebellopontine angle oligodendroglioma after cranial irradiation: a case report and literature review.
    The International journal of neuroscience, 2023, Volume: 133, Issue:4

    Topics: Adult; Astrocytoma; Cerebellopontine Angle; Cranial Irradiation; Humans; Magnetic Resonance Imaging;

2023
Secondary cerebellopontine angle oligodendroglioma after cranial irradiation: a case report and literature review.
    The International journal of neuroscience, 2023, Volume: 133, Issue:4

    Topics: Adult; Astrocytoma; Cerebellopontine Angle; Cranial Irradiation; Humans; Magnetic Resonance Imaging;

2023
Chemotherapy of High-Grade Astrocytomas in Adults.
    Progress in neurological surgery, 2018, Volume: 31

    Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Neoplasm Grading; Te

2018
Chemotherapy of High-Grade Astrocytomas in Adults.
    Progress in neurological surgery, 2018, Volume: 31

    Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Glioblastoma; Glioma; Humans; Neoplasm Grading; Te

2018
Supratentorial low-grade diffuse astrocytoma: medical management.
    Seminars in oncology, 2014, Volume: 41, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Dacarbazine; Disease Progression; Humans; Neoplasm Grading; Nitr

2014
Supratentorial low-grade diffuse astrocytoma: medical management.
    Seminars in oncology, 2014, Volume: 41, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Dacarbazine; Disease Progression; Humans; Neoplasm Grading; Nitr

2014
Astrocytoma malignum in glioblastoma multiforme vertens with long term survival--case report and a literature review.
    Przeglad lekarski, 2014, Volume: 71, Issue:8

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant;

2014
Astrocytoma malignum in glioblastoma multiforme vertens with long term survival--case report and a literature review.
    Przeglad lekarski, 2014, Volume: 71, Issue:8

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant;

2014
Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article.
    Molecules (Basel, Switzerland), 2009, Apr-16, Volume: 14, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbaz

2009
Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy; a review article.
    Molecules (Basel, Switzerland), 2009, Apr-16, Volume: 14, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbaz

2009
[Prescription guidebook for temozolomide usage in brain tumors].
    Bulletin du cancer, 2009, Volume: 96, Issue:5

    Topics: Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Admi

2009
[Prescription guidebook for temozolomide usage in brain tumors].
    Bulletin du cancer, 2009, Volume: 96, Issue:5

    Topics: Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Admi

2009
High-grade glioma mouse models and their applicability for preclinical testing.
    Cancer treatment reviews, 2009, Volume: 35, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biomark

2009
High-grade glioma mouse models and their applicability for preclinical testing.
    Cancer treatment reviews, 2009, Volume: 35, Issue:8

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biomark

2009
Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas.
    International journal of radiation oncology, biology, physics, 2010, Oct-01, Volume: 78, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

2010
Simultaneous integrated boost intensity-modulated radiotherapy in patients with high-grade gliomas.
    International journal of radiation oncology, biology, physics, 2010, Oct-01, Volume: 78, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

2010
Bevacizumab as a treatment option for radiation-induced cerebral necrosis.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2011, Volume: 187, Issue:2

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic A

2011
Bevacizumab as a treatment option for radiation-induced cerebral necrosis.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2011, Volume: 187, Issue:2

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic A

2011
Recent developments in the molecular characterization and treatment of oligodendroglial tumors.
    Neuro-oncology, 2003, Volume: 5, Issue:2

    Topics: Animals; Astrocytoma; Clinical Trials as Topic; Dacarbazine; Humans; Oligodendroglioma; Temozolomide

2003
Recent developments in the molecular characterization and treatment of oligodendroglial tumors.
    Neuro-oncology, 2003, Volume: 5, Issue:2

    Topics: Animals; Astrocytoma; Clinical Trials as Topic; Dacarbazine; Humans; Oligodendroglioma; Temozolomide

2003
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2005, Volume: 21, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Arachnoid Cysts; Astrocytoma; Brain Neoplasms; Child; Child, Pres

2005
Management of pilocytic astrocytoma with diffuse leptomeningeal spread: two cases and review of the literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2005, Volume: 21, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Arachnoid Cysts; Astrocytoma; Brain Neoplasms; Child; Child, Pres

2005
Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.
    Journal of neuro-oncology, 2005, Volume: 71, Issue:3

    Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosomes,

2005
Treatment-related myelodysplastic syndrome after temozolomide for recurrent high-grade glioma.
    Journal of neuro-oncology, 2005, Volume: 71, Issue:3

    Topics: Acute Disease; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosomes,

2005
[New place of the chemotherapy in gliomas].
    Bulletin du cancer, 2005, Volume: 92, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Tr

2005
[New place of the chemotherapy in gliomas].
    Bulletin du cancer, 2005, Volume: 92, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Clinical Tr

2005
[Chemotherapy for gliomas in children].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brai

2005
[Chemotherapy for gliomas in children].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 9

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brai

2005
Treatment of astrocytomas.
    Current opinion in neurology, 2005, Volume: 18, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Therapy; Humans;

2005
Treatment of astrocytomas.
    Current opinion in neurology, 2005, Volume: 18, Issue:6

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Drug Therapy; Humans;

2005
Recent advances in the treatment of malignant astrocytoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Mar-10, Volume: 24, Issue:8

    Topics: Antineoplastic Agents; Astrocytoma; Central Nervous System Neoplasms; Combined Modality Therapy; Dac

2006
Recent advances in the treatment of malignant astrocytoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2006, Mar-10, Volume: 24, Issue:8

    Topics: Antineoplastic Agents; Astrocytoma; Central Nervous System Neoplasms; Combined Modality Therapy; Dac

2006
The role of chemotherapy in the treatment of malignant astrocytomas.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2006, Volume: 33, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Proto

2006
The role of chemotherapy in the treatment of malignant astrocytomas.
    The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2006, Volume: 33, Issue:2

    Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Proto

2006
Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?
    Critical reviews in oncology/hematology, 2006, Volume: 60, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carcinoma; Chemotherapy, Adjuvant;

2006
Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?
    Critical reviews in oncology/hematology, 2006, Volume: 60, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carcinoma; Chemotherapy, Adjuvant;

2006
[Glioma therapy up-date].
    Neurologia (Barcelona, Spain), 2007, Volume: 22, Issue:3

    Topics: Anticoagulants; Anticonvulsants; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemothe

2007
[Glioma therapy up-date].
    Neurologia (Barcelona, Spain), 2007, Volume: 22, Issue:3

    Topics: Anticoagulants; Anticonvulsants; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemothe

2007
Anaplastic astrocytoma in adults.
    Critical reviews in oncology/hematology, 2007, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical T

2007
Anaplastic astrocytoma in adults.
    Critical reviews in oncology/hematology, 2007, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical T

2007
Diagnosis and treatment of high-grade astrocytoma.
    Neurologic clinics, 2007, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Brachytherapy; Brain Neoplasms; Dacarbazine; Diagnosis, Differen

2007
Diagnosis and treatment of high-grade astrocytoma.
    Neurologic clinics, 2007, Volume: 25, Issue:4

    Topics: Antineoplastic Agents; Astrocytoma; Brachytherapy; Brain Neoplasms; Dacarbazine; Diagnosis, Differen

2007
[Recent advances in chemotherapy for malignant gliomas].
    No shinkei geka. Neurological surgery, 2008, Volume: 36, Issue:2

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Repair; Glioma; Humans; Meta-A

2008
[Recent advances in chemotherapy for malignant gliomas].
    No shinkei geka. Neurological surgery, 2008, Volume: 36, Issue:2

    Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Repair; Glioma; Humans; Meta-A

2008
Temozolomide in malignant gliomas.
    Seminars in oncology, 2000, Volume: 27, Issue:3 Suppl 6

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazi

2000
Temozolomide in malignant gliomas.
    Seminars in oncology, 2000, Volume: 27, Issue:3 Suppl 6

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazi

2000
Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis.
    Seminars in oncology, 2000, Volume: 27, Issue:3 Suppl 6

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic;

2000
Temozolomide in early stages of newly diagnosed malignant glioma and neoplastic meningitis.
    Seminars in oncology, 2000, Volume: 27, Issue:3 Suppl 6

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic;

2000
Temozolomide and treatment of malignant glioma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:7

    Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Gliobl

2000
Temozolomide and treatment of malignant glioma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2000, Volume: 6, Issue:7

    Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Gliobl

2000
Temozolomide for recurrent high-grade glioma.
    Seminars in oncology, 2001, Volume: 28, Issue:4 Suppl 13

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Central Nervous System Neoplasms; Clinical Trials as

2001
Temozolomide for recurrent high-grade glioma.
    Seminars in oncology, 2001, Volume: 28, Issue:4 Suppl 13

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Central Nervous System Neoplasms; Clinical Trials as

2001
A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma.
    British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazi

2002
A rapid and systematic review of the effectiveness of temozolomide for the treatment of recurrent malignant glioma.
    British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Dacarbazi

2002

Trials

35 trials available for temozolomide and Astrocytoma

ArticleYear
Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 06-13, Volume: 28, Issue:12

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA M

2022
Temozolomide and Radiotherapy versus Radiotherapy Alone in Patients with Glioblastoma, IDH-wildtype: Post Hoc Analysis of the EORTC Randomized Phase III CATNON Trial.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 06-13, Volume: 28, Issue:12

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; DNA Methylation; DNA M

2022
Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2021, 06-15, Volume: 27, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bayes Theorem; Brain Neoplasms; Dacarba

2021
Phase I Study of Zotiraciclib in Combination with Temozolomide for Patients with Recurrent High-grade Astrocytomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2021, 06-15, Volume: 27, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bayes Theorem; Brain Neoplasms; Dacarba

2021
[Multicenter randomized controlled study of temozolomide versus semustine in the treatment of recurrent malignant glioma].
    Zhonghua yi xue za zhi, 2013, Jan-15, Volume: 93, Issue:3

    Topics: Adult; Astrocytoma; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Neoplasm R

2013
[Multicenter randomized controlled study of temozolomide versus semustine in the treatment of recurrent malignant glioma].
    Zhonghua yi xue za zhi, 2013, Jan-15, Volume: 93, Issue:3

    Topics: Adult; Astrocytoma; Dacarbazine; Female; Glioblastoma; Glioma; Humans; Male; Middle Aged; Neoplasm R

2013
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.
    Journal of neuro-oncology, 2014, Volume: 117, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2014
Neoadjuvant cisplatin plus temozolomide versus standard treatment in patients with unresectable glioblastoma or anaplastic astrocytoma: a differential effect of MGMT methylation.
    Journal of neuro-oncology, 2014, Volume: 117, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2014
Radiotherapy and temozolomide for anaplastic astrocytic gliomas.
    Journal of neuro-oncology, 2015, Volume: 123, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Chemoradiotherapy; Cohort Studies; Daca

2015
Radiotherapy and temozolomide for anaplastic astrocytic gliomas.
    Journal of neuro-oncology, 2015, Volume: 123, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Chemoradiotherapy; Cohort Studies; Daca

2015
Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas.
    Cancer, 2016, Feb-15, Volume: 122, Issue:4

    Topics: Adult; Aged; Alanine Transaminase; Anilides; Antineoplastic Combined Chemotherapy Protocols; Asparta

2016
Phase 1 dose escalation trial of the safety and pharmacokinetics of cabozantinib concurrent with temozolomide and radiotherapy or temozolomide after radiotherapy in newly diagnosed patients with high-grade gliomas.
    Cancer, 2016, Feb-15, Volume: 122, Issue:4

    Topics: Adult; Aged; Alanine Transaminase; Anilides; Antineoplastic Combined Chemotherapy Protocols; Asparta

2016
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2016
The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
    Journal of neuro-oncology, 2016, Volume: 127, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2016
Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813.
    Neuro-oncology, 2017, 02-01, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarke

2017
Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813.
    Neuro-oncology, 2017, 02-01, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarke

2017
Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131.
    Neuro-oncology, 2009, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Astrocytoma; Brain Neoplasms; Chromosome

2009
Phase II trial of preirradiation and concurrent temozolomide in patients with newly diagnosed anaplastic oligodendrogliomas and mixed anaplastic oligoastrocytomas: RTOG BR0131.
    Neuro-oncology, 2009, Volume: 11, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Astrocytoma; Brain Neoplasms; Chromosome

2009
Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies.
    International journal of radiation oncology, biology, physics, 2009, Jun-01, Volume: 74, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Boronic Acids; Bortezomib; Central Nerv

2009
Phase I trial using proteasome inhibitor bortezomib and concurrent temozolomide and radiotherapy for central nervous system malignancies.
    International journal of radiation oncology, biology, physics, 2009, Jun-01, Volume: 74, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Boronic Acids; Bortezomib; Central Nerv

2009
IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.
    Neurology, 2009, Nov-24, Volume: 73, Issue:21

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cohort Studies; Dacarbazine;

2009
IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.
    Neurology, 2009, Nov-24, Volume: 73, Issue:21

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cohort Studies; Dacarbazine;

2009
The outcomes of concomitant radiation plus temozolomide followed by adjuvant temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study.
    Journal of the Egyptian National Cancer Institute, 2009, Volume: 21, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2009
The outcomes of concomitant radiation plus temozolomide followed by adjuvant temozolomide for newly diagnosed high grade gliomas: the preliminary results of single center prospective study.
    Journal of the Egyptian National Cancer Institute, 2009, Volume: 21, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant

2009
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
    Cancer, 2012, Oct-01, Volume: 118, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother

2012
Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.
    Cancer, 2012, Oct-01, Volume: 118, Issue:19

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemother

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Temozolomide chemotherapy alone versus radiotherapy alone for malignant astrocytoma in the elderly: the NOA-08 randomised, phase 3 trial.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazin

2012
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
    British journal of cancer, 2003, Jul-21, Volume: 89, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astro

2003
Phase I study of temozolamide (TMZ) combined with procarbazine (PCB) in patients with gliomas.
    British journal of cancer, 2003, Jul-21, Volume: 89, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astro

2003
A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytoma and glioblastoma multiforme.
    International journal of clinical oncology, 2003, Volume: 8, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease Progres

2003
A first feasibility study of temozolomide for Japanese patients with recurrent anaplastic astrocytoma and glioblastoma multiforme.
    International journal of clinical oncology, 2003, Volume: 8, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease Progres

2003
Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors.
    International journal of radiation oncology, biology, physics, 2004, Jul-15, Volume: 59, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2004
Phase I study pilot arms of radiotherapy and carmustine with temozolomide for anaplastic astrocytoma (Radiation Therapy Oncology Group 9813): implications for studies testing initial treatment of brain tumors.
    International journal of radiation oncology, biology, physics, 2004, Jul-15, Volume: 59, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustine; Dacarbazin

2004
Initial chemotherapy in gliomatosis cerebri.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2004
Initial chemotherapy in gliomatosis cerebri.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2004
Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modalit

2004
Chemotherapy as initial treatment in gliomatosis cerebri: results with temozolomide.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined Modalit

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Phase 1 study of 28-day, low-dose temozolomide and BCNU in the treatment of malignant gliomas after radiation therapy.
    Neuro-oncology, 2004, Volume: 6, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carmustin

2004
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Immediate post-radiotherapy changes in malignant glioma can mimic tumor progression.
    Neurology, 2004, Aug-10, Volume: 63, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Artifacts; Astrocytoma; Brain Edema; Brain Neoplasms

2004
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
Salvage PCV chemotherapy for temozolomide-resistant oligodendrogliomas.
    Neurology, 2004, Sep-14, Volume: 63, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2004
Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas.
    Journal of neuro-oncology, 2004, Volume: 70, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Fe

2004
Phase II study of concurrent continuous Temozolomide (TMZ) and Tamoxifen (TMX) for recurrent malignant astrocytic gliomas.
    Journal of neuro-oncology, 2004, Volume: 70, Issue:1

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Fe

2004
Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas.
    Ideggyogyaszati szemle, 2004, Nov-20, Volume: 57, Issue:11-12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease P

2004
Temozolomide chemotherapy of patients with recurrent anaplastic astrocytomas and glioblastomas.
    Ideggyogyaszati szemle, 2004, Nov-20, Volume: 57, Issue:11-12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease P

2004
Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma.
    Cancer, 2006, Jan-01, Volume: 106, Issue:1

    Topics: Adult; Anaplasia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cyclophosphamide;

2006
Salvage chemotherapy with cyclophosphamide for recurrent temozolomide-refractory anaplastic astrocytoma.
    Cancer, 2006, Jan-01, Volume: 106, Issue:1

    Topics: Adult; Anaplasia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cyclophosphamide;

2006
Surgery, radiotherapy and temozolomide in treating high-grade gliomas.
    Frontiers in bioscience : a journal and virtual library, 2006, May-01, Volume: 11

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Co

2006
Surgery, radiotherapy and temozolomide in treating high-grade gliomas.
    Frontiers in bioscience : a journal and virtual library, 2006, May-01, Volume: 11

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinical Trials as Topic; Co

2006
Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients.
    Acta neurochirurgica, 2006, Volume: 148, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Child; Dacarbazine; Disease Progression;

2006
Role of temozolomide in spinal cord low grade astrocytomas: results in two paediatric patients.
    Acta neurochirurgica, 2006, Volume: 148, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Child; Dacarbazine; Disease Progression;

2006
[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Adult; Aged; Anorexia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

2006
[Efficacy and safety of monotherapy with temozolomide in patients with anaplastic astrocytoma at first relapse--a phase II clinical study].
    Gan to kagaku ryoho. Cancer & chemotherapy, 2006, Volume: 33, Issue:9

    Topics: Adult; Aged; Anorexia; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

2006
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group.
    Cancer, 2007, Oct-01, Volume: 110, Issue:7

    Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neopl

2007
Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma.
    Cancer, 2008, May-01, Volume: 112, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Camptothecin; Dacarbazine; F

2008
Salvage chemotherapy with CPT-11 for recurrent temozolomide-refractory anaplastic astrocytoma.
    Cancer, 2008, May-01, Volume: 112, Issue:9

    Topics: Adolescent; Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Camptothecin; Dacarbazine; F

2008
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:7

    Topics: Administration, Oral; Antineoplastic Agents; Astrocytoma; Brain; Brain Neoplasms; Dacarbazine; Dose-

1993
Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:7

    Topics: Administration, Oral; Antineoplastic Agents; Astrocytoma; Brain; Brain Neoplasms; Dacarbazine; Dose-

1993
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

1999
Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

1999
Health-related quality of life in patients with anaplastic astrocytoma during treatment with temozolomide.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:14

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease P

2000
Health-related quality of life in patients with anaplastic astrocytoma during treatment with temozolomide.
    European journal of cancer (Oxford, England : 1990), 2000, Volume: 36, Issue:14

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease P

2000
Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-01, Volume: 19, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; M

2001
Safety and efficacy of temozolomide in patients with recurrent anaplastic oligodendrogliomas after standard radiotherapy and chemotherapy.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2001, May-01, Volume: 19, Issue:9

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; M

2001
Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.
    Neuro-oncology, 2001, Volume: 3, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Cohort Studies

2001
Phase I study of Gliadel wafers plus temozolomide in adults with recurrent supratentorial high-grade gliomas.
    Neuro-oncology, 2001, Volume: 3, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Cohort Studies

2001

Other Studies

133 other studies available for temozolomide and Astrocytoma

ArticleYear
MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas.
    Neuro-oncology, 2022, 04-01, Volume: 24, Issue:4

    Topics: Algorithms; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Mo

2022
MGMT promoter methylation determined by the MGMT-STP27 algorithm is not predictive for outcome to temozolomide in IDH-mutant anaplastic astrocytomas.
    Neuro-oncology, 2022, 04-01, Volume: 24, Issue:4

    Topics: Algorithms; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Mo

2022
Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells.
    International journal of molecular sciences, 2022, May-07, Volume: 23, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Modification M

2022
Effects of Long-Term Temozolomide Treatment on Glioblastoma and Astrocytoma WHO Grade 4 Stem-like Cells.
    International journal of molecular sciences, 2022, May-07, Volume: 23, Issue:9

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Methylation; DNA Modification M

2022
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3.
    Journal of neuro-oncology, 2022, Volume: 160, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Isocitrate Deh

2022
Limited efficacy of temozolomide alone for astrocytoma, IDH-mutant, CNS WHO grades 2 or 3.
    Journal of neuro-oncology, 2022, Volume: 160, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Isocitrate Deh

2022
    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 2022, Volume: 86, Issue:5

    Topics: Aged; Astrocytoma; Brain Neoplasms; Carbohydrate Metabolism; Dexamethasone; Glioblastoma; Glioma; Gl

2022
    Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko, 2022, Volume: 86, Issue:5

    Topics: Aged; Astrocytoma; Brain Neoplasms; Carbohydrate Metabolism; Dexamethasone; Glioblastoma; Glioma; Gl

2022
Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma.
    Journal of neuro-oncology, 2023, Volume: 164, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Temozol

2023
Long-term treatment outcomes of temozolomide-based chemoradiation in patients with adult-type diffuse IDH-mutant grade 2 astrocytoma.
    Journal of neuro-oncology, 2023, Volume: 164, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Humans; Temozol

2023
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences.
    Acta neuropathologica communications, 2023, 09-05, Volume: 11, Issue:1

    Topics: Adult; Astrocytoma; Child; Glioma; Humans; Mutation; Neoplasm Recurrence, Local; Temozolomide

2023
Molecular profiling of pre- and post-treatment pediatric high-grade astrocytomas reveals acquired increased tumor mutation burden in a subset of recurrences.
    Acta neuropathologica communications, 2023, 09-05, Volume: 11, Issue:1

    Topics: Adult; Astrocytoma; Child; Glioma; Humans; Mutation; Neoplasm Recurrence, Local; Temozolomide

2023
The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma.
    Folia neuropathologica, 2023, Volume: 61, Issue:3

    Topics: Astrocytoma; Brain Neoplasms; CD8-Positive T-Lymphocytes; Glioblastoma; Histocompatibility Antigens

2023
The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma.
    Folia neuropathologica, 2023, Volume: 61, Issue:3

    Topics: Astrocytoma; Brain Neoplasms; CD8-Positive T-Lymphocytes; Glioblastoma; Histocompatibility Antigens

2023
Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
    Acta neuropathologica communications, 2023, 11-06, Volume: 11, Issue:1

    Topics: Astrocytoma; Brain Neoplasms; Genomics; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; Retrospe

2023
Genomic characterization of IDH-mutant astrocytoma progression to grade 4 in the treatment setting.
    Acta neuropathologica communications, 2023, 11-06, Volume: 11, Issue:1

    Topics: Astrocytoma; Brain Neoplasms; Genomics; Glioma; Humans; Isocitrate Dehydrogenase; Mutation; Retrospe

2023
Survey of treatment recommendations for elderly patients with glioblastoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020, Volume: 22, Issue:8

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasm

2020
Survey of treatment recommendations for elderly patients with glioblastoma.
    Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2020, Volume: 22, Issue:8

    Topics: Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasm

2020
Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma.
    Neuro-oncology, 2020, 08-17, Volume: 22, Issue:8

    Topics: Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Copy Number Variations; D

2020
Superiority of temozolomide over radiotherapy for elderly patients with RTK II methylation class, MGMT promoter methylated malignant astrocytoma.
    Neuro-oncology, 2020, 08-17, Volume: 22, Issue:8

    Topics: Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; DNA Copy Number Variations; D

2020
NF-кB inhibition by DHMEQ: in vitro antiproliferative effects on pilocytic astrocytoma and concise review of the current literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020, Volume: 36, Issue:11

    Topics: Astrocytoma; Brain Neoplasms; Cell Proliferation; Child; Humans; NF-kappa B; Temozolomide

2020
NF-кB inhibition by DHMEQ: in vitro antiproliferative effects on pilocytic astrocytoma and concise review of the current literature.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2020, Volume: 36, Issue:11

    Topics: Astrocytoma; Brain Neoplasms; Cell Proliferation; Child; Humans; NF-kappa B; Temozolomide

2020
Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response.
    Scientific reports, 2020, 06-08, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Diffusio

2020
Noninvasive diffusion magnetic resonance imaging of brain tumour cell size for the early detection of therapeutic response.
    Scientific reports, 2020, 06-08, Volume: 10, Issue:1

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Diffusio

2020
Granulocyte-macrophage colony-stimulating factor enhances effect of temozolomide on high-grade glioma cells.
    Anti-cancer drugs, 2020, Volume: 31, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cell Cycle; Central Nervous System Neop

2020
Granulocyte-macrophage colony-stimulating factor enhances effect of temozolomide on high-grade glioma cells.
    Anti-cancer drugs, 2020, Volume: 31, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Cell Cycle; Central Nervous System Neop

2020
Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma.
    Molecular neurobiology, 2020, Volume: 57, Issue:9

    Topics: Adult; Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Cycle; Cell Differentiation;

2020
Nuclear Respiratory Factor 1 (NRF1) Transcriptional Activity-Driven Gene Signature Association with Severity of Astrocytoma and Poor Prognosis of Glioblastoma.
    Molecular neurobiology, 2020, Volume: 57, Issue:9

    Topics: Adult; Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Cycle; Cell Differentiation;

2020
Evaluating survival in subjects with astrocytic brain tumors by dynamic susceptibility-weighted perfusion MR imaging.
    PloS one, 2021, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Ma

2021
Evaluating survival in subjects with astrocytic brain tumors by dynamic susceptibility-weighted perfusion MR imaging.
    PloS one, 2021, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Ma

2021
Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort.
    The oncologist, 2021, Volume: 26, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Humans; Lomustine; Pro

2021
Radiotherapy Plus Procarbazine, Lomustine, and Vincristine Versus Radiotherapy Plus Temozolomide for IDH-Mutant Anaplastic Astrocytoma: A Retrospective Multicenter Analysis of the French POLA Cohort.
    The oncologist, 2021, Volume: 26, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Humans; Lomustine; Pro

2021
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity.
    JCI insight, 2021, 05-10, Volume: 6, Issue:9

    Topics: Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Plastic

2021
CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity.
    JCI insight, 2021, 05-10, Volume: 6, Issue:9

    Topics: Animals; Antigens, CD; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Plastic

2021
Benefit of adjuvant, but not concurrent, temozolomide for IDH-mutant anaplastic astrocytoma.
    The Lancet. Oncology, 2021, Volume: 22, Issue:6

    Topics: Astrocytoma; Glioma; Humans; Temozolomide

2021
Benefit of adjuvant, but not concurrent, temozolomide for IDH-mutant anaplastic astrocytoma.
    The Lancet. Oncology, 2021, Volume: 22, Issue:6

    Topics: Astrocytoma; Glioma; Humans; Temozolomide

2021
Upfront Therapy of Aggressive/High-Risk Low-Grade Glioma: Single-Institution Outcome Analysis of Temozolomide-Based Radio-Chemotherapy and Adjuvant Chemotherapy.
    World neurosurgery, 2021, Volume: 154

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chemoradi

2021
Upfront Therapy of Aggressive/High-Risk Low-Grade Glioma: Single-Institution Outcome Analysis of Temozolomide-Based Radio-Chemotherapy and Adjuvant Chemotherapy.
    World neurosurgery, 2021, Volume: 154

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chemoradi

2021
Commentary on "Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813".
    Neuro-oncology, 2017, 05-01, Volume: 19, Issue:5

    Topics: Adult; Astrocytoma; Humans; Nitrosourea Compounds; Temozolomide

2017
Commentary on "Phase III randomized study of radiation and temozolomide versus radiation and nitrosourea therapy for anaplastic astrocytoma: results of NRG Oncology RTOG 9813".
    Neuro-oncology, 2017, 05-01, Volume: 19, Issue:5

    Topics: Adult; Astrocytoma; Humans; Nitrosourea Compounds; Temozolomide

2017
Reply to letter on results of NRG Oncology RTOG 9813.
    Neuro-oncology, 2017, 05-01, Volume: 19, Issue:5

    Topics: Adult; Astrocytoma; Humans; Medical Oncology; Nitrosourea Compounds; Temozolomide

2017
Reply to letter on results of NRG Oncology RTOG 9813.
    Neuro-oncology, 2017, 05-01, Volume: 19, Issue:5

    Topics: Adult; Astrocytoma; Humans; Medical Oncology; Nitrosourea Compounds; Temozolomide

2017
Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis.
    World neurosurgery, 2017, Volume: 103

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain N

2017
Management and Survival Patterns of Patients with Gliomatosis Cerebri: A SEER-Based Analysis.
    World neurosurgery, 2017, Volume: 103

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain N

2017
TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2016, Volume: 13, Issue:6

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine;

2016
TREATMENT OF PROGRESSION OF DIFFUSE ASTROCYTOMA BY HERBAL MEDICINE: CASE REPORT.
    African journal of traditional, complementary, and alternative medicines : AJTCAM, 2016, Volume: 13, Issue:6

    Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; Dacarbazine;

2016
Temozolomide and sorafenib as programmed cell death inducers of human glioma cells.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Cell Line, Tumor; Dacarbazine; Gene Expression Regula

2017
Temozolomide and sorafenib as programmed cell death inducers of human glioma cells.
    Pharmacological reports : PR, 2017, Volume: 69, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Astrocytoma; Cell Line, Tumor; Dacarbazine; Gene Expression Regula

2017
Glioblastoma entities express subtle differences in molecular composition and response to treatment.
    Oncology reports, 2017, Volume: 38, Issue:3

    Topics: Apoptosis; Astrocytoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle Checkpoi

2017
Glioblastoma entities express subtle differences in molecular composition and response to treatment.
    Oncology reports, 2017, Volume: 38, Issue:3

    Topics: Apoptosis; Astrocytoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle Checkpoi

2017
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma.
    Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Glioma; Humans; Male; Temozolomi

2017
Long-term daily temozolomide with dose-dependent efficacy in MGMT promotor methylation negative recurrent high-grade astrocytoma.
    Cancer chemotherapy and pharmacology, 2017, Volume: 80, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Glioma; Humans; Male; Temozolomi

2017
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.
    World neurosurgery, 2017, Volume: 108

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Chemoradiotherapy, Adjuvant; Dacarbazine; Fat

2017
Spinal Cord Astrocytoma with Isocitrate Dehydrogenase 1 Gene Mutation.
    World neurosurgery, 2017, Volume: 108

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Chemoradiotherapy, Adjuvant; Dacarbazine; Fat

2017
[Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience].
    Neuro-Chirurgie, 2017, Volume: 63, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Chemotherapy, Adjuvant; Dacarbazine; Di

2017
[Contribution of temozolomide chemotherapy for intramedullary grade II spinal cord astrocytomas in adults: Our experience].
    Neuro-Chirurgie, 2017, Volume: 63, Issue:4

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Chemotherapy, Adjuvant; Dacarbazine; Di

2017
Tremor Secondary to a Thalamic Glioma: A Case Report.
    Operative neurosurgery (Hagerstown, Md.), 2018, 06-01, Volume: 14, Issue:6

    Topics: Antineoplastic Agents; Astrocytoma; Biopsy; Chemotherapy, Adjuvant; Combined Modality Therapy; Crani

2018
Tremor Secondary to a Thalamic Glioma: A Case Report.
    Operative neurosurgery (Hagerstown, Md.), 2018, 06-01, Volume: 14, Issue:6

    Topics: Antineoplastic Agents; Astrocytoma; Biopsy; Chemotherapy, Adjuvant; Combined Modality Therapy; Crani

2018
Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient.
    Neurology, 2017, 10-24, Volume: 89, Issue:17

    Topics: Aged, 80 and over; Anaplasia; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Humans; M

2017
Pilocytic astrocytoma with anaplasia arising from the optic chiasm in a very elderly patient.
    Neurology, 2017, 10-24, Volume: 89, Issue:17

    Topics: Aged, 80 and over; Anaplasia; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Humans; M

2017
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults.
    Progress in neurological surgery, 2018, Volume: 31

    Topics: Adult; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Procarbazi

2018
Chemotherapy of Diffuse Astrocytoma (WHO grade II) in Adults.
    Progress in neurological surgery, 2018, Volume: 31

    Topics: Adult; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Dacarbazine; Glioma; Humans; Procarbazi

2018
Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).
    World neurosurgery, 2018, Volume: 114

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Com

2018
Tumor Volume Changes During and After Temozolomide Treatment for Newly Diagnosed Higher-Grade Glioma (III and IV).
    World neurosurgery, 2018, Volume: 114

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Com

2018
A multi-sequence and habitat-based MRI radiomics signature for preoperative prediction of MGMT promoter methylation in astrocytomas with prognostic implication.
    European radiology, 2019, Volume: 29, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; DNA Methylation;

2019
A multi-sequence and habitat-based MRI radiomics signature for preoperative prediction of MGMT promoter methylation in astrocytomas with prognostic implication.
    European radiology, 2019, Volume: 29, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; DNA Methylation;

2019
Brainstem Glioblastoma Multiforme in a Patient with NF1.
    Anticancer research, 2018, Volume: 38, Issue:8

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Stem; Brain Stem Neoplasms; Chemoradiot

2018
Brainstem Glioblastoma Multiforme in a Patient with NF1.
    Anticancer research, 2018, Volume: 38, Issue:8

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Stem; Brain Stem Neoplasms; Chemoradiot

2018
Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.
    Journal of neuro-oncology, 2018, Volume: 140, Issue:2

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Female;

2018
Bevacizumab, irinotecan, temozolomide, tyrosine kinase inhibition, and MEK inhibition are effective against pleomorphic xanthoastrocytoma regardless of V600E status.
    Journal of neuro-oncology, 2018, Volume: 140, Issue:2

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Bevacizumab; Brain Neoplasms; Cell Line, Tumor; Female;

2018
The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma.
    Oncology reports, 2019, Volume: 41, Issue:3

    Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Autophagy; Autophagy-Related Protein

2019
The HIF‑1α/miR‑224‑3p/ATG5 axis affects cell mobility and chemosensitivity by regulating hypoxia‑induced protective autophagy in glioblastoma and astrocytoma.
    Oncology reports, 2019, Volume: 41, Issue:3

    Topics: Adult; Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Autophagy; Autophagy-Related Protein

2019
Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival.
    BMJ case reports, 2019, Feb-13, Volume: 12, Issue:2

    Topics: Astrocytoma; Brain; Chemoradiotherapy; Child; Gene Amplification; High-Throughput Nucleotide Sequenc

2019
Atypical anaplastic astrocytoma with unique molecular features and diffuse leptomeningeal spread in a child with long-term survival.
    BMJ case reports, 2019, Feb-13, Volume: 12, Issue:2

    Topics: Astrocytoma; Brain; Chemoradiotherapy; Child; Gene Amplification; High-Throughput Nucleotide Sequenc

2019
Pattern of failure in anaplastic glioma patients with an IDH1/2 mutation.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2020, Volume: 196, Issue:1

    Topics: Adult; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; DNA Mutational Analysis; Female; Fol

2020
Pattern of failure in anaplastic glioma patients with an IDH1/2 mutation.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2020, Volume: 196, Issue:1

    Topics: Adult; Astrocytoma; Brain Neoplasms; Combined Modality Therapy; DNA Mutational Analysis; Female; Fol

2020
Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series.
    The neurologist, 2019, Volume: 24, Issue:3

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Astrocytoma; Bevaciz

2019
Bevacizumab Use in Refractory Adult Pilocytic Astrocytoma: A Single-Center Case Series.
    The neurologist, 2019, Volume: 24, Issue:3

    Topics: Adult; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Immunological; Astrocytoma; Bevaciz

2019
Case of pleomorphic xanthoastrocytoma with anaplastic features in the pineal gland.
    Brain tumor pathology, 2013, Volume: 30, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemoradiotherapy; Dacarbazine; Diffusi

2013
Case of pleomorphic xanthoastrocytoma with anaplastic features in the pineal gland.
    Brain tumor pathology, 2013, Volume: 30, Issue:4

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chemoradiotherapy; Dacarbazine; Diffusi

2013
Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide.
    Journal of neuro-oncology, 2013, Volume: 113, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Ne

2013
Outcomes for patients with anaplastic astrocytoma treated with chemoradiation, radiation therapy alone or radiation therapy followed by chemotherapy: a retrospective review within the era of temozolomide.
    Journal of neuro-oncology, 2013, Volume: 113, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Ne

2013
Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2013, Volume: 74 Suppl 1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Combined Modality Therapy; Dac

2013
Cerebellar anaplastic astrocytoma in an adult with neurofibromatosis type 1: case report and review of literature.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2013, Volume: 74 Suppl 1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Combined Modality Therapy; Dac

2013
Central diabetes insipidus: a previously unreported side effect of temozolomide.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:10

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Diabetes Insipi

2013
Central diabetes insipidus: a previously unreported side effect of temozolomide.
    The Journal of clinical endocrinology and metabolism, 2013, Volume: 98, Issue:10

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Diabetes Insipi

2013
A case of adult onset medulloblastoma during maintenance chemotherapy for anaplastic astrocytoma one year after radiotherapy.
    Turkish neurosurgery, 2013, Volume: 23, Issue:4

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Chemor

2013
A case of adult onset medulloblastoma during maintenance chemotherapy for anaplastic astrocytoma one year after radiotherapy.
    Turkish neurosurgery, 2013, Volume: 23, Issue:4

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cerebellar Neoplasms; Chemor

2013
Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.
    Toxicology and applied pharmacology, 2013, Dec-15, Volume: 273, Issue:3

    Topics: Apoptosis; Astrocytoma; Autophagy; Caspase 12; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c

2013
Silencing of Hsp27 and Hsp72 in glioma cells as a tool for programmed cell death induction upon temozolomide and quercetin treatment.
    Toxicology and applied pharmacology, 2013, Dec-15, Volume: 273, Issue:3

    Topics: Apoptosis; Astrocytoma; Autophagy; Caspase 12; Caspase 3; Caspase 9; Cell Line, Tumor; Cytochromes c

2013
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors.
    Journal of neuro-oncology, 2014, Volume: 116, Issue:1

    Topics: Aged; Astrocytoma; Brain Neoplasms; Cognition Disorders; Cohort Studies; Dacarbazine; DNA Modificati

2014
Health-related quality of life and cognitive functioning in long-term anaplastic oligodendroglioma and oligoastrocytoma survivors.
    Journal of neuro-oncology, 2014, Volume: 116, Issue:1

    Topics: Aged; Astrocytoma; Brain Neoplasms; Cognition Disorders; Cohort Studies; Dacarbazine; DNA Modificati

2014
Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination.
    Molecular biology reports, 2014, Volume: 41, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, Tumor

2014
Chemotherapeutic resistance in anaplastic astrocytoma cell lines treated with a temozolomide-lomeguatrib combination.
    Molecular biology reports, 2014, Volume: 41, Issue:2

    Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, Tumor

2014
Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto

2014
Vemurafenib in pediatric patients with BRAFV600E mutated high-grade gliomas.
    Pediatric blood & cancer, 2014, Volume: 61, Issue:6

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Proto

2014
IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy.
    Journal of neuro-oncology, 2014, Volume: 118, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers; Brain Neoplasms; Chemoradio

2014
IDH1 mutation and MGMT methylation status predict survival in patients with anaplastic astrocytoma treated with temozolomide-based chemoradiotherapy.
    Journal of neuro-oncology, 2014, Volume: 118, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers; Brain Neoplasms; Chemoradio

2014
The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma.
    Journal of neuro-oncology, 2014, Volume: 120, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant;

2014
The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma.
    Journal of neuro-oncology, 2014, Volume: 120, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adjuvant;

2014
Survival in granular cell astrocytomas.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2015, Volume: 76, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain N

2015
Survival in granular cell astrocytomas.
    Journal of neurological surgery. Part A, Central European neurosurgery, 2015, Volume: 76, Issue:1

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain N

2015
Primary brain tumors: introduction.
    Seminars in oncology, 2014, Volume: 41, Issue:4

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2014
Primary brain tumors: introduction.
    Seminars in oncology, 2014, Volume: 41, Issue:4

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2014
Characterization of a novel anti-cancer compound for astrocytomas.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, T

2014
Characterization of a novel anti-cancer compound for astrocytomas.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Astrocytoma; Cell Cycle; Cell Line, T

2014
The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines.
    Nutrition and cancer, 2014, Volume: 66, Issue:7

    Topics: Adult; Animals; Astrocytes; Astrocytoma; Bees; Cell Line, Tumor; Dacarbazine; Fatty Acids; Glioblast

2014
The interaction of bee products with temozolomide in human diffuse astrocytoma, glioblastoma multiforme and astroglia cell lines.
    Nutrition and cancer, 2014, Volume: 66, Issue:7

    Topics: Adult; Animals; Astrocytes; Astrocytoma; Bees; Cell Line, Tumor; Dacarbazine; Fatty Acids; Glioblast

2014
Salvage therapy with lomustine for temozolomide refractory recurrent anaplastic astrocytoma: a retrospective study.
    Journal of neuro-oncology, 2015, Volume: 122, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazi

2015
Salvage therapy with lomustine for temozolomide refractory recurrent anaplastic astrocytoma: a retrospective study.
    Journal of neuro-oncology, 2015, Volume: 122, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazi

2015
Cerebral peduncle tumor ablated by novel 3-mm laser tip.
    Stereotactic and functional neurosurgery, 2015, Volume: 93, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Camptothecin; Cerebral Ped

2015
Cerebral peduncle tumor ablated by novel 3-mm laser tip.
    Stereotactic and functional neurosurgery, 2015, Volume: 93, Issue:1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Bevacizumab; Camptothecin; Cerebral Ped

2015
Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma: A treatment planning case report.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2015, Volume: 19, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Damage, Chronic; Cell Dedifferentiation; Combi

2015
Volumetric modulated arc therapy for hippocampal-sparing radiotherapy in transformed low-grade glioma: A treatment planning case report.
    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique, 2015, Volume: 19, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Damage, Chronic; Cell Dedifferentiation; Combi

2015
Temozolomide induced bone marrow Suppression--A single institution outcome analysis and review of the literature.
    American journal of hematology, 2015, Volume: 90, Issue:9

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marr

2015
Temozolomide induced bone marrow Suppression--A single institution outcome analysis and review of the literature.
    American journal of hematology, 2015, Volume: 90, Issue:9

    Topics: Adolescent; Adult; Aged; Anemia, Aplastic; Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marr

2015
Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2015, Volume: 191, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradi

2015
Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma: The Mainz experience.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2015, Volume: 191, Issue:8

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chemoradi

2015
High-grade glioma in children and adolescents: a single-center experience.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astro

2016
High-grade glioma in children and adolescents: a single-center experience.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016, Volume: 32, Issue:2

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astro

2016
Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
    Annals of the Academy of Medicine, Singapore, 2015, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2015
Singapore Cancer Network (SCAN) Guidelines for Systemic Therapy of High-Grade Glioma.
    Annals of the Academy of Medicine, Singapore, 2015, Volume: 44, Issue:10

    Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Beva

2015
Residual low ADC and high FA at the resection margin correlate with poor chemoradiation response and overall survival in high-grade glioma patients.
    European journal of radiology, 2016, Volume: 85, Issue:3

    Topics: Area Under Curve; Astrocytoma; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Magneti

2016
Residual low ADC and high FA at the resection margin correlate with poor chemoradiation response and overall survival in high-grade glioma patients.
    European journal of radiology, 2016, Volume: 85, Issue:3

    Topics: Area Under Curve; Astrocytoma; Chemoradiotherapy; Dacarbazine; Female; Glioblastoma; Humans; Magneti

2016
Concurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2017, Volume: 37, Issue:1

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cranial Irradiation; Da

2017
Concurrent TERT promoter and BRAF V600E mutation in epithelioid glioblastoma and concomitant low-grade astrocytoma.
    Neuropathology : official journal of the Japanese Society of Neuropathology, 2017, Volume: 37, Issue:1

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cranial Irradiation; Da

2017
Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up.
    Tumori, 2017, May-12, Volume: 103, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Disease-Free Survival; DNA

2017
Temozolomide low-dose chemotherapy in newly diagnosed low-grade gliomas: activity, safety, and long-term follow-up.
    Tumori, 2017, May-12, Volume: 103, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Dacarbazine; Disease-Free Survival; DNA

2017
Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam.
    BMJ case reports, 2016, Dec-23, Volume: 2016

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cognition Disorders; D

2016
Regression of a glioblastoma multiforme: spontaneous versus a potential antineoplastic effect of dexamethasone and levetiracetam.
    BMJ case reports, 2016, Dec-23, Volume: 2016

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Cognition Disorders; D

2016
A Case of Therapy-Related Acute Myeloid Leukemia Associated with Adjuvant Temozolomide Chemotherapy for Anaplastic Astrocytoma.
    World neurosurgery, 2017, Volume: 101

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Daca

2017
A Case of Therapy-Related Acute Myeloid Leukemia Associated with Adjuvant Temozolomide Chemotherapy for Anaplastic Astrocytoma.
    World neurosurgery, 2017, Volume: 101

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Daca

2017
Outcomes for Anaplastic Glioma Treated With Radiation Therapy With or Without Concurrent Temozolomide.
    American journal of clinical oncology, 2018, Volume: 41, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Chemorad

2018
Outcomes for Anaplastic Glioma Treated With Radiation Therapy With or Without Concurrent Temozolomide.
    American journal of clinical oncology, 2018, Volume: 41, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Chemorad

2018
Quality of life in low-grade glioma patients receiving temozolomide.
    Neuro-oncology, 2009, Volume: 11, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

2009
Quality of life in low-grade glioma patients receiving temozolomide.
    Neuro-oncology, 2009, Volume: 11, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; H

2009
Disseminated salmonellosis in a patient treated with temozolomide.
    The Journal of infection, 2008, Volume: 57, Issue:5

    Topics: Adult; Anti-Infective Agents; Antineoplastic Agents, Alkylating; Arthritis, Infectious; Astrocytoma;

2008
Disseminated salmonellosis in a patient treated with temozolomide.
    The Journal of infection, 2008, Volume: 57, Issue:5

    Topics: Adult; Anti-Infective Agents; Antineoplastic Agents, Alkylating; Arthritis, Infectious; Astrocytoma;

2008
Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
    Journal of neurosurgery, 2009, Volume: 110, Issue:1

    Topics: Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmust

2009
Independent association of extent of resection with survival in patients with malignant brain astrocytoma.
    Journal of neurosurgery, 2009, Volume: 110, Issue:1

    Topics: Aged; Analysis of Variance; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmust

2009
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dac

2009
MGMT promoter hypermethylation correlates with a survival benefit from temozolomide in patients with recurrent anaplastic astrocytoma but not glioblastoma.
    European journal of cancer (Oxford, England : 1990), 2009, Volume: 45, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dac

2009
Characterization of a side population of astrocytoma cells in response to temozolomide.
    Journal of neurosurgery, 2008, Volume: 109, Issue:5

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; ATP Binding Cassette Transporter, Subfamily

2008
Characterization of a side population of astrocytoma cells in response to temozolomide.
    Journal of neurosurgery, 2008, Volume: 109, Issue:5

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; ATP Binding Cassette Transporter, Subfamily

2008
Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain; Brain Neoplasms; Dacarbazi

2009
Long-term use of temozolomide: could you use temozolomide safely for life in gliomas?
    Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2009, Volume: 16, Issue:6

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain; Brain Neoplasms; Dacarbazi

2009
Perioperative high-dose-rate brachytherapy in the treatment of recurrent malignant gliomas.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2009, Volume: 185, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brachytherapy; Brain Neoplasms; Chemoth

2009
Perioperative high-dose-rate brachytherapy in the treatment of recurrent malignant gliomas.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2009, Volume: 185, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brachytherapy; Brain Neoplasms; Chemoth

2009
Inter- and intrapatients comparison of WHO grade II glioma kinetics before and after surgical resection.
    Neurosurgical review, 2010, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazi

2010
Inter- and intrapatients comparison of WHO grade II glioma kinetics before and after surgical resection.
    Neurosurgical review, 2010, Volume: 33, Issue:1

    Topics: Adolescent; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazi

2010
Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytoma: growing evidence for safety and efficacy.
    Annals of surgical oncology, 2010, Volume: 17, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biocompatible Materials; Carmustine; Da

2010
Carmustine wafers (Gliadel) plus concomitant temozolomide therapy after resection of malignant astrocytoma: growing evidence for safety and efficacy.
    Annals of surgical oncology, 2010, Volume: 17, Issue:7

    Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Biocompatible Materials; Carmustine; Da

2010
Pseudoprogression after radiotherapy with concurrent temozolomide in a child with anaplastic astrocytoma.
    Pediatric hematology and oncology, 2010, Volume: 27, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chil

2010
Pseudoprogression after radiotherapy with concurrent temozolomide in a child with anaplastic astrocytoma.
    Pediatric hematology and oncology, 2010, Volume: 27, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Chil

2010
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-.
    Neurologia medico-chirurgica, 2010, Volume: 50, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Corp

2010
Preoperative chemotherapy for infiltrative low-grade oligoastrocytoma: a useful strategy to maximize surgical resection -case report-.
    Neurologia medico-chirurgica, 2010, Volume: 50, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemotherapy, Adjuvant; Corp

2010
Temozolomide (Temodar).
    AJNR. American journal of neuroradiology, 2010, Volume: 31, Issue:8

    Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

2010
Temozolomide (Temodar).
    AJNR. American journal of neuroradiology, 2010, Volume: 31, Issue:8

    Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

2010
Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Apoptosis; Astrocytoma; Blotting, Western; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dacarbazin

2010
Temozolomide, quercetin and cell death in the MOGGCCM astrocytoma cell line.
    Chemico-biological interactions, 2010, Oct-06, Volume: 188, Issue:1

    Topics: Apoptosis; Astrocytoma; Blotting, Western; Brain Neoplasms; Cell Death; Cell Line, Tumor; Dacarbazin

2010
Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation.
    Pediatric blood & cancer, 2010, Volume: 55, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazine; Female; Frontal

2010
Acute lymphoblastic leukemia after temozolomide treatment for anaplastic astrocytoma in a child with a germline TP53 mutation.
    Pediatric blood & cancer, 2010, Volume: 55, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Dacarbazine; Female; Frontal

2010
Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series.
    International journal of radiation oncology, biology, physics, 2011, Sep-01, Volume: 81, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Colorado;

2011
Favorable prognosis in patients with high-grade glioma with radiation necrosis: the University of Colorado reoperation series.
    International journal of radiation oncology, biology, physics, 2011, Sep-01, Volume: 81, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Colorado;

2011
Urticarial hypersensitivity reaction caused by temozolomide.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:9

    Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Da

2010
Urticarial hypersensitivity reaction caused by temozolomide.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:9

    Topics: Adult; Anti-Inflammatory Agents; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Da

2010
First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
    Neuro-oncology, 2011, Volume: 13, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chromosom

2011
First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.
    Neuro-oncology, 2011, Volume: 13, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Chromosom

2011
Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chi-Square Distributio

2011
Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chi-Square Distributio

2011
Dural venous sinus thrombosis in anaplastic astrocytoma following concurrent temozolomide and focal brain radiotherapy plus bevacizumab.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:2

    Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2011
Dural venous sinus thrombosis in anaplastic astrocytoma following concurrent temozolomide and focal brain radiotherapy plus bevacizumab.
    Journal of neuro-oncology, 2011, Volume: 104, Issue:2

    Topics: Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Astrocytom

2011
Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas.
    International journal of radiation oncology, biology, physics, 2012, Feb-01, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2012
Retrospective comparison of chemoradiotherapy followed by adjuvant chemotherapy, with or without prior gliadel implantation (carmustine) after initial surgery in patients with newly diagnosed high-grade gliomas.
    International journal of radiation oncology, biology, physics, 2012, Feb-01, Volume: 82, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combin

2012
Radiation-induced astrocytoma with rapid malignant transformation: case report.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Basal Ganglia; Brain Neoplasms; Cell Transformation,

2011
Radiation-induced astrocytoma with rapid malignant transformation: case report.
    Neurologia medico-chirurgica, 2011, Volume: 51, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Basal Ganglia; Brain Neoplasms; Cell Transformation,

2011
Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.
    Epilepsy research, 2011, Volume: 95, Issue:3

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Electroencephal

2011
Seizure control: a secondary benefit of chemotherapeutic temozolomide in brain cancer patients.
    Epilepsy research, 2011, Volume: 95, Issue:3

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Electroencephal

2011
[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2011, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplas

2011
[Nimotuzumab in combination with chemotherapy for patients with malignant gliomas].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2011, Volume: 33, Issue:3

    Topics: Adolescent; Adult; Antibodies, Monoclonal, Humanized; Antineoplastic Agents, Alkylating; Antineoplas

2011
Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Astrocytoma; Autophagy; Cell Line, Tumor

2011
Kinetic studies of the effects of Temodal and quercetin on astrocytoma cells.
    Pharmacological reports : PR, 2011, Volume: 63, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Antioxidants; Apoptosis; Astrocytoma; Autophagy; Cell Line, Tumor

2011
Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.
    Oncology, 2011, Volume: 80, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2011
Ifosfamide, carboplatin and etoposide in recurrent malignant glioma.
    Oncology, 2011, Volume: 80, Issue:5-6

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2011
Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.
    International journal of clinical oncology, 2012, Volume: 17, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Antiviral Agents; Astrocytoma; Brain Neoplasms; Carrier State; Ch

2012
Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis.
    International journal of clinical oncology, 2012, Volume: 17, Issue:3

    Topics: Antineoplastic Agents, Alkylating; Antiviral Agents; Astrocytoma; Brain Neoplasms; Carrier State; Ch

2012
Prognostic impact of hemoglobin level and other factors in patients with high-grade gliomas treated with postoperative radiochemotherapy and sequential chemotherapy based on temozolomide: a 10-year experience at a single institution.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2011, Volume: 187, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adj

2011
Prognostic impact of hemoglobin level and other factors in patients with high-grade gliomas treated with postoperative radiochemotherapy and sequential chemotherapy based on temozolomide: a 10-year experience at a single institution.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2011, Volume: 187, Issue:12

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chemoradiotherapy, Adj

2011
Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy.
    The neurologist, 2012, Volume: 18, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Child, Preschool; Combined Modality Therapy; Cranial

2012
Successful treatment of leptomeningeal gliomatosis of pilomyxoid astrocytoma after failed frontline chemotherapy.
    The neurologist, 2012, Volume: 18, Issue:1

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Child, Preschool; Combined Modality Therapy; Cranial

2012
Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature.
    Clinical neurology and neurosurgery, 2012, Volume: 114, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Chemoradiotherapy; Dacarbazine

2012
Cerebellar anaplastic pilocytic astrocytoma in a patient of neurofibromatosis type-1: case report and review of the literature.
    Clinical neurology and neurosurgery, 2012, Volume: 114, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Chemoradiotherapy; Dacarbazine

2012
Treatment of elderly patients with glioblastoma.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male;

2012
Treatment of elderly patients with glioblastoma.
    The Lancet. Oncology, 2012, Volume: 13, Issue:7

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Humans; Male;

2012
Knockdown of CDK6 enhances glioma sensitivity to chemotherapy.
    Oncology reports, 2012, Volume: 28, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Pro

2012
Knockdown of CDK6 enhances glioma sensitivity to chemotherapy.
    Oncology reports, 2012, Volume: 28, Issue:3

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Cell Line, Tumor; Cell Pro

2012
Multiple discrete aneurysmal subarachnoid hemorrhages during multimodality management of a hypothalamic glioma--case report.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:5

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Ag

2013
Multiple discrete aneurysmal subarachnoid hemorrhages during multimodality management of a hypothalamic glioma--case report.
    Clinical neurology and neurosurgery, 2013, Volume: 115, Issue:5

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Ag

2013
Presentation, management, and outcome of elderly patients with newly-diagnosed anaplastic astrocytoma.
    Journal of neuro-oncology, 2012, Volume: 110, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined M

2012
Presentation, management, and outcome of elderly patients with newly-diagnosed anaplastic astrocytoma.
    Journal of neuro-oncology, 2012, Volume: 110, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Combined M

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Fasting enhances the response of glioma to chemo- and radiotherapy.
    PloS one, 2012, Volume: 7, Issue:9

    Topics: Animals; Antineoplastic Agents, Alkylating; Astrocytoma; Blood Glucose; Body Weight; Brain Neoplasms

2012
Decision making and management of gliomas: practical considerations.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 10

    Topics: Aged; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA

2012
Decision making and management of gliomas: practical considerations.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23 Suppl 10

    Topics: Aged; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Dacarbazine; DNA Modification Methylases; DNA

2012
Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma.
    Neurologia medico-chirurgica, 2012, Volume: 52, Issue:9

    Topics: Antineoplastic Agents; Astrocytoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine;

2012
Radiation-induced spinal cord anaplastic astrocytoma subsequent to radiotherapy for testicular seminoma.
    Neurologia medico-chirurgica, 2012, Volume: 52, Issue:9

    Topics: Antineoplastic Agents; Astrocytoma; Chemotherapy, Adjuvant; Combined Modality Therapy; Dacarbazine;

2012
Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity reaction.
    Anti-cancer drugs, 2012, Volume: 23, Issue:10

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacar

2012
Celecoxib desensitization: continued temozolomide/celecoxib chemotherapy after a celecoxib-induced hypersensitivity reaction.
    Anti-cancer drugs, 2012, Volume: 23, Issue:10

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Celecoxib; Cyclooxygenase 2 Inhibitors; Dacar

2012
Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report.
    British journal of neurosurgery, 2013, Volume: 27, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Dacarbazine; Ependymoma

2013
Radiation-induced anaplastic ependymoma with a remarkable clinical response to temozolomide: a case report.
    British journal of neurosurgery, 2013, Volume: 27, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Cerebellar Neoplasms; Dacarbazine; Ependymoma

2013
[Treatment of anaplastic astrocytomas and glioblastomas in children by the use of temozolomide (TMZ)].
    Voprosy onkologii, 2002, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Bra

2002
[Treatment of anaplastic astrocytomas and glioblastomas in children by the use of temozolomide (TMZ)].
    Voprosy onkologii, 2002, Volume: 48, Issue:3

    Topics: Adolescent; Adult; Age Factors; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Bra

2002
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
    Neurology, 2003, Mar-11, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2003
Interobserver variability in the radiological assessment of response to chemotherapy in glioma.
    Neurology, 2003, Mar-11, Volume: 60, Issue:5

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplat

2003
Survival of patients with recurrent malignant glioma treated with temozolomide: a retrospective observational study.
    Drugs in R&D, 2003, Volume: 4, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Central Nervous Syst

2003
Survival of patients with recurrent malignant glioma treated with temozolomide: a retrospective observational study.
    Drugs in R&D, 2003, Volume: 4, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Astrocytoma; Central Nervous Syst

2003
Gliomatosis cerebri: better definition, better treatment.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocyt

2004
Gliomatosis cerebri: better definition, better treatment.
    Neurology, 2004, Jul-27, Volume: 63, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Astrocyt

2004
Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-01, Volume: 22, Issue:15

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; C

2004
Temozolomide as initial treatment for adults with low-grade oligodendrogliomas or oligoastrocytomas and correlation with chromosome 1p deletions.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2004, Aug-01, Volume: 22, Issue:15

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; C

2004
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study.
    Neuro-oncology, 2005, Volume: 7, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromos

2005
Neoadjuvant temozolomide followed by complete resection of a 1p- and 19q-deleted anaplastic oligoastrocytoma: case study.
    Neuro-oncology, 2005, Volume: 7, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Chromosome Deletion; Chromos

2005
Maintenance of fertility following treatment with temozolomide for a high grade astrocytoma.
    Journal of neuro-oncology, 2005, Volume: 73, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Fertility; Huma

2005
Maintenance of fertility following treatment with temozolomide for a high grade astrocytoma.
    Journal of neuro-oncology, 2005, Volume: 73, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Fertility; Huma

2005
Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy.
    International journal of radiation oncology, biology, physics, 2005, Oct-01, Volume: 63, Issue:2

    Topics: Adult; Aged; alpha-Methyltyrosine; Analysis of Variance; Antineoplastic Agents, Alkylating; Astrocyt

2005
Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy.
    International journal of radiation oncology, biology, physics, 2005, Oct-01, Volume: 63, Issue:2

    Topics: Adult; Aged; alpha-Methyltyrosine; Analysis of Variance; Antineoplastic Agents, Alkylating; Astrocyt

2005
Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin.
    Journal of neuro-oncology, 2005, Volume: 74, Issue:2

    Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Carmustine; Cell Cycle; Cisplatin; Cyclin-Dep

2005
Inactivation of p53 sensitizes astrocytic glioma cells to BCNU and temozolomide, but not cisplatin.
    Journal of neuro-oncology, 2005, Volume: 74, Issue:2

    Topics: Antineoplastic Agents; Astrocytoma; Blotting, Western; Carmustine; Cell Cycle; Cisplatin; Cyclin-Dep

2005
Salvage temozolomide for prior temozolomide responders.
    Cancer, 2005, Dec-01, Volume: 104, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; G

2005
Salvage temozolomide for prior temozolomide responders.
    Cancer, 2005, Dec-01, Volume: 104, Issue:11

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; G

2005
Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years.
    Journal of neuro-oncology, 2006, Volume: 77, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marrow; Brain Neoplasms; Dacarbazine; Drug Over

2006
Higher dosing of temozolomide? Regression of an anaplastic oligoastrocytoma over more than three years.
    Journal of neuro-oncology, 2006, Volume: 77, Issue:2

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Bone Marrow; Brain Neoplasms; Dacarbazine; Drug Over

2006
A congenital brain tumor associated with assisted in vitro fertilization. Case report.
    Journal of neurosurgery, 2005, Volume: 103, Issue:5 Suppl

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Fe

2005
A congenital brain tumor associated with assisted in vitro fertilization. Case report.
    Journal of neurosurgery, 2005, Volume: 103, Issue:5 Suppl

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Dacarbazine; Fe

2005
Radiotherapy plus concomitant and adjuvant temozolomide for leptomeningeal pilomyxoid astrocytoma: a case study.
    Journal of neuro-oncology, 2006, Volume: 80, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Cerebral Ventricle Neoplasms; Chemotherapy, A

2006
Radiotherapy plus concomitant and adjuvant temozolomide for leptomeningeal pilomyxoid astrocytoma: a case study.
    Journal of neuro-oncology, 2006, Volume: 80, Issue:1

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Cerebral Ventricle Neoplasms; Chemotherapy, A

2006
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.
    Neuro-oncology, 2006, Volume: 8, Issue:3

    Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; As

2006
Survival following adjuvant PCV or temozolomide for anaplastic astrocytoma.
    Neuro-oncology, 2006, Volume: 8, Issue:3

    Topics: Adjuvants, Pharmaceutic; Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; As

2006
[Individualized chemotherapy based on drug sensitivity and resistance assay and MGMT protein expression for patients with malignant glioma--analysis of 42 cases].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

2006
[Individualized chemotherapy based on drug sensitivity and resistance assay and MGMT protein expression for patients with malignant glioma--analysis of 42 cases].
    Ai zheng = Aizheng = Chinese journal of cancer, 2006, Volume: 25, Issue:12

    Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Chi

2006
Fatal outcome related to carmustine implants in glioblastoma multiforme.
    Acta neurochirurgica, 2007, Volume: 149, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Chemothera

2007
Fatal outcome related to carmustine implants in glioblastoma multiforme.
    Acta neurochirurgica, 2007, Volume: 149, Issue:3

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Carmustine; Chemothera

2007
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
    Journal of neurosurgery. Spine, 2007, Volume: 6, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Combined Modality Therapy; Dacarbazine; Femal

2007
Expression of O6-methylguanine-deoxyribose nucleic acid methyltransferase and temozolomide response in a patient with a malignant spinal cord astrocytoma. Case report.
    Journal of neurosurgery. Spine, 2007, Volume: 6, Issue:5

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Combined Modality Therapy; Dacarbazine; Femal

2007
Salvage chemotherapy in progressive high-grade astrocytoma.
    Annals of the Academy of Medicine, Singapore, 2007, Volume: 36, Issue:5

    Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; R

2007
Salvage chemotherapy in progressive high-grade astrocytoma.
    Annals of the Academy of Medicine, Singapore, 2007, Volume: 36, Issue:5

    Topics: Adult; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; Glioblastoma; Humans; Male; Middle Aged; R

2007
Temozolomide in pediatric low-grade glioma.
    Pediatric blood & cancer, 2007, Volume: 49, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplati

2007
Temozolomide in pediatric low-grade glioma.
    Pediatric blood & cancer, 2007, Volume: 49, Issue:6

    Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Carboplati

2007
Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2008, Volume: 88, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Com

2008
Comparative evaluation of radiochemotherapy with temozolomide versus standard-of-care postoperative radiation alone in patients with WHO grade III astrocytic tumors.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2008, Volume: 88, Issue:2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Child; Com

2008
Low grade astrocytoma presenting with visual loss.
    Journal of neuro-oncology, 2008, Volume: 89, Issue:1

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Daca

2008
Low grade astrocytoma presenting with visual loss.
    Journal of neuro-oncology, 2008, Volume: 89, Issue:1

    Topics: Adolescent; Antineoplastic Agents, Alkylating; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Daca

2008
From triazines and triazenes to temozolomide.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:7

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Chemistry, Pharmaceutical; Dacarbazine

1993
From triazines and triazenes to temozolomide.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:7

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Chemistry, Pharmaceutical; Dacarbazine

1993
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Daca

1996
O6-benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU.
    British journal of cancer, 1996, Volume: 73, Issue:9

    Topics: Animals; Antineoplastic Agents; Astrocytoma; Body Weight; Carmustine; Cell Division; Cell Line; Daca

1996
Sensitivity of short-term cultures derived from human malignant glioma to the anti-cancer drug temozolomide.
    Anti-cancer drugs, 1999, Volume: 10, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Dose-Response R

1999
Sensitivity of short-term cultures derived from human malignant glioma to the anti-cancer drug temozolomide.
    Anti-cancer drugs, 1999, Volume: 10, Issue:2

    Topics: Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Dose-Response R

1999
Oral temozolomide approved for refractory brain tumor.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Oct-01, Volume: 56, Issue:19

    Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

1999
Oral temozolomide approved for refractory brain tumor.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1999, Oct-01, Volume: 56, Issue:19

    Topics: Administration, Oral; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine;

1999
Temozolomide for refractory anaplastic astrocytoma.
    The Medical letter on drugs and therapeutics, 1999, Dec-17, Volume: 41, Issue:1068

    Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinic

1999
Temozolomide for refractory anaplastic astrocytoma.
    The Medical letter on drugs and therapeutics, 1999, Dec-17, Volume: 41, Issue:1068

    Topics: Administration, Oral; Adult; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Clinic

1999
NICE verdict on Temozolomide: where next?
    British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease-Free Survival;

2002
NICE verdict on Temozolomide: where next?
    British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4

    Topics: Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Disease-Free Survival;

2002
Temozolomide-induced flare in high-grade gliomas: a new clinical entity.
    Internal medicine journal, 2002, Volume: 32, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; G

2002
Temozolomide-induced flare in high-grade gliomas: a new clinical entity.
    Internal medicine journal, 2002, Volume: 32, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents, Alkylating; Astrocytoma; Brain Neoplasms; Dacarbazine; Female; G

2002